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21. 发明授权

US07211510B2 Stacking circuit elements 有权
标题翻译：堆叠电路元件
公开(公告)号：US07211510B2
公开(公告)日：2007-05-01
申请号：US10937149
申请日：2004-09-09
申请人： Paul Milton Meadows
发明人： Paul Milton Meadows
IPC分类号： H01L21/44 , H01L29/40 , H01L23/52 , H01L23/48 , H01L21/768
CPC分类号： A61N1/375 , A61N1/05 , H01L21/76898 , H01L23/481 , H01L25/0657 , H01L25/50 , H01L2225/06513 , H01L2225/06517 , H01L2225/06541 , H01L2225/06555 , H01L2924/0002 , H01L2924/00
摘要： A method of stacking dice in an electronic circuit includes controlling a size of a hole made in a connection pad on each die of said dice to selectively provide an electrical connection to a particular die in the stack. Additionally, a method of stacking dice in an electronic circuit includes forming holes in each of the dice, and providing electrical connection material selectively at some of the holes to provide for selective electrical connections among the dice. A stack of dice in an electronic circuit includes a number of dice stacked on top of each other, each die in the stack having one or more holes therein, conductive material extending through the holes and making electrical connection between one or more of the dice in the stack and the electronic circuit. An implantable stimulator with a stack of pulse generator integrated circuits (ICs) includes a number of pulse generator ICs stacked on top of each other, each IC having a number of holes formed therein, wherein the holes are aligned, and conductive material extending through the holes and making electrical connection between one or more of said ICs in the stack and an electronic circuit of the stimulator.
摘要翻译：在电子电路中堆叠骰子的方法包括控制在所述骰子的每个管芯上的连接焊盘中形成的孔的尺寸，以选择性地提供与堆叠中的特定管芯的电连接。此外，在电子电路中堆叠骰子的方法包括在每个骰子中形成孔，并且在一些孔处选择性地提供电连接材料，以提供骰子之间的选择性电连接。电子电路中的一堆骰子包括堆叠在彼此之上的多个骰子，堆叠中的每个骰子中具有一个或多个孔，导电材料延伸穿过该孔并使一个或多个骰子之间的电连接堆叠和电子电路。具有脉冲发生器集成电路（IC）的堆叠的可植入刺激器包括堆叠在一起的多个脉冲发生器IC，每个IC具有形成在其中的多个孔，其中孔对准，并且导电材料延伸穿过并且在堆叠中的一个或多个所述IC和刺激器的电子电路之间进行电连接。

22. 发明授权

US07209792B1 RF-energy modulation system through dynamic coil detuning 有权
标题翻译：射频能量调制系统通过动态线圈失谐
公开(公告)号：US07209792B1
公开(公告)日：2007-04-24
申请号：US10133766
申请日：2002-04-26
申请人： Jordi Parramon , Goran N. Marnfeldt
发明人： Jordi Parramon , Goran N. Marnfeldt
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/37205
摘要： An RF-energy modulation system dynamically adjusts tuned receiving circuits within a plurality of slave devices, thereby regulating the level of power reception in each slave device. The slave devices receive power from a single master device, through coupling of a primary antenna in the master device with a secondary antenna in each slave device. The amount of the power received by each slave device is a function of the antenna separation distance, and is thus different at each slave device location. The RF-energy modulation system monitors the power requirements of the slave device within which the modulation system is included, and modulates the tuning of the secondary antenna to maintain the proper power reception level. Advantageously, such modulation controls the power reception by the slave device, versus dissipating energy already received by the slave device. In a preferred embodiment, the RF-energy modulation system controls the power received by a multiplicity of microstimulators implanted in a single patient.
摘要翻译： RF能量调制系统动态调整多个从设备内的调谐接收电路，从而调节每个从设备中的接收电平。从设备通过将主设备中的主天线与每个从设备中的辅助天线耦合，从单个主设备接收电力。每个从设备接收的功率量是天线分离距离的函数，因此在每个从设备位置处是不同的。 RF能量调制系统监视其中包括调制系统的从设备的功率需求，并调制辅助天线的调谐以保持适当的功率接收电平。有利地，这种调制控制从设备的功率接收与从设备已经接收到的耗散功率。在优选实施例中，RF能量调制系统控制由单个患者中植入的多个微刺激器接收的功率。

