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    • 22. 发明申请
    • REGENERATED CUTTING BLADE AND SHEARING TYPE GRINDER
    • 再生切割刀片和剪切型磨床
    • US20150251188A1
    • 2015-09-10
    • US14417344
    • 2012-08-28
    • Naoya WadaNaoki UenoYasuhiko HondaIsao Nagai
    • Naoya WadaNaoki UenoYasuhiko HondaIsao Nagai
    • B02C18/18B02C18/14
    • B02C18/184B02C18/142B02C18/145
    • To present a regenerated cutting blade, capable of regenerating efficiently by saving the cost and labor for regenerating a cutting blade, and improved in the grinding efficiency of a shearing type grinder to be close to that of a new cutting blade, when mounted and used in a shearing type grinder, including a fixed part 125, and a blade tip 127 projecting outward from this fixed part 125, in which the blade tip 127 has a leading end edge 109 pointed toward the rotating direction, and side edges 110 on the lateral side outer periphery including the blade tip 127, the leading end edge 109 and the side edges 110 are regenerated and formed by build-up welding, and the lateral sides are provided with slip preventive build-up welding parts 111, 112, 113 of the workpiece extending from the side edges 110 toward the central side of its rotation or the central direction, being formed by three regenerating processes.
    • 为了提供能够通过节省用于再生切割刀片的成本和劳动力而有效地再生的再生切割刀片,并且将剪切式研磨机的研磨效率提高为接近于新的切割刀片的磨削效率,当安装和使用时 包括固定部分125的剪切式研磨机以及从该固定部125向外突出的叶片尖端127,其中叶片尖端127具有朝向旋转方向指向的前端边缘109,侧面侧的侧边缘110 包括叶片尖端127,前端缘109和侧边缘110的外周边通过堆积焊接再生和形成,并且侧边设置有工件的防滑成型焊接部111,112,113 从侧边缘110向其旋转中心方向或中心方向延伸,由三个再生过程形成。
    • 26. 发明申请
    • PHOTONIC NETWORK PACKET ROUTING METHOD AND PACKET ROUTER FOR PHOTONIC NETWORK
    • PHOTONIC网络的光网络路由路由方法和分组路由器
    • US20110081149A1
    • 2011-04-07
    • US12969176
    • 2010-12-15
    • Naoya WADAHideyuki SotobayashiKen-ichi Kitayama
    • Naoya WADAHideyuki SotobayashiKen-ichi Kitayama
    • H04J14/00
    • H04Q11/0005H04J14/0227H04J14/08H04L45/00H04L45/502H04Q11/0066H04Q2011/002H04Q2011/0024H04Q2011/0039H04Q2011/0041H04Q2011/0077
    • A photonic network packet routing method includes the steps of optically encoding destination address information attached to an IP packet using light attributes, discriminating the encoded address information of the IP packet by optical correlation processing, switching to an output path for the IP packet based on a result of the discrimination, and outputting the IP packet labeled with prescribed address information on the output path selected by the switching step. A packet router for a photonic network includes a device for encoding by use of light attributes destination address information attached to an IP packet, a branching device for sending the IP packet having the encoded destination address information onto two paths, an address processing device for subjecting one IP packet received from the branching device to optical correlation processing and outputting a switch control signal based on a result of the discrimination, and a switch device for selectively outputting the packet by switching an output path of the other packet received from the branching device based on the address control signal from the address control device.
    • 光子网络分组路由方法包括以下步骤:使用光属性光学地编码附加到IP分组的目的地地址信息,通过光学相关处理来识别IP分组的编码地址信息,基于以下步骤切换到IP分组的输出路径 判断结果,并且通过切换步骤选择的输出路径输出标有规定地址信息的IP包。 用于光子网络的分组路由器包括通过使用附加到IP分组的光属性目的地地址信息进行编码的设备,用于将具有编码的目的地地址信息的IP分组发送到两个路径的分支设备,用于对 从分支装置接收到的一个IP分组进行光相关处理,并且基于鉴别结果输出开关控制信号;以及开关装置,用于通过切换从分支装置接收的另一个分组的输出路径来选择性地输出分组, 来自地址控制装置的地址控制信号。
    • 30. 发明授权
    • MKK7 activation inhibitor
    • MKK7激活抑制剂
    • US07195894B2
    • 2007-03-27
    • US10519465
    • 2003-06-27
    • Hirofumi DoiShinya HosogiNaoya Wada
    • Hirofumi DoiShinya HosogiNaoya Wada
    • C12N15/09
    • C07K14/47A61K38/1709G01N2500/00A61K2300/00
    • PAK4 and JIK, both of which bind to MKK7 and directly phosphorylate MKK7, were found in the present invention. The present invention provides an inhibitor of c-Jun phosphorylation caused by JNK3 and a method for inhibiting the same, and an agent for preventing and/or treating a disorder attributable to c-Jun phosphorylation caused by JNK3 and a method for preventing and/or treating the same, all of which comprise inhibiting one member selected from the following: the binding of PAK4 to MKK7, the phosphorylation of MKK7 by PAK4, the binding of JIK to MKK7, and the phosphorylation of MKK7 by JIK. Further, the present invention provides a method for identifying a compound that inhibits the binding of PAK4 to MKK7, the phosphorylation of MKK7 caused by PAK4, the binding of JIK to MKK7, or the phosphorylation of MKK7 caused by JIK, as well as the compound obtained thereby. Furthermore, the present invention provides a pharmaceutical composition containing an effective amount of at least one member selected from the group consisting of the aforementioned compound and the aforementioned inhibitor.
    • 在本发明中发现PAK4和JIK两者都结合MKK7并直接磷酸化MKK7。 本发明提供了由JNK3引起的c-Jun磷酸化抑制剂及其抑制方法,以及用于预防和/或治疗由JNK3引起的由c-Jun磷酸化引起的病症的药剂,以及用于预防和/或 所有这些都包括抑制选自以下的一种:PAK4与MKK7的结合,PAK4的MKK7的磷酸化,JIK与MKK7的结合以及通过JIK的MKK7的磷酸化。 此外,本发明提供了鉴定抑制PAK4与MKK7结合的化合物,由PAK4引起的MKK7的磷酸化,JIK与MKK7的结合或由JIK引起的MKK7的磷酸化的化合物的方法,以及化合物 由此获得。 此外,本发明提供含有有效量的选自上述化合物和上述抑制剂中的至少一种的药物组合物。