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21. 发明申请

US20100028383A1 Chemically defined stabiliser 有权
标题翻译：化学稳定剂
公开(公告)号：US20100028383A1
公开(公告)日：2010-02-04
申请号：US11908028
申请日：2006-03-07
申请人： Petrus Theodorus Johannes Andries van Gelder , Arnoldus Theodorus Petrus Loermans , Mathias Arnold Maassen
发明人： Petrus Theodorus Johannes Andries van Gelder , Arnoldus Theodorus Petrus Loermans , Mathias Arnold Maassen
IPC分类号： A61K47/42 , A61K39/00 , A61K39/02 , A61K39/12 , A61K39/245 , A61K39/155 , A61K39/145 , A61K39/235 , A61K39/205 , A61K39/215 , A61K39/275 , A61P31/04 , A61P31/12
CPC分类号： A61K31/00 , A61K9/19 , A61K31/04 , A61K31/047 , A61K31/132 , A61K31/198 , A61K31/70 , A61K31/7004 , A61K31/7016 , A61K39/0275 , A61K39/085 , A61K39/092 , A61K39/12 , A61K39/145 , A61K39/155 , A61K39/205 , A61K39/215 , A61K39/245 , A61K39/275 , A61K47/183 , A61K47/26 , A61K47/34 , A61K2300/00 , C12N2710/16734 , C12N2710/24034 , C12N2760/16134 , C12N2760/18534 , C12N2760/18634 , C12N2770/20034 , Y02A50/482
摘要： The present invention relates to a stabiliser composition comprising an amino acid, and a sugar wherein all compounds are chemically defined; to a vaccine composition comprising such a stabiliser composition and a biological molecule and/or a micro-organism; to a method for preparing a pharmaceutical composition comprising admixing such a stabiliser composition with a biological molecule and/or a micro-organism; to the use of such a stabiliser composition, and of vaccines prepared therewith.
摘要翻译：本发明涉及包含氨基酸的稳定剂组合物和其中所有化合物都被化学定义的糖; 涉及包含这种稳定剂组合物和生物分子和/或微生物的疫苗组合物; 涉及一种制备药物组合物的方法，包括将这种稳定剂组合物与生物分子和/或微生物混合; 使用这种稳定剂组合物以及用其制备的疫苗。

22. 发明授权

US07462479B2 Infectious bronchitis virus vaccine 有权
标题翻译：传染性支气管炎病毒疫苗
公开(公告)号：US07462479B2
公开(公告)日：2008-12-09
申请号：US11865957
申请日：2007-10-02
申请人： Lillian Melson , Faris F. Jirjis
发明人： Lillian Melson , Faris F. Jirjis
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/215 , A61K2039/5254 , A61K2039/544 , A61K2039/545 , A61K2039/552 , C12N2770/20034 , C12N2770/20064
摘要： Embodiments of the present invention generally relate to a novel attenuated infectious bronchitis virus (IBV) of GA-98 isolate. Further, other embodiments of the present invention generally relate to methods of immunizing avian against an infectious bronchitis virus. As well, further embodiments relate to method of making a vaccine and/or immunogenic composition for protecting avian, such as poultry, from an infectious bronchitis virus of strain GA-98.
摘要翻译：本发明的实施方案一般涉及GA-98分离株的新型减毒感染性支气管炎病毒（IBV）。此外，本发明的其它实施方案一般涉及免疫禽类针对感染性支气管炎病毒的方法。此外，进一步的实施方案涉及制备疫苗和/或免疫原性组合物的方法，所述组合物用于保护鸟类，例如家禽，从菌株GA-98的感染性支气管炎病毒中。

23. 外观设计

USD579956S1 Chiller unit 有权
标题翻译：冷水机组
公开(公告)号：USD579956S1
公开(公告)日：2008-11-04
申请号：US29264818
申请日：2006-08-17
申请人： Phil Bordet-Stead
设计人： Phil Bordet-Stead

24. 发明申请

US20080102086A1 Feline Influenza Vaccine and Method of Use 有权
标题翻译：猫流感疫苗及其使用方法
公开(公告)号：US20080102086A1
公开(公告)日：2008-05-01
申请号：US11924243
申请日：2007-10-25
申请人： Nallakannu Lakshmanan , Melissa Lum , Frank Sterner , Frederick Bethke
发明人： Nallakannu Lakshmanan , Melissa Lum , Frank Sterner , Frederick Bethke
IPC分类号： A61K39/145 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5252 , A61K2039/542 , A61K2039/544 , A61K2039/552 , A61K2039/55566 , C12N2760/16134
摘要： This invention is directed to a vaccine and a method for using the vaccine to protect a feline from influenza virus infection. The vaccine comprises one or more antigens from one or more H3, N8, H7 or N7-type influenza viruses.
摘要翻译：本发明涉及疫苗和使用该疫苗来保护猫科动物免受流感病毒感染的方法。疫苗包含来自一种或多种H3，N8，H7或N7型流感病毒的一种或多种抗原。

