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11. 发明申请

US20180226238A1 Method and Apparatus for Isotope Ratio Mass Spectrometry 审中-公开
公开(公告)号：US20180226238A1
公开(公告)日：2018-08-09
申请号：US15887520
申请日：2018-02-02
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Jens GRIEP-RAMING
IPC分类号： H01J49/00 , G01N30/72 , H01J49/04 , H01J49/40 , H01J49/28 , H01J49/38
CPC分类号： H01J49/0031 , G01N30/7233 , G01N30/8658 , G01N2030/324 , H01J49/0036 , H01J49/0459 , H01J49/282 , H01J49/38 , H01J49/40
摘要： A method of isotope ratio mass spectrometry comprising: flowing a liquid mobile phase through a separation device; reducing the flow rate of the mobile phase through the separation device for at least a portion of time that at least one molecular species is emerging from the separation device to achieve a desired isotope ratio precision, wherein the flow rate is reduced from a first rate to a second rate corresponding to a higher theoretical plate height of the separation device; and mass analyzing the molecular species that has emerged from the separation device at least while the flow rate is reduced; and determining at least one isotope ratio from the intensities of mass peaks of at least two isotopologues, wherein the mass analysis is performed with mass resolving power high enough to resolve the two most abundant mass peaks at the nominal mass of at least one of the isotopologues.

12. 发明授权

US09978572B2 Mass spectrometer with reduced potential drop 有权
公开(公告)号：US09978572B2
公开(公告)日：2018-05-22
申请号：US15307576
申请日：2015-04-30
申请人： MICROMASS UK LIMITED
发明人： Kevin Giles , Steven Derek Pringle , Jason Lee Wildgoose
IPC分类号： H01J49/26 , H01J49/28 , H01J49/40 , H01J49/06 , H01J49/00
CPC分类号： H01J49/0031 , H01J49/004 , H01J49/005 , H01J49/062 , H01J49/063 , H01J49/065 , H01J49/401
摘要： A method of mass spectrometry is disclosed comprising providing a first device and a second device disposed downstream of the first device. The method further comprises introducing a potential difference between the exit of the first device and the entrance of the second device and reducing the total potential drop across the first and second devices by applying a reverse axial electric field to the first device and/or the second device. Ions are driven through the first device and/or the second device against the reverse axial electric field.

13. 发明申请

US20180108522A1 IMR-MS DEVICE 审中-公开
公开(公告)号：US20180108522A1
公开(公告)日：2018-04-19
申请号：US15782281
申请日：2017-10-12
申请人： IONICON ANALYTIK GESELLSCHAFT M.B.H.
发明人： Philipp Sulzer , Simone Jürschik , Jens Herbig , Alfons Jordan , Lukas Märk
IPC分类号： H01J49/16 , H01J49/14 , H01J49/28 , H01J49/42
CPC分类号： H01J49/168 , H01J49/0009 , H01J49/0027 , H01J49/145 , H01J49/286 , H01J49/426
摘要： Ion-molecule-reaction-mass spectrometry (IMR-MS) device, comprising an ion source, an adjacent reaction chamber and a mass spectrometer subsequent to the reaction chamber, wherein the reaction chamber comprises an RF device for creating a temporally changing electromagnetic field and wherein an adjustable reduced electric field strength (E/N) can be applied to the reaction chamber, characterized by an input device for entering a desired reduced electric field strength (E/N) by an operator when operating said IMR-MS device for analysing a sample, and a controlling device that operates the IMR-MS device by adjusting the settings of the IMR-MS device relating to a defined data set of a pseudo reduced electric field strength (PE/N1,2) for the entered reduced electric field strength (E/N), wherein the pseudo reduced electric field strength (PE/N1,2) has been determined by analysing a first analyte (A1) in the IMR-MS device, wherein intensity signals (RS1) of at least two product ions of the analyte (A1) are recorded and wherein the settings of the IMR-MS device are changed until the measured intensity signal (IS1) ratios of the at least two product ions match reference intensity signal (RS1) ratios within a given tolerance level of the at least two product ions determined in an IMR-MS device comprising an ion source, an adjacent reaction chamber with a DC-drift tube and a mass spectrometer subsequent to the reaction chamber, wherein the reaction chamber is operated only with an activated DC-drift tube at a certain actual reduced electric field strength (Ea1/N), wherein these settings of the IMR-MS device relating to the pseudo reduced electric field strength (PE/N1) are stored in the controlling device, wherein the controlling device controls said IMR-MS device by performing analysis of the sample with the settings corresponding to the pseudo reduced electric field strengths (PE/N1).

