会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 22. 发明授权
    • Lipophilic benzothiophenes used for treating endometriosis
    • 用于治疗子宫内膜异位症的亲脂苯并噻吩类
    • US5827844A
    • 1998-10-27
    • US943340
    • 1997-10-03
    • George Joseph CullinanRaymond Francis Kauffman
    • George Joseph CullinanRaymond Francis Kauffman
    • A61K31/00A61K31/40A61K31/445A61K31/4465A61K31/4523A61K31/4525A61P3/00A61P3/06A61P9/00A61P9/10A61P19/00A61P19/10C07D333/56A61K31/58
    • C07D333/56
    • The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R.sub.1 is N-pyrrolidinyl or N-piperidinyl; R.sub.2 and R.sub.3 are independently hydrogen, --CO--(C.sub.10 -C.sub.22 alkyl), --CO--(C.sub.10 -C.sub.22 branched alkyl), --CO--(C.sub.10 -C.sub.22 alkenyl), --CO--(C.sub.10 -C.sub.22 polyalkenyl), --CO--(C.sub.10 -C.sub.22 alkynyl), or --CO--(CH.sub.2).sub.n COR.sub.4 ; provided R.sub.2 and R.sub.3 are not both dodecanoyl, and one of R.sub.2 or R.sub.3 is not hydrogen R.sub.4 is -3-cholesteryl or --O(CH.sub.2).sub.2 (OR.sub.5)CH.sub.2 OR.sub.6 ; R.sub.5 and R.sub.6 are independently hydrogen, --CO--(C.sub.10 -C.sub.22 alkyl), --CO--(C.sub.10 -C.sub.22 branched alkyl), --CO--(C.sub.10 -C.sub.22 alkenyl), --CO--(C.sub.10 -C.sub.22 polyalkenyl), or --CO--(C.sub.10 -C.sub.22 alkynyl); provided one of R.sub.5 or R.sub.6 is not hydrogen; n is 0-4; and pharmaceutically acceptable salts and solvates thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, and the use of such compounds.
    • 本发明提供了式(I)的新型苯并噻吩:其中R 1是N-吡咯烷基或N-哌啶基; R 2和R 3独立地是氢,-CO-(C 10 -C 22烷基),-CO-(C 10 -C 22支链烷基),-CO-(C 10 -C 22烯基),-CO-(C 10 -C 22聚链烯基) - (C 10 -C 22炔基)或-CO-(CH 2)n COOR 4; 提供的R 2和R 3不是十二酰基,R 2或R 3中的一个不是氢。R4是-3-胆甾醇基或-O(CH 2)2(OR 5)CH 2 OR 6; R 5和R 6独立地是氢,-CO-(C 10 -C 22烷基),-CO-(C 10 -C 22支链烷基),-CO-(C 10 -C 22烯基),-CO-(C 10 -C 22聚链烯基) CO-(C 10 -C 22炔基); 提供一个R5或R6不是氢; n为0-4; 及其药学上可接受的盐和溶剂化物。 本发明还提供含有式I化合物的药物组合物,以及这些化合物的用途。
    • 23. 发明授权
    • Lipophilic benzothiophenes
    • 亲脂苯并噻吩
    • US5811415A
    • 1998-09-22
    • US942967
    • 1997-10-03
    • George Joseph CullinanRaymond Francis Kauffman
    • George Joseph CullinanRaymond Francis Kauffman
    • A61K31/00A61K31/40A61K31/445A61K31/4465A61K31/4523A61K31/4525A61P3/00A61P3/06A61P9/00A61P9/10A61P19/00A61P19/10C07D333/56A61K31/58
    • C07D333/56
    • The invention provides novel benzothiophenes of the formula (I): ##STR1## wherein R.sub.1 is N-pyrrolidinyl or N-piperidinyl; R.sub.2 and R.sub.3 are independently hydrogen, --CO--(C.sub.10 -C.sub.22 alkyl), --CO--(C.sub.10 -C.sub.22 branched alkyl), --CO--(C.sub.10 -C.sub.22 alkenyl), --CO--(C.sub.10 -C.sub.22 polyalkenyl), --CO--(C.sub.10 -C.sub.22 alkynyl), or --CO--(CH.sub.2).sub.n COR.sub.4 ; provided R.sub.2 and R.sub.3 are not both dodecanoyl, and one of R.sub.2 or R.sub.3 is not hydrogen R.sub.4 is -3-cholesteryl or --O(CH.sub.2).sub.2 (OR.sub.5)CH.sub.2 OR.sub.6 ; R.sub.5 and R.sub.6 are independently hydrogen, --CO--(C.sub.10 -C.sub.22 alkyl), --CO--(C.sub.10 -C.sub.22 branched alkyl), --CO--(C.sub.10 -C.sub.22 alkenyl), --CO--(C.sub.10 -C.sub.22 polyalkenyl), or --CO--(C.sub.10 -C.sub.22 alkynyl); provided one of R.sub.5 or R.sub.6 is not hydrogen; n is 0-4; and pharmaceutically acceptable salts and solvates thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, and the use of such compounds.
    • 本发明提供了式(I)的新型苯并噻吩:其中R 1是N-吡咯烷基或N-哌啶基; R 2和R 3独立地是氢,-CO-(C 10 -C 22烷基),-CO-(C 10 -C 22支链烷基),-CO-(C 10 -C 22烯基),-CO-(C 10 -C 22聚链烯基) - (C 10 -C 22炔基)或-CO-(CH 2)n COOR 4; 提供的R 2和R 3不是十二酰基,R 2或R 3中的一个不是氢。R4是-3-胆甾醇基或-O(CH 2)2(OR 5)CH 2 OR 6; R 5和R 6独立地是氢,-CO-(C 10 -C 22烷基),-CO-(C 10 -C 22支链烷基),-CO-(C 10 -C 22烯基),-CO-(C 10 -C 22聚链烯基) CO-(C 10 -C 22炔基); 提供一个R5或R6不是氢; n为0-4; 及其药学上可接受的盐和溶剂化物。 本发明还提供含有式I化合物的药物组合物,以及这些化合物的用途。
    • 25. 发明授权
    • Microphone coupler for hearing aid having inverted conical end
configuration
    • 用于助听器的麦克风耦合器具有倒锥形端配置
    • US3979567A
    • 1976-09-07
    • US550196
    • 1975-02-18
    • George Joseph Frye
    • George Joseph Frye
    • H04R25/00H04R29/00
    • H04R25/30
    • A microphone coupler or artificial ear for coupling a microphone and a hearing aid to test the operational characteristics of a hearing aid includes a cavity having a predetermined volume, an opening extending from one end of the coupler to the cavity and is in communication therewith for receiving microphone means therein. The other end of the coupler has an inverted conical configuration in in which an ear mold of a hearing aid is to be disposed, and a hole extends between the inverted conical end and the artificial ear cavity. A non-hardening moldable material is positioned within the inverted conical end around the ear mold which mechanically holds the ear mold in position and provides acoustical sealing during testing of the hearing aid.
    • 用于耦合麦克风和助听器以测试助听器的操作特性的麦克风耦合器或人造耳包括具有预定体积的空腔,从耦合器的一端延伸到空腔并与其通信以接收的空腔 麦克风装置在其中。 耦合器的另一端具有倒置的锥形结构,其中将设置助听器的耳模,并且孔在倒锥形端和人造耳腔之间延伸。 将非硬化的可模制材料定位在围绕耳模的倒锥形端内,其将耳模机械地保持就位并在助听器测试期间提供声学密封。