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21. 发明授权

US5772629A Localized intravascular delivery of TFPI for inhibition of restenosis in recanalized blood vessels 失效
标题翻译：局部血管内输送TFPI用于抑制再通血管再狭窄
公开(公告)号：US5772629A
公开(公告)日：1998-06-30
申请号：US546873
申请日：1995-10-23
申请人： Aaron V. Kaplan
发明人： Aaron V. Kaplan
IPC分类号： A61F2/82 , A61K31/00 , A61K38/00 , A61K38/57 , A61M25/00 , A61M25/10 , A61M29/02 , A61P9/00 , A61M31/00
CPC分类号： A61M25/104 , A61K38/57 , A61M25/0023 , A61M25/10 , A61M2025/1004 , A61M2025/105 , A61M2025/1072
摘要： Restenosis in recanalized blood vessels is inhibited by delivering tissue factor pathway inhibitor (TFPI) intramurally at a target site within the blood vessel. Usually, TFPI is delivered using a catheter having infusion ports at its distal end. Optionally at the distal end of the catheter is radially expanded to engage the infusion ports directly against the blood vessel wall.
摘要翻译：通过在血管内的靶位点递送组织因子途径抑制剂（TFPI）来抑制再通血管再狭窄。通常，使用在其远端具有输注端口的导管递送TFPI。任选地，在导管的远端处径向扩张以将输注端口直接接合血管壁。

22. 发明授权

US5658248A Double-blind infusion device and method 失效
标题翻译：双盲输液装置及方法
公开(公告)号：US5658248A
公开(公告)日：1997-08-19
申请号：US511567
申请日：1995-08-04
申请人： Enrique J. Klein , Aaron V. Kaplan
发明人： Enrique J. Klein , Aaron V. Kaplan
IPC分类号： A61M5/14 , A61M5/00 , A61M5/168 , A61M39/00 , A61M1/00
CPC分类号： A61M5/00
摘要： Type-A (operational) and type-B (non-operational) syringes (2A, 2B), used for double-blind clinical tests, are constructed so the type-B syringe mimics the operation of the type-A syringe while avoiding the delivery of anything into the patient. Each syringe includes an injector (4), a fluid connector (12) coupling the exit port (10) of the injector to a discharge port (14) to which a catheter or needle cannula is connected, a valve (18) positioned along the fluid connector, and a dumping reservoir (24) mounted to the valve. The type-A valve fluidly couples the exit port to the discharge port in both purging and infusion positions. The type-B valve couples the exit port to the discharge port in the purging position, but couples the exit port to the dumping reservoir in the infusion position. The infusate is directed through the catheter and into the patient when in the infusion position with the type-A valve but is directed into the dumping reservoir with the type-B valve.
摘要翻译：构建用于双盲临床试验的A型（可操作）和B型（非操作型）注射器（2A，2B），因此B型注射器模拟A型注射器的操作，同时避免将任何东西交付给患者。每个注射器包括注射器（4），将注射器的出口（10）连接到导管或针插管所连接的排出口（14）的流体连接器（12），沿着流体连接器和安装到阀的倾倒储存器（24）。 A型阀在清洗和排液位置都将出口流体地连接到排出口。 B型阀将出口连接到排气位置的排出口，但将输出端口连接到倾倒储存器的输液位置。当使用A型阀的输液位置时，输注物通过导管引导进入患者，但是用B型阀引导到倾倒储存器中。

23. 发明授权

US5571086A Method and apparatus for sequentially performing multiple intraluminal procedures 失效
公开(公告)号：US5571086A
公开(公告)日：1996-11-05
申请号：US222143
申请日：1994-04-01
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M29/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： Sleeve catheters having an interactive device near their distal ends are provided for introduction while disposed over conventional interventional and imaging catheters. Exemplary interactive devices on the sleeve catheters include ultrasonic imaging arrays, drug delivery lumens, and the like. The sleeve catheters are most commonly used with angioplasty catheters, stent placement catheters, atherectomy catheters, and the like.

