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21. 发明申请

US20030045498A1 Materials and methods for treating ocular-related disorders 审中-公开
标题翻译：用于治疗眼部相关疾病的材料和方法
公开(公告)号：US20030045498A1
公开(公告)日：2003-03-06
申请号：US10211701
申请日：2002-08-02
申请人： GenVec, Inc.
发明人： Imre Kovesdi , Douglas E. Brough , Lisa Wei , Duncan L. McVey
IPC分类号： A61K048/00 , C12N015/85
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0075 , C07K14/71 , C07K14/811 , C12N2710/10343 , C12N2799/022
摘要： The present invention is directed to a method of prophylactically or therapeutically treating an animal for at least one ocular-related disorder, e.g., ocular neovascularization or age-related macular degeneration. The method comprises contacting an ocular cell with an expression vector comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and the same or different nucleic acid sequence encoding a neurotrophic agent. The method also can comprise contacting an ocular cell with different expression vectors, each comprising a nucleic acid sequence encoding an inhibitor of angiogenesis and/or a nucleic acid sequence encoding a neurotrophic agent. In addition, the present invention provides a viral vector comprising a nucleic acid sequence encoding pigment epithelium-derived factor (PEDF) or a therapeutic fragment thereof.
摘要翻译：本发明涉及一种预防性或治疗性地治疗动物至少一种与眼部相关的疾病，例如眼睛新生血管形成或年龄相关性黄斑变性的方法。该方法包括使眼细胞与包含编码血管生成抑制剂的核酸序列和编码神经营养剂的相同或不同核酸序列的表达载体接触。该方法还可以包括使眼细胞与不同的表达载体接触，每种表达载体包含编码血管生成抑制剂的核酸序列和/或编码神经营养剂的核酸序列。此外，本发明提供了包含编码色素上皮衍生因子（PEDF）的核酸序列或其治疗片段的病毒载体。

22. 发明申请

US20030017595A1 Non-adenoviral gene product-based complementing cells for adenoviral vectors 有权
标题翻译：用于腺病毒载体的非腺病毒基因产物互补细胞
公开(公告)号：US20030017595A1
公开(公告)日：2003-01-23
申请号：US09911011
申请日：2001-07-23
申请人： GenVec, Inc.
发明人： Douglas E. Brough , Jason G. D. Gall , Imre Kovesdi
IPC分类号： C12N015/861 , C12N007/01 , C12N005/08
CPC分类号： C12N7/00 , C12N2710/10051 , C12N2710/10052 , C12N2710/10351 , C12N2710/10352
摘要： The invention provides cells and methods of using the cells for the propagation of replication-deficient adenoviral vectors. The cells comprise at least one heterologous nucleic acid sequence which upon expression produces at least one non-adenoviral gene product that complements in trans for a deficiency in at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
摘要翻译：本发明提供了细胞和使用细胞促进复制缺陷型腺病毒载体的方法。所述细胞包含至少一种异源核酸序列，其在表达时产生至少一种非腺病毒基因产物，所述非腺病毒基因产物在腺病毒基因组的一个或多个区域的至少一个必需基因功能缺陷中互补互补，从而传播复制缺陷型腺病毒载体，其包含存在于细胞中时所述一个或多个区域的至少一个必需基因功能缺陷的腺病毒基因组。

23. 发明申请

US20020045160A1 Fluorescence detection 有权
标题翻译：荧光检测
公开(公告)号：US20020045160A1
公开(公告)日：2002-04-18
申请号：US09888681
申请日：2001-06-25
申请人： GenVec, Inc.
发明人： Miguel E. Carrion , Marilyn C. Menger
IPC分类号： C12Q001/70 , C12N013/00 , G01N033/558 , G01N033/559 , G01N033/561
CPC分类号： G01N21/6486 , C12N15/86 , C12N2710/10343 , C12N2710/10351
摘要： The present invention provides methods of detecting and/or characterizing the viral vector particle content of a medium. A medium is provided and contacted with an excitation energy such that, if a viral vector particle is in the medium, an electron associated with the intrinsically fluorogenic portion of the viral vector particle will be raised to an excited energy state. The excited electron is permitted to emit radiation having an emission wavelength which is detected. The viral vector particle content of the medium then can be evaluated by comparing the detected emission wavelength with a standard signal. For example, the number of viral vector particles in a medium can be quantified by comparing the detected wavelength and its corresponding intensity to a standard signal. Similar methods for evaluating the adenoviral vector particle content of a medium and the intrinsically fluorogenic adenoviral structural protein content of a medium are provided.
摘要翻译：本发明提供了检测和/或表征介质的病毒载体颗粒含量的方法。提供介质并与激发能接触，使得如果病毒载体颗粒在介质中，与病毒载体颗粒的固有荧光部分相关的电子将被升高到激发能态。被激发的电子被允许发射具有检测到的发射波长的辐射。然后可以通过将检测到的发射波长与标准信号进行比较来评估介质的病毒载体颗粒含量。例如，可以通过将检测到的波长及其对应的强度与标准信号进行比较来量化介质中病毒载体颗粒的数量。提供了用于评估培养基的腺病毒载体颗粒含量和介质的固有荧光腺病毒结构蛋白含量的类似方法。

