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21. 发明申请

US20150220700A1 METHODS AND DEVICES FOR DETERMINING OPTIMAL AGENT DOSAGES 审中-公开
标题翻译：用于确定最佳剂量的方法和装置
公开(公告)号：US20150220700A1
公开(公告)日：2015-08-06
申请号：US14427775
申请日：2013-09-12
申请人： University of Massachusetts , Analiza, Inc.
发明人： Yossi Chait , Michael J. Germain , Christopher V. Hollot , Joseph Horowitz , William Charles Vogt
IPC分类号： G06F19/00 , A61M5/172 , A61M5/158 , A61K38/18
CPC分类号： G16H20/10 , A61K38/1816 , A61M5/158 , A61M5/1723 , A61M2005/1726 , A61M2205/3303 , A61M2230/20 , G06F19/00 , G06F19/3456 , G16H50/50
摘要： The present invention is generally directed to methods and devices for determining dosing for a medical agent. In some embodiments, a mathematical algorithm is employed for computing erythropoiesis-stimulating agents dosing for treating anemia in a subject, e.g., a human subject. Any suitable dosing may be used, e.g., intravenous, subcutaneous, or oral dosing. In some cases, dosing for a wide range of subject types and health conditions can be achieved using the devices and methods disclosed herein.
摘要翻译：本发明一般涉及用于确定药物剂量的方法和装置。在一些实施方案中，使用数学算法来计算用于治疗受试者例如人受试者的贫血的促红细胞生成刺激剂。可以使用任何合适的剂量，例如静脉内，皮下或口服给药。在一些情况下，可以使用本文公开的装置和方法来实现广泛的受试者类型和健康状况的给药。

22. 发明申请

US20150160246A1 DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS 审中-公开
标题翻译：用于确定和/或分离细胞的装置和方法，例如作为循环癌或细胞
公开(公告)号：US20150160246A1
公开(公告)日：2015-06-11
申请号：US14563151
申请日：2014-12-08
申请人： Analiza, Inc.
发明人： Pavel Idelevich , Arnon Chait , Alan Bauer , Paul David Jackson
IPC分类号： G01N33/84 , G01N33/50 , G01N33/574 , C12Q1/68 , G01N33/569
CPC分类号： G01N33/84 , C12Q1/6806 , G01N33/5091 , G01N33/56966 , G01N33/57492 , G01N2800/385 , C12Q2527/119
摘要： Some embodiments of the present invention generally relate to devices and methods for determining and/or isolating cells. For example, one aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.
摘要翻译：本发明的一些实施方案通常涉及用于确定和/或分离细胞的装置和方法。例如，一个方面通常涉及用于检测，识别，计数和/或潜在地分选血液或其他生物样品中感兴趣的细胞的方法和装置。在一些实施方案中，血液样品（或其他生物流体）可以用信号实体（例如pH敏感实体）来处理，其在适当的内部环境中改变颜色或以其它方式产生信号。例如，某些细胞，如癌症或胎儿细胞，与其他细胞相比，细胞内的pH可能有差异，其可以使用pH敏感的实体来检测。在某些实施方案中，可以基于这种信令实体对细胞进行分类; 例如，在用于分选细胞的合适的机器中照射细胞（例如，使用荧光）可以允许确定细胞，其在一些情况下也可以被回收或分离用于进一步的操作。

23. 发明申请

US20150160198A1 DEVICES AND METHODS FOR DETERMINING AND/OR ISOLATING CELLS SUCH AS CIRCULATING CANCER OR FETAL CELLS 有权
标题翻译：用于确定和/或分离细胞的装置和方法，例如作为循环癌或细胞
公开(公告)号：US20150160198A1
公开(公告)日：2015-06-11
申请号：US14312875
申请日：2014-06-24
申请人： Analiza, Inc.
发明人： Pavel Idelevich , Arnon Chait , Alan Bauer
IPC分类号： G01N33/50
CPC分类号： G01N33/5094 , G01N33/5005 , G01N33/5091 , G01N33/57492 , G01N2333/70514 , G01N2333/70517
摘要： The present invention generally relates to devices and methods for determining and/or isolating cells. One aspect is generally directed to methods and devices for detecting, identifying, counting, and/or potentially sorting cells of interest in blood or other biological sample. In some embodiments, blood samples (or other biological fluids) may be treated with signaling entities, such as pH-sensitive entities, that change color or otherwise produce a signal in suitable internal environments. For example, certain cells, such as cancer or fetal cells, may have differences in intracellular pH compared to other cells, which can be detected using pH-sensitive entities. In certain embodiments, the cells may be sorted based on such signaling entities; for example, illumination of cells in a suitable machine for sorting cells (e.g., using fluorescent light) may allow determination of the cells, which may also be recovered or isolated for further manipulation in some cases.
摘要翻译：本发明一般涉及用于确定和/或分离细胞的装置和方法。一方面通常涉及用于检测，识别，计数和/或潜在地分选血液或其他生物样品中感兴趣的细胞的方法和装置。在一些实施方案中，血液样品（或其他生物流体）可以用信号实体（例如pH敏感实体）来处理，其在适当的内部环境中改变颜色或以其它方式产生信号。例如，某些细胞，如癌症或胎儿细胞，与其他细胞相比，细胞内的pH可能有差异，其可以使用pH敏感的实体来检测。在某些实施方案中，可以基于这种信令实体对细胞进行分类; 例如，在用于分选细胞的合适的机器中照射细胞（例如，使用荧光）可以允许确定细胞，其在一些情况下也可以被回收或分离用于进一步的操作。

