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21. 发明申请

US20120029329A1 ANALYTE DETECTION SYSTEMS AND METHODS USING MULTIPLE MEASUREMENTS 审中-公开
标题翻译：分析检测系统和使用多个测量的方法
公开(公告)号：US20120029329A1
公开(公告)日：2012-02-02
申请号：US13252596
申请日：2011-10-04
申请人： James R. Braig , Peter Rule
发明人： James R. Braig , Peter Rule
IPC分类号： A61B5/1455
CPC分类号： A61B5/150992 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150854 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/3468 , G16H10/40 , G16H20/17
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

22. 发明申请

US20110300619A1 IN VITRO DETERMINATION OF ANALYTE LEVELS WITHIN BODY FLUIDS 有权
公开(公告)号：US20110300619A1
公开(公告)日：2011-12-08
申请号：US13210347
申请日：2011-08-15
申请人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
发明人： James R. Braig , Peter Rule , Philip C. Hartstein , Bernhard B. Sterling , Jennifer H. Gable , Kenneth I. Li
IPC分类号： C12M1/34
CPC分类号： A61B5/157 , A61B5/01 , A61B5/1411 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150083 , A61B5/150213 , A61B5/150358 , A61B5/150412 , A61B5/150458 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/15087 , A61B5/151 , A61B5/15107 , A61B5/15136 , A61B5/1514 , A61B5/15194 , A61B5/6826 , A61B5/6838 , A61B10/0045 , A61B2562/0295 , A61B2562/12 , G01N21/03 , G01N21/0332 , G01N21/35 , G01N21/3577 , G01N21/3581 , G01N33/49 , G01N33/66 , G01N2021/0389 , G01N2201/02 , G01N2201/068
摘要： A reagentless whole-blood analyte detection system that is capable of being deployed near a patient has a source capable of emitting a beam of radiation that includes a spectral band. The whole-blood system also has a detector in an optical path of the beam. The whole-blood system also has a housing that is configured to house the source and the detector. The whole-blood system also has a sample element that is situated in the optical path of the beam. The sample element has a sample cell and a sample cell wall that does not eliminate transmittance of the beam of radiation in the spectral band.

23. 发明申请

US20110264071A1 FLUID COMPONENT ANALYSIS SYSTEMS AND METHODS FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20110264071A1
公开(公告)日：2011-10-27
申请号：US13174610
申请日：2011-06-30
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/168
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

24. 发明授权

US08034015B2 Anti-clotting apparatus and methods for fluid handling system 有权
标题翻译：用于流体处理系统的抗凝装置和方法
公开(公告)号：US08034015B2
公开(公告)日：2011-10-11
申请号：US12111109
申请日：2008-04-28
申请人： James R. Braig , Richard Keenan
发明人： James R. Braig , Richard Keenan
IPC分类号： A61M37/00
CPC分类号： A61B5/157 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M5/14212 , A61M2230/20 , G01N21/35
摘要： A method for maintaining clear passageways in an extracorporeal blood flow system. The method comprises intermittently providing one or more anti-clotting agents to a passageway of the extracorporeal blood flow system. Also disclosed is an extracorporeal blood flow system. The system comprises a passageway, and a device operatively connected to provide one or more anti-clotting agents to a least a portion of said passageway.
摘要翻译：一种用于在体外血液流动系统中保持清晰通道的方法。该方法包括间歇地向体外血液流通系统的通道提供一种或多种抗凝血剂。还公开了一种体外血液流动系统。该系统包括通道和可操作地连接以向所述通道的至少一部分提供一种或多种抗凝血剂的装置。

25. 发明申请

US20110218411A1 FLUID HANDLING CASSETTE SYSTEM FOR BODY FLUID ANALYZER 有权
标题翻译：液体流动分析仪的流体处理系统
公开(公告)号：US20110218411A1
公开(公告)日：2011-09-08
申请号：US12986112
申请日：2011-01-06
申请人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
发明人： Richard Keenan , Jeff Chiou , Jennifer Gable , Ken Li , Roger Tong , Mike Recknor , James R. Braig
IPC分类号： A61B5/157 , G01N33/50
CPC分类号： A61B5/157 , G01N33/50
摘要： A fluid handling system for use in bodily fluid analysis. The system comprises a first fluid handling module configured to interface with a main instrument. The first fluid handling module has a first fluid handling network and the first fluid handling network includes an infusate passage and an infusion fluid pressure member suitable for moving fluid within the infusate passage. The fluid handling system also has a second fluid handling module separate from the first module which is configured to interface with the main instrument. The second fluid handling module has a second fluid handling network and at least one sample analysis cell which is accessible via the second fluid handling network. The first and second modules are configured to interconnect and provide fluid communication between the first and second fluid handling network and the sample cells.
摘要翻译：用于体液分析的流体处理系统。该系统包括被配置为与主仪器接口的第一流体处理模块。第一流体处理模块具有第一流体处理网络，并且第一流体处理网络包括适于在输注通道内移动流体的输注通道和输液流体压力构件。流体处理系统还具有与第一模块分离的第二流体处理模块，第一模块被配置为与主仪器相接触。第二流体处理模块具有第二流体处理网络和可经由第二流体处理网络访问的至少一个样品分析单元。第一和第二模块被配置为在第一和第二流体处理网络和样品池之间互连并提供流体连通。

