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21. 发明授权

US3914379A Substituted (nitrofuryl-acrylidene) hydrazines with antibacterial properties 失效
标题翻译：取代（硝基丙烯酸酯）具有抗菌性的液体
公开(公告)号：US3914379A
公开(公告)日：1975-10-21
申请号：US37917273
申请日：1973-07-13
申请人： LIPHA
发明人： SZARVASI ETIENNE , FONTAINE LOUIS
IPC分类号： A61K31/38
摘要： Compounds of the formula

IN WHICH N 1 OR O, G is a member of the group formed by the furoyl, thenoyl, nitrothenoyl and carbobenzoxy radicals and R, when n 1, is a member of the group formed by hydrogen, the methyl, butyl, isobutyl, delta -(2-furoyl) amino-butyl, hydroxymethyl, benzyl and p-hydroxybenzyl radicals, are endowed with antibacterial properties, and are useful in bacteriocidal compositions.
摘要翻译：式I的化合物，其中N = 1或O，G是由糠酰基，噻吩甲酰基，硝基苯甲酰基和苄氧羰基形成的基团的成员，当n = 1时，R是由氢形成的基团的成员，，丁基，异丁基，δ-（2-糠酰基）氨基丁基，羟甲基，苄基和对羟基苄基具有抗菌性质，并且可用于杀菌组合物。

22. 发明授权

US3888993A Pharmaceutical composition containing amino alcohols derived from ortho-trans-hydroxycinnamic acids, their esters and their amides 失效
标题翻译：含有衍生自羟基转移羟基酸的氨基醇的药物组合物及其衍生物及其衍生物
公开(公告)号：US3888993A
公开(公告)日：1975-06-10
申请号：US35678673
申请日：1973-05-03
申请人： LIPHA
发明人： BOSCHETTI EUGENE , MOLHO DARIUS , FONTAINE LOUIS
IPC分类号： A61K27/00
摘要： Pharmaceutical compositions which contain as active principle a compound represented by the formula

IN WHICH R is an optionally substituted hydroxy, alkoxy or amino radical, R'' is a branched alkyl radical and X is hydrogen or a halogen. The compositions have a strong blocking activity on the Beta -sympathetic receptors in man, particularly in the treatment of chest angina and tachyarrhythmia.

23. 发明授权

US3828095A Aminoalcohols derived from orthotrans-hydroxy-cinnamic acids and esters 失效
标题翻译：衍生自ORTHOTRANS-HYOXOX-CINNAMIC ACIDS AND ESTERS的氨基醇
公开(公告)号：US3828095A
公开(公告)日：1974-08-06
申请号：US24138172
申请日：1972-04-05
申请人： LIPHA
发明人： FONTAINE L , BOSCHETTI E , MOLHO D
IPC分类号： C07C217/32 , C07C279/22 , C07D303/22 , C07C101/18
CPC分类号： C07D303/22 , C07C279/22 , Y10S514/821
摘要： COMPOUNDS REPRESENTED BY THE FORMULA

1-(R-CO-CH=CH-),2-(R''-NH-CH2-CH(-OH)-CH2-O-),X-BENZENE

IN WHICH R IS AN OPTIONALLY SUBSTITUTED HYDROXY, ALKOXY OR AMINO RADICAL, R'' IS A BRANCHED ALKYL RADICAL AND X IS HYDROGEN OR A HALOGEN. THE COMPOUNDS HAVE A STRONG BLOCKING A ACTIVITY ON THE B-SYMPATHETIC RECEPTORS IN MAN, PARTICULARLY IN THE TREATMENT OF CHEST ANGINA AND TACHYARRHYTHMIA.

