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21. 发明授权

US5700258A Complex coils having fibered centers 失效
标题翻译：具有纤维中心的复杂线圈
公开(公告)号：US5700258A
公开(公告)日：1997-12-23
申请号：US540354
申请日：1995-09-29
申请人： Gregory E. Mirigian , Nga Thi Van , Son M. Gia
发明人： Gregory E. Mirigian , Nga Thi Van , Son M. Gia
IPC分类号： A61B17/00 , A61B17/12
CPC分类号： A61B17/12145 , A61B17/12022 , A61B17/1215
摘要： A vasoocclusive coil for placement in the vasculature of an animal to form thrombus in a selected site such as an aneurysm or AVM. The device involves a primary coil form having thrombogenic fibers placed on the coil in a specified fashion. The coil will pass through the lumen of a vascular catheter in the primary coil form and evolve into a convoluted or complex secondary form when ejected from the catheter's distal end. The fibers are attached to the coil and cooperate with the coil so that upon ejection from the catheter, the convoluted coil forms a shape in which the central region or secondary coil form center that contains the majority of these fibers.
摘要翻译：用于放置在动物脉管系统中以在所选位点如动脉瘤或AVM中形成血栓的血管收缩性线圈。该装置涉及具有以特定方式放置在线圈上的血栓形成纤维的初级线圈形式。线圈将以原始线圈形式通过血管导管的内腔，并且当从导管的远端喷出时，其演变成卷积或复杂的次级形式。纤维连接到线圈并与线圈配合，使得当从导管喷射时，卷积的线圈形成中心区域或次级线圈形成中心的形状，其中包含大多数这些纤维。

22. 发明授权

US5683410A Single-lumen balloon catheter having a directional valve 失效
标题翻译：具有方向阀的单腔气囊导管
公开(公告)号：US5683410A
公开(公告)日：1997-11-04
申请号：US428061
申请日：1995-04-27
申请人： Gene Samson
发明人： Gene Samson
IPC分类号： A61F2/958 , A61M25/00 , A61M29/00
CPC分类号： A61M25/0075 , A61M25/10 , A61M2025/1063 , A61M2025/1093 , A61M25/09
摘要： This invention is a single-lumen balloon catheter having a valve seat on the distal end of the catheter, distal of the balloon, which may be operated by a control wire having a valve plug disposed on the wire. The valve seat may be engaged by the valve plug from either direction, depending on the installation of the control wire. In either event, if the valve plug is installed distally of the valve seat in the catheter lumen, the valve is closed by pulling on the control wire (or moving the control wire in a proximal direction) and introducing fluid through the catheter lumen through the balloon. Alternatively, the guidewire, with its integral valve plug, may be introduced from the proximal end of the catheter and may traverse the body of the balloon to engage the valve seat in the distal end of the catheter. Pushing on the control wire will seat the valve, allowing the introduction of fluid through the catheter lumen to inflate the balloon. The latter arrangement allows the control wire to be interchanged with other guidewires a physician may wish to use. The balloon provided for in this invention is of a single length and does not change its axial length as it is inflated.
摘要翻译： PCT No.PCT / US93 / 10638 Sec。 371日期：1995年04月27日 102（e）日期1995年4月27日PCT 1993年11月4日PCT公布。第WO94 / 11047号公报日期1994年5月26日本发明是一种单腔气囊导管，其具有在导管的远端上的阀座，该气囊远离球囊，其可由具有设置在线上的阀塞的控制线操作。取决于控制线的安装，阀座可以由阀塞从任一方向接合。在任一情况下，如果阀塞被安装在导管内腔中阀座的远端，则通过拉动控制线（或沿近端方向移动控制线）并将流体通过导管内腔引入气球。或者，具有其一体式阀塞的导丝线可以从导管的近端导入，并且可以穿过气囊的主体以与导管的远端中的阀座接合。推动控制线将座阀，允许通过导管腔导入流体以使气囊膨胀。后一种布置允许控制线与医生可能希望使用的其它导线互换。在本发明中提供的气囊具有单一长度，并且在膨胀时不改变其轴向长度。