14. 发明申请

US20180068841A1 APPARATUS FOR MASS ANALYSIS OF ANALYTES BY SIMULTANEOUS POSITIVE AND NEGATIVE IONIZATION 审中-公开
公开(公告)号：US20180068841A1
公开(公告)日：2018-03-08
申请号：US15560386
申请日：2016-03-29
申请人： MERIDION, LLC
发明人： Nicholas WILTON
IPC分类号： H01J49/28 , H01J49/14 , H01J49/00 , H01J49/22 , H01J49/32 , H01J49/04
CPC分类号： H01J49/286 , H01J49/0027 , H01J49/0422 , H01J49/147 , H01J49/22 , H01J49/328
摘要： Among other things, we describe methods and apparatus for the ionization of target molecular analytes of interest, e.g., for use in mass spectrometry. In some implementations, a thin molecular stream is emitted in either single or a split mode and encounters both an electron-impact ion source and trochoidal electron monochromator placed sequentially or coincidently. The first ion source emits high-energy electrons (˜70 eV) to generate characteristic positively-charged mass fragment spectra while the second source emits low-energy electrons in a narrow bandwidth to generate negative molecular ions or other ions via electron capture ionization. The dual ion source may be coupled to analytical instruments such as a gas chromatograph and to any number of mass analyzers such as a polarity switching quadrupole mass analyzer or to multiple mass analyzers.

15. 发明授权

US09786485B2 Mass analyser 有权
公开(公告)号：US09786485B2
公开(公告)日：2017-10-10
申请号：US15310990
申请日：2015-04-29
申请人： SHIMADZU CORPORATION
发明人： Li Ding , Aleksandr Rusinov
IPC分类号： H01J49/28 , H01J49/40 , H01J49/06
CPC分类号： H01J49/401 , H01J49/065 , H01J49/067 , H01J49/068 , H01J49/282 , H01J49/406
摘要： A mass analyser comprises a pair of electrode arrays. Each array has a set of focusing electrodes which are supplied, in use, with voltage to create an electrostatic field in a space between the electrode arrays causing ions to undergo periodic, oscillatory motion in the space, ions passing between electrodes of the sets of focusing electrodes and being repeatedly focused at a center plane, mid-way between the electrode arrays. At least one electrode of each set of focusing electrodes has an electrode surface closer to the center plane than the electrode surfaces of other electrodes of the same set. The analyzer may be an ion trap mass analyser or a multi-turn ToF mass analyzer.

16. 发明授权

US09768007B2 Ion trap mass spectrometer 有权
公开(公告)号：US09768007B2
公开(公告)日：2017-09-19
申请号：US14798185
申请日：2015-07-13
申请人： LECO Corporation
发明人： Anatoly N. Verenchikov
IPC分类号： H01J49/28 , H01J49/42 , H01J49/40 , H01J49/00 , H01J49/06
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： A novel MS-MS apparatus utilizing electrostatic traps is disclosed, along with an associated method of analysis. The apparatus may include a chromatograph, an ion source, a first mass spectrometer, a fragmentation cell, an ion guide, a pulsed converter, and a Z-directional elongated electrostatic trap. The electrostatic trap, which may be Z-elongated into a cylindrical electrostatic trap, includes at least one of an image current detector and a time-of-flight detector. The pulsed converter is Z-directionally elongated to match the electrostatic trap. Ion selection from electrostatic traps may be accomplished with an electrode that ejects ion from an oscillation space to a time-of-flight detector, a fragmentation surface, or a passage between E-trap regions.

