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21. 发明授权

US08801627B2 Sampler 有权
标题翻译：取样器
公开(公告)号：US08801627B2
公开(公告)日：2014-08-12
申请号：US10528417
申请日：2004-09-23
申请人： Martinus Antonius Hermanus Maria Wiegerinck , Herman Jan Tijmen Coelingh Bennink , Petrus Johannes Boerrigter
发明人： Martinus Antonius Hermanus Maria Wiegerinck , Herman Jan Tijmen Coelingh Bennink , Petrus Johannes Boerrigter
IPC分类号： A61B10/00 , A61B10/02 , A61B17/34
CPC分类号： A61B10/0045 , A61B10/0051 , A61B10/0096 , A61B10/02 , A61B10/0283 , A61B17/43 , A61B2010/0074 , A61B2017/3419
摘要： Sampler for self-sampling of samples from a body cavity, such as cervical samples. Optimum accessibility of the cervix is achieved through the sampler comprising a rigid plastic tube which is rounded at the front side. During its introduction, the sampler can accurately be moved to the cervix. The sampler is surrounded by the vagina and can prevent leakage of flushing liquid, and it is possible to use a relatively small quantity of flushing liquid while producing a sample with a high concentration of cervical cells. It is possible to reach the sampling location in a simple and more accurate way which does not damage tissue. As a result of the tube simultaneously being designed as a cylinder for a plunger, it is possible, to flush the desired location with a solution using a cylinder-plunger and, to take the sample by drawing the plunger back.
摘要翻译：采样器用于对体腔样品进行自取样，如宫颈样品。通过采样器实现子宫颈的最佳可及性，所述采样器包括在前侧为圆形的刚性塑料管。在其介绍期间，采样器可以准确地移动到子宫颈。采样器被阴道包围，可以防止冲洗液的泄漏，并且可以在生产具有高浓度宫颈细胞的样品的同时使用相对少量的冲洗液。可以以简单且更准确的方式到达采样位置，不会损伤组织。由于管同时被设计成用于柱塞的气缸，所以可以使用气缸柱塞将溶液冲洗所需的位置，并且通过将柱塞拉回来取样。

22. 发明申请

US20120015917A1 Use of Estrogenic Compounds in Combination with Progestogenic Compounds in Hormone-Replacement Therapy 审中-公开
标题翻译：在激素替代治疗中使用雌激素化合物与孕激素化合物的组合
公开(公告)号：US20120015917A1
公开(公告)日：2012-01-19
申请号：US13242034
申请日：2011-09-23
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/57 , A61K31/58 , A61K31/575
CPC分类号： A61K45/06 , A61K31/568 , A61K31/569 , A61K2300/00
摘要： The present invention relates to a pharmaceutical kit comprising a plurality of oral dosage units which comprise a progestogen. The progestogen is levonorgestrel, norgestimate, norethisterone, drospirenone, dydrogesterone, trimegestone, dienogest, precursors thereof and mixtures thereof. The kit comprises an amount of progestogen equivalent to 30-500 mg of levonorgestrel, 1-40 mg of ethinyl estradiol and 02-100 mg dehydroepiandrosterone.
摘要翻译：本发明涉及药物试剂盒，其包含多个包含孕激素的口服剂量单位。孕激素是左炔诺孕酮，诺孕酯，炔诺酮，屈螺酮，地屈孕酮，曲美孕酮，依诺孕酮，其前体及其混合物。试剂盒包含相当于30-500mg左炔诺孕酮，1-40mg乙炔雌二醇和02-100mg脱氢表雄甾酮的孕激素。