25. 发明申请

US20080069843A1 Salmonella vaccine 审中-公开
标题翻译：沙门氏菌疫苗
公开(公告)号：US20080069843A1
公开(公告)日：2008-03-20
申请号：US11980864
申请日：2007-10-30
申请人： Petrus Nuijten , Maarten Witvliet
发明人： Petrus Nuijten , Maarten Witvliet
IPC分类号： A61K39/112
CPC分类号： A61K39/0275 , A61K2039/521 , A61K2039/522 , A61K2039/523 , Y02A50/482
摘要： The present invention relates to Salmonella bacteria. The invention also relates to methods of using Salmonella bacteria, including in vaccines based thereon that are useful for the prevention of microbial pathogenesis. Further, the invention relates to the use of such bacteria or the manufacture of such vaccines. The invention also relates to methods for the preparation of such vaccines.
摘要翻译：本发明涉及沙门氏菌。本发明还涉及使用沙门菌细菌的方法，包括在其上用于预防微生物发病机理的疫苗中。此外，本发明涉及这种细菌的使用或这种疫苗的制造。本发明还涉及制备这种疫苗的方法。

26. 发明申请

US20080057537A1 Nucleic acid encoding polypeptide involved in cellular entrance of the PRRS virus 有权
标题翻译：涉及PRRS病毒细胞入侵的核酸编码多肽
公开(公告)号：US20080057537A1
公开(公告)日：2008-03-06
申请号：US11781558
申请日：2007-07-23
申请人： Maurice Pensaert , Hans Nauwynck , Nathalie Vanderheijden
发明人： Maurice Pensaert , Hans Nauwynck , Nathalie Vanderheijden
IPC分类号： C12N15/12 , C12N15/85 , C12N5/06 , C12N5/10 , C12N7/01 , C12P21/00
CPC分类号： C07K14/705 , A61K38/00 , C12N2799/021
摘要： The present invention relates to a new polynucleotide that encodes a polypeptide involved in cellular entrance of PRRSV, to a recombinant vector comprising said polynucleotide, to a cell capable of expressing said polypeptide, a method of producing said polypeptide as well as to cell culture and to a novel method of producing the PRRSV virus. The present invention further relates to a method of identifying compounds that affect the PRRSV receptor function of the polypeptide as well as to the use of the polypeptide or identified compounds in the manufacture of medicaments. The present inventors have succeeded in isolating a protein from PAM membranes that seems to play a crucial role in virus entry into the cell. The elucidated nucleotide sequence encoding the protein, as well as the amino acid sequence of the protein, were compared with sequences stored in sequence databases. Surprisingly the putative PRRSV receptor provided by the present invention showed a great deal of homology to certain proteins belonging to the Siglec family.
摘要翻译：本发明涉及编码涉及PRRSV的细胞入口的多肽，包含所述多核苷酸的重组载体，能够表达所述多肽的细胞的新多核苷酸，产生所述多肽的方法以及细胞培养，以及一种产生PRRSV病毒的新方法。本发明还涉及鉴定影响多肽的PRRSV受体功能的化合物的方法，以及多肽或鉴定的化合物在制备药物中的用途。本发明人成功地从PAM膜中分离蛋白质，该蛋白质似乎在病毒进入细胞中起关键作用。将编码蛋白质的阐明的核苷酸序列以及蛋白质的氨基酸序列与序列数据库中存储的序列进行比较。令人惊奇的是本发明提供的推定的PRRSV受体与属于Siglec家族的某些蛋白质具有大量的同源性。

27. 发明申请

US20080026449A1 Infectious Bronchitis Virus Vaccine 有权
标题翻译：传染性支气管炎病毒疫苗
公开(公告)号：US20080026449A1
公开(公告)日：2008-01-31
申请号：US11865957
申请日：2007-10-02
申请人： Lillian Melson , Faris Jirjis
发明人： Lillian Melson , Faris Jirjis
IPC分类号： C12N7/04
CPC分类号： C12N7/00 , A61K39/12 , A61K39/215 , A61K2039/5254 , A61K2039/544 , A61K2039/545 , A61K2039/552 , C12N2770/20034 , C12N2770/20064
摘要： Embodiments of the present invention generally relate to a novel attenuated infectious bronchitis virus (IBV) of GA-98 isolate. Further, other embodiments of the present invention generally relate to methods of immunizing avian against an infectious bronchitis virus. As well, further embodiments relate to method of making a vaccine and/or immunogenic composition for protecting avian, such as poultry, from an infectious bronchitis virus of strain GA-98.
摘要翻译：本发明的实施方案一般涉及GA-98分离株的新型减毒感染性支气管炎病毒（IBV）。此外，本发明的其它实施方案一般涉及免疫禽类针对感染性支气管炎病毒的方法。此外，进一步的实施方案涉及制备疫苗和/或免疫原性组合物的方法，所述组合物用于保护鸟类，例如家禽，从菌株GA-98的感染性支气管炎病毒中。

