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11. 发明申请

US20160090578A1 ENZYMES CATALYZING THE GLYCOSYLATION OF POLYPHENOLS 审中-公开
标题翻译：酶催化乙二醇的糖苷化
公开(公告)号：US20160090578A1
公开(公告)日：2016-03-31
申请号：US14892003
申请日：2014-05-28
申请人： UNIVERSITÄT HAMBURG
发明人： Ulrich Rabausch , Wolfgang Streit , Julia Juergensen
IPC分类号： C12N9/10 , C12P19/60
CPC分类号： C12N9/1051 , C12P19/60 , C12Y204/01
摘要： Enzymes catalyzing the glycosylation of polyphenols, in particular flavonoids, benzoic acid derivatives, stilbenoids, chalconoids, chromones, and coumarin derivatives. An enzyme catalyzing the glycosylation of polyphenols, wherein the enzyme a) includes an amino acid sequence according to one of the sequences of SEQ ID NO: 7-12, or b) is encoded by a nucleic acid with a nucleotide sequence of one of the sequences of SEQ ID NO: 1-6, or c) is homologous to one of the enzymes defined in a) or b) above, or d) is encoded by a nucleic acid hybridizing under stringent conditions with a nucleic acid complementary to a sequence with a nucleotide sequence of one of the sequences of SEQ ID NO: 1-6.
摘要翻译：催化多酚的糖基化，特别是类黄酮，苯甲酸衍生物，芪类，ch类，色酮和香豆素衍生物的酶。一种催化多酚糖基化的酶，其中所述酶a）包括根据SEQ ID NO：7-12的序列之一的氨基酸序列，或b）由核酸编码，其核苷酸序列为 SEQ ID NO：1-6的序列，或c）与上述a）或b）中定义的酶之一同源，或d）由在严格条件下与序列互补的核酸的核酸编码与SEQ ID NO：1-6的序列之一的核苷酸序列。

12. 发明申请

US20140228554A1 SYNTHESIS OF NEW FUCOSE-CONTAINING CARBOHYDRATE DERIVATIVES 审中-公开
标题翻译：新型含羧酸的碳氢化合物衍生物的合成
公开(公告)号：US20140228554A1
公开(公告)日：2014-08-14
申请号：US14005796
申请日：2012-03-19
申请人： Glycom A/S
发明人： Elise Champion , Gyula Dekany , Markus Hederos , Karoly Agoston
IPC分类号： C12P19/60 , C07H15/203 , C07H15/18 , C07H17/04
CPC分类号： C12P19/60 , C07H15/08 , C07H15/18 , C07H15/203 , C07H17/04 , Y02P20/55
摘要： A method for the synthesis of a fucooligosaccharide glycosides by reacting a fucosyl donor with H-A-R1 or a salt thereof, wherein A and R1 are as defined herein, under the catalysis of an enzyme capable of transferring fucose is provided. The fucooligosaccharid glycoside compounds, or derivatives thereof, their use in the manufacture of human milk oligosaccharides, and a method of manufacture of human milk oligosaccharides, are also provided.
摘要翻译：提供了通过使岩藻糖基供体与H-A-R1或其盐（其中A和R 1如本文所定义）在能够转移岩藻糖的酶的催化下反应来合成软脂寡糖糖苷的方法。还提供了岩藻糖糖苷化合物或其衍生物，其在制造人乳低聚糖中的用途，以及制造人乳低聚糖的方法。