17. 发明授权

US09741551B2 Ion detection 有权
公开(公告)号：US09741551B2
公开(公告)日：2017-08-22
申请号：US15332734
申请日：2016-10-24
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/00 , H01J49/28 , H01J49/02 , H01J49/38 , H01J49/42 , H01J49/08
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.

18. 发明授权

US09570283B2 Electrostatic trap 有权
标题翻译：静电诱捕器
公开(公告)号：US09570283B2
公开(公告)日：2017-02-14
申请号：US14832978
申请日：2015-08-21
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan R. Horning
IPC分类号： H01J49/42 , H01J49/00 , H01J49/28 , H01J49/02 , H01J49/40
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r, φ, z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ, z) is the result of a perturbation W to an ideal field U(r, φ, z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ, z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than 2 π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，φ，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，φ，z）是对于理想场U（r，φ，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，φ，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子在离子检测周期Tm上具有大于零但小于2π弧度的绝对相位扩展。

19. 发明申请

US20170040152A1 ION DETECTION 有权
标题翻译：离子检测
公开(公告)号：US20170040152A1
公开(公告)日：2017-02-09
申请号：US15332734
申请日：2016-10-24
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Alexander Alekseevich MAKAROV
IPC分类号： H01J49/28 , H01J49/08 , H01J49/02
CPC分类号： H01J49/282 , H01J49/027 , H01J49/08 , H01J49/38 , H01J49/4245
摘要： Mass analyzers and methods of ion detection for a mass analyzer are provided. An electrostatic field generator provides an electrostatic field causing ion packets to oscillate along a direction. A pulse transient signal is detected over a time duration that is significantly shorter than a period of the ion oscillation or using pulse detection electrodes having a width that is significantly smaller than a span of ion harmonic motion. A harmonic transient signal is also detected. Ion intensity with respect to mass-to-charge ratio is then identified based on the pulse transient signal and the harmonic transient signal.
摘要翻译：提供了用于质量分析仪的质量分析仪和离子检测方法。静电场发生器提供静电场，使离子包沿着一个方向振荡。在比离子振荡的周期短的持续时间内检测脉冲瞬态信号，或使用具有明显小于离子谐波运动的跨度的宽度的脉冲检测电极。还检测到谐波瞬态信号。然后基于脉冲瞬态信号和谐波瞬态信号来识别关于质荷比的离子强度。

20. 发明授权

US09472389B2 Ion source assembly for static mass spectrometer 有权
标题翻译：离子源组件用于静态质谱仪
公开(公告)号：US09472389B2
公开(公告)日：2016-10-18
申请号：US14440767
申请日：2013-11-15
申请人： Thermo Fisher Scientific (Bremen) GmbH
发明人： Michael Krummen , Michael Deerberg , Johannes Schwieters
IPC分类号： H01J49/28 , H01J49/10 , H01J49/16
CPC分类号： H01J49/10 , H01J49/168 , H01J49/28
摘要： An ion source assembly for a static mass spectrometer, comprises: a mounting element for locating the assembly within the static mass spectrometer; an ion source for generating ions to be analyzed in the static mass spectrometer, the ion source being spaced from the mounting element and arranged to be held in use at a first relatively high potential V1 with respect to the mounting element; and a spacer mounted between the mounting element and the ion source, the spacer arranged to be held in use at a second potential V2 with respect to the mounting element, which is less than the first potential V1.
摘要翻译：一种用于静态质谱仪的离子源组件，包括：用于将组件定位在静态质谱仪内的安装元件; 用于在所述静态质谱仪中产生要分析的离子的离子源，所述离子源与所述安装元件间隔开并且布置成相对于所述安装元件保持在第一相对高电位V1的使用中; 以及安装在所述安装元件和所述离子源之间的间隔件，所述间隔件布置成相对于所述安装元件保持在使用中的第二电位V2小于所述第一电位V1。

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