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21. 发明授权

US09006268B2 Prolylcarboxypeptidase inhibitors 有权
标题翻译：脯氨酰羧肽酶抑制剂
公开(公告)号：US09006268B2
公开(公告)日：2015-04-14
申请号：US13702656
申请日：2011-06-06
申请人： John S. Debenham , Jinlong Jiang , Christina B. Madsen-Duggan , Dong-Ming Shen
发明人： John S. Debenham , Jinlong Jiang , Christina B. Madsen-Duggan , Dong-Ming Shen
IPC分类号： A61K31/4545 , C07D401/14 , A61K31/366 , A61K31/397 , A61K31/44 , A61K31/519 , C07D413/14 , C07D417/04 , C07D417/14 , A61K31/454 , A61K31/506 , A61K45/06
CPC分类号： C07D401/14 , A61K31/366 , A61K31/397 , A61K31/44 , A61K31/454 , A61K31/4545 , A61K31/506 , A61K31/519 , A61K45/06 , C07D413/14 , C07D417/04 , C07D417/14 , A61K2300/00
摘要： Compounds of structural formula I are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders.
摘要翻译：结构式I的化合物是脯氨酰羧肽酶（PrCP）的抑制剂。本发明的化合物可用于预防和治疗与PrCP的酶活性相关的病症，例如异常代谢，包括肥胖症; 糖尿病; 代谢综合征; 肥胖相关疾病; 和糖尿病相关疾病。

22. 发明授权

US08278304B2 Substituted 4-hydroxypyrimidine-5-carboxamides 有权
标题翻译：取代的4-羟基嘧啶-5-甲酰胺
公开(公告)号：US08278304B2
公开(公告)日：2012-10-02
申请号：US12381468
申请日：2009-03-12
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh
IPC分类号： A61K31/501 , A61K31/4965 , C07D401/06 , C07D239/02
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的取代的4-羟基嘧啶-5-甲酰胺。

23. 发明申请

US20110009406A1 TETRAHYDRO-1H-PYRROLO FUSED PYRIDONES 有权
标题翻译：四氢-1H-吡咯醇加成的吡啶
公开(公告)号：US20110009406A1
公开(公告)日：2011-01-13
申请号：US12919199
申请日：2009-02-11
申请人： Matthew J. Clements , Vincent J. Colandrea , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh
发明人： Matthew J. Clements , Vincent J. Colandrea , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , C07D413/14 , C07D487/04 , A61K31/519 , A61P7/06
CPC分类号： C07D471/04
摘要： The present invention relates to tetrahydro-1H-pyrrolo fused pyridone compounds useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及可用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的四氢-1H-吡咯稠合吡啶酮化合物。

24. 发明授权

US06589760B1 Methods of separating a corn fiber lipid fraction from corn fiber 失效
$Methods of separating a corn fiber lipid fraction from corn fiber$
标题翻译：从玉米纤维中分离玉米纤维脂质部分的方法
公开(公告)号：US06589760B1
公开(公告)日：2003-07-08
申请号：US09501917
申请日：2000-02-10
申请人： Charles M. Buchanan , Norma L. Buchanan , John S. Debenham , Michael C. Shelton , Matthew D. Wood
发明人： Charles M. Buchanan , Norma L. Buchanan , John S. Debenham , Michael C. Shelton , Matthew D. Wood
IPC分类号： C12Q137
CPC分类号： C13K1/08 , A23D9/007 , A23D9/02 , A23K10/37 , A23K20/147 , A23K20/163 , A23L7/107 , A23L7/115 , A23L29/262 , A23L33/11 , A23L33/115 , A23L33/24 , A23V2002/00 , C08B3/00 , C08B11/00 , C08B30/10 , C08B37/0057 , C08B37/006 , C11B1/025 , C11B1/10 , C13K1/02 , C13K13/00 , C13K13/002 , D21C5/00 , D21C5/005 , Y02P60/877 , A23V2250/602 , A23V2250/638 , A23V2250/626
摘要： The invention provides a method of separating from corn fiber a lipid fraction having phytosterol esters and phytosterols where the method has the steps of: (a) heating an aqueous mixture of unground corn fiber; (b) contacting the mixture of step (a) with at least one enzyme suitable for digesting starch for a time and at a temperature suitable to provide a mixture of an essentially destarched corn fiber and a liquid comprising soluble carbohydrates; (c) contacting the mixture of step (a) or (b) with a protease enzyme to provide a proteolyzed corn fiber and a liquid; (d) separating the liquid of step (c) from the corn fiber to provide a destarched, proteolyzed corn fiber; and (e) extracting the destarched, proteolyzed corn fiber with at least one organic solvent. A corn fiber lipid fraction/organic solvent solution having phytosterol esters and phytosterols is provided. The invention also provides a corn fiber lipid fraction containing phytosterols and phytosterol esters obtained via solvent extraction of a proteolyzed corn fiber. The concentration of phytosterols and phytosterol esters in the lipid fraction is at least about 1.4 times greater than the concentration of phytosterols and phytosterol esters in the lipid fraction of a nonproteolyzed corn fiber.
摘要翻译：本发明提供了一种从玉米纤维中分离具有植物甾醇酯和植物甾醇的脂质部分的方法，其中该方法具有以下步骤：（a）加热未研磨的玉米纤维的水性混合物; （b）使步骤（a）的混合物与适合于消化淀粉的至少一种酶接触一段时间，并在适于提供基本上破裂的玉米纤维和包含可溶性碳水化合物的液体的混合物的温度下接触; （c）使步骤（a）或（b）的混合物与蛋白酶接触以提供蛋白水解的玉米纤维和液体; （d）将步骤（c）的液体与玉米纤维分离以提供破坏的蛋白水解的玉米纤维; 和（e）用至少一种有机溶剂萃取破坏了的，蛋白水解的玉米纤维。提供了具有植物甾醇酯和植物甾醇的玉米纤维脂质部分/有机溶剂溶液。本发明还提供了通过蛋白水解的玉米纤维的溶剂提取获得的含有植物甾醇和植物甾醇酯的玉米纤维脂质部分。在脂质部分中植物甾醇和植物甾醇酯的浓度比非分解玉米纤维的脂质部分中的植物甾醇和植物甾醇酯的浓度高至少约1.4倍。

