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21. 发明申请

US20210300871A1 ARYL-N-ARYL DERIVATIVES FOR TREATING A RNA VIRUS INFECTION 有权
公开(公告)号：US20210300871A1
公开(公告)日：2021-09-30
申请号：US17259483
申请日：2019-07-09
申请人： ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER , INSTITUT CURIE
发明人： Didier SCHERRER , Jamal TAZI , Florence MAHUTEAU-BETZER , Romain NAJMAN , Julien SANTO , Cécile APOLIT
IPC分类号： C07D213/38 , C07D401/12 , C07D241/12 , C07D213/75 , C07D239/42 , C07C233/65 , C07D213/81 , A61P31/12
摘要： A compound: wherein X1 represents an alkenylene group, a —NH—CO— group, a —CO—NH— group, Y1 represents an aryl group selected from pyridyl, pyrazinyl or pyrimidinyl, X2 represents —O—, —CO—NH—, —NH—CO—NH—, —OCH2—, —NH—CO—, a divalent 5-membered heteroaromatic ring comprising 1 to 4 heteroatoms or —SO2—NH—, and Y2 represents a hydrogen atom, a hydroxyl group, a morpholinyl group, a piperidinyl group, optionally substituted by a (C1-C4)alkyl group, a piperazinyl group, optionally substituted by a (C1-C4)alkyl group, or —CR1R2R3 or alternatively X2—Y2 represents —CONRcRd, wherein Rc and Rd form, together with the nitrogen atom a heterocyclic ring, optionally substituted by one or two (C1-C4)alkyl group, by a cyclopentyl group thus forming a spirocyclopentyl, or by a trifluoromethyl group, or any of its pharmaceutically acceptable salt, for use in the treatment and/or prevention of a RNA virus infection caused by a RNA virus belonging to group IV or V of the Baltimore classification.

22. 发明申请

US20210047273A1 USE OF QUINOLINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES 有权
公开(公告)号：US20210047273A1
公开(公告)日：2021-02-18
申请号：US16994954
申请日：2020-08-17
申请人： ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE DE MONTPELLIER
发明人： Didier SCHERRER , Jamal TAZI , Florence MAHUTEAU , Romain NAJMAN
IPC分类号： C07D215/38 , A61K31/47 , A61K31/4709 , A61K31/497 , A61K31/5377 , C12Q1/6883 , G01N33/50 , C07D401/12
摘要： The present disclosure relates to the use of a compound of formula (I) or anyone of its pharmaceutically acceptable salts, in the treatment and/or prevention of an inflammatory disease; wherein: means an aromatic ring wherein V is C or N and when V is N; Q is N or O, provided that R″ does not exist when Q is O; R′ independently represent a hydrogen atom or a group chosen among a (C1-C3)alkyl group, a halogen atom, a hydroxyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C1-C3)fluoroalkyl group, a —O—P(═O)—(OR3)(OR4) group, a (C1-C4)alkoxy group and a —CN group, and can further be a group chosen among:

23. 发明申请

US20180222888A1 COMPOUNDS USEFUL FOR TREATING CANCER 审中-公开
公开(公告)号：US20180222888A1
公开(公告)日：2018-08-09
申请号：US15946120
申请日：2018-04-05
申请人： ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE DE MONTPELLIER
发明人： Pierre ROUX , Florence MAHUTEAU , Romain NAJMAN , Gilles GADEA , Jamal TAZI , Didier SCHERRER , Carsten BROCK , Nathalie CAHUZAC
IPC分类号： C07D401/14 , C07D239/42 , C07D213/75 , C07D401/12
摘要： The present invention relates to a compound of formula (I): wherein A and A′ independently represent a phenylene group or a pyridylene group; R2 is a hydrogen atom or a (C1-C4)alkyl group; R3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; R4 is a carbonyl group or a sulfonyl group; and R5 is a —NH—(CH2)a—NR6R7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, R6 and R7 representing independently a (C1-C4)alkyl group, or R6 and R7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.