23. 发明申请

US20110160173A1 Method Of Treating Human Skin And A Skin Care Composition For Use In Such A Method 有权
标题翻译：治疗人类皮肤的方法和用于这种方法的护肤组合物
公开(公告)号：US20110160173A1
公开(公告)日：2011-06-30
申请号：US13017858
申请日：2011-01-31
申请人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten , Christian Franz Holinka
发明人： Herman Jan Tijmen Coelingh Bennink , Evert Johannes Bunschoten , Christian Franz Holinka
IPC分类号： A61K8/63 , A61K31/566 , A61P17/02 , A61P17/10 , A61Q19/08
CPC分类号： A61Q19/004 , A61K8/63 , A61K9/0014 , A61K31/565 , A61K47/22 , A61K47/26 , A61Q19/00 , A61Q19/08
摘要： One aspect of the invention concerns a cosmetic method of treating human skin by delivering an estrogenic component to said skin. The method comprises applying to the skin a composition containing: (i) at least 5 μg/g of an estrogenic component selected from the group consisting of substances represented by the following formula (I) in which formula R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors; and (ii) a cosmetically acceptable vehicle. Other aspects of the invention relate to therapeutic methods of treating or preventing vaginal dryness or acne and a therapeutic method of promoting wound healing. Yet another aspect of the invention relates to a skin care composition comprising the aforementioned estrogenic component and a cosmetically acceptable vehicle.
摘要翻译：本发明的一个方面涉及通过将雌激素成分递送至所述皮肤来治疗人皮肤的美容方法。该方法包括向皮肤施用组合物，其含有：（i）至少5μg/ g的雌激素成分，其选自下式（I）表示的物质，其中式R1，R2，R3，R4独立地表示是氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 在本方法中使用时能够释放根据上述式的物质的前体; 和一种或多种上述物质和/或前体的混合物; 和（ii）美容上可接受的载体。本发明的其它方面涉及治疗或预防阴道干燥或痤疮的治疗方法以及促进伤口愈合的治疗方法。本发明的另一方面涉及包含上述雌激素成分和美容上可接受的载体的护肤组合物。

24. 发明申请

US20090221540A1 Method of Treating An Acute Vascular Disorder 审中-公开
标题翻译：治疗急性血管障碍的方法
公开(公告)号：US20090221540A1
公开(公告)日：2009-09-03
申请号：US12160275
申请日：2007-01-09
申请人： Herman Jan Tijmen Coelingh Bennink
发明人： Herman Jan Tijmen Coelingh Bennink
IPC分类号： A61K31/56 , A61P9/00
CPC分类号： A61K31/34 , A61K31/4045 , A61K31/519 , A61K31/565 , A61K31/57
摘要： The invention relates to a method of treating an acute vascular disorder in a mammal. The method comprises orally administering to the mammal an effective amount of a steroid. The steroid is selected from the group consisting of: substances represented by formula (I), in which R1, R2, R3, R4 independently are a hydrogen atom, a hydroxyl group or an alkoxy group with 1-5 carbon atoms; each of R5, R6, R7 is a hydroxyl group; no more than 3 of R1, R2, R3, R4 are hydrogen atoms; precursors capable of liberating a substance according to the aforementioned formula when used in the present method; and mixtures of one or more of the aforementioned substances and/or precursors.
摘要翻译：本发明涉及一种治疗哺乳动物急性血管疾病的方法。该方法包括向哺乳动物口服有效量的类固醇。类固醇选自：由式（I）表示的物质，其中R 1，R 2，R 3，R 4独立地是氢原子，羟基或具有1-5个碳原子的烷氧基; R5，R6，R7各自为羟基; 不超过3个R 1，R 2，R 3，R 4为氢原子; 在本方法中使用时能够释放根据上述式的物质的前体; 和一种或多种上述物质和/或前体的混合物。

