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21. 发明授权

US10538492B2 Quinolinone or quinazolinone comprising antibiofilm compositions, compounds and methods and uses relating thereto 有权
公开(公告)号：US10538492B2
公开(公告)日：2020-01-21
申请号：US15745632
申请日：2016-08-01
申请人： University College Cork—National University of Ireland
发明人： Fergal O'Gara , Jerry F. Reen , Gerard McGlacken
IPC分类号： C07D215/233 , C07C215/38 , C07D239/91 , A61P31/00
摘要： An antibiofilm composition comprising a compound of formula (A1), (A2) or (A3): wherein each of R1, R2, R3, R4, R5, R6 and R7 is independently selected from hydrogen, alkyl, alkenyl, aryl, halo, alkoxy, hydroxyl, amino, nitro, sulfoxy, thiol, carboxy, alkyl carboxy and amido; and X may be O or S, wherein the composition does not comprise a compound of formula (B1) or (B2):

22. 发明授权

US10356392B2 Coded access optical sensor 有权
公开(公告)号：US10356392B2
公开(公告)日：2019-07-16
申请号：US15163381
申请日：2016-05-24
申请人： University College Cork—National University of Ireland, Cork
发明人： Nabeel Agha Riza
IPC分类号： H04N13/25 , H04N13/236 , G01S17/89 , G01B11/22 , H04N5/232 , G02B26/08 , H04N13/211 , H04N13/254 , H04N5/225 , H04N13/239 , H04N5/235
摘要： A method for performing high dynamic range optical image detection of a scene. The method comprises imaging incident light from a scene onto an object plane of an Optical Array Device, the OAD operating in time modulation mode; determining the locations of those pixels in the object plane of a first light level; detecting the optical irradiance values of those pixels of the first light level to produce a first detected image; detecting the optical irradiance values of those pixels of a second light level to produce a second detected image; and generating a high dynamic range optical irradiance map of the scene by combining the first detected image and the second detected image into a single image.

23. 发明授权

US10071244B2 Thoracoscopic electroporation device with a suction head and with needle electrodes 有权
公开(公告)号：US10071244B2
公开(公告)日：2018-09-11
申请号：US14652740
申请日：2013-12-19
申请人： UNIVERSITY COLLEGE CORK—NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Declan Soden , John Hinchion
IPC分类号： A61N1/32 , A61N1/05 , A61B17/00 , A61B18/14 , A61B17/30 , A61B18/00
CPC分类号： A61N1/325 , A61B17/00234 , A61B18/1482 , A61B2017/00292 , A61B2017/00809 , A61B2017/00867 , A61B2017/308 , A61B2018/00291 , A61B2018/00541 , A61B2018/00613 , A61B2018/143 , A61B2018/1475 , A61N1/0502 , A61N1/327
摘要： A thoracoscopic electroporation device for carrying out electroporation on tissue includes a suction head and a plurality of needle electrodes. The needle electrodes include a central needle providing a first electrode and a plurality of second needles which are spaced-apart around the periphery of the suction head. The electrodes are movable from a retracted configuration to a deployed configuration and in the deployed configuration the needles extend from the suction head. The suction head has a retracted delivery configuration and an expanded deployed configuration. The suction head includes a suitable flexible material for biasing the suction head into the expanded deployed configuration. The suction head has channels for the needles and the needles are movable through the channels from the retracted to the deployed configuration. In the deployed configuration, the central first needle extends beyond the peripheral needles.

24. 发明申请

US20170281830A1 IGF-I FOR MYOCARDIAL REPAIR 审中-公开
公开(公告)号：US20170281830A1
公开(公告)日：2017-10-05
申请号：US15498860
申请日：2017-04-27
申请人： UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Noel Caplice
IPC分类号： A61L29/04 , A61L29/16
CPC分类号： A61L29/048 , A61L29/16 , A61L2300/414 , A61L2300/602
摘要： Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-I directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.

