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21. 发明申请

US20110083961A1 MICROFLUIDIC SYSTEM AND CORRESPONDING OPERATING METHOD 失效
标题翻译：微流控系统及相应的操作方法
公开(公告)号：US20110083961A1
公开(公告)日：2011-04-14
申请号：US12161267
申请日：2007-01-17
申请人： Torsten Müller , Thomas Schnelle
发明人： Torsten Müller , Thomas Schnelle
IPC分类号： G01N27/26 , B03C5/02
CPC分类号： C12N13/00 , B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/0421
摘要： The invention relates to an operating method for a microfluidic system, including the following steps: feeding of a carrier flow with particles (5) of a first particle type suspended therein into the microfluidic system; charging of a plurality of electrical field cages (1′, 1″) in the microfluidic system with the supplied particles (5) of the first particle type; the supplying of a carrier flow with particles (6) of a second particle type suspended therein into the microfluidic system; and charging the field cages (1′, 1″) in the microfluidic system with the supplied particles (6) of the second particle type in such a manner that a particle (5) of the first particle type and a particle (6) of the second particle type is present in at least one of the field cages (1′, 1′). The invention also relates to a corresponding microfluidic system.
摘要翻译：本发明涉及一种用于微流体系统的操作方法，包括以下步骤：将载体流与悬浮于其中的第一颗粒类型的颗粒（5）进料到微流体系统中; 在微流体系统中与所提供的第一颗粒类型的颗粒（5）充电多个电场笼（1'，1“）; 将载体流与悬浮在其中的第二颗粒类型的颗粒（6）供应到微流体系统中; 以及将所述微流体系统中的所述场笼（1'，1“）与所提供的所述第二颗粒类型的颗粒（6）以使得所述第一颗粒类型的颗粒（5）和所述第一颗粒类型的颗粒（6）第二粒子类型存在于至少一个场笼（1'，1'）中。本发明还涉及相应的微流体系统。

22. 发明申请

US20100155246A1 ELECTRIC FIELD CAGE AND ASSOCIATED OPERATING METHOD 审中-公开
标题翻译：电场笼及相关操作方法
公开(公告)号：US20100155246A1
公开(公告)日：2010-06-24
申请号：US12161062
申请日：2007-01-17
申请人： Thomas Schnelle , Torsten Müller
发明人： Thomas Schnelle , Torsten Müller
IPC分类号： B01D57/02
CPC分类号： B01L3/502761 , B01L2200/0668 , B01L2300/0645 , B01L2400/0415 , B01L2400/0424 , B03C5/005 , B03C5/026
摘要： The invention relates to an electric field cage (6) for spatially fixing particles (2, 3) which are suspended in a carrier liquid, in particular in a microfluidic system, including a plurality of cage electrodes (7, 8), which can be electrically driven, for generating a capture field. It is proposed that at least one of the cage electrodes (8) is annular and surrounds the other cage electrode (7). The invention also covers an associated operating method.
摘要翻译：本发明涉及用于空间固定颗粒（2,3）的电场笼（6），其悬浮在载体液体中，特别是在包括多个笼电极（7,8）的微流体系统中，其可以是电驱动，用于产生捕获场。提出至少一个保持架电极（8）是环形的并且围绕着另一个笼状电极（7）。本发明还涵盖相关的操作方法。

23. 发明授权

US11501420B2 Reconstructing phase images with deep learning 有权
公开(公告)号：US11501420B2
公开(公告)日：2022-11-15
申请号：US17028448
申请日：2020-09-22
申请人： PerkinElmer Cellular Technologies Germany GmbH , PerkinElmer Health Sciences Canada, Inc.
发明人： Kaupo Palo , Abdulrahman Alhaimi
IPC分类号： G06T5/50 , G06N20/00 , G01N33/483 , G06N3/08 , G06T5/00
摘要： Aspects relate to reconstructing phase images from brightfield images at multiple focal planes using machine learning techniques. A machine learning model may be trained using a training data set comprised of matched sets of images, each matched set of images comprising a plurality of brightfield images at different focal planes and, optionally, a corresponding ground truth phase image. An initial training data set may include images selected based on image views of a specimen that are substantially free of undesired visual artifacts such as dust. The brightfield images of the training data set can then be modified based on simulating at least one visual artifact, generating an enhanced training data set for use in training the model. Output of the machine learning model may be compared to the ground truth phase images to train the model. The trained model may be used to generate phase images from input data sets.