25. 发明授权

US07999107B2 Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators 失效
标题翻译：取代的吡喃并[2,3-B]吡啶衍生物作为大麻素-1受体调节剂
公开(公告)号：US07999107B2
公开(公告)日：2011-08-16
申请号：US12009114
申请日：2008-01-16
申请人： John S. Debenham , Jeffrey J. Hale , Pei Huo , Christina B. Madsen-Duggan , Thomas F. Walsh , Lin Yan
发明人： John S. Debenham , Jeffrey J. Hale , Pei Huo , Christina B. Madsen-Duggan , Thomas F. Walsh , Lin Yan
IPC分类号： C07D491/052 , A61K31/436
CPC分类号： C07D491/052 , C07D491/16 , C07D495/16
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，阿尔茨海默病，偏头痛，神经病，包括多发性硬化症和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的中枢作用药物脑血管意外，头部创伤，焦虑障碍，压力，癫痫，帕金森病，亨廷顿病运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻，肝硬化，非酒精性脂肪性肝病（NAFLD ），非酒精性脂肪性肝炎（NASH），以及促进觉醒。

26. 发明申请

US20090239876A1 Substituted 4-Hydroxypyrimidine-5-Carboxamides 有权
标题翻译：取代的4-羟基嘧啶-5-羧酰胺
公开(公告)号：US20090239876A1
公开(公告)日：2009-09-24
申请号：US12381468
申请日：2009-03-12
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christian B. Madsen-Duggan , Thomas F. Walsh
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christian B. Madsen-Duggan , Thomas F. Walsh
IPC分类号： A61K31/501 , A61K31/497 , A61K31/506 , C07D403/04 , C07D401/04 , C07D405/14 , C07D415/00 , C07D401/14
CPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D417/04 , C07D417/14
摘要： The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
摘要翻译：本发明涉及用作HIF脯氨酰羟化酶抑制剂治疗贫血和类似病症的取代的4-羟基嘧啶-5-甲酰胺。

27. 发明申请

US20080269279A1 Substituted furo[2,3-B] pyridine derivatives as cannabinoid-1 receptor modulators 审中-公开
标题翻译：取代的呋喃并[2,3-B]吡啶衍生物作为大麻素-1受体调节剂
公开(公告)号：US20080269279A1
公开(公告)日：2008-10-30
申请号：US12082013
申请日：2008-04-07
申请人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh , Andrey V. Peresypkin , Roy Helmy
发明人： Matthew J. Clements , John S. Debenham , Jeffrey J. Hale , Christina B. Madsen-Duggan , Thomas F. Walsh , Andrey V. Peresypkin , Roy Helmy
IPC分类号： A61K31/4355 , C07D471/04 , A61P25/00 , A61P3/04
CPC分类号： C07D491/048
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，阿尔茨海默病，偏头痛，神经病，包括多发性硬化症和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的中枢作用药物脑血管意外，头部创伤，焦虑障碍，压力，癫痫，帕金森病，运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻，肝硬化，非酒精性脂肪性肝病（NAFLD ），非酒精性脂肪性肝炎（NASH），以及促进觉醒。

