专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US5371003A Electrotransformation process 失效
标题翻译：电转换过程
公开(公告)号：US5371003A
公开(公告)日：1994-12-06
申请号：US126138
申请日：1993-09-23
申请人： Lynn E. Murry , Ralph M. Sinibaldi , Paul S. Dietrich , Sharon C. H. Alfinito
发明人： Lynn E. Murry , Ralph M. Sinibaldi , Paul S. Dietrich , Sharon C. H. Alfinito
IPC分类号： A01H1/02 , C07K14/325 , C12N13/00 , C12N15/82 , C12N15/87
CPC分类号： A01H1/02 , C07K14/325 , C12N13/00 , C12N15/8206 , C12N15/87
摘要： Novel processes for introducing DNA into plant material utilizing non-pulsed electric current, and plant cell lines, differentiated plant tissues and plants produced by said processes.
摘要翻译：使用非脉冲电流将DNA引入植物材料的新方法，以及由所述方法产生的植物细胞系，分化的植物组织和植物。

22. 发明授权

US6015883A Rantes homolog from prostate 失效
标题翻译：来自前列腺的Rantes同系物
公开(公告)号：US6015883A
公开(公告)日：2000-01-18
申请号：US936772
申请日：1997-09-24
申请人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
发明人： Phillip R. Hawkins , Olga Bandman , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K38/00 , A61K45/00 , A61K48/00 , A61P11/00 , A61P11/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/08 , C07K14/52 , C07K14/715 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K38/19
CPC分类号： C07K14/523 , A61K38/00 , A61K48/00 , C12N2799/026 , Y10S930/14
摘要： The present invention provides a polynucleotide (PTEC) isolated from a prostate cDNA library which identifies and encodes a novel human rantes homolog PTEC (prostate expressed chemokine). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PTEC. The invention also provides for the therapeutic use of purified PTEC in the treatment of immune deficiency diseases, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of conditions or diseases associated with the expression of PTEC. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供从前列腺cDNA文库分离的多核苷酸（PTEC），其鉴定并编码新的人类群同系物PTEC（前列腺表达的趋化因子）。本发明提供了包含编码PTEC的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的PTEC在治疗免疫缺陷疾病中的治疗用途，以及用于治疗与PTEC表达相关的病症或疾病的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

23. 发明授权

US5965423A Human lysophospholipase 失效
公开(公告)号：US5965423A
公开(公告)日：1999-10-12
申请号：US22940
申请日：1998-02-12
申请人： Jennifer L. Hillman , Purvi Shah , Lynn E. Murry
发明人： Jennifer L. Hillman , Purvi Shah , Lynn E. Murry
IPC分类号： C12N15/00 , A61K38/00 , A61K45/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/02 , A61P7/06 , A61P9/04 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P19/00 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P27/00 , A61P35/00 , A61P37/04 , A61P37/08 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12Q1/68 , C12N9/20 , C12N15/09 , C12N15/70
CPC分类号： C12N9/18 , A61K38/00
摘要： The invention provides a human lysophospholipase (NHLP) and polynucleotides which identify and encode NHLP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of NHLP.

24. 发明授权

US5948626A Method of detecting human phospholipase inhibitor 失效
标题翻译：检测人磷脂酶抑制剂的方法
公开(公告)号：US5948626A
公开(公告)日：1999-09-07
申请号：US153751
申请日：1998-09-15
申请人： Phillip R. Hawkins , Lynn E. Murry
发明人： Phillip R. Hawkins , Lynn E. Murry
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6876 , C07K14/4703 , A61K38/00 , C12Q2600/158
摘要： The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
摘要翻译：本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

