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21. 发明申请

US20180251728A1 ANDROGENETIC HAPLOID EMBRYONIC STEM CELL, AND PREPARATION METHOD AND USE THEREOF 审中-公开
公开(公告)号：US20180251728A1
公开(公告)日：2018-09-06
申请号：US15740974
申请日：2015-07-02
申请人： SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES CHINESE ACADEMY OF SCIENCES
发明人： JINSONG LI , YUXUAN WU , CUIQING ZHONG , QI YIN , ZHENFEI XIE , MEIZHU BAI
IPC分类号： C12N5/0735 , C12N15/873 , C12N15/85
CPC分类号： C12N5/0606 , A01K67/0276 , C12N15/85 , C12N15/8509 , C12N15/873 , C12N2500/10 , C12N2500/50 , C12N2501/065 , C12N2501/235 , C12N2501/727 , C12N2502/99
摘要： The present invention relates to an AG-haESCs in which H19 DMR and IG-DMR are knocked out, a method for preparing the AG-haESCs, and use of the AG-haESCs in constructing a genetically modified semi-cloned animal and a library of a genetically modified semi-cloned animal. The AG-haESCs is capable of obtaining characteristics resembling a round spermatid, and upon injection into an oocyte, a viable SC mouse is stably obtained. The present invention is capable of being effectively used in multi-gene genetic manipulation, advancing the acquisition of animals with multiple genetic modifications.

22. 发明申请

US20180016585A1 METHOD FOR IMPROVING HETEROLOGOUS SYNTHESIS OF ESCHERICHIA COLI INTO POLYKETIDES AND USE OF SAME 审中-公开
公开(公告)号：US20180016585A1
公开(公告)日：2018-01-18
申请号：US15523829
申请日：2015-05-18
申请人： Shanghai Institutes for Biological Sciences Chinese Academy of Sciences
发明人： Yong Wang , Zhiqiang Xiong , Shujie Song , Qiaoxia Liu , Jianfeng Wang
IPC分类号： C12N15/70 , C12Q1/18 , C12N15/09 , C12R1/465 , C07H17/08
CPC分类号： C12N15/70 , C07H17/08 , C12N9/1288 , C12N15/09 , C12N15/113 , C12N2320/12 , C12N2330/31 , C12N2330/50 , C12P17/08 , C12P19/62 , C12Q1/18 , C12R1/465
摘要： The present invention relates to a method for improving the heterologous synthesis of a polyketide by E. coli and use thereof. The yield of the polyketide heterologously synthesized by E. coli is significantly increased by attenuating the expression of seventy-two genes, such as sucC and talB, in a host strain, wherein the highest yield increase rate can reach 60% or more. Currently, erythromycin is the most clear model compound in the study on the biosynthesis of polyketids. The production strain of the present invention enables massive accumulation of 6-deoxyerythronolide (6-dEB), an erythromycin precursor, in the fermentation process, laying the foundation for the industrial production of the heterologous synthesis of erythromycin by E. coli.

23. 发明授权

US09416348B2 Hepatocyte-like cells and uses thereof 有权
标题翻译：肝细胞样细胞及其用途
公开(公告)号：US09416348B2
公开(公告)日：2016-08-16
申请号：US13883748
申请日：2011-11-04
申请人： Lijian Hui , Pengyu Huang , Xin Wang
发明人： Lijian Hui , Pengyu Huang , Xin Wang
IPC分类号： C12N5/00 , C12N5/02 , C12N5/071 , A61M37/00
CPC分类号： C12N5/067 , A61M37/00 , C12N2501/60 , C12N2506/1307 , C12N2510/00
摘要： The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells.
摘要翻译：本发明涉及肝细胞样细胞。还公开了制备细胞和使用细胞的方法。

