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21. 发明授权

US09145453B2 Orally bioavailable lipid-based constructs 有权
标题翻译：口服生物可利用的基于脂质的构建体
公开(公告)号：US09145453B2
公开(公告)日：2015-09-29
申请号：US12732952
申请日：2010-03-26
申请人： W. Blair Geho , John R. Lau
发明人： W. Blair Geho , John R. Lau
IPC分类号： A61K9/127 , A61K38/28 , C07K16/00 , A23L1/30 , A23L1/302 , A23L1/305 , A61K31/198 , A61K31/4045 , A61K31/4188 , A61K38/39 , A61K47/48 , A61K9/48 , A61K39/00
CPC分类号： C07K16/00 , A23L33/10 , A23L33/15 , A23L33/17 , A61K9/1272 , A61K9/4858 , A61K31/198 , A61K31/4045 , A61K31/4188 , A61K38/39 , A61K47/544 , A61K2039/505 , A61K2039/542 , A61K2300/00
摘要： The present invention is embodied by a composition capable inducing weight loss in a patient in need thereof.
摘要翻译：本发明通过能够在有需要的患者中引起体重减轻的组合物来实现。

22. 发明授权

US08962015B2 Orally bioavailable lipid-based constructs 有权
标题翻译：口服生物可利用的基于脂质的构建体
公开(公告)号：US08962015B2
公开(公告)日：2015-02-24
申请号：US11904937
申请日：2007-09-28
申请人： John R. Lau , W. Blair Geho
发明人： John R. Lau , W. Blair Geho
IPC分类号： A61K9/127 , A61K38/28 , A61P3/00
CPC分类号： A61K9/127 , A61K9/1277 , A61K31/4045 , A61K38/21 , A61K38/23 , A61K38/28 , A61K47/24
摘要： The present invention is embodied by a composition capable of chaperoning a typically non-orally available therapeutic or diagnostic agent through the environment of the digestive tract such that the therapeutic or diagnostic agent is bioavailable. The composition may or may not be targeted to specific cellular receptors, such as hepatocytes. Therapeutic agents include, but are not limited to, insulin, calcitonin, serotonin, and other proteins. Targeting is accomplished with biotin or metal based targeting agents.
摘要翻译：本发明通过能够通过消化道环境伴随通常非口服的治疗或诊断剂使得治疗或诊断剂具有生物可利用性的组合物实现。组合物可以或不可以靶向特定的细胞受体，例如肝细胞。治疗剂包括但不限于胰岛素，降钙素，5-羟色胺和其它蛋白质。用生物素或金属靶向剂完成靶向。

23. 发明申请

US20110135727A1 Hepatocyte Delivery Vehicle for Delivery of a Combination of Recombinant Human Regular Insulin and Recombinant Human Insulin Isophane to a Mammal 有权
标题翻译：用于将重组人正常胰岛素和重组人胰岛素分子联合用于哺乳动物的肝细胞递送载体
公开(公告)号：US20110135727A1
公开(公告)日：2011-06-09
申请号：US12953013
申请日：2010-11-23
申请人： John R. Lau , W. Blair Geho
发明人： John R. Lau , W. Blair Geho
IPC分类号： A61K38/28 , A61K9/10 , A61P3/08 , A61P3/10
CPC分类号： A61K49/1812 , A61K9/1271
摘要： The instant invention is drawn to a hepatocyte targeted composition comprising a mixture of free recombinant human insulin isophane and free Recombinant human regular insulin insulin and a mixture of recombinant human insulin isophane and Recombinant human regular insulin insulin associated with a water insoluble target molecule complex, wherein the complex comprises multiple linked individual units and a supra-molecular lipid construct matrix. Recombinant human insulin isophane and Recombinant human regular insulin insulin are present within the complex in at least one form wherein the recombinant human insulin isophane and Recombinant human regular insulin insulin have regions of positive charge which interacts with a negative charge on the complex. The invention also includes methods for the manufacture of the composition and methods of managing blood glucose levels in individuals with Type I and Type II diabetes.
摘要翻译：本发明涉及一种肝细胞靶向组合物，其包含游离重组人胰岛素异
环烷和游离的重组人正常胰岛素胰岛素的混合物，以及与水不溶性靶分子复合体缔合的重组人胰岛素异
构体和重组人正常胰岛素胰岛素的混合物，其中复合物包含多个连接的单个单元和超分子脂质构建体基质。重组人胰岛素异环素和重组人正常胰岛素胰岛素以至少一种形式存在于复合物内，其中重组人胰岛素异环烷和重组人正常胰岛素胰岛素具有与复合物上的负电荷相互作用的正电荷区域。本发明还包括用于制备I型和II型糖尿病个体的血糖水平组合物和方法的方法。

