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21. 发明授权

US4137307A Process for preparing haptoglobin aqueous solution using strong anion exchanger 失效
标题翻译：使用强阴离子交换剂制备触珠蛋白水溶液的方法
公开(公告)号：US4137307A
公开(公告)日：1979-01-30
申请号：US788921
申请日：1977-04-19
申请人： Satoshi Funakoshi , Takao Omura , Takeshi Ohshiro
发明人： Satoshi Funakoshi , Takao Omura , Takeshi Ohshiro
IPC分类号： A61L2/00 , C07K14/47 , A61K37/04 , A61K37/06 , C07G7/00
CPC分类号： A61L2/0023 , C07K14/47 , Y10S530/806 , Y10S530/83 , Y10S530/831
摘要： An aqueous solution of haptoglobin is obtained by subjecting an aqueous solution of .alpha. and .beta.-globulin fractions of human blood plasma to further fractionation by use of ammonium sulfate, collecting fractions precipitated at a concentration between 30% and 40% saturation of ammonium sulfate, contacting a reconstituted aqueous solution of the collected fractions with an anion exchanger to adsorb haptoglobin on said anion exchanger, selectively eluting the haptoglobin from the anion exchanger, and then concentrating the resulting aqueous eluate solution. The aqueous solution of haptoglobin is subjected to heat treatment in the presence of a selected stabilizing agent for inactivating hepatitis B virus at an optional step of the process.The thus obtained aqueous solution of haptoglobin has less than 10% hypotensive activity, highly stable during storage, and free from the risk of hepatitis B virus infection. This haptoglobin preparation is used for prevention and treatment of renal disorders caused by hemolysis.
摘要翻译：接触球蛋白的水溶液是通过使人血浆的α和β-球蛋白部分的水溶液通过使用硫酸铵进一步分级而获得的，收集以硫酸铵的30％至40％饱和浓度沉淀的级分，接触用阴离子交换剂重新收集的级分的水溶液以吸附所述阴离子交换剂上的触珠蛋白，从阴离子交换剂中选择性洗脱触珠蛋白，然后浓缩所得的水性洗脱液。在所选择的用于灭活乙型肝炎病毒的稳定剂的存在下，在该方法的任选步骤，对触珠蛋白的水溶液进行热处理。

22. 发明授权

US4113712A HBsAG Particle composed of single polypeptide subunits and the preparation procedure 失效
标题翻译： HBsAG颗粒由单个多肽亚基组成，其制备方法
公开(公告)号：US4113712A
公开(公告)日：1978-09-12
申请号：US664983
申请日：1976-03-08
申请人： Satoshi Funakoshi
发明人： Satoshi Funakoshi
IPC分类号： A61K39/00 , C07K14/02 , G01N33/576 , G01N33/96 , A61K39/12 , A61K39/42 , C07G7/00 , G01N33/16
CPC分类号： C07K14/005 , G01N33/5764 , G01N33/96 , A61K39/00 , C12N2730/10122 , Y10S436/82 , Y10S436/826 , Y10S530/806 , Y10S530/831
摘要： Hepatitis B surface antigen particles composed of single polypeptide subunits having a molecular weight of about 55,000 dalton are prepared by heating hepatitis B surface antigen in isotonic sodium chloride solution at about neutral pH containing a surfactant capable of delipidation such as alkali-metal salts of bile acids or of lauroylsarcosinic acid, or poloxyethylene alkylphenol containing an average oxyethylene of 7 to 10 molecules, or polyoxyethylene sorbitan monoalkylester containing an average oxyethylene of 20 molecules.A uniform hepatitis B surface antigen particle thus obtained has a spherical form 18 to 22 nm in diameter with an empty core, a molecular weight of about 2,200,000 dalton, and the characteristic of low toxicity.This hepatitis B surface antigen particle is useful for the preparation of vaccines, as a standard antigen reagent for testing hepatitis B surface antigen and the antibody, and as an antigen for immunizing animals to obtain a highly specific and strong antibody.
摘要翻译：由分子量约55,000道尔顿的单个多肽亚单位组成的乙型肝炎表面抗原颗粒是通过在含有能够脱脂的表面活性剂的等渗氯化钠溶液中加热乙肝表面抗原来制备的，所述表面活性剂含有能够脱脂的表面活性剂，例如胆汁酸的碱金属盐或月桂酰肌氨酸或含有7〜10分子的平均氧化乙烯的聚氧乙烯烷基苯酚，或含有20分子的平均氧化乙烯的聚氧乙烯山梨糖醇酐单烷基酯。