25. 发明申请

US20160348175A1 A METHOD OF IDENTIFYING A NEONATE AT RISK OF HAVING OR DEVELOPING HYPOXIC-ISCHAEMIC ENCEPHALOPATHY (HIE) 审中-公开
标题翻译：鉴别患有或发展为高血压性心律失常（HIE）的风险的新生儿的方法
公开(公告)号：US20160348175A1
公开(公告)日：2016-12-01
申请号：US15112036
申请日：2015-01-16
申请人： UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Deirdre Murray , Ann Marie Looney , Geraldine Boylan , John Cryan
IPC分类号： C12Q1/68 , A61F7/00
CPC分类号： C12Q1/6883 , A61F7/00 , C12Q2600/178
摘要： A method for screening a distressed neonate for risk of having or developing HIE comprises the steps of assaying a biological sample obtained from the distressed neonate, the mother of the neonate, or from the umbilical cord or placenta, for an abundance of miR-374a in the sample, and comparing the abundance of miR-374a in the sample with a reference abundance of miR-374a, wherein a reduced abundance of miR-374a in the sample compared with the reference abundance of miR-374a is indicative of the distressed neonate being at risk of having or developing HIE. Risk of severe HIE can be determined by assaying a biological sample from the distressed neonate identified as being at risk of HIE for an abundance of a plurality of metabolites including succinate, glycerol, acetone and 3-hydroxybutyrate, providing the sum of glycerol and succinate abundance and the sum of acetone and 3-hydroxybutyrate; and correlating the sums with risk of severe HIE.
摘要翻译：用于筛选患有或发展HIE风险的不良新生儿的方法包括以下步骤：测定从苦闷的新生儿，新生儿的母亲或从脐带或胎盘获得的生物样品，以获得丰富的miR-374a 样品，并将样品中miR-374a的丰度与miR-374a的参考丰度进行比较，其中与miR-374a的参考丰度相比，样品中miR-374a的丰度降低，表示不良新生儿为有发生或发展HIE的风险。严重HIE的风险可以通过测定来自被认定为具有HIE风险的危重新生儿的生物样品来确定大量多种代谢物，包括琥珀酸盐，甘油，丙酮和3-羟基丁酸盐，提供甘油和琥珀酸盐丰度的总和丙酮和3-羟基丁酸的总和; 并将这些总和与严重HIE的风险相关联。

26. 发明申请

US20160240381A1 PROCESS FOR MOLECULAR LAYER DOPING OF GERMANIUM SUBSTRATES 审中-公开
标题翻译：锗基体的分子层析方法
公开(公告)号：US20160240381A1
公开(公告)日：2016-08-18
申请号：US15043360
申请日：2016-02-12
申请人： University College Cork, National University of Ireland, Cork
发明人： Brenda Long , Justin Holmes , Ray Duffy
IPC分类号： H01L21/228 , H01L29/36 , H01L21/268 , H01L29/167 , H01L21/02 , H01L21/324
CPC分类号： H01L29/36 , H01L21/02052 , H01L21/02057 , H01L21/2254 , H01L21/3081 , H01L29/0673 , H01L29/16 , H01L29/167 , H01L29/66803
摘要： A method of molecular layer doping of a germanium substrate comprises the steps of cleaning a surface of the germanium substrate to remove oxides, reacting the cleaned surface with a dopant solution comprising dopant material and a suitable solvent for the dopant at low temperature for a suitable period of time while irradiating the substrate with UV light, and thermal annealing of the germanium substrate.
摘要翻译：锗基底的分子层掺杂的方法包括以下步骤：清洁锗衬底的表面以去除氧化物，使清洁后的表面与掺杂剂材料和掺杂剂的合适溶剂在低温下反应合适的时间的时间，同时用UV光照射基板，以及锗基板的热退火。

27. 发明申请

US20150342590A1 INFLATABLE LAPAROSCOPIC RETRACTOR FOR ATRAUMATIC RETRACTION IN ABDOMINAL SURGERY 审中-公开
标题翻译：腹腔镜手术中可逆性腹腔镜放大器
公开(公告)号：US20150342590A1
公开(公告)日：2015-12-03
申请号：US14654508
申请日：2013-12-20
申请人： UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Padraig Cantillon-Murphy , Conor O'Shea , Michael O'Riordain , Conor O'Donoghue , Grace Burke , Daniel Cummins , Richard Finn
IPC分类号： A61B17/02
CPC分类号： A61B17/0218 , A61B2017/00314 , A61B2017/00323 , A61B2017/00557 , A61B2017/2908 , A61B2017/2927 , A61B2034/302
摘要： A laparoscopic retractor (11) comprises a shaft (8) having a proximal and distal end, the distal end of the shaft being configured for adjustment from a substantially straight orientation to a curved orientation having a substantially U-shaped hook suitable for laparoscopic retraction. The proximal end of the shaft comprises a handle (1) operably connected to the distal end of the shaft for adjustment of the distal end from the substantially straight orientation to the curved orientation. The distal end of the shaft is enclosed within a flexible sheath (4) that is adapted to be inflated, and wherein a portion of the sheath covering the distal end of the shaft comprises inflatable balloon means such as one or more inflatable balloons (5) which cover the substantially U-shaped hook.
摘要翻译：腹腔镜牵开器（11）包括具有近端和远端的轴（8），所述轴的远端构造成用于从基本上直的取向调整到具有适于腹腔镜收缩的大致U形钩的弯曲取向。轴的近端包括可操作地连接到轴的远端的手柄（1），用于将远端从基本上直的取向调整到弯曲取向。轴的远端封闭在适于膨胀的柔性护套（4）中，并且其中覆盖轴的远端的护套的一部分包括可膨胀的气囊装置，例如一个或多个可充气球囊（5）其覆盖基本上U形的钩。