24. 发明授权

US3780102A Substituted cinnamamides 失效
标题翻译：取代的CINNAMAMIDES
公开(公告)号：US3780102A
公开(公告)日：1973-12-18
申请号：US3780102D
申请日：1971-09-10
申请人： LIPHA
发明人： GRAND M , BAYSSAT M , FONTAINE L
IPC分类号： A61K31/165 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/12 , C07C233/29 , C07C235/34 , C07C103/30
CPC分类号： A61K31/165 , C07C233/12 , Y10S514/906
摘要： C2H5NH-COO-C2H4-
THE PRESENT INVENTION CONCERNS NEW CINNAMAMIDES OF FORMULA:

(R1,R2,R3-PHENYL)-C(-R4)=C(-R5)-CO-N(-R6)-C(-R7)(-R8)-

CH(-R9)-R10

IN WHICH R1 AND R3 ARE HYDROGEN, A LOWER ALKYL OR LOWER ALKOXY RADICAL; R2 IS HYDROGEN, A HALOGEN, A LOWER ALKYL OR LOWER ALKOXY RADICAL; R4 AND R5 ARE HYDROGEN OR A LOWER ALKYL RADICAL; R6 IS HYDROGEN, A LOWER ALKYL OR LOWER HYDROXYL ALKYL RADICAL ARYL RADICAL OR

R7 AND R8 ARE HYDROGEN, A LOW ALKYL OR LOWER HYDROXY, ALKYL RADICAL; R9 IS HYDROGEN, A LOWER ALKYL OR LOWER HYDROXY ALKYL RADICAL; R10=HALOGEN, A HYDROXY RADICAL EXCEPT WHEN R1 TO R9=H AND R1, R2, R3=CH3O, R4=CH3 AND R5 TO R9=H, A LOWER ALKYL RADICAL, A LOWER HYDROXYALKYL RADICAL, NH2-COO, A LOWER ALKYL RADICAL -NH-COO AND ARYL RADICAL-NH-COO. THE INVENTION IS RELATIVE TO PREPARATION PROCESSES AND MEDICINE CONTAINING AS ACTIVE PRINCIPLE A CINNAMAMIDE OF FORMULA I, IN WHICH THE RADICALS R1 TO R9 HAVE THE SAME MEANINGS A S ABOVE AND R10=HALOGEN, A HYDROXY RADICAL-EXCEPT WHEN R1, R2, R3=CH3O, R4=CH3 AND R5 TO R9=H-LOWER HYDROXY ALKYL, NH2COO, LOWER ALKYL-NHCOO-ARYL NHCOO.

25. 发明授权

US3659014A Substituted cinnamamides in myorelaxant compositions 失效
标题翻译：松香组合物中取代的新兴化合物
公开(公告)号：US3659014A
公开(公告)日：1972-04-25
申请号：US3659014D
申请日：1970-03-31
申请人： LIPHA
发明人： BAYSSAT MICHEL , GRAND MARCEL
IPC分类号： A61K31/165 , C07C67/00 , C07C231/00 , C07C231/02 , C07C233/12 , C07C233/29 , C07C235/34 , A61K27/00
CPC分类号： A61K31/165 , C07C233/12 , Y10S514/906
摘要： THE PRESENT INVENTION CONCERNS NEW CINNAMAMIDES OF FORMULA:

(R1,R2,R3-PHENYL)-C(-R4)=C(-R5)-CO-N(-R6)-C(-R7)(-R8)-

CH(-R9)-R10

IN WHICH R1 AND R3 ARE HYDROGEN, A LOWER LAKYL OR LOWER ALKOXY RADICAL; R2 IS HYDROGEN, A HALOGEN, A LOWER ALKYL OR LOWER ALKOXY RADICAL; R4 AND R5 ARE HYDROGEN OR A LOWER ALKYL RADICAL; R6 IS HYDROGEN, A LOWER ALKYL OR LOWER HYDROXY ALKYL RADICAL ARYL RADICAL OR

C2H5NH-COO-C2H4-

R7 AND R8 ARE HYDROGEN, A LOWER ALKYL OR LOWER HYDROXY, ALKYL RADICAL; R9 IS HYDROGEN, A LOWER ALKYL OR LOWER HYDROXY ALKYL RADICAL; R10=HALOGEN, A HYDROXY RADICAL-EXCEPT WHEN R1 TO R9=H AND R1,R2,R3=CH3O,R4=CH3 AND R5 TO R9=H, A LOWER ALKYL RADICAL, A LOWER HYDROXYALKYL RADICAL, NH2-COO, A LOWER ALKYL RADICAL