24. 发明申请

US20110135725A1 Lipid Construct for Delivery of Insulin to a Mammal 审中-公开
标题翻译：用于将哺乳动物输送胰岛素的脂质构建体
公开(公告)号：US20110135725A1
公开(公告)日：2011-06-09
申请号：US11920905
申请日：2006-05-16
申请人： John R. Lau , W. Blair Geho
发明人： John R. Lau , W. Blair Geho
IPC分类号： A61K38/28 , A61K47/38 , A61K9/00 , A61K47/28 , A61P3/10
CPC分类号： A61K9/1271 , A61K9/1272 , A61K38/28 , A61K47/14 , A61K47/24 , A61K47/28
摘要： The instant invention is drawn to a hepatocyte targeted composition comprising insulin associated with a lipid construct comprising an amphipathic lipid and an extended amphipathic lipid that targets the construct to a receptor displayed by an hepatocyte. The composition can comprise a mixture of free insulin and insulin associated with the complex. The composition can be modified to protect insulin and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading insulin into the composition and recycling various components of the composition. Methods of treating individuals inflicted with diabetes.
摘要翻译：本发明涉及一种肝细胞靶向组合物，其包含与脂质构建体相关的胰岛素，所述脂质构建体包含两亲性脂质和将构建体靶向由肝细胞显示的受体的扩展两亲性脂质。组合物可以包含与复合物相关的游离胰岛素和胰岛素的混合物。可以修饰组合物以保护胰岛素和复合物免于降解。本发明还包括用于制备组合物并将胰岛素装载到组合物中并回收组合物的各种组分的方法。治疗糖尿病患者的方法

25. 发明申请

US20100310599A1 Orally Bioavailable Lipid-Based Constructs 有权
公开(公告)号：US20100310599A1
公开(公告)日：2010-12-09
申请号：US12816009
申请日：2010-06-15
申请人： W. Blair GEHO , John R. LAU
发明人： W. Blair GEHO , John R. LAU
IPC分类号： A61K31/736 , A61K36/82 , A61K31/337 , A61K31/137 , A61K31/5375 , A61K31/555 , A61K31/201 , A61K36/24 , A61K31/35 , A61K31/423 , A61K31/485 , A61K31/343 , A61K31/496 , A61P3/04 , A61P3/00 , A23L2/38 , A23L1/30
CPC分类号： A61K47/28 , A23L33/10 , A23V2002/00 , A61K9/127 , A61K9/4858 , A61K31/198 , A61K31/4045 , A61K31/4188 , A61K47/24 , A61K47/544 , A61K47/557 , A61K2039/505 , A61K2039/542 , C07K16/00 , A23V2200/332 , A23V2250/72 , A23V2250/5432 , A23V2200/3262
摘要： The present invention is embodied by a composition capable inducing weight loss in a patient in need thereof.

