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21. 发明授权

US5219965A Surface modification of polymer objects 失效
标题翻译：聚合物对象的表面改性
公开(公告)号：US5219965A
公开(公告)日：1993-06-15
申请号：US619282
申请日：1990-11-27
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Yu-Chin Lai
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Yu-Chin Lai
IPC分类号： C08F2/00 , C08F290/00 , C08F290/04 , C08F290/06 , C08F290/14 , C08F299/00 , C08J7/04 , C08L101/00 , G02B1/04 , G02C7/04
CPC分类号： C08F290/14 , C08F290/04 , G02B1/043
摘要： A method of modifying the surfaces of polymeric objects by adding a polymerizable surfactant to the monomer mix used to form the object. Also disclosed are surface-modified objects prepared by this method, which is particularly suited for modifying the surfaces of contact lenses.
摘要翻译：一种通过向用于形成物体的单体混合物中加入可聚合表面活性剂来改性聚合物体表面的方法。还公开了通过该方法制备的表面改性物体，其特别适用于改变隐形眼镜的表面。

22. 发明授权

US4289924A Injectable grommet assembly 失效
标题翻译：注射索环组件
公开(公告)号：US4289924A
公开(公告)日：1981-09-15
申请号：US190446
申请日：1980-09-24
申请人： Warren Pearce, Jr. , Stephan H. Schramme , John L. Lightner , Joseph A. McGee
发明人： Warren Pearce, Jr. , Stephan H. Schramme , John L. Lightner , Joseph A. McGee
IPC分类号： H01B17/58 , F16B5/07 , H01B17/30 , H02G3/22
CPC分类号： H01B17/306 , B60R16/0222 , H02G3/22
摘要： An injectable grommet assembly for passing a bundle of insulated electric wires through a bulkhead comprises a pair of assembled shells having complementary grommet and flange segments. The grommet segments form an annular seal chamber which surrounds the bundle of insulated electric wires. A wire clip disposed in this chamber spreads out the bundle of insulated wires so that sealant injected into the chamber also fills spaces between the insulated electric wires. The assembly also includes a gasket for sealing against the face of the bulkhead.
摘要翻译：用于使绝缘电线束穿过隔板的可注射索环组件包括具有互补的护环和凸缘段的一对组装的壳体。索环段形成围绕绝缘电线束的环形密封室。设置在该室中的线夹将该绝缘电线束分散开，使得注入室中的密封剂也填充绝缘电线之间的空间。该组件还包括用于密封隔板的表面的垫圈。

23. 发明申请

US20100168851A1 Surface Modified Biomedical Devices 审中-公开
标题翻译：表面改性生物医学装置
公开(公告)号：US20100168851A1
公开(公告)日：2010-07-01
申请号：US12641412
申请日：2009-12-18
申请人： David Paul Vanderbilt , Paul L. Valint, JR. , Joseph A. McGee
发明人： David Paul Vanderbilt , Paul L. Valint, JR. , Joseph A. McGee
IPC分类号： A61F2/16 , B05D7/00 , B65B55/02 , G02C7/04
CPC分类号： G02B1/043 , A61F2/1613 , C08L63/00 , C08L85/04 , C08L33/068
摘要： Disclosed are surface modified biomedical devices having a coating on a surface thereof, the coating comprising an inner layer comprising a polymer comprising monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety, and an outer layer comprising a hydrophilic hydrolyzed reactive polymer comprising monomeric units derived from an ethylenically unsaturated containing monomer having hydrolyzable reactive functionalities.
摘要翻译：公开了在其表面上具有涂层的表面改性的生物医学装置，该涂层包含内层，该内层包含衍生自含有硼酸部分的烯属不饱和单体的单体单元的聚合物，以及包含亲水性水解反应性聚合物的外层，其包含单体衍生自具有可水解反应性官能团的含烯属不饱和单体的单元。