23. 发明授权

US07203548B2 Cavernous nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：通过动作电位的单向传播进行海绵体神经刺激
公开(公告)号：US07203548B2
公开(公告)日：2007-04-10
申请号：US10176743
申请日：2002-06-20
申请人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
发明人： Todd K Whitehurst , James P McGivern , Rafael Carbunaru , Matthew I Haller , Tom Xiaohai He , Kerry Bradley
IPC分类号： A61N1/05 , A61N1/18
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes. In one aspect, a method includes providing at least one implantable stimulator with at least two electrodes, disposing the electrodes to apply stimulation that unidirectionally propagates action potentials along a cavernous nerve; and applying the stimulation to the cavernous nerve, thereby treating erectile dysfunction while limiting side effects of bidirectional stimulation.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。一方面，一种方法包括：提供至少一个可植入的刺激器，其具有至少两个电极，设置所述电极以施加沿着海绵体神经单向传播动作电位的刺激; 并将刺激施加到海绵状神经，从而治疗勃起功能障碍，同时限制双向刺激的副作用。

24. 发明授权

US07177698B2 Telemetry system for use with microstimulator 有权
标题翻译：用于微型激励器的遥测系统
公开(公告)号：US07177698B2
公开(公告)日：2007-02-13
申请号：US10607962
申请日：2003-06-27
申请人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
发明人： Daniel J. Klosterman , Kelly H. McClure , Goran N. Marnfeldt , Jordi Parramon , Matthew I. Haller , Rudolph V. Park
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation employs a bi-directional RF telemetry link for allowing data-containing signals to be sent to and from the implantable microstimulator from at least two external devices. Further, a separate electromagnetic inductive telemetry link allows data containing signals to be sent to the implantable microstimulator from at least one of the two external devices. The RF bidirectional telemetry link allows the microstimulator to inform the patient or clinician regarding the status of the microstimulator device, including the charge level of a power source, and stimulation parameter states. The microstimulator has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case.
摘要翻译：被配置为植入在患者皮肤下方进行组织刺激的可植入微型刺激器使用双向RF遥测链路，用于允许从至少两个外部设备向可植入微型激励器发送含数据信号。此外，单独的电磁感应遥测链路允许从两个外部设备中的至少一个将包含信号的数据发送到可植入微型激励器。 RF双向遥测链路允许微刺激器通知患者或临床医生关于微刺激器装置的状态，包括电源的充电水平和刺激参数状态。微型激励器具有圆柱形密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。

25. 发明授权

US07177691B2 Implantable pulse generators using rechargeable zero-volt technology lithium-ion batteries 有权
标题翻译：使用可充电零伏技术的锂离子电池的可植入脉冲发生器
公开(公告)号：US07177691B2
公开(公告)日：2007-02-13
申请号：US10419002
申请日：2003-04-18
申请人： Paul M Meadows , Carla Mann Woods , Hisashi Tsukamoto , Joey Chen
发明人： Paul M Meadows , Carla Mann Woods , Hisashi Tsukamoto , Joey Chen
IPC分类号： A61N1/375
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/36071
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithiumion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation. A multi-rate charge algorithm is employed that minimizes charging time while ensuring the battery cell is safely charged. Fast charging occurs at safer lower battery voltages (e.g., battery voltage above about 2.5 V), and slower charging occurs when the battery nears full charge higher battery voltages (e.g., above about 4.0 V). When potentially less-than-safe very low voltages are encountered (e.g., less than 2.5 V), then very slow (trickle) charging occurs to bring the battery voltage back up to the safer voltage levels where more rapid charging can safely occur. The battery charging and protection circuitry also continuously monitors the battery voltage and current. If the battery operates outside of a predetermined range of voltage or current, the battery protection circuitry disconnects the battery from the particular fault, i.e. charging circuitry or load circuits.
摘要翻译：可植入医疗装置，例如与脊髓刺激（SCS）系统一起使用的植入式脉冲发生器（IPG），包括具有阳极电极的可再充电锂离子电池，该阳极电极基本上由钛制成。这种电池结构允许可再充电电池被放电到零伏特而不损坏电池。可植入医疗装置包括电池充电和保护电路，其控制电池的充电，以确保其可靠和安全的操作。使用多速率充电算法，其最小化充电时间，同时确保电池单元被安全地充电。快速充电发生在更安全的较低的电池电压（例如，电池电压高于约2.5V）时，并且当电池接近充满更高的电池电压（例如高于约4.0V）时，发生较慢的充电。当遇到潜在的不太安全的非常低的电压（例如，小于2.5V）时，发生非常慢的（涓流）充电，以使电池电压恢复到更安全的电压水平，其中可以安全地发生更快速的充电。电池充电和保护电路还连续监测电池电压和电流。如果电池在预定的电压或电流范围之外运行，则电池保护电路将电池与特定故障（即充电电路或负载电路）断开连接。