24. 发明申请

US20150315173A1 NEW ANTI-INVASIVE COMPOUNDS 有权
标题翻译：新的防静电化合物
公开(公告)号：US20150315173A1
公开(公告)日：2015-11-05
申请号：US14432328
申请日：2013-09-30
申请人： ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE DE MONTPELLIER
发明人： Pierre ROUX , Florence MAHUTEAU , Romain NAJMAN , Gilles GADEA , Jamal TAZI , Didier SCHERRER , Carsten BROCK , Nathalie CAHUZAC
IPC分类号： C07D401/14 , C07D239/42 , C07D401/12 , C07D213/75
CPC分类号： C07D401/14 , C07D213/75 , C07D239/42 , C07D401/12
摘要： The present invention relates to a compound of formula (I): wherein A and A′ independently represent a phenylene group or a pyridylene group; R2 is a hydrogen atom or a (C1-C4)alkyl group; R3 is a 2-pyridyl group, 3-pyridyl group, a 4-pyridyl group, a 2-pyrimidinyl group, a 4-pyrimidinyl group or a 5-pyrimidinyl group; R4 is a carbonyl group or a sulfonyl group; and R5 is a —NH—(CH2)a—NR6R7 group or a 4-methylpiperazinyl group, with a being an integer from 1 to 4, R6 and R7 representing independently a (C1-C4)alkyl group, or R6 and R7 together with the nitrogen atom to which they are linked forming a heterocycle group which is chosen among a 4-methylpiperazinyl group, a morpholino group, a pyrrolidinyl group and a piperidino group; or any one of its pharmaceutically acceptable salt.
摘要翻译：本发明涉及式（I）化合物：其中A和A'独立地表示亚苯基或亚吡啶基; R2是氢原子或（C1-C4）烷基; R3是2-吡啶基，3-吡啶基，4-吡啶基，2-嘧啶基，4-嘧啶基或5-嘧啶基; R4是羰基或磺酰基; 并且R 5为-NH-（CH 2）a -NR 6 R 7基或4-甲基哌嗪基，其为1至4的整数，R 6和R 7独立地表示（C 1 -C 4）烷基，或者R 6和R 7一起与它们相连的氮原子形成选自4-甲基哌嗪基，吗啉基，吡咯烷基和哌啶子基的杂环基; 或其药学上可接受的盐中的任何一种。

25. 发明申请

US20150361491A1 miRNA-124 AS A BIOMARKER 审中-公开
标题翻译： miRNA-124作为BIOMARKER
公开(公告)号：US20150361491A1
公开(公告)日：2015-12-17
申请号：US14761674
申请日：2014-01-17
申请人： ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE MONTPELLIER
发明人： Jamal TAZI , Didier SCHERRER , Aude GARCEL , Noëlie CAMPOS , Romain NAJMAN , Florence MAHUTEAU-BETZER
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6876 , C12Q1/70 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： A use of at least one miRNA, said at least one miRNA being miR-124, as a biomarker, in particular of a viral infection, or of an efficacy of a therapeutic treatment of said viral infection.
摘要翻译：使用至少一种miRNA，所述至少一种miRNA是miR-124，作为生物标志物，特别是病毒感染，或治疗性治疗所述病毒感染的功效。

26. 发明申请

US20220145406A1 BIOMARKERS, AND USES IN TREATMENT OF VIRAL INFECTIONS, INFLAMMATIONS, OR CANCER 有权
公开(公告)号：US20220145406A1
公开(公告)日：2022-05-12
申请号：US17416988
申请日：2019-12-19
申请人： ABIVAX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITÉ DE MONTPELLIER
发明人： Philippe POULETTY , Hartmut EHRLICH , Didier SCHERRER , Jamal TAZI , Laurent MANCHON
IPC分类号： C12Q1/70 , A61K31/706 , C12N15/113
摘要： Biomarkers and uses thereof in monitoring, assessing, and/or treatment of viral infections, or inflammatory diseases, disorders, or conditions, or cancer.

