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21. 发明授权

US06565814B1 CLOSURE STRUCTURE FOR VACUUM SPECIMEN COLLECTION CONTAINER, VACUUM SPECIMEN COLLECTION CONTAINER, VACUUM SPECIMEN COLLECTION SYSTEM, HOLDER FOR VACUUM SPECIMEN COLLECTION SYSTEM AND THERMOPLASTIC ELASTOMER COMPOSITION FOR FORMING CLOSURE STRUCTURE 失效
标题翻译：真空样品收集容器，真空样品收集容器，真空样品收集系统，真空样品收集系统保持器和形成闭合结构的热塑性弹性体组合物的闭合结构
公开(公告)号：US06565814B1
公开(公告)日：2003-05-20
申请号：US09622891
申请日：2000-08-30
申请人： Hideo Anraku , Ryusuke Okamoto
发明人： Hideo Anraku , Ryusuke Okamoto
IPC分类号： B01L300
CPC分类号： B01L3/50825
摘要： A closure structure is provided for a vacuum specimen collection container which can maintain a vacuum pressure within the specimen collection tube and which includes a needle cannula penetrating portion having needle hole sealability. The closure structure can be detachably fitted in an open end of a specimen collection container in an airtight manner to maintain a vacuum condition within the specimen collection container. The closure structure includes a grip section, a rubber elastic needle cannula penetrating portion disposed to fill up a through-hole in a grip section and a rubber elastic fitting portion configured to follow an interior surface profile of an open end of a specimen collection container, thereby to fit therein in a airtight fashion. The grip section has a higher rigidity relative to the needle cannula penetrating portion and the fitting portion. A tubular side wall of a grip section has on its inner side at least one raised portion or recessed portion to prevent kickback.
摘要翻译：为真空样本采集容器提供封闭结构，其能够保持样品收集管内的真空压力，并且其包括具有针孔密封性的针插管穿透部分。封闭结构可以以气密的方式可拆卸地装配在样本收集容器的开口端，以保持样本收集容器内的真空状态。封闭结构包括握持部分，设置成填充握持部分中的通孔的橡胶弹性针插管穿透部分和构造成跟随样本收集容器的开口端的内表面轮廓的橡胶弹性配合部分，从而以气密方式装配在其中。握持部具有相对于针插管穿透部和配合部的更高的刚性。把手部分的管状侧壁的内侧具有至少一个凸起部分或凹进部分，以防止反冲。

22. 发明授权

US5776357A Serum or plasma separating compositions 失效
标题翻译：血清或血浆分离组合物
公开(公告)号：US5776357A
公开(公告)日：1998-07-07
申请号：US809421
申请日：1997-04-28
申请人： Ryusuke Okamoto , Hideo Anraku
发明人： Ryusuke Okamoto , Hideo Anraku
IPC分类号： B01D17/02 , B01D21/00 , G01N33/48 , G01N33/49
CPC分类号： G01N33/491 , B01D17/0208 , B01D21/01 , G01N33/48 , B01D2221/10
摘要： The present invention relates to a serum or plasma separating composition comprising an oligomer of cyclopentadiene, an organic gelling agent and a dispersant for the organic gelling agent. The organic gelling agent is a condensation product of sorbitol and an aromatic aldehyde. The dispersant for the organic gelling agent is a polyoxyethylene-polyoxypropylene block copolymer having HLB of 1.0 to 9.0. The invention provides a serum or plasma separating composition which does not give out a bad smell by sterilization with radiation, has no influence derived from hemolysis, etc. on biochemical examination values of serum or plasma, does not cause phase separation of components, and is equal to the prior art in serum or plasma separating property, preservation stability, etc. Furthermore, the invention provides a serum or plasma separating composition which hardly brings about flow during preservation by standing in a horizontal lying position and hardly exhibits impaired invertibility with the lapse of time.
摘要翻译： PCT No.PCT / JP96 / 02390 Sec。 371日期1997年04月28日 102（e）1997年4月28日PCT PCT 1996年8月26日PCT公布。出版物WO97 / 08548 日本3月6日公开本发明涉及包含环戊二烯低聚物，有机胶凝剂和有机胶凝剂分散剂的血清或血浆分离组合物。有机胶凝剂是山梨糖醇与芳族醛的缩合产物。有机胶凝剂的分散剂是HLB为1.0〜9.0的聚氧乙烯 - 聚氧丙烯嵌段共聚物。本发明提供一种血清或血浆分离组合物，其通过放射线灭菌不会产生不良气味，对血清或血浆的生物化学检查值没有影响来自溶血等，不会引起组分的相分离，并且是等同于现有技术的血清或血浆分离性能，保存稳定性等。此外，本发明提供一种血清或血浆分离组合物，其通过在水平躺卧位置站立而几乎不会在保存期间产生流动，并且几乎不显示与经过的可逆性受损的时间。