23. 发明授权

US5624449A Electrolytically severable joint for endovascular embolic devices 失效
标题翻译：用于血管内栓塞装置的电解分离接头
公开(公告)号：US5624449A
公开(公告)日：1997-04-29
申请号：US431827
申请日：1995-04-28
申请人： Pete P. Pham , Hong Doan , Ivan Sepetka , Joseph Eder , Edward Snyder
发明人： Pete P. Pham , Hong Doan , Ivan Sepetka , Joseph Eder , Edward Snyder
IPC分类号： A61B17/00 , A61B17/12 , A61F2/82 , A61F2/84 , A61M25/01
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00004 , A61B2017/12063
摘要： This invention is an apparatus for endovascular occlusion through the formation of thrombi in arteries, veins, aneurysms, vascular malformations, and arteriovenous fistulas. In particular, it deals with an improved sacrificial link between an endovascular device which is introduced to and is intended to remain at the desired thrombus formation site and the device used to introduce the device. The invention further includes a method for introduction of the device and its electrolytic separation.
摘要翻译：本发明是通过在动脉，静脉，动脉瘤，血管畸形和动静脉瘘中形成血栓的血管内闭塞的装置。特别地，它涉及在引入到并期望保留在期望的血栓形成部位的血管内装置和用于引入装置的装置之间的改进的牺牲连接。本发明还包括引入该装置及其电解分离的方法。

24. 发明授权

US5540680A Endovascular electrolytically detachable wire and tip for the formation of thrombus in arteries, veins, aneurysms, vascular malformations and arteriovenous fistulas 失效
公开(公告)号：US5540680A
公开(公告)日：1996-07-30
申请号：US311508
申请日：1994-09-23
申请人： Guido Guglielmi , Ivan Sepetka
发明人： Guido Guglielmi , Ivan Sepetka
IPC分类号： A61B18/00 , A61B17/00 , A61B17/12 , A61B18/12 , A61B18/14 , A61B19/00 , A61F2/82 , A61M25/00 , A61M37/00 , A61B17/38
CPC分类号： A61M25/09 , A61B17/12022 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B18/1492 , A61B2017/00292 , A61B2017/12063 , A61B2017/12095 , A61B2017/22038 , A61B2018/00678 , A61B2018/00761 , A61B2018/00875 , A61B2018/00886 , A61B2018/1226 , A61B2018/1253 , A61B2018/126 , A61B2018/1266 , A61B2018/1435 , A61B2018/1495 , A61B2090/3966 , A61B90/39 , A61M2025/09175
摘要： An artery, vein, aneurysm, vascular malformation or arterial fistula is occluded through endovascular occlusion by the endovascular insertion of a platinum wire and/or tip into the vascular cavity. The vascular cavity is packed with the tip to obstruct blood flow or access of blood in the cavity such that the blood clots in the cavity and an occlusion if formed. The tip may be elongate and flexible so that it packs the cavity by being folded upon itself a multiple number of times, or may pack the cavity by virtue of a filamentary or fuzzy structure of the tip. The tip is then separated from the wire mechanically or by electrolytic separation of the tip from the wire. The wire and the microcatheter are thereafter removed leaving the tip embedded in the thrombus formed within the vascular cavity. Movement of wire in the microcatheter is more easily tracked by providing a radioopaque proximal marker on the microcatheter and a corresponding indicator marker on the wire. Electrothrombosis is facilitate by placing the ground electrode on the distal end of the microcatheter and flowing current between the microcatheter electrode and the tip.

25. 发明授权

US5522822A Vasoocclusion coil with attached tubular woven or braided fibrous covering 失效
公开(公告)号：US5522822A
公开(公告)日：1996-06-04
申请号：US323951
申请日：1994-10-17
申请人： James J. Phelps , Nga T. Van
发明人： James J. Phelps , Nga T. Van
IPC分类号： A61B17/12 , A61F2/01 , D04C1/06 , A61B17/00
CPC分类号： D04C1/06 , A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B17/1215 , A61F2/01 , A61F2002/011 , A61F2002/016 , A61F2230/0006 , A61F2230/0069 , A61F2230/0076 , A61F2230/0091
摘要： This invention is in the field of vasoocclusion devices. More particularly, it relates to a vasoocclusion coil which may be segmented, onto which a fibrous, woven or braided, tubular covering or element is attached.