24. 发明申请

US20020031831A1 Complementary adenoviral vector systems and cell lines 有权
标题翻译：互补腺病毒载体系统和细胞系
公开(公告)号：US20020031831A1
公开(公告)日：2002-03-14
申请号：US09964065
申请日：2001-09-26
申请人： GenVec, Inc.
发明人： Imre Kovesdi , Douglas E. Brough , Duncan L. McVey , Joseph T. Bruder , Alena Lizonova
IPC分类号： C12N015/861 , C12N007/01
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , A61K2039/5256 , C07K14/005 , C07K14/4712 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10352 , C12N2810/60 , C12N2810/6081 , C12N2830/002 , C12N2830/85 , C12N2840/20 , C12N2840/203 , C12N2840/44 , Y10S977/799
摘要： The present invention provides multiply deficient adenoviral vectors and complementing cell lines. Also provided are recombinants of the multiply deficient adenoviral vectors and a therapeutic method, particularly relating to gene therapy, vaccination, and the like, involving the use of such recombinants.
摘要翻译：本发明提供多重缺陷型腺病毒载体和补体细胞系。还提供了多重缺陷型腺病毒载体的重组体和涉及使用这种重组体的基因治疗，疫苗接种等的治疗方法。

25. 发明申请

US20020031823A1 Use of trans-activation and CIS-activation to modulate the persistence of expression of a transgene 失效
公开(公告)号：US20020031823A1
公开(公告)日：2002-03-14
申请号：US09873486
申请日：2001-06-04
申请人： GenVec, Inc.
发明人： Douglas E. Brough , Imre Kovesdi
IPC分类号： A61K048/00 , C12N015/86
CPC分类号： C12N15/86 , C07K14/005 , C12N15/63 , C12N2710/10322 , C12N2710/10345 , C12N2710/16622 , C12N2830/60 , C12N2840/60
摘要： Provided are methods of modulating the persistence of the expression in a cell of a transgene, such as a transgene in a non-Herpes vector or in at least E4null adenoviral vector, and related systems. One method comprises contacting the cell with a non-Herpes vector comprising and expressing a gene encoding HSV ICP0, whereupon expression of HSV ICP0 the persistence of expression of the transgene is modulated. Further provided is a system for modulating the persistence of expression of a transgene, which system comprises a non-Herpes vector comprising (i) a gene encoding HSV ICP0 and (ii) a transgene, wherein the HSV ICP0 modulates the persistence of expression of the transgene and either the non-Herpes vector comprises the transgene or the system further comprises a vector, in which case the vector comprises the transgene. Another method comprises contacting the cell with an at least E4null adenoviral vector comprising (i) a transgene and (ii) a gene encoding a trans-acting factor, wherein the trans-acting factor modulates the persistence of expression of the transgene and the gene encoding the trans-acting factor is not from the E4 region of an adenovirus. Yet another method comprises contacting a cell simultaneously or sequentially with (i) an at least E4null adenoviral vector comprising a transgene and (ii) a viral vector comprising a gene encoding a trans-acting factor, which is not from the E4 region of an adenovirus and which modulates the persistence of expression of the transgene. Also provided is a system for modulating the persistence of expression of a transgene in an at least E4null adenoviral vector, which system comprises (i) an at least E4null adenoviral vector comprising a transgene and (ii) a gene encoding a trans-acting factor, wherein the gene encoding the trans-acting factor is not from the E4 region of an adenovirus, the trans-acting factor modulates the persistence of expression of the transgene, and either the at least E4null adenoviral vector comprises the gene encoding the trans-acting factor or the system comprises a viral vector, in which case the viral vector comprises the gene encoding the trans-acting factor.