24. 发明授权

US08998927B2 Mechanically registered videoscopic myringotomy/tympanostomy tube placement system 有权
公开(公告)号：US08998927B2
公开(公告)日：2015-04-07
申请号：US12754304
申请日：2010-04-05
申请人： Aaron V. Kaplan , Joseph Tartaglia , Robert Vaughan , Christopher Jones
发明人： Aaron V. Kaplan , Joseph Tartaglia , Robert Vaughan , Christopher Jones
IPC分类号： A61F11/00
CPC分类号： A61F11/002 , A61B90/30 , A61B90/37 , A61F11/004
摘要： Devices, systems, methods, and kits for treating the tissue structures of the ear make use of a guide structure that can mechanically register a treatment probe with a target region of a target tissue, the guide structure being fittingly received in an auditory canal and often comprising a conformable body such as a compressible foam, or the like. The guide structure may include an articulating mechanism for selectively orienting the treatment probe toward the target region of, for example, a tympanic membrane. The guide structure may also support a videoscopic image capture device, illumination transmitting optical fibers, an aiming beam transmitter, and the like. Such structures facilitate myringotomy, tympanostomy tube placement, and the like, under local anesthesia in a doctor's office.

25. 发明授权

US08996133B2 Methods and apparatus for lead placement on a surface of the heart 有权
公开(公告)号：US08996133B2
公开(公告)日：2015-03-31
申请号：US11742165
申请日：2007-04-30
申请人： Aaron V. Kaplan , Kevin F. Hahnen
发明人： Aaron V. Kaplan , Kevin F. Hahnen
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N2001/0578
摘要： The methods and apparatus for lead placement on a surface of the heart are employed using an elongated body having proximal and distal end portions. The body defines a lead receiving passageway extending between a proximal inlet and a distal outlet for receiving a lead therethrough for contact with the heart surface. The elongated body is adapted for insertion between a pericardium and an epicardial surface. At least a portion of the body may have a non-circular cross-sectional shape adapted to retain the body orientation between the pericardium and the epicardial surface.

26. 发明授权

US5609574A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5609574A
公开(公告)日：1997-03-11
申请号：US241428
申请日：1994-05-11
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a first embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. In a second embodiment, the infusion array is a separate component and slidably received over the expansion member, which may be a balloon dilatation catheter. In both embodiments, the infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在第一实施例中，柔性导管主体具有连接到其远端的膨胀构件与膨胀通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输注排列。在第二实施例中，输注阵列是单独的部件，并且可滑动地容纳在膨胀部件上，膨胀部件可以是球囊扩张导管。在两个实施例中，输注阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

27. 发明授权

US5336178A Intravascular catheter with infusion array 失效
标题翻译：输液阵列血管内导管
公开(公告)号：US5336178A
公开(公告)日：1994-08-09
申请号：US47737
申请日：1993-04-15
申请人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
发明人： Aaron V. Kaplan , James R. Kermode , Enrique J. Klein
IPC分类号： A61M25/00 , A61B8/12 , A61F2/00 , A61F2/06 , A61F2/84 , A61M29/02 , A61M37/00 , A61M31/00
CPC分类号： A61M25/104 , A61B8/12 , A61B8/4488 , A61F2/958 , A61M29/02 , A61F2250/0067 , A61M2025/0057 , A61M2025/0063 , A61M2025/09183 , A61M2025/105 , A61M2025/1075 , A61M2025/1079 , A61M2025/1081 , A61M2025/1084 , A61M25/0054 , A61M25/1002 , A61M37/0092
摘要： An intravascular catheter provides means for infusing an agent into a treatment site in a body lumen and means for deploying the infusing means adjacent the treatment site which operate independently of one another. In a preferred embodiment, a flexible catheter body has an expansion member attached to its distal end in communication with an inflation passage, and an infusion array disposed about the expansion member in communication with one or more delivery passages. The infusion array includes a plurality of delivery conduits having laterally oriented orifices. The delivery conduits may be extended radially from the catheter body to contact a treatment site by expanding the expansion member with an inflation fluid. An agent may be introduced into the delivery passages and infused into the treatment site through orifices in the delivery conduits. The expansion member may be expanded for dilatation of the lumen before, during, or after infusion.
摘要翻译：血管内导管提供用于将药剂注入体腔内的治疗部位的装置，以及用于在邻近治疗部位部署相互独立操作的输注装置的装置。在优选实施例中，柔性导管主体具有连接到其远端的膨胀构件，其与充气通道连通，以及设置在与一个或多个输送通道连通的膨胀构件周围的输液阵列。输液阵列包括具有侧向定向孔的多个输送管道。输送管道可以从导管主体径向延伸，以通过用膨胀流体膨胀膨胀构件来接触治疗部位。可以将药剂引入输送通道并通过输送管道中的孔注入治疗部位。膨胀构件可以在输液之前，期间或之后膨胀以扩张内腔。