28. 发明申请

US20150329923A1 EXOPOLYSACCHARIDE-PRODUCING BACTERIA, AND USES THEREOF FOR PROTECTING HEART HEALTH 有权
标题翻译：外源性生产细菌及其用于保护心脏健康的用途
公开(公告)号：US20150329923A1
公开(公告)日：2015-11-19
申请号：US14425236
申请日：2013-09-02
申请人： University College Cork-National University of Ireland, Cork , Agriculture and Food Development Authority (TEAGASC)
发明人： Catherine Stanton , Paul Ross , Gerald F. Fitzgerald , Noel Caplice , Fergus Shanahan
IPC分类号： C12R1/225 , A23C9/123 , C08B37/00 , C12N1/20 , A61K35/747
CPC分类号： A61K35/747 , A23C9/1234 , A23C2220/206 , A23L33/135 , A23Y2220/00 , C08B37/006 , C12N1/20 , C12P19/04 , C12R1/225
摘要： An isolated Lactobacillus mucosae (DPC6426) strain deposited with the National Collection of Industrial and Marine Bacteria Limited (NCIMB) on 27 Jul. 2012 under NCIMB Deposit Accession No. 42015.
摘要翻译：在NCIMB存款登记号42015下，于2007年7月27日保藏于National Chemical of Industrial and Marine Bacteria Limited（NCIMB）的隔离乳杆菌粘膜（DPC6426）菌株。

29. 发明授权

US09187766B2 Accumulation of metabolic products in bacterial microcompartments 有权
标题翻译：细菌微室中代谢产物的积累
公开(公告)号：US09187766B2
公开(公告)日：2015-11-17
申请号：US14347527
申请日：2012-09-27
申请人： University College Cork National University of Ireland , University of Kent
发明人： Michael Prentice , Martin Warren , Mingzhi Liang
IPC分类号： C07K14/19 , C12Q1/02 , C12P3/00 , A23L1/30 , C07K14/195 , C12N1/20 , C12N9/12 , C12N15/70 , C12P21/00 , A61K38/45
CPC分类号： C12P3/00 , A23L33/135 , A61K38/45 , C07K14/195 , C12N1/20 , C12N9/1229 , C12N15/70 , C12P21/00 , C12Y207/04001 , Y02A50/473
摘要： A non-therapeutic method of accumulating a polymeric or high molecular weight molecular product within a bacterial microcompartment in bacterial cytoplasm, which method employs a recombinant bacteria which is transformed to express a microcompartment containing an enzyme capable of converting a low molecular weight substrate into a polymeric or high molecular weight product, the method comprising the steps of: incubating the recombinant bacteria with the low-molecular weight substrate, or a precursor of the low molecular weight substrate which is capable of being metabolized to the substrate within the recombinant bacteria, such that the substrate or precursor is taken up by the bacteria, wherein the substrate enters the microcompartment and the enzyme within the microcompartment converts the substrate to a polymeric or high molecular weight molecular product, and wherein the polymeric or high molecular weight molecular product is accumulated within the microcompartment due to its size.
摘要翻译：在细菌细胞质的细菌微室中积聚聚合物或高分子量分子产物的非治疗方法，该方法使用重组细菌，其转化以表达含有能够将低分子量底物转化为聚合物的酶的微型包装或高分子量产物，所述方法包括以下步骤：将重组细菌与低分子量底物或低分子量底物的前体孵育，所述前体能够被代谢至重组细菌内的底物，使得底物或前体被细菌吸收，其中基质进入微型隔间并且微室内的酶将底物转化为聚合物或高分子量分子产物，并且其中聚合物或高分子量分子产物积聚在微型隔间由于其尺寸。

30. 发明授权

US09155761B2 Method for the treatment of cancer 有权
标题翻译：癌症治疗方法
公开(公告)号：US09155761B2
公开(公告)日：2015-10-13
申请号：US13784903
申请日：2013-03-05
申请人： UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
发明人： Sharon McKenna , Gerald C. O'Sullivan , Tracey O'Donovan
IPC分类号： A61K33/24 , A61K31/282 , A61K33/14 , A61K31/436 , A61K31/513 , A61K45/06
CPC分类号： A61K33/14 , A61K31/282 , A61K31/436 , A61K31/513 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and prevent the recovery following drug withdrawal, of cancer cells. In vivo, drug resistance from a failure to adequately engage in apoptotic programmed cell death leads to a recurrence of cancer and tumors can remain dormant for periods of time before re-emerging as drug resistant metastases. It has been hypothesized that autophagy (Type II cell death) may help cancer cells survive in response to growth limiting conditions, such as nutrient depletion, hypoxia, absence of growth factor, or presence of cytotoxic drug. LiCl is a known autophagy inducer and accelerates cell survival to autophagic programmed cell death.
摘要翻译：本发明基于令人惊奇的发现，即使用化疗剂如5-氟尿嘧啶（5-FU）和自噬诱导剂的治疗有效地抑制癌细胞的持续生长并且阻止药物停药后的恢复。在体内，由于不能充分参与凋亡程序性细胞死亡的耐药性导致癌症的复发，并且肿瘤可以在再次出现之前的时间段内保持休眠作为耐药转移。已经假设自噬（II型细胞死亡）可以帮助癌细胞响应于生长限制条件（例如营养物耗竭，缺氧，不存在生长因子或细胞毒性药物的存在）而存活。 LiCl是一种已知的自噬诱导物，可加速细胞存活至自噬程序性细胞死亡。

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