25. 发明授权

US5935812A Human GTP binding protein gamma-3 失效
标题翻译：人GTP结合蛋白γ-3
公开(公告)号：US5935812A
公开(公告)日：1999-08-10
申请号：US715527
申请日：1996-09-18
申请人： Olga Bandman , Surya K. Goli , Lynn E. Murry
发明人： Olga Bandman , Surya K. Goli , Lynn E. Murry
IPC分类号： G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , G01N33/15 , G01N33/566 , C12P21/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides a polynucleotide which identifies and encodes a novel human GTP binding protein gamma-3 (HGPG) and HGPG itself. The invention provides for genetically engineered expression vectors, host cells containing the vector and a method for producing HGPG. The invention also provides a method for identifying pharmaceutical compositions inhibiting the expression and activity of HGPG and for the use of such compositions for the treatment of cancer. The invention also provides diagnostic assays which utilize the polynucleotide to hybridize with the transcripts encoding HGPG or anti-HGPG antibodies which specifically bind to HGPG in normal or diseased tissues.
摘要翻译：本发明提供鉴定和编码新的人GTP结合蛋白γ-3（HGPG）和HGPG本身的多核苷酸。本发明提供了遗传工程表达载体，含有载体的宿主细胞和用于产生HGPG的方法。本发明还提供了用于鉴定抑制HGPG的表达和活性以及使用这些组合物治疗癌症的药物组合物的方法。本发明还提供了利用多核苷酸与编码在正常或患病组织中特异性结合HGPG的HGPG或抗HGPG抗体的转录物进行杂交的诊断测定。

26. 发明授权

US5858756A Human lysophospholipase 失效
公开(公告)号：US5858756A
公开(公告)日：1999-01-12
申请号：US844120
申请日：1997-04-29
申请人： Jennifer L. Hillman , Purvi Shah , Lynn E. Murry
发明人： Jennifer L. Hillman , Purvi Shah , Lynn E. Murry
IPC分类号： A61K38/00 , C12N9/18 , C12N15/09 , C07K14/435 , C12N9/14
CPC分类号： C12N9/18 , A61K38/00
摘要： The present invention provides a human lysophospholipase (NHLP) and polynucleotides which identify and encode NHLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing NHLP and for treating or preventing disorders associated with expression of NHLP.

27. 发明授权

US5834192A Human cachexia associated protein 失效
标题翻译：人类恶病质相关蛋白
公开(公告)号：US5834192A
公开(公告)日：1998-11-10
申请号：US628413
申请日：1996-04-05
申请人： Ingrid Erika Akerblom , Lynn E. Murry
发明人： Ingrid Erika Akerblom , Lynn E. Murry
IPC分类号： C12N15/02 , A61K31/00 , A61K31/70 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/00 , A61P3/04 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00
摘要： The present invention provides a polynucleotide (hcap) isolated from a breast tumor library which identifies and encodes a human cachexia-associated protein (HCAP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding HCAP. The invention also provides for the therapeutic use of purified HCAP in the treatment of severe or moderate obesity, and for the therapeutic use of antisense molecules, antibodies, antagonists or inhibitors in the treatment of tumor-induced cachexia. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, or fragments thereof, or antibodies which specifically bind to the polypeptide.
摘要翻译：本发明提供了从乳腺肿瘤文库分离的多核苷酸（hcap），其鉴定和编码人恶病质相关蛋白（HCAP）。本发明提供了包含编码HCAP的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化的HCAP在治疗重度或中度肥胖中的治疗用途，以及用于治疗肿瘤诱导的恶病质的反义分子，抗体，拮抗剂或抑制剂的治疗用途。本发明还描述了利用包含特异性结合多肽的多核苷酸或其片段或抗体的诊断组合物的诊断测定法。

28. 发明授权

US5817480A DNA encoding a histamine H2 receptor 失效
标题翻译：编码组胺H2受体的DNA
公开(公告)号：US5817480A
公开(公告)日：1998-10-06
申请号：US748485
申请日：1996-11-07
申请人： Lynn E. Murry , Janice Au-Young , Karl J. Guegler , Surya K. Goli
发明人： Lynn E. Murry , Janice Au-Young , Karl J. Guegler , Surya K. Goli
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/00 , A61P25/00 , A61P29/00 , C07K14/705 , C07K14/72 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , C12N15/66
CPC分类号： C07K14/723 , A61K38/00
摘要： The present invention provides a novel histamine H2 receptor (H2RH) and polynucleotides which identify and encode H2RH. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding H2RH and a method for producing H2RH. The invention also provides for agonists, antibodies, or antagonists specifically binding H2RH, and their use, in the prevention and treatment of diseases in which H2RH is expressed. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding H2RH for the treatment of diseases associated with the expression of H2RH. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding H2RH.
摘要翻译：本发明提供了一种新型的组胺H2受体（H2RH）和识别和编码H2RH的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码H2RH的核酸序列和生产H2RH的方法。本发明还提供了特异性结合H2RH的激动剂，抗体或拮抗剂及其在预防和治疗其中表达H2RH的疾病中的用途。另外，本发明提供了将反义分子用于编码H2RH的多核苷酸用于治疗与H2RH表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合H2RH的抗体的诊断测定法。

