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21. 发明授权

US08129197B2 Cholesterol loaded insect cell membranes as test proteins 有权
标题翻译：胆固醇负载的昆虫细胞膜作为测试蛋白
公开(公告)号：US08129197B2
公开(公告)日：2012-03-06
申请号：US12300479
申请日：2007-05-14
申请人： György Báthori , Dóra Méhn , Pál Ákos , Péter Krajcsi , Lajos Szente , Éva Fenyvesi , Ágnes Telbisz , Balázs Sarkadi , András Váradi , Szilvia Gedey , Hristos Glavinas , Emese Kis , Tünde Nagy , Attila Németh , Éva Molnár
发明人： György Báthori , Dóra Méhn , Pál Ákos , Péter Krajcsi , Lajos Szente , Éva Fenyvesi , Ágnes Telbisz , Balázs Sarkadi , András Váradi , Szilvia Gedey , Hristos Glavinas , Emese Kis , Tünde Nagy , Attila Németh , Éva Molnár
IPC分类号： G01N33/567 , G01N33/53 , C12P1/00 , C12P21/06 , C12N5/07 , C12N5/00
CPC分类号： G01N33/6872 , G01N33/92
摘要： The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane.
摘要翻译：本发明提供了与昆虫细胞膜的生理胆固醇水平相比具有增加的胆固醇水平或控制没有胆固醇负荷的昆虫细胞膜制剂的新型胆固醇负载的昆虫细胞膜制剂，其中所述胆固醇负载的膜制剂包含具有由于膜的胆固醇水平升高导致的底物转运活性增加。本发明还涉及包含本发明制剂的试剂盒。本发明还涉及用于制备所述制剂的方法和用于测量存在于胆固醇负载膜中的ABC转运蛋白的任何类型的活性的方法，以及在该测定系统中研究或测试化合物和化合物和ABC转运蛋白的相互作用。本发明还提供了一种用于测试ABC转运蛋白是否可以在昆虫细胞膜中被胆固醇激活的测试系统。

22. 发明申请

US20110224168A1 FAT-BINDING COMPOSITIONS 有权
标题翻译：脂肪结合组合物
公开(公告)号：US20110224168A1
公开(公告)日：2011-09-15
申请号：US13046762
申请日：2011-03-13
申请人： Lajos SZENTE
发明人： Lajos SZENTE
IPC分类号： A61K31/724 , C08B37/16 , A61P3/06
CPC分类号： C08L5/16 , A23L27/75 , A23L29/35 , A23L33/10 , A23L33/20 , A23V2002/00 , C08B37/0015 , A23V2250/5114 , A23V2200/332 , A23V2250/0612 , A23V2250/0644 , A23V2250/306
摘要： A fat-binding composition contains an inclusion complex with a host molecule and a guest molecule. The guest molecule includes one or more amino acids, vitamins, flavorants or related compounds, rutin, betanin, derivatives thereof, and mixtures thereof. The fat-binding composition may be in the form of a tablet or powder, for example, and may be incorporated into a food or beverage product. If in the form of a powder or tablet, the composition may optionally contain a carbonation-forming component and may be dissolved in carbonated or non-carbonated water. The fat-binding composition may also be employed in a method for binding fat ingested by an animal which includes having the animal ingest the composition, or a food or beverage product containing the same.
摘要翻译：脂肪结合组合物含有与宿主分子和客体分子的包合物。客体分子包括一种或多种氨基酸，维生素，调味剂或相关化合物，芦丁，甜菜碱，其衍生物及其混合物。脂肪结合组合物可以是例如片剂或粉末的形式，并且可以并入食品或饮料产品中。如果以粉末或片剂的形式，组合物可以任选地含有碳酸化形成组分，并且可以溶解在碳酸化或非碳酸化的水中。脂肪结合组合物还可以用于结合由动物摄入的动物的脂肪组合物的方法或包含其的食品或饮料产品。

23. 发明申请

US20100260818A1 STABLE MEDICATED CHEWING GUM COMPRISING CYCLODEXTRIN INCLUSION COMPLEX 审中-公开
标题翻译：包含CYCLODEXTRIN包装复合物的稳定的药用茶叶
公开(公告)号：US20100260818A1
公开(公告)日：2010-10-14
申请号：US12668410
申请日：2008-07-11
申请人： Carsten Andersen , My Ly Lao , Julianna Szeman , Lajos Szente
发明人： Carsten Andersen , My Ly Lao , Julianna Szeman , Lajos Szente
IPC分类号： A61K9/68 , A61K31/495 , A61P27/14
CPC分类号： B82Y5/00 , A23G4/12 , A23G4/20 , A61K9/0058 , A61K9/2086 , A61K31/495 , A61K31/496 , A61K47/6951
摘要： The present invention provides stable medicament-containing chewing gum compositions comprising an inclusion complex comprising cyclodextrin and one or more active compound(s) according to formula I, such as cetirizine, and methods for preparing such chewing gum.
摘要翻译：本发明提供了稳定的含药物的口香糖组合物，其包含包含环糊精和一种或多种根据式I的活性化合物的包合物，例如西替利嗪，以及制备这种口香糖的方法。

24. 发明申请

US20080287553A1 PHARMACEUTICAL COMPOSITIONS COMPRISING PERANHYDROCYCLODEXTRIN 审中-公开
标题翻译：药物组合物包含肾上腺皮质激素
公开(公告)号：US20080287553A1
公开(公告)日：2008-11-20
申请号：US12173439
申请日：2008-07-15
申请人： Lajos Szente , Jozsef Szejtli , Laszlo Jicsinszky , Georg Ludwig Kis , Christian Schoch
发明人： Lajos Szente , Jozsef Szejtli , Laszlo Jicsinszky , Georg Ludwig Kis , Christian Schoch
IPC分类号： A61K47/40
CPC分类号： A61K9/0048 , A61K47/40
摘要： The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
摘要翻译：本发明涉及一种包含环戊二烯环糊精，药物和载体的药物组合物，以使用环戊二烯环糊精作为药物转运增强剂（例如渗透促进剂），以及在制备药物组合物中使用环糊精协同辅助系统。

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