-NH-COO

AND ARYL RADICAL-NH-COO. THE INVENTION IS REALTIVE TO PREPARATION PROCESSES AND MEDICINE CONTAINING AS ACITVE PRINCIPLE A CINNAMAMIDE OF FORMULA I, IN WHICH THE RADICALS R1 TO R9 HAVE THE SAME MEANINGS AS ABOVE AND R10=HALOGEN, A HYDROXY RADICAL EXCEPT WHEN R1, R2, R3=CH3O, R4=CH3 AND R5 TO R9=H-LOWER HYDROXY ALKYL, NH2COO, LOWER ALKYL

-NHCOO-ARYL-NHCOO

26. 发明授权

US3651091A Derivatives of 4-hydroxy coumarin and the preparation thereof 失效
标题翻译： 4-羟基甘氨酸的衍生物及其制备方法
公开(公告)号：US3651091A
公开(公告)日：1972-03-21
申请号：US3651091D
申请日：1969-11-21
申请人： LIPHA
发明人： BOSCHETTI EUGENE , MOLHO DARIUS , FONTAINE LOUIS
IPC分类号： C07D311/12 , A01N43/16 , A61K31/37 , C07D311/42 , C07D409/06 , E04G21/26 , C07D7/30
CPC分类号： A01N43/16 , A61K31/37 , C07D311/42 , C07D409/06 , E04G21/26 , Y10S514/822
摘要： THE 4-HYDROXY COUMARINS ARE REPRESENTED BY THE FORMULA

2-(O=),3-(R1-CH(-OH)-CH2-CH(-R)-),4-(HO-),R2-2H-CHROMENE

IN WHICH R IS A MEMBER OF THE GROUP FORMED BY HYDROGEN, THE PHENYL, HALOPHENYL, HIHALOPHENYL, NITROPHENYL, METHOXPENYL, TOLYL, METHYLENE DIOXPHENYL AND FURYL RADICALS; R1 IS A MEMBER OF THE GROUP FORMED BY THE METHYL, PHENYL, HALOPHENYL, NITROPHENYL, DIPHENYL, HALODIPHENYL, NITRODIPHENYL AND NAPHTHYL RADICALS; AND R2 IS HYDROGEN OR A HALOGEN. THESE ARE 4-HYDROXY COUMARINS HAVE VERY POWERFUL ORAL ANTICOAGULATING ACTIONS OF THE ANTIVITAMIN K TYPE.

27. 发明授权

US3585214A Hydroxyl derivatives of coumarine and processes for the preparation thereof 失效
标题翻译：化学式的羟基衍生物及其制备方法
公开(公告)号：US3585214A
公开(公告)日：1971-06-15
申请号：US3585214D
申请日：1968-03-15
申请人： LIPHA
发明人： BOSCHETTI EUGENE , MOLHO DARIUS , FONTAINE LOUIS
IPC分类号： C07D311/12 , C07D311/16 , C07D7/38
CPC分类号： C07D311/16 , C07D311/12
摘要： THIS INVENTION DISCLOSES A NEW SERIES OF DERIVATIVES OF COUMARINE, HAVING STRONG HYPOTENSIVE ACTIVITY, SPASMOLYTIC ACTIVITY ON THE SPHINCTER OF ODDI AND CHOLERETIC ACTIVITY, WHICH COME WITHIN THE SCOPE OF THE FORMULA.

3-R,4-R1,5-R2,6-R3,7-R4,8-R5-CHROMEN-2-ONE

WHEREIN, DEPENDING ON THE COMPOUND, R IS A HYDROXY, ALKYL, ARALKYL, PYRIDYL ALKYL, ARYL OR AMINO RADICAL, R1, R2, R3, R4 AND R5 ARE HYDROGEN OR A HYDROXY RADICAL.