24. 发明申请

US20110218738A1 CHARACTERIZATION OF MOLECULES 有权
标题翻译：分子表征
公开(公告)号：US20110218738A1
公开(公告)日：2011-09-08
申请号：US13110345
申请日：2011-05-18
申请人： Arnon Chait , Boris Zaslavsky
发明人： Arnon Chait , Boris Zaslavsky
IPC分类号： G06F19/00
CPC分类号： G01N33/5375 , G01N33/53 , G01N33/68 , Y10T436/10 , Y10T436/105831
摘要： The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity.
摘要翻译：本发明涉及获得物种（包括化学，生物或生物化学分子）的签名和/或物种之间的相互作用的签名，并使用它们来表征物种，表征相互作用，和/或识别可在各种设置中有用的物种。可以使用水性多相分配获得签名，并且可以用于预测用于药物发现的应用的分子相互作用。多个水性多相分配装置可以定义提供信息密集型签名的整体系统，从而使精度和灵敏度最大化。

25. 发明授权

US07968350B2 Characterization of molecules 有权
标题翻译：分子的表征
公开(公告)号：US07968350B2
公开(公告)日：2011-06-28
申请号：US10293959
申请日：2002-11-12
申请人： Arnon Chait , Boris Zaslavsky
发明人： Arnon Chait , Boris Zaslavsky
IPC分类号： G01N33/536
CPC分类号： G01N33/5375 , G01N33/53 , G01N33/68 , Y10T436/10 , Y10T436/105831
摘要： The invention involves obtaining signatures of species (including chemical, biological, or biochemical molecules) and/or signatures of interactions between species and using them to characterize species, characterize interactions, and/or identify species that could be useful in a variety of settings. Signatures can be obtained using aqueous multi-phase partitioning and can be used to predict molecular interactions for applications such as drug discovery. A plurality of aqueous multi-phase partitioning arrangements can define an overall system providing an information-intensive signature, maximizing precision and sensitivity.
摘要翻译：本发明涉及获得物种（包括化学，生物或生物化学分子）的签名和/或物种之间的相互作用的签名，并使用它们来表征物种，表征相互作用，和/或识别可在各种设置中有用的物种。可以使用水性多相分配获得签名，并且可以用于预测用于药物发现的应用的分子相互作用。多个水性多相分配装置可以定义提供信息密集型签名的整体系统，从而使精度和灵敏度最大化。

26. 发明授权

US11866795B2 RNA separation and related techniques for determining viruses such as coronaviruses 有权
公开(公告)号：US11866795B2
公开(公告)日：2024-01-09
申请号：US17987973
申请日：2022-11-16
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： C12N15/10 , C12Q1/68 , C12Q1/6809 , C12Q1/70 , C12Q1/6834 , A61K9/51 , A61K39/215 , G01N33/52 , G01N33/569
CPC分类号： C12Q1/701 , A61K9/51 , A61K39/215 , G01N33/523 , G01N33/56983 , G01N2333/165
摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses such as coronaviruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, free RNA or other nucleic acids may preferentially partition into one phase, while intact viruses may be present in the other phase or in both phases. Accordingly, in some cases, free RNA or other nucleic acids may be preferentially removed, e.g., as compared to intact RNA or other nucleic acids present within a virus. In some cases, the phase containing intact viruses can be determined to determine the infectiousness, e.g., of a sample arising from a subject. This may be useful, for example, for distinguishing subjects who are capable of spreading an infection from those who are not infectious.