24. 发明授权

US11249295B2 Methods and systems for automated imaging of three-dimensional objects 有权
公开(公告)号：US11249295B2
公开(公告)日：2022-02-15
申请号：US17012578
申请日：2020-09-04
申请人： PERKINELMER CELLULAR TECHNOLOGIES GERMANY GMBH
发明人： S Chris Hinnah , Kaupo Palo , Olavi Ollikainen , Thomas Steinkamp , Hartwig Preckel
IPC分类号： H04N9/47 , A62B1/04 , H04N7/18 , G02B21/00 , G02B21/02 , G02B21/36 , H04N5/89 , H04N13/00
摘要： Certain configurations are described of methods and systems that can be used to image three-dimensional objects such as biological cells, biological tissues or biological organisms. The methods and systems can image the three-dimensional objects at reduced imaging times and with reduced data volumes.

25. 发明申请

US20210220833A1 LABWARE ALIGNING SYSTEMS AND LIQUID HANDLING SYSTEMS AND METHODS INCLUDING SAME 有权
公开(公告)号：US20210220833A1
公开(公告)日：2021-07-22
申请号：US17147356
申请日：2021-01-12
申请人： PerkinElmer Cellular Technologies Germany, GmbH
发明人： Nils Nissen , Guido Harmsen , Christoph Klaunick
IPC分类号： B01L9/00 , B01L3/00
摘要： A labware aligning system for use with a labware includes a frame and fixation system. The frame includes a seat. The fixation system includes a pusher and a pusher actuator. The pusher is movable relative to the frame between an open position and a closed position. The pusher actuator includes an actuator linkage and a biasing mechanism. The actuator linkage is configured to: move the pusher from the closed position toward the open position when the actuator linkage is displaced; and, permit the pusher to move toward the closed position when the actuator linkage is not displaced. The biasing mechanism is operative to force the pusher toward the closed position when the actuator linkage is not displaced and to thereby cause the pusher to align the labware in the seat.

26. 发明申请

US20210096347A1 METHODS AND SYSTEMS FOR AUTOMATED IMAGING OF THREE-DIMENSIONAL OBJECTS 有权
公开(公告)号：US20210096347A1
公开(公告)日：2021-04-01
申请号：US17012578
申请日：2020-09-04
申请人： PERKINELMER CELLULAR TECHNOLOGIES GERMANY GMBH
发明人： S Chris Hinnah , Kaupo Palo , Ollavi Ollikainen , Thomas Steinkamp , Hartwig Preckel
IPC分类号： G02B21/00 , G02B21/02 , G02B21/36
摘要： Certain configurations are described of methods and systems that can be used to image three-dimensional objects such as biological cells, biological tissues or biological organisms. The methods and systems can image the three-dimensional objects at reduced imaging times and with reduced data volumes.

27. 发明授权

US10598915B2 Method for autofocusing a microscope at a correct autofocus position in a sample 有权
公开(公告)号：US10598915B2
公开(公告)日：2020-03-24
申请号：US15320984
申请日：2015-06-23
申请人： PerkinElmer Cellular Technologies Germany GmbH
发明人： Jürgen Rolf Müller
IPC分类号： G02B21/24 , G02B21/06 , G02B21/02
摘要： A method for autofocusing a microscope at a correct autofocus position in a sample includes the steps: generating a reference pattern by an autofocus light device, projecting the reference pattern towards a sample, whereby the reference pattern is backscattered by at least two interfaces being located at or close to the sample, projecting the backscattered reference pattern towards a detector which provides spatial resolution, obtaining a superposition of a number of detection patterns, each detection pattern related to one of the interfaces, on the detector, analyzing the superposition of detection patterns to identify at least one autofocus detection pattern related to at least one of the interfaces, and analyzing the at least one autofocus detection pattern to determine the direction and/or magnitude of deviation of the microscope's current focus position from the correct focus position.

