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21. 发明授权

US06962992B2 Crown ether derivatives 失效
标题翻译：冠醚衍生物
公开(公告)号：US06962992B2
公开(公告)日：2005-11-08
申请号：US10026302
申请日：2001-12-19
申请人： Vladimir V. Martin , Kyle R. Gee , Richard P. Haugland , Zhenjun Diwu
发明人： Vladimir V. Martin , Kyle R. Gee , Richard P. Haugland , Zhenjun Diwu
IPC分类号： C07D273/00 , C07H21/00 , C09B57/10 , C09B69/00 , G01N33/58 , G01N33/84 , C07D413/04 , C07D273/08 , C07D317/28
CPC分类号： A61K49/0052 , A61K49/0021 , A61K49/0041 , C07D273/00 , C07H21/00 , C09B11/24 , C09B23/04 , C09B57/00 , C09B57/10 , C09B69/00 , G01N33/582 , G01N33/84
摘要： The invention describes crown ether chelators, including crown ethers having the formula and aza-substituted and thia-substituted analogs thereof. These crown ethers are substituted by a dye moiety, a chemically reactive group, a conjugated substance, or a combination thereof. Chelators that are substituted by fluorescent dyes are particularly useful as indicators for metal cations, particularly Na+ and K+ ions, and particularly where binding of the target ion results in a change in the fluorescence properties of the indicator that can be correlated with the ion concentration. Methods are provided for utilizing reactive groups on the chelators for conjugation to dyes, lipids and polymers and methods for enhancing entry of the indicators into living cells.
摘要翻译：本发明描述了冠醚螯合剂，包括具有下式的冠醚和其氮杂取代和硫取代的类似物。这些冠醚被染料部分，化学反应性基团，共轭物质或其组合取代。被荧光染料取代的螯合剂特别可用作金属阳离子，特别是Na +和K + +离子的指示剂，特别是当目标离子的结合导致变化时在可以与离子浓度相关的指示剂的荧光特性中。提供了利用螯合剂上的反应性基团与染料偶联的方法，脂质和聚合物以及用于增强指示剂进入活细胞的方法。

22. 发明授权

US06716979B2 Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings 有权
标题翻译：含稠环的1,2-二氢-7-羟基喹啉的衍生物
公开(公告)号：US06716979B2
公开(公告)日：2004-04-06
申请号：US09922333
申请日：2001-08-04
申请人： Zhenjun Diwu , Jiaxing Liu , Richard P. Haugland , Kyle R. Gee
发明人： Zhenjun Diwu , Jiaxing Liu , Richard P. Haugland , Kyle R. Gee
IPC分类号： C07D49122
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04 , C07D495/14 , G01N33/582 , Y10S436/80
摘要： The present invention describes novel dyes, including coumarins, rhodamines, and rhodols that incorporate additional fused aromatic rings. The dyes of the invention absorb at a longer wavelength than structurally similar dyes that do not possess the fused aromatic rings. Many of the dyes of the invention are useful fluorescent dyes. The invention includes chemically reactive dyes, dye-conjugates, and the use of such dyes in staining samples and detecting ligands or other analytes.
摘要翻译：本发明描述了新颖的染料，包括掺入另外的稠合芳环的香豆素，罗丹明和罗丹醇。本发明的染料比不具有稠合芳环的结构相似的染料长的波长吸收。本发明的许多染料是有用的荧光染料。本发明包括化学活性染料，染料共轭物，以及这些染料在染色样品和检测配体或其它分析物中的用途。