26. 发明申请

US20070032839A1 Method for Controlling Telemetry in an Implantable Medical Device Based on Power Source Capacity 有权
标题翻译：基于电源容量的可植入医疗器械遥测方法
公开(公告)号：US20070032839A1
公开(公告)日：2007-02-08
申请号：US11534548
申请日：2006-09-22
申请人： Jordi Parramon , Goran Marnfeldt
发明人： Jordi Parramon , Goran Marnfeldt
IPC分类号： A61N1/00
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： An implantable microstimulator configured to be implanted beneath a patient's skin for tissue stimulation to prevent and/or treat various disorders, e.g., neurological disorders, uses a self-contained power source such as a primary battery, a rechargeable battery, or other energy sources. For the rechargeable battery, and other energy sources that may require a periodic or occasional replenishment, such recharging or replenishment is accomplished, for example, by inductive coupling with an external device. A suitable bidirectional telemetry link allows the microstimulator system to inform the patient or clinician regarding the status of the system, including the charge level of the power source, and stimulation parameter states. Processing circuitry within the microstimulator automatically controls the applied stimulation pulses to match a set of programmed stimulation parameters established for a particular patient. The microstimulator preferably has a cylindrical hermetically sealed case having a length no greater than about 27 mm and a diameter no greater than about 3.3 mm. A reference electrode is located on one end of the case and an active electrode is located on the other end of the case. Further, the case is externally coated on selected areas with conductive and non-conductive materials.
摘要翻译：被配置为植入在患者皮肤下面用于组织刺激以防止和/或治疗各种疾病（例如神经障碍）的可植入微刺激器使用诸如一次电池，可再充电电池或其他能量源的独立电源。对于可充电电池和可能需要定期或偶尔的补充的其他能量源，例如通过与外部设备的电感耦合来实现这种再充电或补充。合适的双向遥测链路允许微刺激器系统通知患者或临床医生关于系统的状态，包括电源的充电水平和刺激参数状态。微刺激器内的处理电路自动控制所施加的刺激脉冲，以匹配为特定患者建立的一组编程刺激参数。微型激励器优选具有圆柱形气密密封的外壳，其长度不大于约27mm，直径不大于约3.3mm。参考电极位于壳体的一端，有源电极位于壳体的另一端。此外，外壳在导电和非导电材料的外围涂覆在选定的区域上。

27. 发明授权

US07174215B2 Method for determining stimulation parameters 有权
标题翻译：确定刺激参数的方法
公开(公告)号：US07174215B2
公开(公告)日：2007-02-06
申请号：US10728455
申请日：2003-12-05
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/08
摘要： A method is provided for determining optimal stimulus pulsewidth and stimulus amplitude for stimulating nerves with at least one electrode (17). The method comprises: providing a predetermined calibration curve comprising a set of pulsewidth and amplitude values; and delivering sets of pulsewidths and amplitude values which are part of the calibration curve to the at least one electrode (17) to determine at least the optimal pulsewidth. A pulsewidth (70) and an amplitude can be efficiently selected that is efficacious and provides an ample clinical usage range (UR).
摘要翻译：提供一种用于确定用至少一个电极（17）刺激神经的最佳刺激脉冲宽度和刺激振幅的方法。该方法包括：提供包括一组脉冲宽度和振幅值的预定校准曲线; 以及将作为校准曲线的一部分的脉冲宽度和振幅值的集合传送到至少一个电极（17）以确定至少最佳脉冲宽度。脉冲宽度（70）和振幅可被有效地选择，这是有效的并且提供充足的临床使用范围（UR）。

28. 发明授权

US07167754B1 Low power inverted alterphasic stimulation in a cochlear implant 有权
标题翻译：耳蜗植入物中的低功率反向相对刺激
公开(公告)号：US07167754B1
公开(公告)日：2007-01-23
申请号：US10993991
申请日：2004-11-19
申请人： Stefaan Peeters , Filiep Vanpoucke
发明人： Stefaan Peeters , Filiep Vanpoucke
IPC分类号： A61N1/32
CPC分类号： A61N1/37247 , A61N1/36036
摘要： An alterphasic inverting stimulation strategy for use with a multichannel cochlear implant system consumes less power than similar strategies, yet provides better sound quality. The alterphasic inverting strategy is a strategy wherein stimulation pulses are strictly sequential, and wherein the timing and polarity of the channels is chosen such that positive and negative pulses are alternating in time in accordance with a defined pattern that staggers application of the pulses spatially across all the channels and inverts the polarity of pulses that are near each other either spatially or in time.
摘要翻译：与多声道耳蜗植入系统一起使用的相反反转刺激策略比类似的策略消耗更少的功率，但是提供更好的声音质量。相反反转策略是其中刺激脉冲是严格顺序的策略，并且其中选择通道的定时和极性，使得正和负脉冲在时间上根据定义的模式交替，脉冲在空间上跨越所有脉冲通道并在空间上或时间上颠倒彼此靠近的脉冲的极性。