24. 发明授权

US06759496B2 Poly(2-oxazoline) biomedical devices 有权
标题翻译：聚（2-恶唑啉）生物医学装置
公开(公告)号：US06759496B2
公开(公告)日：2004-07-06
申请号：US10008441
申请日：2001-12-06
申请人： Jay F. Kunzler , Yu-Chin Lai , Joseph A. McGee , Paul L. Valint, Jr.
发明人： Jay F. Kunzler , Yu-Chin Lai , Joseph A. McGee , Paul L. Valint, Jr.
IPC分类号： C08F12600
CPC分类号： G02B1/043 , A61L27/18 , C08L79/02 , C08L79/04
摘要： Biomedical devices are formed from the polymerization product of a monomeric mixture including a poly(2-oxazoline) endcapped with an ethylenically unsaturated radical, such as poly(2-oxazoline) macromonomers and telechelics. Preferred devices are ophthalmic lenses, especially contact lenses and intraocular lenses.
摘要翻译：生物医学装置由包含与烯键式不饱和基团（例如聚（2-恶唑啉））大分子单体和电视电解质封端的聚（2-恶唑啉）的单体混合物的聚合产物形成。优选的装置是眼科镜片，特别是隐形眼镜和人工晶状体。

25. 发明授权

US06599559B1 Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers 失效
公开(公告)号：US06599559B1
公开(公告)日：2003-07-29
申请号：US09541588
申请日：2000-04-03
申请人： Joseph A. McGee , Paul L. Valint, Jr. , James A. Bonafini, Jr.
发明人： Joseph A. McGee , Paul L. Valint, Jr. , James A. Bonafini, Jr.
IPC分类号： C08J704
CPC分类号： G02B1/043 , A61L27/34 , C08J7/047 , Y10T428/31511 , Y10T428/31663 , C08L83/00 , C08L43/04
摘要： The present invention is directed toward the renewable surface treatment of medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a removable hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.

26. 发明授权

US06440571B1 Surface treatment of silicone medical devices with reactive hydrophilic polymers 失效
公开(公告)号：US06440571B1
公开(公告)日：2002-08-27
申请号：US09315620
申请日：1999-05-20
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Joseph C. Salamone , Ricahrd M. Ozark
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Joseph C. Salamone , Ricahrd M. Ozark
IPC分类号： B32B2708
CPC分类号： C08J7/047 , A61L27/34 , C08J2383/04 , G02B1/043 , Y10T428/31663 , C08L83/10
摘要： The present invention is directed toward the surface treatment of silicone medical devices such as contact lenses and medical implants. In particular, the present invention is directed to a method of modifying the surface of a medical device to increase its biocompatibility or hydrophilicity by coating the device with a hydrophilic polymer by means of reaction between reactive functionalities on the hydrophilic polymer which functionalities are complementary to reactive functionalities on or near the surface of the medical device. The present invention is also directed to a contact lens or other medical device having such a surface coating.

27. 发明授权

US5981675A Silicone-containing macromonomers and low water materials 有权
标题翻译：含硅氧烷的大分子单体和低水的材料
公开(公告)号：US5981675A
公开(公告)日：1999-11-09
申请号：US206470
申请日：1998-12-07
申请人： Paul L. Valint, Jr. , Joseph A. McGee , Richard M. Ozark
发明人： Paul L. Valint, Jr. , Joseph A. McGee , Richard M. Ozark
IPC分类号： C08F290/04 , C08F290/12 , G02B1/04 , C08F30/08
CPC分类号： C08F290/12 , C08F290/04 , G02B1/043
摘要： Low water siloxane macromonomer are disclosed. This macromonomer can be copolymerized with unsaturated silicone containing monomers to prepare polymeric materials useful as biomedical devices. These macromonomers are particularly suited for soft contact lens applications.
摘要翻译：公开了低水硅氧烷大分子单体。这种大分子单体可以与含有不饱和硅氧烷的单体共聚以制备用作生物医学装置的聚合材料。这些大分子单体特别适用于软性隐形眼镜应用。