23. 发明授权

US4565697A Process for producing a hepatitis B infection preventing vaccine 失效
标题翻译：生产乙型肝炎感染预防疫苗的方法
公开(公告)号：US4565697A
公开(公告)日：1986-01-21
申请号：US552079
申请日：1983-11-15
申请人： Takao Ohmura , Terufumi Fujiwara , Akimasa Ohmizu , Satoshi Funakoshi
发明人： Takao Ohmura , Terufumi Fujiwara , Akimasa Ohmizu , Satoshi Funakoshi
IPC分类号： A61K39/29 , A61K35/14 , A61K35/16 , A61K39/00 , C07K14/02 , A61K39/12 , C12N7/02 , C12N7/04
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122
摘要： A process for producing a hepatitis B infection preventing vaccine containing hepatitis B surface antigen as a main component thereof which comprises removing human plasma components possibly causing adverse effects and components capable of causing hepatitis B infection by incorporating steps of fractionation using ammonium sulfate, adsorption on a colloidal silicate and fractionation using polyethylene glycol into the purification stage after heat treatment and further carrying out a treatment for infectivity inactivation without causing any antigenicity impairment.
摘要翻译：一种生产含有乙型肝炎表面抗原的乙型肝炎感染预防疫苗作为其主要成分的方法，其包括通过使用硫酸铵进行分级的步骤，除去可能引起不良反应的人血浆成分和能够引起乙型肝炎感染的成分，胶体硅酸盐和使用聚乙二醇进行热处理后的纯化阶段的分级，并进一步进行感染性失活的治疗，而不引起任何抗原性损伤。

24. 发明授权

US4424206A Process for heat treatment of aqueous solution containing cold insoluble globulin to inactivate hepatitis virus 失效
标题翻译：用于热处理含有冷不溶性球蛋白的水溶液以灭活肝炎病毒的方法
公开(公告)号：US4424206A
公开(公告)日：1984-01-03
申请号：US351299
申请日：1982-02-22
申请人： Takao Ohmura , Yutaka Hirao , Satoshi Funakoshi
发明人： Takao Ohmura , Yutaka Hirao , Satoshi Funakoshi
IPC分类号： C07K14/705 , A61K35/14 , A61K38/00 , A61K38/16 , A61L2/00 , C07K14/02 , C07K14/10 , C07K14/18 , C07K14/435 , C07K14/78 , C07K16/00 , A61K37/00
CPC分类号： C07K14/78 , A61L2/0023 , A61K38/00
摘要： Cold insoluble globulin which may have hepatitis virus activity can be virus-inactivated with keeping at a minimum the damage of the cold insoluble globulin by heating its aqueous solution at 50.degree. to 80.degree. C. for 5 to 20 hours in the presence of 10% (W/V) or more of at least one principal stabilizer of neutral amino acids, monosaccharides, disaccharides, and sugar alcohols with or without 10% (W/V) or more of at least one auxiliary stabilizer of salts of hydrocarbon carboxylic acids or hydroxyhydrocarbon carboxylic acids both having 3 to 10 carbon atoms.
摘要翻译：可能具有肝炎病毒活性的冷不溶性球蛋白可以病毒灭活，通过在50℃至80℃下加热其水溶液5％至20小时，在10％（W / V）或更多的至少一种主要稳定剂的中性氨基酸，单糖，二糖和糖醇，其具有或不具有10％（W / V）或更多的至少一种烃羧酸盐的辅助稳定剂或具有3至10个碳原子的羟基烃羧酸。