13. 发明授权

US08486664B2 Enzymatic production of an ethylenically unsaturated glycoside using polysaccharides 失效
标题翻译：使用多糖酶促生产烯属不饱和糖苷
公开(公告)号：US08486664B2
公开(公告)日：2013-07-16
申请号：US13192761
申请日：2011-07-28
申请人： Harald Keller , Katja Loos , Wouter Kloosterman
发明人： Harald Keller , Katja Loos , Wouter Kloosterman
IPC分类号： C12P19/60
CPC分类号： C12P19/44 , C07H15/10 , C12P19/14 , C12P19/18 , C12Y204/01019 , C12Y302/01004 , C12Y302/01133
摘要： Ethylenically unsaturated glycosides of formula I wherein Y, Y′, m, A, X, R3 and R4 have the meanings given in the description, are produced by reacting an ethylenically unsaturated compound of formula II with a polysaccharide comprising 10 or more monosaccharide units, such as starch, amylose, amylopectin, cellulose, in the presence of a glycosidase, such as an amylase, cellulase, glucosidase or and galactosidase, or a glycosyltransferase, such a cyclomaltodextrin glucanotransferase.
摘要翻译：其中Y，Y'，m，A，X，R 3和R 4具有说明书中给出的含义的式I的烯键式不饱和糖苷通过使式II的烯属不饱和化合物与包含10个或更多个单糖单元的多糖反应，例如淀粉，直链淀粉，支链淀粉，纤维素，在糖苷酶如淀粉酶，纤维素酶，葡糖苷酶或半乳糖苷酶或糖基转移酶的存在下，例如环糊精葡聚糖转移酶。

14. 发明申请

US20130122541A1 MICROORGANISM PRODUCTION OF HIGH-VALUE CHEMICAL PRODUCTS, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS 审中-公开
公开(公告)号：US20130122541A1
公开(公告)日：2013-05-16
申请号：US13575581
申请日：2011-01-27
申请人： Michael D. Lynch , Ryan T. Gill , Tanya E.W. Lipscomb
发明人： Michael D. Lynch , Ryan T. Gill , Tanya E.W. Lipscomb
IPC分类号： C12N1/21 , C12M1/00 , C12P19/60 , C12N1/19 , C12P29/00 , C12P19/62
CPC分类号： C12P7/42 , C12N9/0008 , C12N9/0036 , C12N9/88 , C12N9/93 , C12P7/52 , C12P7/66 , C12P17/18 , C12P19/62 , C12P19/623 , C12P21/005 , C12P29/00 , C12Y604/01002
摘要： This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes polyketides and 3-hydroxypropionic acid.

15. 发明申请

US20110237533A1 NOVEL POLYPHENOL COMPOUND 审中-公开
标题翻译：新型聚苯酚化合物
公开(公告)号：US20110237533A1
公开(公告)日：2011-09-29
申请号：US13078108
申请日：2011-04-01
申请人： Kenzo NOMURA , Yayoi Kanbayashi
发明人： Kenzo NOMURA , Yayoi Kanbayashi
IPC分类号： A61K31/7048 , C07D493/04 , A61K31/357 , C07H15/26 , A61P3/04 , C12P19/60 , C12P17/18
CPC分类号： C07D493/04 , A23L2/52 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/357 , A61K31/7048 , C07D519/00 , C07H17/07 , C12P17/181 , A23V2250/2132 , A23V2200/332
摘要： Compounds represented by formula (I) wherein the symbols are as defined in the description, exhibit a lipase inhibitory activity, and are useful for foods, drinks, and the like.
摘要翻译：由式（I）表示的化合物，其中符号如说明书中所定义，表现出脂肪酶抑制活性，可用于食品，饮料等。