28. 发明授权

US5525691A Surface modification of polymeric objects 失效
标题翻译：聚合物表面改性
公开(公告)号：US5525691A
公开(公告)日：1996-06-11
申请号：US457182
申请日：1995-06-01
申请人： Paul L. Valint, Jr. , Joseph A. McGee
发明人： Paul L. Valint, Jr. , Joseph A. McGee
IPC分类号： C08F2/00 , C08F290/00 , C08F290/04 , C08F290/06 , C08F290/14 , C08F299/00 , C08J7/04 , C08L101/00 , G02B1/04 , G02C7/04 , C08F18/20 , C08F12/30 , C08F20/22 , C08F30/08
CPC分类号： C08F290/14 , C08F290/04 , G02B1/043
摘要： A class of polymerizable surfactants are described by the formulaDC(A.sub.x B.sub.y)wherein A is a monomer unit derived from at least one ethylenically unsaturated hydrophilic monomer, B is a monomer unit derived from at least one ethylenically unsaturated hydrophobic monomer, C is a functional chain transfer agent, D is an ethylenically unsaturated end group, y is within the range from about 0.1 to about 0.9, and x+y=1. The polymerizable surfactants are useful for modifying the surfaces of polymeric objects, especially contact lenses.
摘要翻译：一类可聚合表面活性剂由式DC（AxBy）描述，其中A是衍生自至少一种烯属不饱和亲水性单体的单体单元，B是衍生自至少一种烯属不饱和疏水性单体的单体单元，C是功能链转移剂，D是烯键式不饱和端基，y在约0.1至约0.9的范围内，x + y = 1。可聚合表面活性剂可用于改性聚合物体，特别是隐形眼镜的表面。

29. 发明授权

US5387663A Macromonomers 失效
标题翻译：大分子单体
公开(公告)号：US5387663A
公开(公告)日：1995-02-07
申请号：US186204
申请日：1994-01-25
申请人： Joseph A. McGee , Paul L. Valint, Jr.
发明人： Joseph A. McGee , Paul L. Valint, Jr.
IPC分类号： G02C7/04 , C08F2/38 , C08F30/08 , C08F290/00 , C08F290/04 , C08F299/00 , G02B1/04 , C08F230/08 , C08F228/02
CPC分类号： C08F290/04 , C08F2/38 , G02B1/043
摘要： Novel siloxane macromonomers are disclosed which can be copolymerized with hydrophilic monomers or hydrophobic monomers to prepare polymeric materials useful as biomedical devices. The copolymers made from hydrophilic monomers exhibit good oxygen permeability and are particularly suitable for use in contact lenses.
摘要翻译：公开了新的硅氧烷大分子单体，其可以与亲水单体或疏水单体共聚以制备用作生物医学装置的聚合物材料。由亲水性单体制得的共聚物表现出良好的透氧性，特别适用于隐形眼镜。

30. 发明授权

US08377126B2 Renewable polymeric lens coating 失效
标题翻译：可再生聚合物镜片涂层
公开(公告)号：US08377126B2
公开(公告)日：2013-02-19
申请号：US12641422
申请日：2009-12-18
申请人： Joseph A. McGee , David Paul Vanderbilt , Paul L. Valint, Jr.
发明人： Joseph A. McGee , David Paul Vanderbilt , Paul L. Valint, Jr.
IPC分类号： A61F2/16
CPC分类号： G02B1/043 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2430/16
摘要： Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed.
摘要翻译：公开了在其表面的一部分上具有亲水涂层的生物医学装置，所述生物医学装置包括：（a）由单体混合物的聚合产物获得的生物医学装置，其包含（i）含有硼酸部分的可聚合单体和吸电子部分; 和（ii）生物医学装置形成共聚单体; 和（b）沿着聚合物链具有互补的反应性官能团的亲水性反应性聚合物，其中沿着（b）的亲水性反应性聚合物的聚合物链的互补反应性官能团与（a）的生物医学装置的硼酸部分结合，从而产生生物相容性涂层，其可以被去除并重新施加以将生物医学装置的表面性质恢复到基本上新的状态。还公开了用于治疗生物医学装置的方法。

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