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    • 23. 发明授权
    • 3,4-dioxythiophene derivatives
    • 3,4-二氧噻吩衍生物
    • US07183419B2
    • 2007-02-27
    • US11011515
    • 2004-12-14
    • Helmut-Werner HeuerRolf Wehrmann
    • Helmut-Werner HeuerRolf Wehrmann
    • C07D409/00
    • C07D495/04
    • A process for the production of 3,4-dioxythiophene compounds represented by the following formula (I), is described. In formula (I) A, B, C and D in each case independently denote a bond, optionally substituted alkylene, optionally substituted cycloalkylene, optionally substituted arylene or (O—(CR1R2)m)x, where R1 and R2 in each case mutually independently denote hydrogen or optionally substituted alkyl, m denotes an integer from 1 to 10 and x denotes an integer from 1 to 10, provided that at least one of the units A, B, C or D does not denote a bond. The process involves reacting a 3,4-dihydroxythiophene or the alkali metal salt thereof with the following compound, TosO-A-B-C-D-OTos, thus forming an intermediate 3,4-dioxythiophene diester. The intermediate 3,4-dioxythiophene diester is saponified, thus forming an intermediate 3,4-dioxythiophene dicarboxylic acid, which is then decarboxylated, thereby forming the 3,4-dioxythiophene compound represented by formula-(I).
    • 描述了由下式(I)表示的3,4-二氧噻吩化合物的制造方法。 在式(I)中,A,B,C和D各自独立地表示键,任选取代的亚烷基,任选取代的亚环烷基,任选取代的亚芳基或(O-(CR 1 R 2) 其中R 1和R 2各自相互独立地表示氢原子 或任选取代的烷基,m表示1至10的整数,x表示1至10的整数,条件是单元A,B,C或D中的至少一个不表示键。 该方法包括使3,4-二羟基噻吩或其碱金属盐与以下化合物反应:<?in-line-formula description =“In-line Formulas”end =“lead”→> TosO-ABCD-OTos, 因此,形成中间体3,4-二氧噻吩二酯。 将中间体3,4-二氧噻吩二酯皂化,形成中间体3,4-二氧噻吩二羧酸,然后脱羧,形成由式(I)表示的3,4-二氧噻吩化合物。