26. 发明授权

US5522819A Dual coil medical retrieval device 失效
标题翻译：双线圈医疗检索装置
公开(公告)号：US5522819A
公开(公告)日：1996-06-04
申请号：US241651
申请日：1994-05-12
申请人： Virgil B. Graves , Alan Rappe , Ivan Sepetka , Son Gia , Pete P. Pham , Gene Samson
发明人： Virgil B. Graves , Alan Rappe , Ivan Sepetka , Son Gia , Pete P. Pham , Gene Samson
IPC分类号： A61B17/221 , A61B17/12 , A61B17/22 , A61B17/50 , A61B19/00 , A61F2/82
CPC分类号： A61B17/221 , A61B17/12022 , A61B2017/22035 , A61B2017/2212 , A61B90/39
摘要： A device for retrieving foreign bodies, such as a vaso-occlusive coil or other articles, from within vessels such as those of the cardiovascular system. Two small snare coils are joined at their distal ends to form a loop. The proximal ends of the loops are attached to one or more elongated actuator members. The loop size is adjusted by manipulation of one or more of the proximal ends of the elongated actuator members. This retrieval device may be used to ensnare and either reposition or remove foreign bodies located within a vessel lumen.
摘要翻译：用于从例如心血管系统的血管内的血管中检索诸如血管闭塞线圈或其他物品的异物的装置。两个小的圈套线圈在其远端连接形成环路。环的近端附接到一个或多个细长的致动器构件。通过操纵细长致动器构件的一个或多个近端来调节环尺寸。这种检索装置可用于捕获并重新定位或移除位于血管内腔内的异物。

27. 发明授权

US5454795A Kink-free spiral-wound catheter 失效
标题翻译：无弯曲螺旋缠绕导管
公开(公告)号：US5454795A
公开(公告)日：1995-10-03
申请号：US266540
申请日：1994-06-27
申请人： Gene Samson
发明人： Gene Samson
IPC分类号： A61L29/04 , A61L29/06 , A61L29/08 , A61M25/00
CPC分类号： A61L29/08 , A61L29/041 , A61L29/049 , A61L29/06 , A61M25/005 , A61M25/0053
摘要： This invention is a surgical device. In particular, it is a catheter suitable for treating a tissue target within the body, which target is accessible through the vascular system. Central to the invention is the use of stiffener ribbons, typically metallic, wound within the catheter body in such a way as to create a catheter having controllable stiffness.
摘要翻译：本发明是一种手术装置。特别地，它是适合于治疗身体内的组织靶的导管，该靶可通过血管系统进入。本发明的中心是使用加强筋，通常是金属的，缠绕在导管体内，以便产生具有可控刚度的导管。

28. 发明授权

US5443455A Guidewire and method of pretreating metal surfaces for subsequent polymer coating 失效
标题翻译：导丝和预处理后续聚合物涂层的金属表面的方法
公开(公告)号：US5443455A
公开(公告)日：1995-08-22
申请号：US97458
申请日：1993-07-27
申请人： Robert Hergenrother , Uriel H. Chee , Laurent Schaller
发明人： Robert Hergenrother , Uriel H. Chee , Laurent Schaller
IPC分类号： A61L29/08 , A61L33/00 , A61M25/09 , B32B15/08 , C23C16/30 , C23C16/50 , A61M25/00
CPC分类号： A61M25/09 , A61L29/085 , A61L33/0029 , Y10T428/2942
摘要： This invention relates to a new technique for preparing metal devices such as guidewires for the subsequent attachment of hydrophilic coatings. The invention also relates to guidewires and other devices made according to that method.In one embodiment of the method of this invention, a hydrocarbon residue undercoat is applied to a metal guidewire core by plasma deposition. A photoactive hydrophilic polymer is then deposited on the hydrocarbon residue coating and activated by ultraviolet light. The hydrocarbon residue coating acts as a tie layer between the hydrophilic polymer and the metal guidewire core apparently by providing C--C bonds for the covalent linking of the coating material to the tie layer. The resulting article of this invention is a guidewire having the maneuverability of a metal guidewire and the biocompatibility of a lubricious, hydrophilic polymer.
摘要翻译：本发明涉及一种用于制备金属装置的新技术，例如用于随后附着亲水涂层的导线。本发明还涉及根据该方法制造的导线和其它装置。在本发明方法的一个实施方案中，通过等离子体沉积将烃基底涂层施加到金属导丝芯上。然后将光活性亲水性聚合物沉积在烃残余物涂层上并通过紫外光激活。烃残留涂层在亲水性聚合物和金属导丝芯之间起粘结层的作用，显然是通过提供用于涂层材料与粘结层的共价连接的C-C键。本发明的所得物品是具有金属导丝的机动性和润滑的亲水性聚合物的生物相容性的导丝。

