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21. 发明申请

US20130316994A1 Methods of Reducing Risk of Hepatobiliary Dysfunction During Rapid Weight Loss with METAP-2 Inhibitors 审中-公开
标题翻译：使用METAP-2抑制剂减轻快速减肥期间肝胆功能障碍风险的方法
公开(公告)号：US20130316994A1
公开(公告)日：2013-11-28
申请号：US13990170
申请日：2011-11-29
申请人： Thomas E. Hughes
发明人： Thomas E. Hughes
IPC分类号： A61K31/336 , A61K45/06
CPC分类号： A61K31/336 , A61K31/00 , A61K31/7105 , A61K45/06
摘要： The invention generally relates in part to methods of reducing hepatobiliary dysfunction and reducing risk of incident hepatobiliary dysfunction, comprising administering a MetAP2 inhibitor to patients in need thereof. The invention also relates in part to methods of effecting weight loss while reducing hepatic injury or risk thereof, comprising administering a MetAP2 inhibitor.
摘要翻译：本发明一般部分地涉及减少肝胆功能障碍并降低肝胆管功能障碍发生风险的方法，包括对有需要的患者施用MetAP2抑制剂。本发明还部分地涉及在减少肝损伤或其风险的同时减轻体重减轻的方法，包括施用MetAP2抑制剂。

22. 发明申请

US20120034233A1 Methods of Treating an Overweight or Obese Subject 有权
标题翻译：治疗超重或肥胖症的方法
公开(公告)号：US20120034233A1
公开(公告)日：2012-02-09
申请号：US13133060
申请日：2009-12-04
申请人： Thomas E. Hughes , James E. Vath
发明人： Thomas E. Hughes , James E. Vath
IPC分类号： A61K39/395 , A61K31/336 , A61P3/04 , A61K31/7088
CPC分类号： A61K31/336 , A61K31/4015 , A61K31/439 , A61K45/06
摘要： The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
摘要翻译：本发明一般涉及治疗超重或肥胖受试者以及治疗超重或肥胖相关病症的方法。在某些实施方案中，本发明提供了治疗超重或肥胖受试者的方法，包括施用MetAP2抑制剂，其中给药量基本上不调节血管发生。

23. 发明申请

US20100261564A1 ROTARY TENSIONER 审中-公开
标题翻译：旋转张力器
公开(公告)号：US20100261564A1
公开(公告)日：2010-10-14
申请号：US12422638
申请日：2009-04-13
申请人： Thomas E. Hughes
发明人： Thomas E. Hughes
IPC分类号： F16H7/12 , F16H7/08
CPC分类号： F16H7/1281 , F16H2007/0806 , F16H2007/0893
摘要： An assembly for maintaining tension in a drive belt features a housing mounted on a base. The housing contains a biasing element that exerts torque on the housing to bias the housing. An arm is connected to the housing and rotates with the housing in response to the bias of the biasing element. A pulley is connected to the lever arm and engages a drive belt in response to the bias force of the biasing element on the lever arm. The pulley deflects the shape of the belt to provide tension in the belt. A sealing element provides prevents migration of debris into the housing and provides a biasing force to impede translatory movement of a first half of the housing from a second half of the housing, while allowing rotation of the first half relative to the second half.
摘要翻译：用于维持传动带中的张力的组件具有安装在基座上的壳体。壳体包含偏压元件，该偏置元件在壳体上施加扭矩以偏置壳体。臂连接到壳体并响应于偏置元件的偏压而与壳体一起旋转。滑轮连接到杠杆臂并响应于杠杆臂上的偏置元件的偏压力而啮合驱动带。皮带轮使皮带的形状偏转以在皮带中提供张力。密封元件防止碎片进入壳体并且提供偏置力以阻止壳体的第一半部从壳体的第二半部平移运动，同时允许第一半部相对于第二半部旋转。

24. 外观设计

USD364538S Tubular compartmentalized beverage cooling wrap 失效
公开(公告)号：USD364538S
公开(公告)日：1995-11-28
申请号：US26926
申请日：1994-08-09
申请人： Thomas E. Hughes
设计人： Thomas E. Hughes

25. 发明授权

US09173865B2 Treatment of obesity using non-daily administration of 6-O-(4-dimethylaminoethoxy) cinnamoyl fumagillol 有权
公开(公告)号：US09173865B2
公开(公告)日：2015-11-03
申请号：US13990271
申请日：2011-11-29
申请人： Thomas E. Hughes
发明人： Thomas E. Hughes
IPC分类号： A61K31/336
CPC分类号： A61K31/336 , A61K9/0019
摘要： The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of e.g, a MetAP-2 inhibitor.