27. 发明申请

US20140288120A1 COMPOUNDS USEFUL FOR TREATING AIDS 有权
标题翻译：用于治疗艾滋病的化合物
公开(公告)号：US20140288120A1
公开(公告)日：2014-09-25
申请号：US14256334
申请日：2014-04-18
申请人： SOCIETE SPLICOS , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE MONTPELLIER 2
发明人： Jamal TAZI , Florence MAHUTEAU , Romain NAJMAN , Didier SCHERRER , Noelie CAMPOS , Aude GARCEL
IPC分类号： C07D401/12
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/4985 , C07D213/74 , C07D215/38 , C07D215/42 , C07D215/46 , C07D241/44 , C07D401/12
摘要： A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R″ is a hydrogen atom or a (C1-C4)alkyl group; n′ is 1 or 2; n is 1, 2, or 3; R independently represents a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —NR1R2 group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a (C1-C3)fluoroalkoxy, and a (C1-C4)alkoxy group; R′ is a hydrogen atom, a halogen atom, or a group selected from a (C1-C3)alkyl group, a —COOR1 group, a —NO2 group, a —NR1R2 group, a (C1-C4)alkoxy group, and a CN group; R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group; with the proviso that when R and R′ are not simultaneously a hydrogen atom: when n is 1, R is not a methyl group in an ortho or para position with respect to N, when R′ is a hydrogen atom, R is not a bromine atom or a chlorine atom, and when R is a hydrogen atom, R is not a methyl or ethyl group, a —COOH group, a —COOC2H5 group, or a bromine atom that is in an ortho position of the bond linked to NR″.
摘要翻译：具有下式的化合物或其药学上可接受的盐：其中：R“是氢原子或（C 1 -C 4）烷基; n'为1或2; n为1,2或3; R独立地表示氢原子，卤素原子或选自（C1-C3）烷基，-CN基，羟基，-NR1R2基，-COOR1基，（C1-C3）氟烷基，-NO 2基，（C1-C3）氟烷氧基和（C1-C4）烷氧基; R'是氢原子，卤素原子或选自（C1-C3）烷基，-COOR1基，-NO2基，-NR1R2基，（C1-C4）烷氧基的基团和 CN组; R1和R2是氢原子或（C1-C3）烷基; 条件是当R和R'不同时为氢原子时：当n为1时，当R'为氢原子时，R不为相对于N的邻位或对位的甲基，R不为溴原子或氯原子，当R为氢原子时，R不是甲基或乙基，-COOH基团，-COOC2H5基团或与NR键合的邻位的溴原子 “。

28. 发明申请

US20150299129A1 COMPOUNDS FOR TREATING CANCER 有权
标题翻译：化合物治疗癌症
公开(公告)号：US20150299129A1
公开(公告)日：2015-10-22
申请号：US14789149
申请日：2015-07-01
申请人： ABIVAX , CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE MONTPELLIER 2
发明人： Pierre ROUX , Florence MAHUTEAU , Romain NAJMAN , Jamal TAZI , Gilles GADEA , Didier SCHERRER , Carsten BROCK , Nathalie CAHUZAC
IPC分类号： C07D215/42 , C07D215/38 , C07D215/46
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/4985 , C07D213/74 , C07D215/38 , C07D215/42 , C07D215/46 , C07D241/44 , C07D401/12
摘要： A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group.
摘要翻译：一种预防，抑制或治疗癌症的方法，包括使细胞与至少一种式（Ia）化合物或其药学上可接受的盐接触：其中：R独立地表示氢原子，卤素原子，（C1-C3 ）烷基，-CN基，羟基，-COOR1基，（C1-C3）氟代烷基，-NO2基，-NR1R2基或（C1-C3）烷氧基; R'是氢原子，卤素原子，（C1-C3）烷基，-NO2基，（C1-C3）烷氧基或-NR1R2基团; 并且R 1和R 2是氢原子或（C 1 -C 3）烷基。