28. 发明申请

US20120089215A1 METHODS AND APPARATUS FOR LEAD PLACEMENT ON A SURFACE OF THE HEART 审中-公开
标题翻译：在心脏表面上的铅放置的方法和装置
公开(公告)号：US20120089215A1
公开(公告)日：2012-04-12
申请号：US13271908
申请日：2011-10-12
申请人： Aaron V. Kaplan , Kevin F. Hahnen
发明人： Aaron V. Kaplan , Kevin F. Hahnen
IPC分类号： A61N1/375
CPC分类号： A61N1/0587 , A61N2001/0578
摘要： The methods and apparatus for lead placement on a surface of the heart are employed using an elongated body having proximal and distal end portions. The body defines a lead receiving passageway extending between a proximal inlet and a distal outlet for receiving a lead therethrough for contact with the heart surface. The elongated body is adapted for insertion between a pericardium and an epicardial surface. At least a portion of the body may have a non-circular cross-sectional shape adapted to retain the body orientation between the pericardium and the epicardial surface.
摘要翻译：使用具有近端部分和远端部分的细长体使用在心脏表面上的铅放置的方法和装置。主体限定了在近端入口和远端出口之间延伸的引线接收通道，用于接收穿过其中的与心脏表面接触的引线。细长体适于插入在心包和心外膜表面之间。身体的至少一部分可以具有适于在心包和心外膜表面之间保持身体取向的非圆形横截面形状。

29. 发明授权

US07972369B2 Method for delivering a luminal prosthesis 有权
标题翻译：输送管腔假体的方法
公开(公告)号：US07972369B2
公开(公告)日：2011-07-05
申请号：US11781201
申请日：2007-07-20
申请人： Aaron V. Kaplan , Jaime Vargas
发明人： Aaron V. Kaplan , Jaime Vargas
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/856 , A61F2/915 , A61F2/954 , A61F2/958 , A61F2/97 , A61F2002/821 , A61F2002/91508 , A61F2002/91516 , A61F2002/91525 , A61F2002/91533 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2002/9583 , A61F2250/0039 , A61M25/1002
摘要： An embodiment of the invention provides a prosthesis delivery system comprising a delivery catheter having an expandable member and a prosthesis carried over the expandable member. The prosthesis includes a radially expandable scaffold section and at least two anchors extending axially from an end thereof; and means for capturing at least the anchors to prevent the anchors from divaricating from the expandable member as the catheter is advanced through a patient's vasculature.
摘要翻译：本发明的一个实施例提供了一种假体输送系统，其包括具有可扩张构件的输送导管和承载在可膨胀构件上的假体。假体包括径向可扩展的支架部分和从其端部轴向延伸的至少两个锚固件; 以及用于捕获至少锚固件的装置，以防止当导管穿过病人的脉管系统时锚固件从可膨胀构件脱离。

30. 发明授权

US06770080B2 Mechanically registered videoscopic myringotomy/tympanostomy tube placement system 有权
标题翻译：机械注册的视像摄影鼓膜切开术/鼓膜造口管放置系统
公开(公告)号：US06770080B2
公开(公告)日：2004-08-03
申请号：US09843541
申请日：2001-04-26
申请人： Aaron V. Kaplan , Joseph Tartaglia , Robert Vaughan , Christopher Jones
发明人： Aaron V. Kaplan , Joseph Tartaglia , Robert Vaughan , Christopher Jones
IPC分类号： A61F1100
CPC分类号： A61F11/002 , A61B90/30 , A61B90/37 , A61F11/004
摘要： Devices, systems, methods, and kits for treating the tissue structures of the ear make use of a guide structure that can mechanically register a treatment probe with a target region of a target tissue, the guide structure being fittingly received in an auditory canal and often comprising a conformable body such as a compressible foam, or the like. The guide structure may include an articulating mechanism for selectively orienting the treatment probe toward the target region of, for example, a tympanic membrane. The guide structure may also support a videoscopic image capture device, illumination transmitting optical fibers, an aiming beam transmitter, and the like. Such structures facilitate myringotomy, tympanostomy tube placement, and the like, under local anesthesia in a doctor's office.
摘要翻译：用于治疗耳朵的组织结构的装置，系统，方法和试剂盒使用可以将治疗探针机械地对准靶组织的靶区域的引导结构，所述引导结构适合地接收在听道中，并且经常包括适形体，例如可压缩泡沫等。引导结构可以包括用于将治疗探针朝向例如鼓膜的靶区域选择性地定向的关节运动机构。引导结构还可以支持视频图像捕获设备，照明发射光纤，瞄准光束发射器等。在医院的局部麻醉下，这种结构便于鼓膜切开术，鼓膜造口管放置等。

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