16. 发明申请

US20100121041A1 METHOD FOR PRODUCTION OF SUGAR OXAZOLINE DERIVATIVE 有权
标题翻译：蔗糖衍生物的生产方法
公开(公告)号：US20100121041A1
公开(公告)日：2010-05-13
申请号：US12528547
申请日：2008-03-07
申请人： Shinichiro Shoda , Atsushi Kobayashi , Masato Noguchi , Tomonari Tanaka , Hidetoshi Gyakushi
发明人： Shinichiro Shoda , Atsushi Kobayashi , Masato Noguchi , Tomonari Tanaka , Hidetoshi Gyakushi
IPC分类号： C07H17/00 , C12P19/60
CPC分类号： C07H9/06 , C08B37/0069
摘要： Disclosed is a process for producing an oxazoline derivative from a non-protected sugar in a simple manner. Also disclosed is a process for producing a glycoside by utilizing the product of the aforementioned process. A sugar oxazoline derivative is synthesized in one step in an aqueous solution from a sugar having a free hemiacetalic hydroxy group and an amido group by using a haloformamidinium derivative as a dehydrating agent. A glycoside compound is produced by using the oxazoline derivative as a sugar donor and also using a sugar dehydrogenase. The method can be applied to the production of a compound having a long sugar chain, and is therefore useful for the production of a physiologically active oligosaccharide, a carrier for a drug delivery system, a surfactant, a carbohydrate-based drug, a glycopeptide, a glycoprotein, a carbohydrate polymer or the like.
摘要翻译：公开了以简单的方式从非保护糖生产恶唑啉衍生物的方法。还公开了利用上述方法的产物生产糖苷的方法。通过使用卤代甲脒衍生物作为脱水剂，在具有游离半缩醛羟基和酰胺基的糖的水溶液中一步合成糖恶唑啉衍生物。通过使用恶唑啉衍生物作为糖供体并且还使用糖脱氢酶来制备糖苷化合物。该方法可用于生产具有长糖链的化合物，因此可用于生产生物活性寡糖，药物递送系统的载体，表面活性剂，碳水化合物基药物，糖肽，糖蛋白，碳水化合物聚合物等。

17. 发明申请

US20090191593A1 METHODS AND ORGANISMS FOR UTILIZING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL 有权
标题翻译：使用合成气或其他气态碳源和甲醇的方法和有机体
公开(公告)号：US20090191593A1
公开(公告)日：2009-07-30
申请号：US12358217
申请日：2009-01-22
申请人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
发明人： Mark J. Burk , Christophe H. Schilling , Anthony P. Burgard , John D. Trawick
IPC分类号： C12P19/60 , C12N1/00
CPC分类号： C12P7/18 , C12N9/0008 , C12N9/0036 , C12N9/1007 , C12N9/93 , C12N15/70 , C12P19/32 , Y02E50/343
摘要： The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention provides a non-naturally occurring microorganism, comprising one or more exogenous proteins conferring to the microorganism a pathway to convert CO, CO2 and/or H2 to acetyl-coenzyme A (acetyl-CoA), methyl tetrahydrofolate (methyl-THF) or other desired products, wherein the microorganism lacks the ability to convert CO or CO2 and H2 to acetyl-CoA or methyl-THF in the absence of the one or more exogenous proteins. For example, the microbial organism can contain at least one exogenous nucleic acid encoding an enzyme or protein in an acetyl-CoA pathway. The microbial organism is capable of utilizing synthesis gases comprising CO, CO2 and/or H2, alone or in combination with methanol, to produce acetyl-CoA. The invention additionally provides a method for producing acetyl-CoA, for example, by culturing an acetyl-CoA producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding an acetyl-CoA pathway enzyme or protein in a sufficient amount to produce acetyl-CoA, under conditions and for a sufficient period of time to produce acetyl-CoA.
摘要翻译：本发明提供具有乙酰-CoA途径的非天然存在的微生物生物体，以及利用合成气或合成气和甲醇的能力。在一个实施方案中，本发明提供非天然存在的微生物，其包含一种或多种外源蛋白质，赋予微生物将CO，CO 2和/或H 2转化为乙酰辅酶A（乙酰辅酶A），甲基四氢叶酸（甲基 -THF）或其它所需产物，其中微生物缺乏在不存在一种或多种外源蛋白的情况下将CO或CO 2和H 2转化为乙酰辅酶A或甲基-THF的能力。例如，微生物生物体可以含有至少一种编码乙酰辅酶A途径中的酶或蛋白质的外源核酸。微生物生物能够单独或与甲醇组合使用包含CO，CO 2和/或H 2的合成气体，以产生乙酰辅酶A。本发明另外提供了生产乙酰辅酶A的方法，例如通过培养产生乙酰辅酶A的微生物，其中微生物生物体表达至少一种编码乙酰辅酶A途径酶或蛋白质的外源核酸，其量足够在条件下和足够的时间内产生乙酰辅酶A产生乙酰辅酶A。