29. 发明申请

US20060271109A1 Implantable microstimulator with dissecting tip and/or retrieving anchor and methods of manufacture and use 失效
标题翻译：具有解剖尖端和/或检索锚的可植入微型刺激器以及制造和使用方法
公开(公告)号：US20060271109A1
公开(公告)日：2006-11-30
申请号：US11138598
申请日：2005-05-25
申请人： Janusz Kuzma , Tom He , Anne Pianca
发明人： Janusz Kuzma , Tom He , Anne Pianca
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/0551 , A61N1/36003 , A61N1/37205 , A61N1/3756 , A61N2001/0578
摘要： An implantable microstimulator can include a housing having a first end; an electronic subassembly disposed within the housing; a plurality of electrodes disposed on the housing and coupled to the electronic subassembly; and a dissecting tip disposed at the first end of the housing. Another implantable microstimulator includes a housing having a first end; an electronic subassembly disposed within the housing; a plurality of electrodes disposed on the housing and coupled to the electronic subassembly; and a extraction aid disposed at the first end of the housing and configured and arranged for attachment of an extraction line.
摘要翻译：可植入微型刺激器可以包括具有第一端的壳体; 设置在所述壳体内的电子组件; 多个电极，设置在所述壳体上并联接到所述电子子组件; 以及设置在所述壳体的第一端处的解剖尖端。另一种可植入微型激励器包括具有第一端的外壳; 设置在所述壳体内的电子组件; 多个电极，设置在所述壳体上并联接到所述电子子组件; 以及设置在壳体的第一端处并被构造和布置成用于附接提取管线的提取助剂。

30. 发明授权

US07120992B2 Method of making an electronic module 有权
标题翻译：制作电子模块的方法
公开(公告)号：US07120992B2
公开(公告)日：2006-10-17
申请号：US10609452
申请日：2003-06-27
申请人： Tom Xiaohai He , Matthew I. Haller , Jordi Parramon , Goran N. Marnfeldt
发明人： Tom Xiaohai He , Matthew I. Haller , Jordi Parramon , Goran N. Marnfeldt
IPC分类号： H01F7/06
CPC分类号： A61N1/37276 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37217 , A61N1/37223 , A61N1/37229 , A61N1/37235 , A61N1/3727 , A61N1/375 , A61N1/3787 , H01L2224/45144 , H01L2224/45147 , H01L2224/48465 , H01L2224/49175 , H01L2924/00011 , H01L2924/1461 , H01L2924/19105 , H01L2924/19107 , H01L2924/3011 , H01L2924/30111 , H02J7/025 , H02J7/345 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10 , Y10T29/4902 , Y10T29/49071 , Y10T29/49073 , Y10T29/49128 , Y10T29/4913 , Y10T29/49155 , Y10T29/49169 , Y10T29/49826 , Y10T29/49945 , Y10T29/49968 , Y10T428/12264 , Y10T428/12271 , Y10T428/12347 , Y10T428/12375 , Y10T428/12396 , Y10T428/12535 , Y10T428/12806 , H01L2924/00 , H01L2924/01005 , H01L2924/01033
摘要： Compact electronic modules, which may be used with implantable microstimulators and other medical and non-medical devices, and manufacture/assembly of such modules are described. Component and circuitry designs utilize unique redistribution techniques and attachment methods. A number of component designs and packaging configurations maximize the volume efficiency of electronic modules. Also included are improved processes and systems enabling the manufacture and assembly of such compact packages.
摘要翻译：描述了可与可植入微型刺激器和其他医疗和非医疗装置一起使用的紧凑型电子模块以及这种模块的制造/组装。组件和电路设计采用独特的再分配技术和附件方法。许多组件设计和封装配置使电子模块的体积效率最大化。还包括改进的工艺和系统，能够制造和组装这些紧凑型封装。

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