28. 发明申请

US20080207666A1 Substituted pyrano[2,3-B]pyridine derivatives as cannabinoid-1 receptor modulators 失效
标题翻译：取代的吡喃并[2,3-B]吡啶衍生物作为大麻素-1受体调节剂
公开(公告)号：US20080207666A1
公开(公告)日：2008-08-28
申请号：US12009114
申请日：2008-01-16
申请人： John S. Debenham , Jeffrey J. Hale , Pei Huo , Christina B. Madsen-Duggan , Thomas F. Walsh , Lin Yan
发明人： John S. Debenham , Jeffrey J. Hale , Pei Huo , Christina B. Madsen-Duggan , Thomas F. Walsh , Lin Yan
IPC分类号： A61K31/527 , C07D471/10 , A61K31/4433 , C07D471/04 , A61P25/28
CPC分类号： C07D491/052 , C07D491/16 , C07D495/16
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, Alzheimer's disease, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, Huntington's disease movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, cirrhosis of the liver, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and the promotion of wakefulness.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，阿尔茨海默病，偏头痛，神经病，包括多发性硬化症和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的中枢作用药物脑血管意外，头部创伤，焦虑障碍，压力，癫痫，帕金森病，亨廷顿病运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻，肝硬化，非酒精性脂肪性肝病（NAFLD ），非酒精性脂肪性肝炎（NASH），以及促进觉醒。

29. 发明授权

US07271266B2 Substituted 2,3-diphenyl pyridines 失效
标题翻译：取代的2,3-二苯基吡啶
公开(公告)号：US07271266B2
公开(公告)日：2007-09-18
申请号：US10508043
申请日：2003-03-24
申请人： Paul E. Finke , Laura C. Meurer , John S. Debenham , Richard B. Toupence , Thomas F. Walsh
发明人： Paul E. Finke , Laura C. Meurer , John S. Debenham , Richard B. Toupence , Thomas F. Walsh
IPC分类号： C07D211/82 , C07D211/60
CPC分类号： C07D213/79 , C04B35/632 , C07D213/65 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/85 , C07D213/86 , C07D213/87 , C07D401/12
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管事故和头部创伤，焦虑障碍，压力，癫痫，帕金森病，运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

30. 发明授权

US06388069B1 Corn fiber for the production of advanced chemicals and materials:arabinoxylan and arabinoxylan derivatives made therefrom 失效
标题翻译：用于生产先进化学品和材料的玉米纤维：由其制成的阿拉伯木聚糖和阿拉伯木聚糖衍生物
公开(公告)号：US06388069B1
公开(公告)日：2002-05-14
申请号：US09502077
申请日：2000-02-10
申请人： Charles M. Buchanan , Norma L. Buchanan , John S. Debenham , Michael C. Shelton , Matthew D. Wood
发明人： Charles M. Buchanan , Norma L. Buchanan , John S. Debenham , Michael C. Shelton , Matthew D. Wood
IPC分类号： C12P1900
CPC分类号： C13K1/08 , A23D9/007 , A23D9/02 , A23K10/37 , A23K20/147 , A23K20/163 , A23L7/107 , A23L7/115 , A23L29/262 , A23L33/11 , A23L33/115 , A23L33/24 , A23V2002/00 , C08B3/00 , C08B11/00 , C08B30/10 , C08B37/0057 , C08B37/006 , C11B1/025 , C11B1/10 , C13K1/02 , C13K13/00 , C13K13/002 , D21C5/00 , D21C5/005 , Y02P60/877 , A23V2250/602 , A23V2250/638 , A23V2250/626
摘要： In one aspect, the invention provides a method of extracting arabinoxylan from corn fiber wherein the method comprises the steps of: (a) heating an aqueous mixture of corn fiber and a liquid; (b) contacting the mixture of step (a) with a protease enzyme, thereby providing a proteolyzed corn fiber and a liquid; (c) separating the liquid from the proteolyzed corn fiber; (d) contacting the proteolyzed corn fiber at least once with an alkaline extractant, thereby providing an insoluble cellulose material and a liquid comprising arabinoxylan; (e) separating the insoluble cellulose material from the liquid comprising arabinoxylan; and (f) reducing the volume of the liquid comprising arabinoxylan by removing excess alkaline extractant, thereby providing a concentrated liquid comprising from about 10% to about 50% solids, wherein the solids comprise arabinoxylan. In a further aspect, the invention provides methods of preparing novel arabinoxylan esters and ethers. Still further, the invention provides novel arabinoxylan esters and ethers.
摘要翻译：一方面，本发明提供了一种从玉米纤维中提取阿拉伯木聚糖的方法，其中该方法包括以下步骤：（a）加热玉米纤维和液体的含水混合物; （b）使步骤（a）的混合物与蛋白酶接触，从而提供蛋白水解的玉米纤维和液体; （c）从蛋白水解的玉米纤维中分离液体; （d）使蛋白水解的玉米纤维与碱性萃取剂至少接触一次，从而提供不溶性纤维素材料和包含阿拉伯木聚糖的液体; （e）从包含阿拉伯木聚糖的液体中分离不溶性纤维素材料; 和（f）通过除去过量的碱性萃取剂来降低包含阿拉伯木聚糖的液体的体积，从而提供包含约10％至约50％固体的浓缩液体，其中固体包含阿拉伯木聚糖。在另一方面，本发明提供了制备新型阿拉伯木聚糖酯和醚的方法。此外，本发明提供新的阿拉伯木聚糖酯和醚。

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