25. 发明申请

US20080280861A1 Method of Female Contraception and a Kit For Use Therein 审中-公开
标题翻译：女性避孕方法及其使用的一套
公开(公告)号：US20080280861A1
公开(公告)日：2008-11-13
申请号：US11663814
申请日：2004-09-27
申请人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
发明人： Herman Jan Tijmen Coelingh Bennink , Monique Visser
IPC分类号： A61K31/57 , A61P15/18
CPC分类号： A61K31/565 , A61K31/57 , A61K2300/00
摘要： The invention is concerned with a method of contraception in a female mammal of childbearing capability. The method has two alternating phases—a preservation phase and a shedding phase—and has at least two sequences of (a) a preservation phase of 3-12 months involving continuous oral administration to the female of dosage units containing: (i) an estrogen selected from 17β-estradiol, esters of 17β-estradiol and combinations thereof, in an amount equivalent to a daily oral dosage of 2.2-5 mg 17β-estradiol, and (ii) a progestogen in an amount equivalent to a daily oral dosage of 30-750 μg levonorgestrel; and (b) a shedding phase of 4-12 days during which no progestogen is administered. The invention also relates to a contraceptive kit having one or more packaging units that are separately packaged, individually removable oral dosage units for use in the aforementioned contraceptive method.
摘要翻译：本发明涉及一种女性哺乳动物避孕方法。该方法具有两个交替阶段 - 保存阶段和脱落阶段 - 并且具有至少两个序列（a）3-12个月的保存期，其连续口服给予含有以下的剂量单位的雌性：（i）雌激素选自17β-雌二醇，17β-雌二醇的酯和其组合，其量相当于2.2-5mg17β-雌二醇的每日口服剂量，和（ii）相当于每日口服剂量30的量的孕激素 -750杯左炔诺孕酮; 和（b）4-12天的脱落期，在此期间不服用孕激素。本发明还涉及具有单独包装的一个或多个包装单元的避孕套件，用于上述避孕方法的单独可移除的口服剂量单元。

26. 发明授权

US06506390B2 Progestogen-anti-progestogen regimens 失效
标题翻译：孕激素 - 抗孕激素方案
公开(公告)号：US06506390B2
公开(公告)日：2003-01-14
申请号：US09757048
申请日：2001-01-08
申请人： Herman Jan Tijmen Coelingh Bennink , Pieter M. Verbost
发明人： Herman Jan Tijmen Coelingh Bennink , Pieter M. Verbost
IPC分类号： A61K900
CPC分类号： A61K31/565 , A61K31/57 , A61K31/58 , A61K2300/00
摘要： A contraceptive and/or HRT (hormone replacement therapy) kit comprising sequential daily dosage units each containing as the sole contraceptively effective ingredient a progestogen, or as the effective ingredient for HRT a progestogen with or without an estrogen or an estrogen only, and further two or more dosage units comprising an anti-progestogen. The present invention also provides contraceptive and HRT methods comprising administering daily dosage units of a progestogen and anti-progestogen.
摘要翻译：避孕和/或HRT（激素替代疗法）试剂盒，其包括连续的每日剂量单位，每个单位含有作为避孕有效成分的唯一孕激素，或作为HRT的有效成分，仅有雌激素或雌激素的孕激素，还有两个或更多的剂量单位，其包含抗孕激素。本发明还提供避孕和HRT方法，其包括施用孕激素和抗孕激素的每日剂量单位。

27. 发明授权

US10179107B2 Tablet containing dehydroepiandrosterone (DHEA) 有权
公开(公告)号：US10179107B2
公开(公告)日：2019-01-15
申请号：US14233666
申请日：2012-07-17
申请人： Herman Jan Tijmen Coelingh Bennink , Johannes Jan Platteeuw
发明人： Herman Jan Tijmen Coelingh Bennink , Johannes Jan Platteeuw
IPC分类号： A61K9/20 , A61K31/567 , A61K31/5685
摘要： The present invention relates to a tablet having a weight of 30-200 mg and consisting of: 60-100 wt. % of granules consisting of: 50-90% by weight of the granules of dehydroepiandrosterone (DHEA); 6-35% by weight of the granules of microcrystalline cellulose; 0-20% by weight of the granules of one or more other pharmaceutically acceptable granule ingredients; and 0-40 wt. % of one or more other pharmaceutically acceptable tablet components. These tablets can suitably be used to orally administer DHEA in dosages of around 50 mg and are sufficiently small to be incorporated in, for instance, ordinary oral contraceptive blister packs.