29. 发明授权

US5811520A Human phospholipase inhibitor protein 失效
标题翻译：人类磷脂酶抑制蛋白
公开(公告)号：US5811520A
公开(公告)日：1998-09-22
申请号：US919706
申请日：1997-08-29
申请人： Phillip R. Hawkins , Lynn E. Murry
发明人： Phillip R. Hawkins , Lynn E. Murry
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K45/00 , A61K48/00 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/99 , C12N15/09 , C12Q1/68 , C07K1/00
CPC分类号： C12Q1/6876 , C07K14/4703 , A61K38/00 , C12Q2600/158
摘要： The present invention provides a polynucleotide (gipl) the partial sequence for which was initially isolated from a THP-1 cDNA library and which identifies and encodes a novel human phospholipase inhibitor (GIPL). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding GIPL. The invention also provides for the use of purified GIPL and its agonists in pharmaceutical compositions for the treatment of diseases associated with the abnormal or excess phospholipase activity. Additionally, the invention provides for the use of antisense molecules to gipl or inhibitors of GIPL in pharmaceutical compositions for the prevention of pregnancy or treatment of Alzheimer's disease. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of gipl, or anti-GIPL antibodies which specifically bind to the polypeptide, GIPL.
摘要翻译：本发明提供了一种多核苷酸（gipl），其部分序列最初从THP-1 cDNA文库中分离，并鉴定并编码新的人磷脂酶抑制剂（GIPL）。本发明提供了包含编码GIPL的核酸序列的遗传工程表达载体和宿主细胞。本发明还提供了纯化GIPL及其激动剂在药物组合物中用于治疗与异常或过量磷脂酶活性相关的疾病的用途。另外，本发明提供了用于预防妊娠或治疗阿尔茨海默病的药物组合物中的GIP1或GIPL抑制剂的反义分子的用途。本发明还描述了利用包含多核苷酸，其片段或其互补物的诊断组合物的诊断测定法，其与gipl的基因组序列或转录物或特异性结合多肽GIPL的抗GIPL抗体杂交。

30. 发明授权

US5798249A Human protein disulfide isomerase 失效
标题翻译：人蛋白二硫键异构酶
公开(公告)号：US5798249A
公开(公告)日：1998-08-25
申请号：US650275
申请日：1996-05-16
申请人： Scott Michael Braxton , Lynn E. Murry
发明人： Scott Michael Braxton , Lynn E. Murry
IPC分类号： A61K38/00 , C12N9/90 , C12N15/61 , C07H21/02 , C07H21/04 , C12P21/06
CPC分类号： C12N9/90 , A61K38/00
摘要： The present invention provides a polynucleotide (pdih) the partial sequence for which was initially isolated from a lung cDNA library and which identifies and encodes a novel human protein disulfide isomerase (PDIH). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding PDIH. The invention also provides for the use of purified PDIH and its agonists in the commercial production of recombinant proteins and in pharmaceutical compositions for the treatment of diseases associated with the abnormal expression of PDIH. Additionally, the invention provides for the use of antisense molecules to pdih or inhibitors of PDIH in pharmaceutical compositions for treatment of diseases resulting secretion of PDIH. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of pdih, or anti-PDIH antibodies which specifically bind to the polypeptide, PDIH.
摘要翻译：本发明提供了一种多核苷酸（pdih），其部分序列最初从肺cDNA文库中分离，并鉴定并编码新的人蛋白质二硫键异构酶（PDIH）。本发明提供了包含编码PDIH的核酸序列的基因工程表达载体和宿主细胞。本发明还提供纯化的PDIH及其激动剂在商业生产重组蛋白质和用于治疗与PDIH异常表达相关的疾病的药物组合物中的用途。另外，本发明提供了在用于治疗导致PDIH分泌的疾病的药物组合物中使用pdih的反义分子或PDIH抑制剂。本发明还描述了使用包含其多肽，其片段或其互补物的诊断组合物的诊断测定法，其与pIIh的基因组序列或转录物或与PDIH特异性结合的抗PDIH抗体杂交。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式