23. 发明授权

US06229055B1 Synthesis of fluorinated xanthene derivatives 有权
标题翻译：氟化呫吨衍生物的合成
公开(公告)号：US06229055B1
公开(公告)日：2001-05-08
申请号：US09632251
申请日：2000-08-03
申请人： Dieter H. Klaubert , Kyle R. Gee
发明人： Dieter H. Klaubert , Kyle R. Gee
IPC分类号： C07C3910
CPC分类号： C09B11/00 , C07C37/055 , C07C41/18 , C07C201/08 , C07C201/12 , C07C205/26 , C07C205/37 , C07C209/10 , C07C213/02 , C07C213/08 , C07C245/20 , C07D311/82 , C09B11/24 , G01N1/30 , Y10S430/116 , Y10S430/126 , C07C39/245 , C07C211/52 , C07C217/84 , C07C215/76 , C07C43/225
摘要： Facile syntheses for fluorinated resorcinol and aminophenol derivatives are provided that yield isomer-free products in good yield. These novel methods use generally available precursors and standard laboratory reagents and equipment to reproducibly produce these synthetically useful reagents in relatively large quantities. The resulting fluorinated resorcinols and aniinophenols possess utility in the preparation of fluorinated fluorescein and rhodol dyes.
摘要翻译：提供氟化间苯二酚和氨基苯酚衍生物的简便合成，其以良好的收率产生无异构体的产物。这些新颖的方法通常使用可用的前体和标准实验室试剂和设备以相当大的量重复地生产这些合成有用的试剂。得到的氟化间苯二酚和苯醌具有用于制备氟化荧光素和罗丹明染料。

24. 发明授权

US5888829A Photolabile caged ionophores and method of using in a membrane separation process 失效
标题翻译：光不稳定的笼式离子载体和在膜分离过程中使用的方法
公开(公告)号：US5888829A
公开(公告)日：1999-03-30
申请号：US638261
申请日：1996-04-26
申请人： Kyle R. Gee , Paul J. Millard
发明人： Kyle R. Gee , Paul J. Millard
IPC分类号： A61K41/00 , C07C229/08 , C07C229/24 , C07C323/58 , C07D207/40 , C07D207/404 , C07D493/10 , C07F9/09 , C07F9/165 , C07H19/06 , C07H19/20 , G01N21/00 , C07H1/06 , G01N33/558
CPC分类号： A61K41/0042 , C07C229/08 , C07C229/24 , C07C323/58 , C07D207/404 , C07D493/10 , C07F9/094 , C07F9/1653 , C07H19/06 , C07H19/20 , C07B2200/07
摘要： The present invention describes a family of photolabile caged ionophores. The compounds of the present invention are photolytically cleavable esters of nigericin, ionomycin, A-23187, 4-Br-A-23187 and monensin. The photolysis of the present compounds allows the release of the free ionophore in vivo or in vitro with precise spatial and temporal control. The compounds are useful in the study of ion transport and control in cells and across membranes.
摘要翻译：本发明描述了一种光不稳定的笼式离子载体。本发明的化合物是尼可霉素，离子霉素，A-23187,4-Br-A-23187和莫能菌素的可光解裂解的酯。本发明化合物的光解使得体内或体外释放游离离子载体具有精确的空间和时间控制。这些化合物可用于研究细胞和膜间的离子转运和控制。

25. 发明授权

US5872243A Caged nucleotides 失效
标题翻译：笼状核苷酸
公开(公告)号：US5872243A
公开(公告)日：1999-02-16
申请号：US497183
申请日：1995-06-30
申请人： Kyle R. Gee , Hon Cheung Lee , Robert Aarhus , Richard P. Haugland , Timothy F. Walseth , Richard M. Graeff
发明人： Kyle R. Gee , Hon Cheung Lee , Robert Aarhus , Richard P. Haugland , Timothy F. Walseth , Richard M. Graeff
IPC分类号： C07H19/20 , C07H21/02 , C07H1/00 , C07H21/00
CPC分类号： C07H19/20 , C07H21/02
摘要： The present invention describes a family of photolabile caged nucleotides, including cyclic nucleotides. The compounds of the present invention are caged analogs and derivatives of NAD.sup.+, NADH, NADP, NADPH, NAADP and cADPR. The photolysis of the present compounds allows the release of the free nucleotide in vivo or in vitro with precise spatial and temporal control. The compounds are useful for the photolytic generation of free nucleotides in aqueous samples, for example, in the study of calcium mobilization in cells and cell homogenates.
摘要翻译：本发明描述了一种包含环状核苷酸的光不稳定笼状核苷酸家族。本发明的化合物是NAD +，NADH，NADP，NADPH，NAADP和cADPR的笼养类似物和衍生物。本发明化合物的光解使得体内或体外释放游离核苷酸具有精确的空间和时间控制。这些化合物可用于水溶液样品中游离核苷酸的光解产生，例如在细胞和细胞匀浆中钙迁移的研究中。