26. 发明申请

US20010047081A1 Adenoviral capsid containing chimeric protein IX 有权
标题翻译：含有嵌合蛋白IX的腺病毒衣壳
公开(公告)号：US20010047081A1
公开(公告)日：2001-11-29
申请号：US09780224
申请日：2001-02-09
申请人： GenVec, Inc.
发明人： Petrus W. Roelvink , Imre Kovesdi , Thomas J. Wickham
IPC分类号： C12N001/20 , C07K001/00 , C07K014/00 , C07K017/00
CPC分类号： C07K14/005 , A61K47/06 , A61K48/00 , C07K2319/00 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/10 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/859 , C12N2830/008
摘要： The present invention provides a chimeric protein IX (pIX). The chimeric pIX protein has an adenoviral pIX domain and also a non-native amino acid. Where the non-native amino acid is a ligand that binds to a substrate present on the surface cells, the chimeric pIX can be used to target vectors containing such proteins to desired cell types. Thus, the invention provides vector systems including such chimeric pIX proteins as well as methods of infecting cells using such vector systems.
摘要翻译：本发明提供了嵌合蛋白IX（pIX）。嵌合pIX蛋白具有腺病毒pIX结构域和非天然氨基酸。当非天然氨基酸是与表面细胞上存在的底物结合的配体时，嵌合pIX可以用于将含有这种蛋白质的载体靶向所需的细胞类型。因此，本发明提供了包括这种嵌合pIX蛋白质的载体系统以及使用这种载体系统感染细胞的方法。

27. 发明授权

US6057155A Targeting adenovirus with use of constrained peptide motifs 有权
公开(公告)号：US6057155A
公开(公告)日：2000-05-02
申请号：US130225
申请日：1998-08-06
申请人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
发明人： Thomas J. Wickham , Petrus W. Roelvink , Imre Kovesdi
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , C07K14/075 , C12N5/10 , C12N15/34 , C12N15/861 , C12P21/04 , C12R1/92 , C12N15/86
CPC分类号： C12N7/00 , C07K14/005 , C12N15/86 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/405 , C12N2810/60
摘要： The present invention provides a chimeric adenovirus fiber protein, which differs from the wild-type coat protein by the introduction of a nonnative amino acid sequence in a conformationally-restrained manner. Such a chimeric adenovirus fiber protein according to the invention is able to direct entry into cells of a vector comprising the chimeric fiber protein that is more efficient than entry into cells of a vector that is identical except for comprising a wild-type adenovirus fiber protein rather than the chimeric adenovirus fiber protein. The nonnative amino acid sequences encodes a peptide motif that comprises an epitope for an antibody, or a ligand for a cell surface receptor, that can be employed in cell targeting. The present invention also pertains to vectors comprising such a chimeric adenovirus fiber protein, and to methods of using such vectors.

28. 发明授权

US11155832B2 Adenovectors for delivery of therapeutic genetic material into T cells 有权
公开(公告)号：US11155832B2
公开(公告)日：2021-10-26
申请号：US16338075
申请日：2017-09-29
申请人： GenVec, Inc.
发明人： Sebastien M. Maloveste , Damodar Ettyreddy , Douglas E. Brough
IPC分类号： C12N15/00 , A61K39/23 , C12N15/86 , C07K14/005
摘要： The invention provides adenoviral vectors and compositions for the highly efficient transduction of T cells.

29. 发明授权

US10787682B2 Simian (gorilla) adenovirus or adenoviral vectors and methods of use 有权
公开(公告)号：US10787682B2
公开(公告)日：2020-09-29
申请号：US16043501
申请日：2018-07-24
申请人： GenVec, Inc.
发明人： Douglas E. Brough , Jason G. D. Gall , Duncan McVey
IPC分类号： C12N15/86 , C07K14/005 , C12N7/00 , A61K48/00
摘要： The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

30. 发明授权

US10125174B2 Herpes simplex virus vaccine 有权
公开(公告)号：US10125174B2
公开(公告)日：2018-11-13
申请号：US15618740
申请日：2017-06-09
申请人： GenVec, Inc.
发明人： Lisa Wei , Douglas E. Brough , Christopher Lazarski
IPC分类号： C07K14/005 , A61K39/12 , C12N7/00 , A61K39/245 , A61K39/00
摘要： Herpes Simplex Virus (HSV) antigens that elicit an HSV-specific immune response and can be used to treat or prevent HSV infection are provided. Nucleic acid sequences, polypeptides, vectors, and compositions, as well as methods to induce an immune response against HSV, treat or prevent HSV disease, induce a T cell response against HSV, and induce an antibody response against HSV also are provided.

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