26. 发明申请

US20100209492A1 Targeted Liposomal Drug Delivery System 有权
标题翻译：靶向脂质体药物递送系统
公开(公告)号：US20100209492A1
公开(公告)日：2010-08-19
申请号：US12687843
申请日：2010-01-14
申请人： John R. Lau , W. Blair Geho , George H. Snedeker
发明人： John R. Lau , W. Blair Geho , George H. Snedeker
IPC分类号： A61K9/127 , A61P43/00
CPC分类号： A61K9/1271 , A61K38/28
摘要： A metal targeting complex which associates with a charged liposomal structure is provided. The metal targeting complex provides the targetability of the liposomal construct to the desired receptor sites of a warm-blooded host for therapy or diagnostic use.
摘要翻译：提供了与带电脂质体结构相关联的金属靶向复合物。金属靶向复合物将脂质体构建体的靶向性提供给用于治疗或诊断用途的温血动物宿主的所需受体位点。

27. 发明申请

US20100129428A1 SUPRA MOLECULAR CONSTRUCT FOR DELIVERY OF INTERFERON TO A MAMMAL 审中-公开
标题翻译：用于将干扰物递送给妈妈的SUPRA分子结构
公开(公告)号：US20100129428A1
公开(公告)日：2010-05-27
申请号：US11920891
申请日：2006-05-16
申请人： John R. Lau , W. Blair Geho
发明人： John R. Lau , W. Blair Geho
IPC分类号： A61K9/127 , A61K38/21 , A61P31/12
CPC分类号： A61K38/21 , A61K9/0019 , A61K9/08 , A61K9/127 , A61K38/212 , A61K38/215 , A61K38/217 , Y02A50/463
摘要： The instant invention is drawn to a hepatocyte targeted composition comprising interferon associated with a lipid construct comprising amphipathic lipid molecules and receptor binding molecule. The composition can comprise a mixture of free interferon and interferon associated with the complex. The composition can be modified to protect interferon and the complex from degradation. The invention also includes methods for the manufacture of the composition and loading interferon into the composition and recycling various components of the composition and methods of treating individuals infected with the hepatitis C and other hepatitis viruses.
摘要翻译：本发明涉及包含与包含两亲性脂质分子和受体结合分子的脂质构建体相关的干扰素的肝细胞靶向组合物。组合物可以包含与复合物相关的游离干扰素和干扰素的混合物。可以修饰组合物以保护干扰素和复合物免于降解。本发明还包括制备组合物并将干扰素加载到组合物中并回收组合物的各种组分的方法以及治疗感染丙型肝炎和其他肝炎病毒的个体的方法。

28. 发明授权

US5436010A Hair penetrant and carrier 失效
标题翻译：头发渗透剂和载体
公开(公告)号：US5436010A
公开(公告)日：1995-07-25
申请号：US99346
申请日：1993-07-30
申请人： John R. Lau , W. Blair Geho , Darryl H. Woods
发明人： John R. Lau , W. Blair Geho , Darryl H. Woods
IPC分类号： A61K8/14 , A61K8/34 , A61K8/55 , A61K9/127 , A61Q5/00
CPC分类号： A61Q5/00 , A61K8/14 , A61K8/345 , A61K8/553 , A61K9/127 , Y10T428/2984
摘要： This invention discloses the phenomenon of penetrating the hair shaft with a hydroxysphere and glycerin carrier system ("HS-GL"), manufactured using materials that are Generally Regarded As Safe ("GRAS"). The penetration of the hair shaft by the HS-GL carrier system provides a means of transporting materials such as hair care agents, moisturizers, coloring agents, therapeutics, hair setting agents, and agents used for hair care cosmetic applications, through the cuticle and the cortex to the medulla region in the center of the hair shaft. The resulting benefits that can be achieved using this HS-GL carrier system alone, are greater hair manageability, greater ease of combing, higher sheen, better hair set, longer-lasting hair curl, and a restoration of softness in dry hair and also in hair which is brittle and damaged by split ends. Penetration of the hair shaft by the HS-GL carrier system is also reversible with water.
摘要翻译：本发明公开了使用通常被视为安全（“GRAS”）的材料制造的用羟基球和甘油载体系统（“HS-GL”）渗透毛干的现象。通过HS-GL载体系统对毛干的穿透提供了通过角质层和头发护理剂，保湿剂，着色剂，治疗剂，头发定型剂和用于护发化妆品应用的试剂的材料的输送方法，皮质到头发中心的髓质区域。可以使用这种HS-GL载体系统单独实现的所得益处是更大的头发可管理性，更容易梳理，更高的光泽，更好的头发套，更持久的头发卷曲以及干燥头发柔软的恢复，以及头发脆弱，被分叉破坏。通过HS-GL载体系统渗透毛干也可与水反转。