29. 发明申请

US20150307478A1 COMPOUNDS USEFUL FOR TREATING AIDS 有权
标题翻译：用于治疗艾滋病的化合物
公开(公告)号：US20150307478A1
公开(公告)日：2015-10-29
申请号：US14789250
申请日：2015-07-01
申请人： ABIVAX , CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE , INSTITUT CURIE , UNIVERSITE MONTPELLIER 2
发明人： Jamal TAZI , Florence MAHUTEAU , Romain NAJMAN , Didier SCHERRER , Noelie CAMPOS , Aude GARCEL
IPC分类号： C07D403/12 , C07D215/38 , C07D241/44 , C07D401/12
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/4985 , C07D213/74 , C07D215/38 , C07D215/42 , C07D215/46 , C07D241/44 , C07D401/12
摘要： A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NR1R2 group, a (C1-C3)fluoroalkoxy group, a —NO2 group, a phenoxy group, or a (C1-C4)alkoxy group, R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group, R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, or a (C1-C4)alkoxy group, R″ is a hydrogen atom or a (C1-C4)alkyl group, n is 1, 2, or 3, and n′ is 1 or 2.
摘要翻译：具有下式的化合物或其药学上可接受的盐：其中：R独立地表示氢原子，卤素原子，（C1-C3）烷基，-NR1R2基，（C1-C3）氟烷氧基， -NO 2基，苯氧基或（C1-C4）烷氧基，R1和R2独立地为氢原子或（C1-C3）烷基，R'为氢原子，卤素原子，（C1 -C 3）烷基或（C 1 -C 4）烷氧基，R“为氢原子或（C 1 -C 4）烷基，n为1,2或3，n'为1或2。

30. 发明申请

US20140080831A1 COMPOUNDS USEFUL FOR TREATING CANCER 有权
标题翻译：化合物可用于治疗癌症
公开(公告)号：US20140080831A1
公开(公告)日：2014-03-20
申请号：US14087762
申请日：2013-11-22
申请人： CENTRE NATIONALE DE RECHERCHE SCIENTIFIQUE , UNIVERSITE MONTPELLIER 2 , SOCIETE SPLICOS , INSTITUT CURIE
发明人： Pierre ROUX , Florence MAHUTEAU , Romain NAJMAN , Jamal TAZI , Gilles GADEA , Didier SCHERRER , Carsten BROCK , Nathalie CAHUZAC
IPC分类号： C07D401/12 , C07D215/46 , C07D403/12 , C07D215/42 , C07D215/38 , C07D241/44
CPC分类号： C07D403/12 , A61K31/4709 , A61K31/4985 , C07D213/74 , C07D215/38 , C07D215/42 , C07D215/46 , C07D241/44 , C07D401/12
摘要： A method of preventing, inhibiting, or treating cancer that includes contacting a cell with at least one compound of formula (Ia) or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —CN group, a hydroxyl group, a —COOR1 group, a (C1-C3)fluoroalkyl group, a —NO2 group, a —NR1R2 group, or a (C1-C3)alkoxy group; R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NO2 group, a (C1-C3)alkoxy group, or a —NR1R2 group; and R1 and R2 are a hydrogen atom or a (C1-C3)alkyl group.
摘要翻译：一种预防，抑制或治疗癌症的方法，包括使细胞与至少一种式（Ia）化合物或其药学上可接受的盐接触：其中：R独立地表示氢原子，卤素原子，（C1-C3 ）烷基，-CN基，羟基，-COOR1基，（C1-C3）氟代烷基，-NO2基，-NR1R2基或（C1-C3）烷氧基; R'是氢原子，卤素原子，（C1-C3）烷基，-NO2基，（C1-C3）烷氧基或-NR1R2基团; 并且R 1和R 2是氢原子或（C 1 -C 3）烷基。

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