24. 发明授权

US08895805B2 Method for modifying insect resistance of plants by utilizing RNAi technique 有权
标题翻译：利用RNAi技术改良植物抗虫性的方法
公开(公告)号：US08895805B2
公开(公告)日：2014-11-25
申请号：US12312934
申请日：2007-12-04
申请人： Xiaoya Chen , Yingbo Mao , Zhiping Lin , Lingjian Wang
发明人： Xiaoya Chen , Yingbo Mao , Zhiping Lin , Lingjian Wang
IPC分类号： C12N15/82 , C12N15/87 , A01H1/00
CPC分类号： C12N15/8286 , C12N15/8218 , Y02A40/162
摘要： A method for improving insect resistance of plants, in which dsRNA of insect's gene is expressed in plants by using transgenic technique, and then the interfering RNAs are formed in the plants. The interfering RNAs then enter into insects' bodies after being ingested by the insect that eats the plant, and conduct RNA interference against the target gene, thereby expression of the target gene is suppressed by RNA interference. A new plant-mediated method for improving insect resistance by suppressing the growth of insects by RNA interference mechanism.
摘要翻译：一种提高植物抗虫性的方法，其中通过使用转基因技术在植物中表达昆虫基因的dsRNA，然后在植物中形成干扰RNA。干扰RNA然后在被植物摄取的昆虫摄入后进入昆虫体内，对靶基因进行RNA干扰，从而通过RNA干扰抑制靶基因的表达。一种通过RNA干扰机制抑制昆虫生长来提高昆虫抗性的新植物介导方法。

25. 发明申请

US20140248254A1 THE USE OF ACHE AS NUCLEASE 审中-公开
标题翻译：使用ACHE作为核苷酸
公开(公告)号：US20140248254A1
公开(公告)日：2014-09-04
申请号：US14237204
申请日：2012-08-08
申请人： Xuejun Zhang , Jing Xie , Aiying Du , Kaijie Guo , Jun Wu
发明人： Xuejun Zhang , Jing Xie , Aiying Du , Kaijie Guo , Jun Wu
IPC分类号： C12N9/18 , C12Q1/46 , A61K38/46 , C12N15/85 , C12N15/113
CPC分类号： C12N9/18 , A61K38/465 , C07K2319/00 , C07K2319/09 , C12N15/1137 , C12N15/85 , C12Q1/46 , C12Y301/01007 , G01N33/573 , G01N2333/918 , G01N2500/02
摘要： This invention provides the use of AChE as nuclease. The use of AChE in regulating the stability of nucleic acid and cell apoptosis, as well as a series of agents based on the use, including the agents for promoting or inhibiting cell apoptosis, the agents for inhibiting tumors, and the agents for protecting nucleic acid from impairing, are provided.
摘要翻译：本发明提供了AChE作为核酸酶的用途。使用AChE调节核酸和细胞凋亡的稳定性，以及基于使用的一系列试剂，包括用于促进或抑制细胞凋亡的药剂，用于抑制肿瘤的药剂和用于保护核酸的试剂提供损害。

26. 发明申请

US20130330304A1 Hepatocyte-Like Cells and Uses Thereof 有权
标题翻译：肝细胞样细胞及其用途
公开(公告)号：US20130330304A1
公开(公告)日：2013-12-12
申请号：US13883748
申请日：2011-11-04
申请人： Lijian Hui , Pengyu Huang , Xin Wang
发明人： Lijian Hui , Pengyu Huang , Xin Wang
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , A61M37/00 , C12N2501/60 , C12N2506/1307 , C12N2510/00
摘要： The present invention relates to hepatocyte-like cells. Also disclosed are methods of making the cells and using the cells.
摘要翻译：本发明涉及肝细胞样细胞。还公开了制备细胞和使用细胞的方法。

27. 发明授权

US08461419B2 Plant height regulatory gene and uses thereof 有权
标题翻译：植物高度调节基因及其用途
公开(公告)号：US08461419B2
公开(公告)日：2013-06-11
申请号：US12672803
申请日：2008-08-11
申请人： Zuhua He , Yingying Zhang , Qun Li
发明人： Zuhua He , Yingying Zhang , Qun Li
IPC分类号： C12N15/87 , A01H5/00 , A01H1/00
CPC分类号： C12N15/8261 , C07K14/415 , C12N9/0077 , C12N15/8225 , C12N15/8226 , C12N15/827 , Y02A40/146
摘要： Provided are a crop height regulatory gene from Arabidopsis thaliana, expression regulatory sequences thereof and uses thereof. The crop regulatory gene can be used to regulate the plant height, volume, tiller, yield, flower organ size, or seed size of crops.
摘要翻译：提供拟南芥的作物高度调节基因，其表达调控序列及其用途。作物调节基因可用于调节作物的植物高度，体积，分蘖，产量，花器官大小或种子大小。