28. 发明申请

US20080008718A1 Ornithobacterium Rhinotracheale Subunit Vaccines 审中-公开
标题翻译：燕麦Rhinotracheale亚基疫苗
公开(公告)号：US20080008718A1
公开(公告)日：2008-01-10
申请号：US10588992
申请日：2005-02-09
申请人： Danielle Schuijffel , Petrus Nuijten
发明人： Danielle Schuijffel , Petrus Nuijten
IPC分类号： A61K39/40 , A61K39/02 , A61K39/102 , A61K39/112 , A61K39/12 , A61P31/04 , C07H21/00 , C12N1/00 , C07K14/195 , A61P31/12 , A61P31/00 , A61K39/17 , A61K39/255 , A61K39/265
CPC分类号： C07K14/195 , A61K39/00
摘要： The present invention relates to nucleic acids encoding Ornithobacterium rhinotracheale proteins, to DNA fragments, recombinant DNA molecules, live recombinant carriers and host cells comprising such nucleic acids, to Ornithobacterium rhinotracheale proteins, to antibodies against such proteins, to such proteins for use in vaccines, to the use of such proteins in the manufacturing of such vaccines, to vaccines comprising such nucleic acids, DNA fragments, recombinant DNA molecules, live recombinant carriers, host cells, proteins or antibodies against such proteins, and to methods for the preparation of such vaccines.
摘要翻译：本发明涉及编码鸟氨酸鼻杆菌蛋白质的核酸，DNA片段，重组DNA分子，活重组载体和包含这种核酸的宿主细胞，鼻咽鼻气管炎蛋白质，抗这种蛋白质的抗体，用于疫苗中使用的蛋白质，关于在制造这种疫苗中使用这样的蛋白质，涉及包含这种核酸的疫苗，DNA片段，重组DNA分子，活重组载体，宿主细胞，针对这种蛋白质的蛋白质或抗体，以及用于制备这种疫苗的方法。

29. 发明授权

US07183404B1 Vaccine against ISA virus 有权
标题翻译：针对ISA病毒的疫苗
公开(公告)号：US07183404B1
公开(公告)日：2007-02-27
申请号：US09979967
申请日：2000-05-29
申请人： Espen Rimstad
发明人： Espen Rimstad
IPC分类号： C07H21/00 , A61K39/12
CPC分类号： C07K14/005 , A61K2039/53 , C12N2760/16022 , C12N2760/16034
摘要： The invention relates to vaccine against infectious salmon anaemia (ISA) virus, DNA sequences endocing immunogenic proteins from ISA virus, diagnostic kit for detection of ISA specific nucleic acid sequences and proteins and exploitation of the ISA virus genome or parts of it as a general model organism.
摘要翻译：本发明涉及针对感染性鲑鱼贫血（ISA）病毒的疫苗，从ISA病毒引起免疫原性蛋白质的DNA序列，用于检测ISA特异性核酸序列和蛋白质的诊断试剂盒以及ISA病毒基因组或其部分的开发作为一般模型生物。

30. 发明授权

US5885589A Pasteurella vaccine 失效
标题翻译：巴斯德氏菌疫苗
公开(公告)号：US5885589A
公开(公告)日：1999-03-23
申请号：US453141
申请日：1995-05-30
申请人： Niels T.ae butted.kker Foged , Svend Petersen
发明人： Niels T.ae butted.kker Foged , Svend Petersen
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C07K16/12 , G01N33/569 , A61K39/102
CPC分类号： C07K16/1242 , C07K14/285 , G01N33/56911 , A61K39/00
摘要： A vaccine for immunizing animals against diseases caused by microorganisms producing an osteolytic toxin is disclosed. The vaccine contains a Pasteurella multocida toxin or derivative thereof that has been rendered non-toxic by genetic and/or biochemical means. The toxin or derivative is encoded by a nucleotide sequence from Pasteurella multocida toxin which is inserted in an expression vector capable of replicating ina suitable host microorganism in which the sequence may be expressed.
摘要翻译：公开了一种疫苗，用于免疫动物，以抵抗由产生溶骨毒素的微生物引起的疾病。该疫苗含有通过遗传和/或生化手段使其无毒的多杀巴斯德氏菌多毒素或其衍生物。毒素或衍生物由来自多杀巴斯德氏杆菌毒素的核苷酸序列编码，其插入能够在其中可以表达序列的合适的宿主微生物中复制的表达载体。

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