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21. 发明申请

US20130303448A1 Therapeutic or Preventive Agent for Diabetes 有权
标题翻译：糖尿病治疗或预防剂
公开(公告)号：US20130303448A1
公开(公告)日：2013-11-14
申请号：US13981258
申请日：2012-01-25
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Tadashi Yoshimoto , Hiroshi Oyama
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Tadashi Yoshimoto , Hiroshi Oyama
IPC分类号： A61K38/39
CPC分类号： A61K38/39 , A61K38/05 , A61K38/06 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06104 , C07K5/0806 , C07K5/0812 , C07K5/0819 , C07K5/0823
摘要： A collagen peptide mixture containing three or more kinds selected from Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, chemically-modified substances thereof and pharmaceutically acceptable salts thereof, and at least one peptide selected from the group consisting of Glu-Hyp-Gly, Glu-Hyp, Leu-Hyp-Gly, Pro-Ala, Ser-Hyp, Ala-Hyp-Gly, Pro-Hyp-Gly, Leu-Hyp, Ile-Hyp, Ser-Hyp-Gly, Gly-Pro-Hyp, (Pro-Hyp-Gly)5, Pro-Hyp, Hyp-Gly, Pro-Gly, Pro-Pro and Ala-Hyp or a chemically-modified substance thereof or a pharmaceutically acceptable salt thereof have DPPTV inhibitory activity and/or GLP-1 secretion accelerating activity, and hence are effective as a therapeutic or preventive agent or the like for diabetes.
摘要翻译：含有选自Glu-Hyp-Gly，Glu-Hyp，Leu-Hyp-Gly，Pro-Ala，Ser-Hyp，Ala-Hyp-Gly，化学修饰物质和药学上可接受的盐的三种或更多种的胶原肽混合物以及至少一种选自Glu-Hyp-Gly，Glu-Hyp，Leu-Hyp-Gly，Pro-Ala，Ser-Hyp，Ala-Hyp-Gly，Pro-Hyp-Gly，Leu -Hyp，Ile-Hyp，Ser-Hyp-Gly，Gly-Pro-Hyp，（Pro-Hyp-Gly）5，Pro-Hyp，Hyp-Gly，Pro-Gly，Pro-Pro和Ala-Hyp或化学其改性物质或其药学上可接受的盐具有DPPTV抑制活性和/或GLP-1分泌促进活性，因此作为糖尿病的治疗或预防剂等有效。

22. 发明申请

US20110166365A1 Collagen peptide, dipeptide and malady inhibitor 有权
标题翻译：胶原肽，二肽和恶性抑制剂
公开(公告)号：US20110166365A1
公开(公告)日：2011-07-07
申请号：US12443298
申请日：2008-11-14
申请人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
发明人： Fumihito Sugihara , Naoki Inoue , Seiko Koizumi , Chinfang Liu , Hajime Takasaki , Hisayuki Kobayashi , Hiroshi Mano , Sachie Nakatani , Masahiro Wada
IPC分类号： C07D207/12
CPC分类号： C07K5/06139 , A61K38/05 , C07K5/06165
摘要： A problem that the present invention is to solve is to provide: a main body of a peptide molecule which is effective for inhibition of various maladies such as osteoporosis, osteoarthritis and pressure ulcer, particularly, a dipeptide which is easy to absorb into a body in an intestine; a collagen peptide which comprises the dipeptide as an essential dipeptide; and a malady inhibitor which comprises the dipeptide as an essential effective component. As a means of solving such a problem, a collagen peptide according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential dipeptide. A dipeptide according to the present invention is characterized by having a structure of Hyp-Gly. A malady inhibitor according to the present invention is characterized by comprising a dipeptide having a structure of Hyp-Gly as an essential effective component.
摘要翻译：本发明要解决的问题是提供：对于抑制诸如骨质疏松症，骨关节炎和压力性溃疡等各种疾病的肽分子的主体，特别是容易吸收到体内的二肽肠包含二肽作为必需二肽的胶原肽; 以及包含二肽作为基本有效成分的疾病抑制剂。作为解决上述问题的方法，本发明的胶原肽的特征在于，含有具有Hyp-Gly结构的二肽作为必需二肽的二肽。根据本发明的二肽的特征在于具有Hyp-Gly的结构。根据本发明的疾病抑制剂的特征在于包含具有Hyp-Gly结构作为必需有效成分的二肽。

