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21. 发明授权

US06955651B2 ALGORITHMS, SYSTEMS, AND METHODS FOR ESTIMATING CARBON DIOXIDE STORES, TRANSFORMING RESPIRATORY GAS MEASUREMENTS, AND OBTAINING ACCURATE NONINVASIVE PULMONARY CAPILLARY BLOOD FLOW AND CARDIAC OUTPUT MEASUREMENTS 有权
标题翻译：用于估算二氧化碳储存库，改变呼吸气体测量和获得精确非侵入性血管毛细血管流量和心脏输出量度的算法，系统和方法
公开(公告)号：US06955651B2
公开(公告)日：2005-10-18
申请号：US10121219
申请日：2002-04-11
申请人： Kai Kück , Joseph A. Orr , Lara Brewer
发明人： Kai Kück , Joseph A. Orr , Lara Brewer
IPC分类号： A61B5/026 , A61B5/08 , A61B5/083 , A61B5/087 , G01N1/22 , A61B5/00
CPC分类号： A61B5/0836 , A61B5/029 , G01N33/497 , G01N2001/2244
摘要： Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.
摘要翻译：用于估计个体呼吸道二氧化碳储存体积的方法包括确定二氧化碳储存容积，其中二氧化碳消除的相应信号与个体血液中二氧化碳含量的指标被优化之间的相关性。包括个人呼吸道或肺的模型的二氧化碳储存量的估算可以用作改善二氧化碳消除和二氧化碳含量信号中的一种或两种的准确性的转化。还公开了转换或滤波算法，以及可以使用方法和算法的系统。方法，算法和系统可用于精确地和非侵入性地确定个体的肺毛细血管血流量和心输出量中的一个或两个。

22. 发明申请

US20050124907A1 Noninvasive effective lung volume estimation 有权
标题翻译：无创有效肺容量估计
公开(公告)号：US20050124907A1
公开(公告)日：2005-06-09
申请号：US10973815
申请日：2004-10-25
申请人： Kai Kuck , Joseph Orr , Lara Brewer
发明人： Kai Kuck , Joseph Orr , Lara Brewer
IPC分类号： A61B5/083 , A61B5/091 , G01N1/22 , A61B5/08 , B32B5/02 , G01N31/00 , G01N33/497
CPC分类号： A61B5/0836 , A61B5/091
摘要： Methods for noninvasively measuring, or estimating, functional residual capacity or effective lung volume include obtaining carbon dioxide and flow measurements at or near the mouth of a subject. Such measurements are obtained during baseline breathing and during and shortly after inducement of a change in the subject's effective ventilation. The obtained measurements are evaluated to determine the amount of time required for exhaled carbon dioxide levels to return to normal—effectively an evaluation of carbon dioxide “washout” from the subject's lungs. Conversely, carbon dioxide and flow measurements may be evaluated to determine the amount of time it takes carbon dioxide to “wash in,” or reach peak levels within, the lungs of the subject following the change in the subject's effective ventilation. Apparatus for effective such methods are also disclosed.
摘要翻译：用于非侵入性测量或估计功能残余容量或有效肺体积的方法包括在受试者的嘴部或附近获得二氧化碳和流量测量。在基线呼吸期间和受试者的有效通气改变之后及之后不久，获得这些测量。评估所获得的测量值，以确定呼出二氧化碳水平回复正常有效地评估受试者肺部二氧化碳“冲洗”所需的时间。相反，可以评估二氧化碳和流量测量，以确定在受试者有效通气改变之后二氧化碳“洗涤”所需的时间，或达到受试者肺部内的峰值水平。还公开了用于有效的这种方法的装置。

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