26. 发明授权

US08591359B2 Tensioner assembly with sealed pulley 有权
标题翻译：带有密封皮带轮的张紧器总成
公开(公告)号：US08591359B2
公开(公告)日：2013-11-26
申请号：US12125398
申请日：2008-05-22
申请人： Christopher B Ward , Thomas E Hughes , Matthew B Neal
发明人： Christopher B Ward , Thomas E Hughes , Matthew B Neal
IPC分类号： F16H7/12
CPC分类号： F16H7/20 , F16C13/006 , F16C2361/63 , F16H2007/0865
摘要： A pulley assembly operable in connection with a tensioner assembly is provided for tensioning a belt. The pulley assembly includes one or more elements for sealing the pulley to protect the pulley assembly in harsh environments. For instance, the pulley assembly may include one or more shields for protecting the pulley from contaminants entering the interior of the pulley assembly that can lead to premature failure.
摘要翻译：提供可与张紧器组件连接操作的滑轮组件，用于张紧皮带。滑轮组件包括用于密封滑轮以在恶劣环境中保护滑轮组件的一个或多个元件。例如，滑轮组件可以包括一个或多个屏蔽件，用于保护滑轮免于进入滑轮组件内部的污染物，这可能导致过早的故障。

27. 发明授权

US08367721B2 Methods of treating an overweight or obese subject 有权
标题翻译：治疗超重或肥胖受试者的方法
公开(公告)号：US08367721B2
公开(公告)日：2013-02-05
申请号：US13568800
申请日：2012-08-07
申请人： Thomas E. Hughes , James E. Vath
发明人： Thomas E. Hughes , James E. Vath
IPC分类号： A01N43/20 , A01N43/24 , A01N37/12 , A01N37/44 , A01N37/02 , A61K31/335 , A61K31/24 , A61K31/22
CPC分类号： A61K31/336 , A61K31/4015 , A61K31/439 , A61K45/06
摘要： The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions. In certain embodiments, the invention provides a method of treating an overweight or obese subject including administering a MetAP2 inhibitor in which the amount administered does not substantially modulate angiogenesis.
摘要翻译：本发明一般涉及治疗超重或肥胖受试者以及治疗超重或肥胖相关病症的方法。在某些实施方案中，本发明提供了治疗超重或肥胖受试者的方法，包括施用MetAP2抑制剂，其中给药量基本上不调节血管发生。

28. 发明申请

US20130023513A1 Methods and Compositions for Treating Cardiovascular Disorders 审中-公开
标题翻译：治疗心血管疾病的方法和组成
公开(公告)号：US20130023513A1
公开(公告)日：2013-01-24
申请号：US13521530
申请日：2011-01-11
申请人： Thomas E. Hughes
发明人： Thomas E. Hughes
IPC分类号： A61K31/336 , A61P9/10 , A61P9/04 , A61P25/00 , A61P3/06 , A61K31/505 , A61K31/397 , A61K31/366 , A61K31/40 , A61K31/4418 , A61K31/404 , A61K31/47 , A61P9/00 , A61K31/455
CPC分类号： A61K31/336 , A61K31/00 , A61K31/192 , A61K31/216 , A61K31/366 , A61K31/397 , A61K31/40 , A61K31/404 , A61K31/4418 , A61K31/455 , A61K31/47 , A61K31/505 , A61K31/7088 , A61K45/06 , A61K2300/00
摘要： The invention generally relates to methods of treating a patient having, and/or at risk of, cardiovascular or cerebrovascular disorders. Such methods may include administering a MetAP2 inhibitor at a dose that does not substantially modulate angiogenesis.
摘要翻译：本发明一般涉及治疗患有心血管或脑血管障碍和/或处于心血管或脑血管障碍风险的患者的方法。这样的方法可以包括以基本上不调节血管发生的剂量施用MetAP2抑制剂。

29. 发明授权

US06435874B1 Elastic dental device 失效
标题翻译：弹性牙科装置
公开(公告)号：US06435874B1
公开(公告)日：2002-08-20
申请号：US09899707
申请日：2001-07-05
申请人： Thomas E. Hughes
发明人： Thomas E. Hughes
IPC分类号： A61C700
CPC分类号： A61C5/85
摘要： Structures and methods are disclosed which may be used for applying force to the base of a matrix band or cavity filling material mold during a cavity filling procedure. In a preferred exemplary embodiment of the present invention, a unitary body of elastic material is stretched preferably by applying force in opposite directions to the opposite ends of the unitary body such that a central portion of the body of material is thinned. The thinned portion of the unitary body may then be easily inserted in the space between two adjacent teeth next to the base of a matrix band or cavity filling material mold. After the unitary body has been inserted into the space between two adjacent teeth next to the base of the matrix band or cavity filling material mold, the force which has been applied to the opposite ends of the unitary body is then removed. As a result, the previously stretched elastic unitary body contracts and becomes thicker in its central portion that had been previously thinned. The contraction and thickening of the unitary body in the space between adjacent teeth fills this space and applies and outward force to the walls of this cavity. Accordingly, the contracted unitary body applies a force on the base of the matrix band or cavity filling material mold which forces the base of the matrix band or filling material mold adjacent to the base of the tooth to be filled.
摘要翻译：公开了可以用于在空腔填充程序期间向矩阵带或空腔填充材料模具的基部施加力的结构和方法。在本发明的优选示例性实施例中，弹性材料的整体通过相对于整体的相对端施加力而被拉伸，使得材料体的中心部分变薄。然后，可以容易地将单体的薄化部分插入紧邻基质带或空腔填充材料模具的基部的两个相邻齿之间的空间中。在单体被插入紧邻基质带或空腔填充材料模具的基部的两个相邻齿之间的空间之后，已经施加到整体的相对端的力被去除。结果，先前拉伸的弹性单体在其先前变薄的中心部分收缩并变厚。相邻齿之间的空间中的整体的收缩和增厚填满了这个空间，并向该空腔的壁施加向外的力。因此，收缩单体在矩阵带或空腔填充材料模的基部施加力，迫使基体带的基部或填充材料模具与待填充的牙齿的基部相邻。

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