23. 发明申请

US20080014637A1 Process for culturing cells sampled for biopsy 有权
标题翻译：用于培养用于活组织检查取样的细胞的方法
公开(公告)号：US20080014637A1
公开(公告)日：2008-01-17
申请号：US11812879
申请日：2007-06-22
申请人： Kazuhiko Minamigawa , Hisayuki Kobayashi , Toshikazu Takano
发明人： Kazuhiko Minamigawa , Hisayuki Kobayashi , Toshikazu Takano
IPC分类号： C12N5/06
CPC分类号： C12N5/0018 , C12N2503/00
摘要： The present invention provide: a novel process for culturing animal cells and a kit for culturing animal cells, in which, even if the number of cells as sampled for biopsy is extremely small, the proliferation can sufficiently be maintained so as to enable to carry out various culture and/or tests, especially anticancer agent sensitivity tests, and the contamination with bacteria can be inhibited without damaging physiological activity of cells, especially sensitivity to anticancer agents. The process for culturing animal cells, according to the present invention, comprises the step of culturing a sample containing animal cells obtained from living body tissue in order to subject the sample to further culture and/or a test, with the process being characterized in that a culture medium is used wherein the culture medium has a proliferating action and physiological activity-retaining action on the animal cells, and further has a killing action and/or multiplication-inhibition action on bacteria.
摘要翻译：本发明提供：用于培养动物细胞的新方法和用于培养动物细胞的试剂盒，其中即使用于活组织检查取样的细胞数量非常少，可以充分地维持增殖，从而能够进行可以抑制各种培养和/或试验，特别是抗癌剂敏感性试验，并且可以抑制细菌的污染，而不损害细胞的生理活性，特别是对抗癌剂的敏感性。根据本发明的培养动物细胞的方法包括培养含有从活体组织获得的动物细胞的样品以使样品进一步培养和/或测试的步骤，其过程的特征在于使用其中培养基对动物细胞具有增殖作用和生理活性保持作用的培养基，并且还对细菌具有杀伤作用和/或增殖抑制作用。

24. 发明授权

US07229971B2 Regulation of biodegradability of composite biomaterials 有权
标题翻译：复合生物材料生物降解性调节
公开(公告)号：US07229971B2
公开(公告)日：2007-06-12
申请号：US10937732
申请日：2004-09-10
申请人： Junzo Tanaka , Masanori Kikuchi , Noriichi Ito , Yoshinobu Mandai , Hiroko Matsumoto , Yoshihisa Koyama , Kazuo Takakuda
发明人： Junzo Tanaka , Masanori Kikuchi , Noriichi Ito , Yoshinobu Mandai , Hiroko Matsumoto , Yoshihisa Koyama , Kazuo Takakuda
IPC分类号： A61K38/39
CPC分类号： A61K33/06 , A61K33/42 , A61K38/39 , A61L27/46 , A61L27/58 , A61K2300/00 , C08L89/06
摘要： This invention relates to a method for regulating the biodegradability of composite biomaterials comprising calcium salt (particularly hydroxyapatite) and collagen, improved composite biomaterials obtained via such method, and a method for increasing bone mass with the use of such composite biomaterials.
摘要翻译：本发明涉及一种用于调节包含钙盐（特别是羟基磷灰石）和胶原的复合生物材料的生物降解性的方法，通过这种方法获得的改进的复合生物材料以及使用这种复合生物材料增加骨量的方法。

25. 发明授权

US5342441A Biologically compatible hardening material for dental or medical applications 失效
标题翻译：用于牙科或医疗应用的生物相容性硬化材料
公开(公告)号：US5342441A
公开(公告)日：1994-08-30
申请号：US902024
申请日：1992-06-22
申请人： Yoshinobu Mandai , Kohji Nagatomi , Kazuhiko Minamigawa , Fumihito Sugihara
发明人： Yoshinobu Mandai , Kohji Nagatomi , Kazuhiko Minamigawa , Fumihito Sugihara
IPC分类号： A61F2/00 , A61K6/00 , A61K6/033 , A61L24/02 , A61L27/12 , A61K6/02
CPC分类号： A61L27/12 , A61K6/033 , A61K6/0643 , A61L24/02 , A61F2310/00293
摘要： A hardenable, biocompatible composition for repairing firm living tissue which includes a powder component containing Ca.sub.4 P.sub.2 O.sub.9 and at least one of CaHPO.sub.4 and CaHPO.sub.4.H.sub.2 O at a molar ratio of Ca:P of 1.16-1.95; and a liquid component containing 1 mM to 2M of a second phosphate ion and 1 mM to 2M of an organic ion. The weight ratio of the powder component to the liquid component is 0.5-4.0.
摘要翻译：一种用于修复固体活组织的可硬化的生物相容性组合物，其包含Ca:P为1.16-1.95的摩尔比的含有Ca4P2O9和CaHPO4和CaHPO4·H2O的至少一种的粉末成分; 和含有1mM至2M的第二磷酸根离子和1mM至2M的有机离子的液体组分。粉末成分与液体成分的重量比为0.5〜4.0。