28. 发明授权

US09612428B2 Apparatus for confocal observation of a specimen 有权
公开(公告)号：US09612428B2
公开(公告)日：2017-04-04
申请号：US14901774
申请日：2014-06-25
申请人： Perkinelmer Cellular Technologies Germany GmbH
发明人： Kaupo Palo , Peet Kask , Stefan Lupke
IPC分类号： G02B21/00 , G02B21/06 , G02B21/04
CPC分类号： G02B21/0076 , G02B21/0032 , G02B21/0044 , G02B21/0064
摘要： An apparatus for confocal observation of a specimen includes an illumination device. The illumination device generates illumination radiations of at least two different wavelengths. With the aid of a mask device illuminated by the illumination radiations, one mask image is generated per wavelength. An objective serves for imaging said mask images in the specimen. With the aid of a beam splitter device, the emission radiations emitted by the specimen are divided based on the wavelengths, and are detected based on the wavelengths by a detection device.

29. 发明授权

US09478020B2 Method for analysing the effect of a test substance on biological and/or biochemical samples 有权
标题翻译：分析测试物质对生物和/或生物化学样品的影响的方法
公开(公告)号：US09478020B2
公开(公告)日：2016-10-25
申请号：US12991236
申请日：2009-04-29
申请人： Dennis Trede , Peter Maass , Hartwig Preckel
发明人： Dennis Trede , Peter Maass , Hartwig Preckel
IPC分类号： G01N33/48 , G06T7/00 , G06F19/28 , G06G7/58 , G06F19/24
CPC分类号： G06T7/0012 , G06F19/24 , G06F19/28 , G06T2207/30072
摘要： Disclosed are methods for analyzing the effect of a test substance on biological and/or biochemical samples in which a plurality of samples, each comprising a known concentration of the test substance in at least three different concentrations, are used to obtain measurements which provide raw data. An evaluation rule utilizes the raw data of the sample determining the effect of the test substance, at the particular concentration, on the sample. The evaluation rule is influenced by at least one control parameter, and at least one starting value for the at least one control parameter is determined. The raw data is evaluated and correspondence between the determined activities and a functional model resulting from theoretical considerations yields a dose/effect curve describing the dependence of the activities on the concentration of the test substance. The steps are modified and repeated until an abort criterion has been reached.
摘要翻译：公开了用于分析测试物质对生物和/或生物化学样品的影响的方法，其中使用多个样品，每个样品包含至少三种不同浓度的已知浓度的测试物质，以获得提供原始数据的测量。评估规则利用样品的原始数据，确定测试物质在特定浓度下对样品的影响。评估规则受到至少一个控制参数的影响，并确定至少一个控制参数的起始值。评估原始数据，确定的活性与由理论考虑产生的功能模型之间的对应性产生描述活性对测试物质浓度的依赖性的剂量/效应曲线。这些步骤被修改并重复，直到达到中止标准。

30. 发明申请

US20150201896A1 METHOD AND SYSTEM FOR AUTOMATED DETECTION OF TISSUE INTERIOR TO A MAMMALIAN RIBCAGE FROM AN IN VIVO IMAGE 有权
标题翻译：方法和系统，用于自动检测体外图像中的哺乳动物的组织
公开(公告)号：US20150201896A1
公开(公告)日：2015-07-23
申请号：US14162693
申请日：2014-01-23
申请人： PerkinElmer Cellular Technologies Germany GmbH
发明人： Olavi Ollilainen , Peet Kask
IPC分类号： A61B6/00
CPC分类号： A61B6/5217 , A61B6/466 , A61B6/469 , A61B6/505 , A61B6/508 , A61B6/563 , G06T7/11 , G06T7/155 , G06T2207/10072 , G06T2207/20152 , G06T2207/20156 , G06T2207/30008
摘要： Described herein are systems and methods for efficient and accurate, automated detection of a region of interest interior to the ribcage from an in vivo mammalian image. It is found that efficient, automated identification of the region of interest interior to the ribcage can be achieved by the use of both a bone distance mask and a surface distance mask. The technique solves the problem of accurate and fast identification of the region of interest for a wide range of sizes and shapes of mammals, e.g., small mammals such as mice.
摘要翻译：本文描述的是用于从体内哺乳动物图像有效且准确地自动检测胸腔内部感兴趣区域的系统和方法。已经发现，通过使用骨距离掩模和表面距离掩模，可以实现胸腔内部感兴趣区域的有效的自动识别。该技术解决了哺乳动物（例如小型哺乳动物例如小鼠）的各种尺寸和形状的准确和快速识别感兴趣区域的问题。

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