28. 发明申请

US20110245145A1 METHODS AND REAGENTS FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF INSULIN RESISTANCE 有权
标题翻译：诊断，预防和治疗胰岛素抵抗的方法和试剂
公开(公告)号：US20110245145A1
公开(公告)日：2011-10-06
申请号：US13132750
申请日：2009-12-03
申请人： Gang Pei , Bing Luan , Jian Zhao
发明人： Gang Pei , Bing Luan , Jian Zhao
IPC分类号： A61K38/02 , C12N15/63 , C07K14/47 , G01N33/566 , C12Q1/68 , A61K31/7088 , C07K16/18 , C07H21/00 , A61P3/10 , A61P3/08 , A61P3/04 , A61P9/12 , A61P9/00 , A61P19/06
CPC分类号： A61K38/1709
摘要： The present invention provides the use of βarrestin2 protein or its up-regulators for manufacturing a composition for the prevention or treatment of insulin resistance or related disease in mammals. The reagents and the kits for the specific identification of βarrestin2 protein or its coding gene or transcript are also provided which can be used in diagnosis of insulin resistance or related diseases.
摘要翻译：本发明提供了用于制备用于预防或治疗哺乳动物的胰岛素抵抗或相关疾病的组合物的抑制蛋白2或其上调节剂的用途。还提供了用于特异性鉴定和抑制蛋白2或其编码基因或转录物的试剂和试剂盒，其可用于胰岛素抵抗或相关疾病的诊断。

29. 发明授权

US08026073B2 Screening G protein-coupled receptor antagonists for methods of treating Alzheimer's disease 有权
标题翻译：筛选G蛋白偶联受体拮抗剂治疗阿尔茨海默病的方法
公开(公告)号：US08026073B2
公开(公告)日：2011-09-27
申请号：US12159183
申请日：2006-12-26
申请人： Gang Pei , Yanxiang Ni , Xiaohui Zhao
发明人： Gang Pei , Yanxiang Ni , Xiaohui Zhao
IPC分类号： G01N33/53
CPC分类号： G01N33/5035 , G01N2333/726 , G01N2500/10 , G01N2800/2821
摘要： A method for screening a reagent for treating or preventing Alzheimer's disease or related neurological pathology includes the steps of: (a) activating a receptor and determining a first extent of endocytosis of the receptor, wherein the receptor is a G-protein coupled receptor that associates with presenilin-1; (b) activating the receptor under the same conditions as in step (a), in the presence of a candidate reagent, and determining a second extent of endocytosis of the receptor; (c) determining a difference between the first extent of endocytosis and the second extent of endocytosis; and (d) repeating steps (a)-(c), if the difference is less than a threshold. Uses of receptor antagonists for manufacturing medicaments for treating or preventing Alzheimer's disease or related neurological pathology, wherein the receptor antagonists inhibit endocytosis of a G-protein coupled receptor that associates with presenilin-1 during endocytosis.
摘要翻译：用于筛选用于治疗或预防阿尔茨海默病或相关神经病理学的试剂的方法包括以下步骤：（a）激活受体并测定受体的第一内吞程度，其中所述受体是G蛋白偶联受体，与早老素-1; （b）在与候选试剂的存在下在与步骤（a）相同的条件下活化受体，并确定受体的第二程度的胞吞作用; （c）确定第一内吞程度与第二内吞程度之间的差异; 和（d）如果差值小于阈值，则重复步骤（a） - （c）。用于制备用于治疗或预防阿尔茨海默病或相关神经病理学的药物的受体拮抗剂的用途，其中所述受体拮抗剂抑制内吞作用期间与早老蛋白-1相关的G蛋白偶联受体的内吞。

30. 发明授权

US07939497B2 Detection and modulation of slit and roundabount (robo) mediated angiogenesis and uses thereof 有权
标题翻译：狭缝和圆形（robo）介导的血管发生的检测和调节及其用途
公开(公告)号：US07939497B2
公开(公告)日：2011-05-10
申请号：US10386386
申请日：2003-03-10
申请人： Jian-Guo Geng
发明人： Jian-Guo Geng
IPC分类号： A61K38/16 , A61K39/395 , C07K14/00
CPC分类号： C07K16/303 , A61K2039/505 , C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/76
摘要： This invention is generally in the field of methods for diagnosis, treatment and prevention of various disorders involving the Slit2 mediated angiogenesis.
摘要翻译：本发明通常涉及用于诊断，治疗和预防涉及Slit2介导的血管生成的各种疾病的方法领域。

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