26. 发明公开

US20240342289A1 LEAKAGE INHIBITING AGENT FOR LOCAL INJECTION PREPARATION, LOCAL INJECTION PREPARATION INCLUDING THE SAME, AND METHOD FOR PRODUCING LOCAL INJECTION PREPARATION 审中-公开
公开(公告)号：US20240342289A1
公开(公告)日：2024-10-17
申请号：US18291846
申请日：2022-08-31
申请人： NITTA GELATIN INC.
发明人： Kazuki KOTANI , Yosuke HIRAOKA
IPC分类号： A61K47/42 , A61K9/00 , A61K9/08
CPC分类号： A61K47/42 , A61K9/0019 , A61K9/08
摘要： A leakage inhibiting agent includes a gelatin hydrolysate having a weight average molecular weight of 5000 or lees, wherein a degree of viscosity at 25° C. of a first solution obtained by dissolving the gelatin hydrolysate in phosphate buffered saline and adjusting the concentration of the gelatin hydrolysate to 40% by mans is 20 mPa·s or less.

27. 发明公开

US20230149281A1 PEPTIDE COMPOSITION AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：US20230149281A1
公开(公告)日：2023-05-18
申请号：US17917416
申请日：2021-03-22
申请人： NITTA GELATIN INC.
发明人： Masaya SHINODA , Masayuki MIMASU , Mona SATO , Toshirou WATANABE
IPC分类号： A61K8/65 , C12N1/16 , A61K8/33 , A61K8/34 , A23L33/18
CPC分类号： A61K8/65 , C12N1/16 , A61K8/33 , A61K8/342 , A23L33/18
摘要： A peptide composition comprises a collagen peptide, and at least three first compounds selected from the group consisting of isovaleric aldehyde, 1-octen-3-ol, phenylacetaldehyde and methional.

28. 发明申请

US20220305090A1 HAIR GROWING AGENT AND FOOD OR BEVERAGE PRODUCT COMPRISING SAME 有权
公开(公告)号：US20220305090A1
公开(公告)日：2022-09-29
申请号：US17606115
申请日：2020-07-13
申请人： NITTA GELATIN INC.
发明人： Seiko KOIZUMI , Hiroshi MANO , Jun SHIMIZU , Yoshifumi KIMIRA , Kaho NOMURA
IPC分类号： A61K38/39 , A61P17/14 , A61K31/401 , A61K38/05 , A61K38/06 , A23L33/175 , A23L33/18
摘要： A hair growing agent comprises one or more amino acids or peptides selected from the group consisting of Hyp, Pro-Hyp, Hyp-Gly, Gly-Pro, Leu-Hyp, Phe-Hyp, Pro-Ala, Pro-Gly, Pro-Pro, Glu-Hyp, Gly-Pro-Hyp, Ala-Hyp-Gly, Glu-Hyp-Gly, Pro-Ala-Gly and Ser-Hyp-Gly, a salt thereof, or a chemically modified product thereof.

29. 发明申请

US20210228675A1 HYPERTROPHIC SCAR INHIBITING COMPOSITION 有权
公开(公告)号：US20210228675A1
公开(公告)日：2021-07-29
申请号：US16972381
申请日：2019-05-28
申请人： FUKUOKA UNIVERSITY , NITTA GELATIN INC.
发明人： Shiro JIMI , Masahiko KIMURA , Naoki INOUE , Maiko SHIMIZU , Seiko KOIZUMI
IPC分类号： A61K38/05 , A61K9/00 , A61K38/39 , A61P17/02
摘要： A composition for inhibiting the formation of hypertrophic scar, comprising at least one of a polypeptide consisting of an amino acid sequence having a dipeptide sequence represented by Pro-Hyp or Hyp-Gly, a chemically-modified form thereof, or a pharmaceutically acceptable salt thereof.

30. 发明授权

US10632177B2 Myoblast differentiation promoter 有权
公开(公告)号：US10632177B2
公开(公告)日：2020-04-28
申请号：US15299172
申请日：2016-10-20
申请人： NITTA GELATIN INC.
发明人： Seiko Koizumi , Fumihito Sugihara , Naoki Inoue
IPC分类号： A61K38/39 , C07K5/062 , C07K5/072 , C07K5/083 , C07K5/078 , C07K5/097 , A23L33/18 , A23K20/147 , A61K38/00
CPC分类号： A61K38/39 , A23K20/147 , A23L33/18 , C07K5/06026 , C07K5/06043 , C07K5/06104 , C07K5/06165 , C07K5/0806 , C07K5/0808 , C07K5/0823 , A61K38/00
摘要： A peptide selected from the group consisting of Ala-Hyp-Gly, Hyp-Gly-Pro, Leu-Hyp, Glu-Hyp, Gly-Pro-Hyp, Pro-Ala, Hyp-Gly and Pro-Hyp, or a pharmaceutically acceptable salt thereof has a myoblast differentiation promoting effect superior to conventional arts.

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