28. 发明授权

US3574234A Derivatives of 4-hydroxy coumarine 失效
标题翻译： 4-羟基甘氨酸的衍生物
公开(公告)号：US3574234A
公开(公告)日：1971-04-06
申请号：US3574234D
申请日：1967-12-11
申请人： LIPHA
发明人： BOSCHETTI EUGENE , MOLHO DARIUS , FONTAINE LOUIS
IPC分类号： C07D311/12 , A01N43/16 , A61K31/37 , C07D311/42 , C07D409/06 , E04G21/26 , A61K27/00 , C07D63/12
CPC分类号： A01N43/16 , A61K31/37 , C07D311/42 , C07D409/06 , E04G21/26 , Y10S514/822
摘要： 4-HYDROXY COUMARINES REPRESENTED BY THE FORMULA

2-(O=),3-(R1-CH(-OH)-CH2-CH(-R)-),4-(HO-)-2H-CHROMENE

IN WHICH: R IS A MEMBER OF THE GROUP FORMED BY THE THIENYL, METHYL-THIENYL, HALOTHIENYL AND NITROTHIENYL RADICALS; AND R1 IS A MEMBER OF THE GROUP FORMED BY THE METHYL, PHENYL, HALOPHENYL, NITROPHENYL, DIPHENYL, HALODIPHENYL AND NITRODIPHENYL RADICALS, AND PROCESSES FOR THEIR PREPARATION.

29. 发明授权

US3915998A Disubstituted carboxylic acids and disubstituted ethyl malonates for use as intermediates 失效
标题翻译：二取代羧酸和二取代乙基丙二酸酯用作中间体
公开(公告)号：US3915998A
公开(公告)日：1975-10-28
申请号：US40091973
申请日：1973-09-26
申请人： LIPHA
发明人： SZARVASI ETIENNE
IPC分类号： C07D307/16 , C07D307/12
CPC分类号： C07D307/16 , Y10S514/929
摘要： The present invention relates to substituted tetrahydrofurfuryl aminoesters. The novel tetrahydrofurfuryl dialkyl aminoesters are represented by the formula

in which R is a member of the group formed by the 2-naphthyl, 2naphthyl substituted in the 6-position with alkoxy and 5,6,7,8tetrahydro-1-naphthyl radicals. The addition salts with the therapeutically acceptable acids, the starting and intermediate products of these aminoesters, also form the subject of the invention.
摘要翻译：本发明涉及取代的四氢糠基氨基酯。新的四氢糠基二烷基氨基酯由式C2H5 R-CH2-CH-CO2CH2-CH2N ANGLE | -C2H5 ||| CH2-角度O表示，其中R是由2-萘基，2-萘基，在6-位被烷氧基和5,6,7,8-四氢-1-萘基取代的萘基。与治疗上可接受的酸的加成盐，这些氨基酯的起始和中间产物也形成本发明的主题。

30. 发明授权

US3867546A Novel rodenticides compositions 失效
标题翻译：新型罗丹明组合物
公开(公告)号：US3867546A
公开(公告)日：1975-02-18
申请号：US26051272
申请日：1972-06-07
申请人： LIPHA
发明人： LECHEVIN JEAN-CLAUDE
IPC分类号： A01N25/00 , A01N25/02 , A01N9/28
CPC分类号： A01N25/004 , A01N25/02
摘要： The invention relates to novel rodenticides compositions. The said rodenticide compositions are constituted by solutions in polyoxyethylene glycols of an anti-coagulant substance such as 2diphenylacetyl-1,3 indandione; 2 - ( Alpha - p-chlorophenyl Alpha -phenylacetyl) - 1,3- indandione; 3- - ( Alpha (3 - oxo 2'' - phenyl) butyl) - 4 - hydroxycoumarin or 3 - ((3'' - oxo- 2'', p -chlorophenyl) butyl) - 4 - hydroxycoumarin. The aqueous dilutions of these solutions may be offered as toxic beverages for the rodents, and they may be atomized on plants consumed by the rodents, and on any powder and absorbent substance capable of constituting a ''''run'''' poison.
摘要翻译：本发明涉及新型杀鼠剂组合物。所述灭鼠剂组合物由2-二苯基乙酰基-1,3-茚满二酮等抗凝剂物质的聚氧乙烯二醇溶液构成， 2-（α-对氯苯基-α-苯基乙酰基）-1,3-茚满二酮; 3-（α（3-氧代-2'-苯基）丁基] -4-羟基香豆素或3 - [（3'-氧代-2'，对氯苯基）丁基] -4-羟基香豆素。

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