23. 发明授权

US08795957B2 Blood collection container 有权
标题翻译：采血容器
公开(公告)号：US08795957B2
公开(公告)日：2014-08-05
申请号：US13033120
申请日：2011-02-23
申请人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
发明人： Tomonori Inoue , Yuuji Setoguchi , Ryusuke Okamoto , Katsuya Togawa
IPC分类号： A01N1/02
CPC分类号： A61B5/150755 , A61B5/15003 , A61B5/150351 , A61B5/154 , B01L3/5082 , B01L2300/163
摘要： The present invention provides a blood collection container capable of allowing blood to coagulate in a short time and preventing blood from coagulating with bubbles contained therein and thus preventing formation of bubbly clots when used to collect blood therein. A blood collection container 1 stores a blood coagulation promoting agent 4 for promoting blood coagulation and an antifoaming agent 5, which is a polyoxyalkylene or a derivative thereof. The amount of the antifoaming agent 5 is 2.0×10−3 to 0.2 mg per mL of blood to be collected in the blood collection container 1.
摘要翻译：本发明提供一种采血容器，其能够使血液在短时间内凝结，并且防止血液凝结，其中含有气泡，从而防止在用于在其中收集血液时形成气泡凝块。采集容器1存储促凝血用促凝剂4和作为聚氧化烯或其衍生物的消泡剂5。消肿剂5的量在采血容器1中收集的每毫升血液量为2.0×10-3〜0.2mg。

24. 发明授权

US07993847B2 Plasma or serum separation membrane and filter apparatus including the plasma or serum separation membrane 有权
公开(公告)号：US07993847B2
公开(公告)日：2011-08-09
申请号：US11635240
申请日：2006-12-07
申请人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
发明人： Katsuya Togawa , Ryusuke Okamoto , Hironobu Isogawa
IPC分类号： G01N1/00 , G01N33/53
CPC分类号： B01D69/02 , B01D61/18 , B01L3/502 , B01L3/5082 , B01L2300/047 , B01L2300/0681 , B01L2400/0487 , G01N33/491 , Y10T436/11 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： A Plasma or serum separation membrane that enables omitting centrifugal separation, is free from hemolysis attributed to destruction of red blood cells and realizes easy and rapid separation of plasma or serum from blood; and a filter apparatus including the plasma or serum separation membrane. In particular, a plasma or serum separation membrane being a membrane for separation of plasma or serum from blood and having a void ratio of 30% or below; and a filter apparatus comprising a filter member capable of attaining movement of plasma swifter than movement of blood cells and a plasma or serum separation membrane connected in series with a rear side of the filter member.

25. 发明申请

US20100248329A1 BLOOD COAGULATION PROMOTER AND BLOOD COLLECTION TUBE 审中-公开
标题翻译：血液凝血促进剂和血液收集管
公开(公告)号：US20100248329A1
公开(公告)日：2010-09-30
申请号：US12757956
申请日：2010-04-09
申请人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
发明人： Ryusuke Okamoto , Katsuya Togawa , Hironobu Isogawa
IPC分类号： C12N9/48 , C12M1/00
CPC分类号： A61B5/150755 , A61B5/150015 , B01L3/5082 , C08L29/04 , C08L39/06 , C08L71/02 , C08L2203/02 , C08L2666/04
摘要： The present invention provides a blood coagulation promoter capable of exerting both excellent blood coagulation promoting ability and excellent blood clot detaching ability, and a blood collection tube accommodating the blood coagulation promoter. The present invention provides a blood coagulation promoter which includes a hardly water soluble polyoxyalkylene derivative; a partially saponificated polyvinyl alcohol; at least one substance selected from the group consisting of adsorptive inorganic substances and hydrolases capable of hydrolyzing a bond between Arg and an arbitrary amino acid reside and/or a bond between Lys and an arbitrary amino acid residue in a peptide chain; a polyvinylpyrrolidone; and preferably a water-soluble silicone oil, and a blood collection tube in which the blood coagulation promoter is accommodated in a tubular vessel having a bottom.
摘要翻译：本发明提供能够发挥优异的凝血促进能力和优异的血块分离能力的凝血促进剂，以及容纳凝血促进剂的采血管。本发明提供一种凝血促进剂，其包含难溶于水的聚氧化烯衍生物; 部分皂化聚乙烯醇; 选自吸附性无机物质和能够水解Arg和任意氨基酸之间的键的水解物中的至少一种物质存在于肽链中Lys和任意氨基酸残基之间的和/或之间的键; 聚乙烯吡咯烷酮优选水溶性硅油，以及血液收集管，其中所述血液凝固促进剂容纳在具有底部的管状容器中。

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