29. 发明授权

US5387219A Medical retrieval snare with coil wrapped loop 失效
标题翻译：线圈包裹回路的医疗检索圈套
公开(公告)号：US5387219A
公开(公告)日：1995-02-07
申请号：US175500
申请日：1993-12-30
申请人： Alan H. Rappe
发明人： Alan H. Rappe
IPC分类号： A61B17/12 , A61B17/22 , A61B17/221 , A61B17/50 , A61B19/00 , A61F2/82
CPC分类号： A61B17/221 , A61B17/1214 , A61B17/12022 , A61B17/50 , A61B2017/22035 , A61B2017/2212 , A61B90/39 , A61F2/82
摘要： A device for retrieving foreign bodies, such as a vasoocclusive coil or elements, from within vessels such as those of the cardiovascular system includes a tubular member and a flexible wire that extends axially through the tubular member with its distal end extending out the distal end of the tubular member and looped back and affixed to the distal end of the tubular member to form a loop whose size may be adjusted by axial movement of the wire relative to the tubular member and which may be used to ensnare the foreign bodies and remove them from the vessel.
摘要翻译：用于从诸如心血管系统的血管内的诸如血管闭塞的线圈或元件中检索异物的装置包括管状构件和柔性线，所述管状构件和柔性线轴向延伸穿过管状构件，其远端延伸出远端管状构件并环绕并且固定到管状构件的远端以形成环，其尺寸可以通过线相对于管状构件的轴向运动来调节，并且可用于捕获异物并将其从船只。

30. 发明授权

US5304198A Single-lumen balloon catheter having a directional valve 失效
标题翻译：具有方向阀的单腔气囊导管
公开(公告)号：US5304198A
公开(公告)日：1994-04-19
申请号：US976197
申请日：1992-11-13
申请人： Gene Samson
发明人： Gene Samson
IPC分类号： A61M25/00 , A61M29/02 , A61M39/00
CPC分类号： A61M25/104 , A61M25/0045 , A61M25/0075 , A61M2025/0076 , A61M2025/1093 , A61M29/02
摘要： This invention is a single-lumen balloon catheter having a valve seat on the distal end of the catheter, distal of the balloon, which may be operated by a control wire having a valve plug disposed on the wire. The valve seat may be engaged by the valve plug from either direction, depending on the installation of the control wire. In either event, if the valve plug is installed distally of the valve seat in the catheter lumen, the valve is closed by pulling on the control wire (or moving the control wire in a proximal direction) and introducing fluid through the catheter lumen through the balloon. Alternatively, the guidewire, with its integral valve plug, may be introduced from the proximal end of the catheter and may traverse the body of the balloon to engage the valve seat in the distal end of the catheter. Pushing on the control wire will seat the valve, allowing the introduction of fluid through the catheter lumen to inflate the balloon. The latter arrangement allows the control wire to be interchanged with other guidewires a physician may wish to use. The balloon provided for in this invention is of a single length and does not change its axial length as it is inflated.
摘要翻译：本发明是一种单腔气囊导管，其在导管的远端上具有阀座，该气囊导管的远端位于球囊的远端，该气囊可以由具有设置在线上的阀塞的控制线来操作。取决于控制线的安装，阀座可以由阀塞从任一方向接合。在任一情况下，如果阀塞被安装在导管内腔中阀座的远端，则通过拉动控制线（或沿近端方向移动控制线）并将流体通过导管内腔引入气球。或者，具有其一体式阀塞的导丝线可以从导管的近端导入，并且可以穿过气囊的主体以与导管的远端中的阀座接合。推动控制线将座阀，允许通过导管腔导入流体以使气囊膨胀。后一种布置允许控制线与医生可能希望使用的其它导线互换。在本发明中提供的气囊具有单一长度，并且在膨胀时不改变其轴向长度。

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