25. 发明授权

US4371520A Process for preparing immunoglobulin suitable for intravenous injection 失效
标题翻译：制备适合静脉注射的免疫球蛋白的方法
公开(公告)号：US4371520A
公开(公告)日：1983-02-01
申请号：US316042
申请日：1981-10-28
申请人： Yahiro Uemura , Takashi Goto , Yoshiaki Kano , Satoshi Funakoshi
发明人： Yahiro Uemura , Takashi Goto , Yoshiaki Kano , Satoshi Funakoshi
IPC分类号： A61K38/00 , C07K16/06 , A61K39/00
CPC分类号： C07K16/065 , A61K38/00 , Y10S530/83 , Y10S530/831
摘要： A process for preparing immunoglobulin suitable for intravenous injection, comprising treating with an acid a plasma or fraction I+II+III, fraction II+III, fraction II, or fraction III (hereinafter these are sometimes referred collectively to as starting material) obtained from plasma by Cohn's cold alcohol fractionation method, and subjecting to fractionation using an alkylene oxide polymer or copolymer having a molecular weight of 2,000 to 20,000.
摘要翻译：一种制备适用于静脉注射的免疫球蛋白的方法，包括用酸将血浆或级分I + II + III，级分II + III，级分II或级分III（以下有时统称为原料）等离子体，并使用分子量为2,000〜20,000的烯化氧聚合物或共聚物进行分馏。

26. 发明授权

US4343736A Process for recovering interferon 失效
标题翻译：干扰素回收方法
公开(公告)号：US4343736A
公开(公告)日：1982-08-10
申请号：US280687
申请日：1981-07-06
申请人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yahiro Uemura , Hirofumi Arimura , Hiroshi Morise , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C12P21/00 , A61K38/21 , C07K1/22 , C07K14/52 , C07K14/555 , C07K14/56 , C07K14/57 , A61K45/02 , C07G7/00
CPC分类号： C07K14/555 , Y10S435/811 , Y10S530/829 , Y10S530/837 , Y10S530/838 , Y10S530/848
摘要： A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolubilized sulfated polysaccharide and then selectively eluting the interferon with an aqueous solution of an inorganic salt.

27. 发明授权

US4335099A Employment of enteric coated IgA for hypoproteinemia in intestinal infectious diseases 失效
标题翻译：肠道包衣IgA用于肠道传染病中的低蛋白血症
公开(公告)号：US4335099A
公开(公告)日：1982-06-15
申请号：US185929
申请日：1980-09-10
申请人： Satoshi Funakoshi , Katuhiro Uriyu , Yahiro Uemura , Katashi Nakane , Akio Yamane
发明人： Satoshi Funakoshi , Katuhiro Uriyu , Yahiro Uemura , Katashi Nakane , Akio Yamane
IPC分类号： A61K39/395 , A61K9/32 , A61K9/48 , A61K9/50 , A61K9/52 , A61K38/00 , A61P37/04 , C07K16/12 , A61K9/34 , A61K9/36 , A61K9/40 , A61K31/74 , A61K31/78 , A61K31/79 , A61K39/00
CPC分类号： C07K16/12 , A61K9/4891 , A61K9/5073 , A61K38/00 , Y10S424/804
摘要： A method of treating hypoproteinemia is disclosed in which an enteric film coated IgA-rich gamma globulin is administered orally to a person suffering therefrom until total serum content and plasma content are restored. The film coating is soluble in neutral or alkaline media by insoluble in acid media.
摘要翻译：公开了一种治疗低蛋白血症的方法，其中将含有肠溶膜的含有IgA的γ球蛋白经口给予患有这种血小板的人，直至全部血清含量和血浆含量恢复。薄膜包衣在酸性介质中不溶于中性或碱性介质。

28. 发明授权

US4010074A Method for purification and recovery of urokinase 失效
标题翻译：尿激酶的纯化和回收方法
公开(公告)号：US4010074A
公开(公告)日：1977-03-01
申请号：US683239
申请日：1976-05-04
申请人： Yahiro Uemura , Katuhiro Uriyu , Satoshi Funakoshi
发明人： Yahiro Uemura , Katuhiro Uriyu , Satoshi Funakoshi
IPC分类号： C12N9/72 , C07G7/02
CPC分类号： C12N9/6462 , C12Y304/21073 , Y10S435/815
摘要： Highly purified urokinase is obtained in a high yield by adsorbing urokinase from an aqueous crude urokuinase solution including human urine at a pH of about 4.0 to about 7.0 on a water-insoluble polysaccharide containing agarose and agaropectin, for example, agar and Sepharose, and by eluting urokinase with an alkaline solution (pH of about 8 to 11) or concentrated salt solution.
摘要翻译：通过在含有约4.0至约7.0的pH值的人尿液水性粗尿素酶溶液中，在含有琼脂糖和琼脂糖的水不溶性多糖例如琼脂和琼脂糖上吸附尿激酶，并通过以下方式获得高纯度的尿激酶：用碱性溶液（约8至11的pH）或浓盐溶液洗脱尿激酶。

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