27. 发明公开

US20230151443A1 RNA SEPARATION AND RELATED TECHNIQUES FOR DETERMINING VIRUSES SUCH AS CORONAVIRUSES 审中-公开
公开(公告)号：US20230151443A1
公开(公告)日：2023-05-18
申请号：US17987973
申请日：2022-11-16
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： C12Q1/70 , A61K9/51 , A61K39/215 , G01N33/52 , G01N33/569
CPC分类号： C12Q1/701 , A61K9/51 , A61K39/215 , G01N33/523 , G01N33/56983 , G01N2333/165
摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses such as coronaviruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, free RNA or other nucleic acids may preferentially partition into one phase, while intact viruses may be present in the other phase or in both phases. Accordingly, in some cases, free RNA or other nucleic acids may be preferentially removed, e.g., as compared to intact RNA or other nucleic acids present within a virus. In some cases, the phase containing intact viruses can be determined to determine the infectiousness, e.g., of a sample arising from a subject. This may be useful, for example, for distinguishing subjects who are capable of spreading an infection from those who are not infectious.

28. 发明授权

US11535902B2 RNA separation and related techniques for determining viruses such as coronaviruses 有权
公开(公告)号：US11535902B2
公开(公告)日：2022-12-27
申请号：US17695994
申请日：2022-03-16
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： C12N15/10 , C12N9/22 , C12N15/11 , C12N15/63 , C12Q1/6816 , C12Q1/70 , A61K9/51 , A61K39/215 , G01N33/52 , G01N33/569
摘要： Certain aspects of the present disclosure generally relate to systems and methods for determining viruses such as coronaviruses. For instance, some aspects are directed to systems and methods for determining viruses using a partitioning system. Within the partitioning system, free RNA or other nucleic acids may preferentially partition into one phase, while intact viruses may be present in the other phase or in both phases. Accordingly, in some cases, free RNA or other nucleic acids may be preferentially removed, e.g., as compared to intact RNA or other nucleic acids present within a virus. In some cases, the phase containing intact viruses can be determined to determine the infectiousness, e.g., of a sample arising from a subject. This may be useful, for example, for distinguishing subjects who are capable of spreading an infection from those who are not infectious.

29. 发明授权

US10613087B2 Methods and devices for analyzing species to determine diseases 有权
公开(公告)号：US10613087B2
公开(公告)日：2020-04-07
申请号：US14420166
申请日：2013-08-08
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/574 , G16H50/30 , G16H50/20
CPC分类号： G01N33/574 , G01N33/57407 , G01N33/57488 , G01N33/57492 , G01N33/57496 , G16H50/20 , G16H50/30
摘要： The present invention, in some embodiments thereof, generally relates to methods and devices for determining the health status of a subject, e.g., whether the subject has a disease or other condition. In some embodiments, a plurality or mixture of species may be differentially solubilized in a single two-phase aqueous system, or other multi-phase aqueous system. The nature or degree of the solubilization of the species may be used to determine the health status of a subject. For example, some embodiments are directed to devices and methods for determining a disease or other condition as a function of the changes to the structure of two or more species. The species may be selected based on their differential solubility behavior in a two-phase or other multi-phase aqueous system. Preferential enrichment of the species concentrations in one of the phases, and/or the ratios of species in the phases may be determined, and in some cases compared to their respective values for healthy and/or diseased subjects to determine the health status of the subject.

30. 发明申请

US20170242017A1 METHODS AND DEVICES FOR DETERMINING A DISEASE STATE 审中-公开
公开(公告)号：US20170242017A1
公开(公告)日：2017-08-24
申请号：US15590215
申请日：2017-05-09
申请人： Analiza, Inc.
发明人： Arnon Chait , Boris Y. Zaslavsky
IPC分类号： G01N33/574 , G01N33/543
CPC分类号： G01N33/57488 , G01N33/54366 , G01N33/57415 , G01N33/68 , G01N33/6893 , G01N2333/765 , G01N2800/085 , G01N2800/56
摘要： The present invention, in some embodiments thereof, relates to methods and devices for determining a disease state in a patient. In some embodiments, human serum albumin may be analyzed for associated molecules, wherein the associated molecules are related to a disease such as cancer. Certain aspects of the invention are generally directed to devices and methods for determining a disease state as a function of the three-dimensional structure of a blood protein, human serum albumin (HSA) or its complex with other ligands, e.g., due to binding to disease-specific ligands. HSA interacts with biomolecules associated with a disease presence, and liganded HSA may differentially partition between aqueous phases of a predetermined partitioning system, wherein the partitioning behavior differs between HSA from healthy individuals and HSA from people harboring the predetermined disease, such as breast cancer.

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