29. 发明授权

US4863896A Diabetic control by combined insulin forms 失效
标题翻译：糖尿病控制联合胰岛素形式
公开(公告)号：US4863896A
公开(公告)日：1989-09-05
申请号：US143180
申请日：1988-01-13
申请人： W. Blair Geho , John R. Lau
发明人： W. Blair Geho , John R. Lau
IPC分类号： A61K8/14 , A61K9/127 , A61K38/28 , A61K47/48 , A61Q11/00
CPC分类号： A61K8/14 , A61K38/28 , A61K47/48815 , A61K9/127 , A61K9/1271 , A61Q11/00
摘要： Peripherally administered insulin fails to provide liver hormone function. Hepatocyte directed vesicles with encapsulated insulin will restore liver function, but there is no non-targeted insulin to bypass the liver for peripheral use, as in natural, healthy body function.Whenever a prescribed dosage of insulin is divided between free and encapsulated hepatocyte targeted forms, a very small fraction of the dose in encapsulated form is sufficient to elicit full liver function, and non-targeted insulin supplies the needs of the body muscle and tissue.
摘要翻译：外周施用的胰岛素不能提供肝激素功能。具有包封的胰岛素的肝细胞定向囊泡将恢复肝功能，但是没有非靶向胰岛素绕过肝脏进行外周使用，如在天然，健康的身体功能中。每当规定剂量的胰岛素在游离和封装的肝细胞靶向形式之间分配时，封装形式的剂量的非常小部分足以引起完全的肝功能，并且非靶向胰岛素供应身体肌肉和组织的需要。

30. 发明授权

US4705804A Diarrheal antitoxin 失效
标题翻译：腹泻抗毒素
公开(公告)号：US4705804A
公开(公告)日：1987-11-10
申请号：US730830
申请日：1985-05-06
申请人： W. Blair Geho , John R. Lau , Joseph Jacob
发明人： W. Blair Geho , John R. Lau , Joseph Jacob
IPC分类号： A61K9/127 , A61K9/42 , A61K31/375 , A61K31/34 , A61K9/70
CPC分类号： A61K9/127 , A61K31/375 , Y10S514/867
摘要： This disclosure teaches a method of inactivating bacterial toxins, such as produced by Vibrio cholerae and Escherichia coli (hereinafter V. cholerae and E. coli) that are responsible for diarrhea in warm-blooded animals, comprising the placing of an effective dosage of ascorbic acid salts thereof, or derivatives such as the ester ascorbyl palmitate in the intestinal tract.Definition: Ascorbic acid, salts thereof, and derivatives thereof such as ascorbyl palmetate have been identified as suitable detoxifying material according to this invention. For the sake brevity, the term "ascorbic acid" hereinafter shall include the salts and esters.Diarrhea as used herein will include other toxins effecting the lower duodenum and intestines.
摘要翻译：本公开教导了灭活霍乱弧菌和大肠杆菌（以下称为霍乱弧菌和大肠杆菌）的细菌毒素的方法，所述细菌毒素是造成温血动物腹泻的原因，包括将有效剂量的抗坏血酸其盐或衍生物，例如肠道中的抗坏血酸棕榈酸酯。定义：根据本发明，抗坏血酸，其盐及其衍生物如抗坏血酸棕榈酸酯已被鉴定为合适的解毒材料。为了简洁起见，以下术语“抗坏血酸”应包括盐和酯。本文所用的腹泻将包括影响下十二指肠和肠道的其他毒素。

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