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21. 发明授权

US6124317A 2-substituted piperidine analogs and their use as subtype-selective NMDA receptor antagonists 失效
标题翻译： 2-取代的哌啶类似物及其作为亚型选择性NMDA受体拮抗剂的用途
公开(公告)号：US6124317A
公开(公告)日：2000-09-26
申请号：US91593
申请日：1998-11-18
申请人： Christopher F. Bigge , John F. W. Keana , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Anthony P. Guzikowski
发明人： Christopher F. Bigge , John F. W. Keana , Sui Xiong Cai , Eckard Weber , Richard Woodward , Nancy C. Lan , Anthony P. Guzikowski
IPC分类号： A61K31/445 , A61K31/454 , C07D211/14 , C07D401/12 , A01N43/40
CPC分类号： C07D401/12 , A61K31/445 , A61K31/454 , C07D211/14
摘要： Novel 2-substituted piperidine analogs, pharmaceutical compositions containing the same and the method of using 2-substituted piperidine analogs as selectively active antagonists of N-methyl-D-aspartatc (NMDA) receptor subtypes for treating conditions such as stroke, cerebral ischemia, central nervous system trauma, hypoglycemia, anxiety, convulsions, amioglycoside antibiotics-induced hearing loss, migraine headaches, chronic pain, glaucoma, CMV retinitis, psychosis, urinary incontinence, opioid tolerance or withdrawal, or neurodegenerative disorders, such as lathyrism, Alzheimer's Disease, Parkinsonism and Huntington's Disease are described.
摘要翻译： PCT No.PCT / US96 / 20767 Sec。 371日期：1998年11月18日 102（e）1998年11月18日日期PCT 1996年12月20日PCT公布。出版物WO97 / 23215 PCT 日期1997年7月3日新颖的2-取代的哌啶类似物，含有它们的药物组合物和使用2-取代的哌啶类似物作为N-甲基-D-天冬氨酸（NMDA）受体亚型的选择性活性拮抗剂的方法，用于治疗诸如中风脑缺血，中枢神经系统创伤，低血糖，焦虑症，惊厥，阿糖苷类抗生素诱发的听力损失，偏头痛，慢性疼痛，青光眼，CMV视网膜炎，精神病，尿失禁，阿片样物质耐受或戒断，或神经退行性疾病，阿尔茨海默病，帕金森综合征和亨廷顿氏病。

22. 外观设计

USD392819S Double hexagonal rotating display rack 失效
公开(公告)号：USD392819S
公开(公告)日：1998-03-31
申请号：US53649
申请日：1996-04-30
申请人： Richard Woodward
设计人： Richard Woodward

23. 发明授权

US4860413A Method of and apparatus for use in forming diametrically opposed studs on tubular connectors 失效
标题翻译：用于在管状连接器上形成直径相对的螺柱的方法和装置
公开(公告)号：US4860413A
公开(公告)日：1989-08-29
申请号：US123959
申请日：1987-11-23
申请人： Richard Woodward
发明人： Richard Woodward
IPC分类号： B23Q39/04
CPC分类号： B23Q39/042 , Y10T29/49996 , Y10T29/5124 , Y10T29/513 , Y10T409/303808 , Y10T409/307504
摘要： Diametrically opposed studs are formed from a flange on the unfinished portion of a tubular threaded connector by first milling the flange to leave diametrically disposed portions of a cross sectional area such that a stud may be formed from each such portion. Apparatus for use in thus forming the studs enables each connector to be held with its unfinished portion exposed by means of a selected one of the four collets mounted on a turntable and spaced 90.degree. apart. The turntable is indexed from a loading and unloading station to a second station where the major part of the flange at one side of a connector is removed when a collet reaches that station. When the turntable is again indexed, the connector held by that collet is held at a third station where a like portion of the flange is removed from the opposite side to establish the wanted, diametrically opposed portions. When the turntable is again indexed, that connector is brought to a fourth station where the studs are formed from the remaining flange portions. On the next indexing of the table, the finished connector is brought to the loading and unloading station where it is removed and replaced while other connectors are being advanced from one station to the next. While the operator starts each index, a computer controls the operations at the second, third and fourth stations.
摘要翻译：径向相对的螺柱由管状螺纹连接器的未完成部分上的凸缘形成，通过首先铣削凸缘以留下直径设置的横截面积的部分，使得可以从每个这样的部分形成螺柱。用于这样形成螺柱的装置使得每个连接器能够保持其未完成的部分通过安装在转盘上并隔开90°的四个夹头中的所选择的一个夹套露出。转盘从加载和卸载站索引到第二站，其中当夹头到达该站时，连接器一侧的法兰的主要部分被移除。当转台再次被转位时，由该夹头保持的连接器被保持在第三工位，其中凸缘的相似部分从相对侧移除以建立所需的直径相对的部分。当转盘再次被转位时，该连接器被带到第四站，在该第四站处，螺栓由剩余的凸缘部分形成。在下一个工作台的索引中，完成的连接器被带到卸载和卸载站，在其他连接器从一个站到另一个站点进行更换。当操作员启动每个索引时，计算机控制第二，第三和第四站的操作。

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