28. 发明申请

US20140235882A1 PROCESS FOR THE PREPARATION OF ESTETROL 审中-公开
标题翻译：制备ESTETROL的方法
公开(公告)号：US20140235882A1
公开(公告)日：2014-08-21
申请号：US14233362
申请日：2012-07-18
申请人： Johannes Jan Platteeuw , Herman Jan Tijmen Coelingh Bennink , Franciscus Wilhelmus Petrus Damen , Michiel Christine Alexander Van Vliet
发明人： Johannes Jan Platteeuw , Herman Jan Tijmen Coelingh Bennink , Franciscus Wilhelmus Petrus Damen , Michiel Christine Alexander Van Vliet
IPC分类号： C07J1/00
CPC分类号： C07J1/007 , C07J1/0059 , C07J13/005 , C07J75/00 , Y02P20/55
摘要： The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15α,16α,17β-tetraol (estetrol), via a silyl enol ether derivative 17-B-oxy-3-A-oxy-estra-1,3,5(10),16-tetraene, wherein A is a protecting group and B is —Si(R2)3. The invention further relates to a process for the synthesis of 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is a protecting group, via said silyl enol ether derivative.
摘要翻译：本发明涉及一种通过甲硅烷基烯醇醚衍生物17-B-氧基 - 三烯衍生物制备雌-1,3,5（10） - 三烯-3,15α，16α，17β-四醇（雌酮）的方法， 3-A-oxy-estra-1,3,5（10），16-四烯，其中A是保护基，B是-Si（R2）3。本发明还涉及通过所述甲硅烷基烯醇醚衍生物合成其中A为保护基的3-A-氧 - 雌-1,3,5（10），15-四烯-17-酮的方法。

29. 发明申请

US20140235598A1 TABLET CONTAINING DEHYDROEPIANDROSTERONE (DHEA) 审中-公开
标题翻译：含有脱氢赖氨酸酮（DHEA）的片剂
公开(公告)号：US20140235598A1
公开(公告)日：2014-08-21
申请号：US14233666
申请日：2012-07-17
申请人： Herman Jan Tijmen Coelingh Bennink , Johannes Jan Platteeuw
发明人： Herman Jan Tijmen Coelingh Bennink , Johannes Jan Platteeuw
IPC分类号： A61K9/20 , A61K31/567 , A61K31/5685
CPC分类号： A61K9/2095 , A61K9/2054 , A61K9/2077 , A61K31/567 , A61K31/5685
摘要： The present invention relates to a tablet having a weight of 30-200 mg and consisting of: 60-100 wt. % of granules consisting of: 50-90% by weight of the granules of dehydroepiandrosterone (DHEA); 6-35% by weight of the granules of microcrystalline cellulose; 0-20% by weight of the granules of one or more other pharmaceutically acceptable granule ingredients; and 0-40 wt. % of one or more other pharmaceutically acceptable tablet components. These tablets can suitably be used to orally administer DHEA in dosages of around 50 mg and are sufficiently small to be incorporated in, for instance, ordinary oral contraceptive blister packs.
摘要翻译：本发明涉及一种重量为30-200mg的片剂，其组成为：60-100wt。％的颗粒组成：50-90％重量的脱氢表雄酮（DHEA）颗粒; 6-35重量％的微晶纤维素颗粒; 0-20重量％的一种或多种其它药学上可接受的颗粒成分的颗粒; 和0-40wt。％的一种或多种其它药学上可接受的片剂组分。这些片剂可以适当地用于以约50mg的剂量口服给予DHEA，并且足够小以加入到例如普通口服避孕吸塑包装中。

30. 发明申请

US20140200202A1 USE OF ESTETROL AS EMERGENCY CONTRACEPTIVE 有权
标题翻译：使用ESTETROL作为紧急合同
公开(公告)号：US20140200202A1
公开(公告)日：2014-07-17
申请号：US14238310
申请日：2012-08-09
申请人： Wout Wouters , Herman Jan Tijmen Coelingh Bennink , Ludivine Petit , Jean-Michel Foidart
发明人： Wout Wouters , Herman Jan Tijmen Coelingh Bennink , Ludivine Petit , Jean-Michel Foidart
IPC分类号： A61K31/565
CPC分类号： A61K31/565 , A61K2300/00
摘要： The present invention relates to a new use of tetrahydroxylated estrogens such as estetrol (1,3,5(10)-estratrien-3,15α,16α,17β-tetrol), namely in a method of emergency contraception. The method of emergency contraception according to the invention comprises the oral administration of estetrol in a single dose within 120 hours of sexual intercourse.
摘要翻译：本发明涉及四羟基化雌激素如雌酮（1,3,5（10） - 雌三醇-3,15α，16α，17β-四醇）的新用途，即紧急避孕方法。根据本发明的紧急避孕方法包括在性交后120小时内以单次剂量口服给予雌酮。

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