26. 发明授权

US5830912A Derivatives of 6,8-difluoro-7-hydroxycoumarin 失效
标题翻译： 6,8-二氟-7-羟基香豆素的衍生物
公开(公告)号：US5830912A
公开(公告)日：1998-11-03
申请号：US749684
申请日：1996-11-15
申请人： Kyle R. Gee , Richard P. Haugland , Wei-Chuan Sun
发明人： Kyle R. Gee , Richard P. Haugland , Wei-Chuan Sun
IPC分类号： C07D311/16 , C07D311/54 , C07F9/655 , C09B57/02 , A61K31/37 , C07D311/14
CPC分类号： C07D311/16 , C07D311/54 , C07F9/65522 , C09B57/02
摘要： The present invention comprises 6,8-difluoro-7-hydroxycoumarins and derivatives of 6,8-difluoro-7-hydroxycoumarins, including reactive dyes, dye-conjugates and enzyme substrates. These fluorine-substituted fluorescent dyes typically possess greater photostability and lower pH sensitivity in the physiological pH range than their nonfluorinated analogs, exhibit less fluorescence quenching when conjugated to a substance, possess absorption and emission spectra that closely match those of their nonfluorinated analogs, and also exhibit higher quantum yields than their nonfluorinated analogs.
摘要翻译：本发明包括6,8-二氟-7-羟基香豆素和6,8-二氟-7-羟基香豆素的衍生物，包括活性染料，染料共轭物和酶底物。这些氟取代的荧光染料通常在生理pH范围内比其非氟化类似物具有更高的光稳定性和较低的pH敏感性，当与物质缀合时显示较少的荧光猝灭，具有与其非氟化类似物的吸收和发射光谱非常接近的吸收和发射光谱，以及表现出比其非氟化类似物更高的量子产率。

27. 发明授权

US5514710A Photocleavable derivatives of hydroxyprenesulfonic acids 失效
标题翻译：羟基磺酸的可透光衍生物
公开(公告)号：US5514710A
公开(公告)日：1996-05-07
申请号：US180543
申请日：1994-01-11
申请人： Richard P. Haugland , Kyle R. Gee
发明人： Richard P. Haugland , Kyle R. Gee
IPC分类号： C07C309/43 , A61K31/265 , A61K31/185 , C07C69/96 , C07C309/38
CPC分类号： C07C309/43
摘要： The invention describes the synthesis and use of photoactivated (or caged) fluorescent dyes. Upon illumination at less than about 400 nm the caged dyes release highly fluorescent, water soluble hydroxypyrenesulfonic acid dyes according to the following equation: ##STR1## X, Y, and Z are independently sulfonic acid, a sulfonic acid salt, a hydroxyl group, or hydrogen, with at least one of X, Y, and Z being a sulfonic acid or sulfonic acid salt. LINK is either an ether linkage or a carbonate linkage. BLOCK is a caging group whose photolysis results in liberation of a free hydroxypyrenesulfonic acid dye.The caged fluorescent dyes are useful for application in aqueous solutions, including fluids of biological origin. The caged dyes of the present invention are especially useful for flow tagging velocimetry.
摘要翻译：本发明描述了光活化（或笼式）荧光染料的合成和应用。在小于约400nm的照射下，笼状染料根据以下等式释放高度荧光的水溶性羟基苯磺酸染料：X，Y和Z独立地为磺酸，磺酸盐，羟基或氢，X，Y和Z中的至少一个为磺酸或磺酸盐。 LINK是醚键或碳酸酯键。 BLOCK是一种闭孔组，其光解导致游离羟基苯磺酸染料的释放。笼式荧光染料可用于水溶液，包括生物来源的流体。本发明的笼状染料特别适用于流动标签测速。

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