26. 发明授权

US07907985B2 Fluid handling cassette with a fluid control interface and sample separator 有权
标题翻译：流体处理盒带有流体控制界面和样品分离器
公开(公告)号：US07907985B2
公开(公告)日：2011-03-15
申请号：US11316676
申请日：2005-12-21
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/00 , A61M1/00 , G01N35/00 , G01N9/30
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module that is removably engageable with a bodily fluid analyzer is provided. The module may comprise a fluid handling element, and a fluid component separator that is accessible via the fluid handling element and configured to separate at least one component of a bodily fluid transported to the fluid component separator. The fluid handling element may have at least one control element interface.
摘要翻译：提供了可移除地与体液分析器接合的流体处理模块。模块可以包括流体处理元件和流体部件分离器，其可经由流体处理元件接近并且被配置为分离输送到流体组分分离器的体液的至少一个组分。流体处理元件可以具有至少一个控制元件接口。

27. 发明申请

US20100240964A1 SYSTEM AND METHOD FOR DETERMINING A TREATMENT DOSE FOR A PATIENT 有权
标题翻译：用于确定患者治疗剂量的系统和方法
公开(公告)号：US20100240964A1
公开(公告)日：2010-09-23
申请号：US12702196
申请日：2010-02-08
申请人： Bernhard B. Sterling , James R. Braig , Peter Rule , Richard A. King
发明人： Bernhard B. Sterling , James R. Braig , Peter Rule , Richard A. King
IPC分类号： A61B5/00
CPC分类号： A61B5/150992 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150854 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/00 , G06F19/3468 , G16H10/40 , G16H20/17
摘要： In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
摘要翻译：在某些实施例中，维持患者健康的方法使用分析物检测系统。分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

28. 发明申请

US20100030137A1 APPARATUS AND METHODS FOR ANALYZING BODY FLUID SAMPLES 审中-公开
公开(公告)号：US20100030137A1
公开(公告)日：2010-02-04
申请号：US12511014
申请日：2009-07-28
申请人： W. Dale Hall , David N. Callicoat , Jennifer H. Gable , James R. Braig , Kenneth G. Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Dale Hall , David N. Callicoat , Jennifer H. Gable , James R. Braig , Kenneth G. Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M5/168
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

29. 发明申请

US20090326343A1 FLUID HANDLING CASSETTE HAVING A SPECTROSCOPIC SAMPLE CELL 有权
标题翻译：具有光谱样品池的流体处理箱
公开(公告)号：US20090326343A1
公开(公告)日：2009-12-31
申请号：US12359874
申请日：2009-01-26
申请人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
发明人： Jennifer H. Gable , James R. Braig , Kenneth I. Li , Mark Wechsler , Peng Zheng , Richard Keenan
IPC分类号： A61B5/15
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , G06F19/00 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A fluid handling module is configured for removable engagement with a reusable main fluid handling instrument. The module includes a module housing and a first fluid passageway extending from the module housing. The first fluid passageway has a patient end remote from the housing. The first fluid passageway is configured to provide fluid communication with a bodily fluid in a patient. A fluid component separator is in fluid communication with the first fluid passageway. The fluid component separator is configured to separate at least one component from a portion of the bodily fluid drawn from the patient. A spectroscopic sample cell is configured to hold at least a portion of the first component.
摘要翻译：流体处理模块被配置为可移除地与可重复使用的主流体处理装置接合。模块包括模块壳体和从模块壳体延伸的第一流体通道。第一流体通道具有远离壳体的患者端。第一流体通道被配置为提供与患者体内的体液的流体连通。流体组分分离器与第一流体通道流体连通。流体部件分离器构造成将至少一个部件与从患者抽出的体液的一部分分离。光谱样品池被配置为保持第一组分的至少一部分。

30. 发明申请

US20080161723A1 INFUSION FLOW INTERRUPTION METHOD AND APPARATUS 审中-公开
标题翻译：输注流中断方法和装置
公开(公告)号：US20080161723A1
公开(公告)日：2008-07-03
申请号：US11850972
申请日：2007-09-06
申请人： Richard Keenan , Jeffrey Chiou , Peter Rule , James R. Braig
发明人： Richard Keenan , Jeffrey Chiou , Peter Rule , James R. Braig
IPC分类号： A61B5/00 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150267 , A61B5/150305 , A61B5/150755 , A61B5/150786 , A61B5/150824 , A61B5/150854 , A61B5/153 , A61B5/157 , A61M1/3609 , A61M5/14 , A61M5/1415 , A61M2005/1404 , A61M2005/1726 , A61M2230/201
摘要： Disclosed are systems, apparatus and methods for determining information related to analyte(s) (e.g., concentration) in a sample such as biological fluid. An analysis system for determining information relating to at least one analyte in a sample of biological fluid can be configured to: withdraw the sample of biological fluid from the source of biological fluid; interrupt the flow of infusion fluid while the sample of biological fluid is withdrawn; analyze the withdrawn biological fluid to determine information relating to at least one analyte; and resume the flow of infusion fluid after the sample of biological fluid is withdrawn. A method of interrupting flow of an infusion fluid without triggering an alarm can comprise, while the flow of the infusion fluid is interrupted, diverting the flow of the infusion fluid from a fluid passageway to an expandable volume at a rate that maintains constant flow from an infusion pump.
摘要翻译：公开了用于确定样品（例如生物流体）中与分析物（例如浓度）相关的信息的系统，装置和方法。用于确定与生物流体样品中的至少一种分析物相关的信息的分析系统可以被配置为：从生物流体源中抽出生物流体的样品; 中断生物流体样本取出时输液的流动; 分析所抽取的生物流体以确定与至少一种分析物有关的信息; 并在取出生物流体的样品后恢复输注液的流动。一种在不触发报警的情况下中断输注流体的流动的方法可以包括在输注流体的流动被中断的同时将输注流体的流动从流体通道转移到可膨胀体积，其速率保持恒定的流量输液泵。

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