18. 发明授权

US07211413B2 Process for producing purified anthocyanin and crystalline anthocyanin 失效
标题翻译：生产纯化花青素和结晶花青素的方法
公开(公告)号：US07211413B2
公开(公告)日：2007-05-01
申请号：US10380056
申请日：2001-09-11
申请人： Hitoshi Matsumoto , Satoshi Hanamura , Masao Hirayama
发明人： Hitoshi Matsumoto , Satoshi Hanamura , Masao Hirayama
IPC分类号： C12P19/60
CPC分类号： C07H17/00 , C07H17/065 , C09B61/00 , C12P19/14 , C12P19/44
摘要： Provided are a process for producing purified anthocyanidin glucoside in which a rhamnose end of anthocyanidin rutinoside is cleaved using rhamnosidase to convert the anthocyanidin rutinoside component into anthocyanidin glucoside, the anthocyanidin glucoside component being then purified and isolated; or a crystalline anthocyanidin glucoside salt obtained by further crystallizing the purified anthocyanidin glucoside and a process for producing the same.Also provided are a process for producing purified anthocyanidin rutinoside in which a glucose end of anthocyanidin glucoside is cleaved using β-glucosidase to degrade and remove the end, the anthocyanidin rutinoside component being then purified and isolated; or a crystalline anthocyanidin rutinoside salt obtained by further crystallizing the purified anthocyanidin rutinoside and a process for producing the same.
摘要翻译：提供了使用鼠李糖苷酶将花色素芸香糖苷成分转化为花色素苷葡糖苷的花青素芸香糖苷的鼠李糖末端切割纯化花青素葡糖苷的方法，然后纯化和分离花色素苷苷组分; 或通过进一步结晶纯化的花青素葡糖苷获得的结晶花色素苷糖苷及其制备方法。还提供了生产纯化的花青素芸香糖苷的方法，其中使用β-葡糖苷酶切割花青素葡糖苷的葡萄糖末端以降解和除去末端，然后纯化和分离花色素芸香糖苷组分; 或通过进一步结晶纯化的花青素芸香苷获得的结晶花色素芸香糖苷盐及其制备方法。

19. 发明申请

US20060099690A1 Extraction, purification and conversion of flavonoids from plant biomass 审中-公开
标题翻译：从植物生物量提取，纯化和转化类黄酮
公开(公告)号：US20060099690A1
公开(公告)日：2006-05-11
申请号：US10528877
申请日：2003-09-23
申请人： Peter Chang , Alister Muir
发明人： Peter Chang , Alister Muir
IPC分类号： C12P19/60 , A61K31/7048
CPC分类号： A61K31/7048 , A23L33/105 , A61K8/602 , A61Q17/04 , A61Q19/08 , C12P17/06 , C12P19/60
摘要： A process for preparing a rutin-enriched composition from plant biomass comprises extraction with an aqueous solution, and precipitation. An enzyme preparation, such as naringinase, is used for the transformation of rutin to higher value compositions containing increased proportions of isoquercitrin and quercetin.
摘要翻译：从植物生物质制备富含芦丁的组合物的方法包括用水溶液萃取和沉淀。使用酶制剂如柚皮苷酶将芦丁转化成含有增加比例的异槲皮素和槲皮素的较高价值组合物。

20. 发明申请

US20050080247A1 Leinamycin biosynthesis gene cluster and its components and their uses 审中-公开
标题翻译：雷尼霉素生物合成基因簇及其成分及其用途
公开(公告)号：US20050080247A1
公开(公告)日：2005-04-14
申请号：US10473193
申请日：2002-03-22
申请人： Ben Shen , Yi-qiang Cheng , Gong-li Tang
发明人： Ben Shen , Yi-qiang Cheng , Gong-li Tang
IPC分类号： C12N15/09 , C07H21/04 , C07K14/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12N9/00 , C12N9/02 , C12N9/10 , C12N15/52 , C12N15/74 , C12P17/16 , C12P17/18 , C12P19/60 , C12P21/02
CPC分类号： C12N15/52 , C12P17/185
摘要： This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of leinamycin in Streptomyces atroolivaceus. The leinamycin gene cluster provides a hybrid polyketide synthase/nonribosomal peptide synthetase pathway. Elucidation of the various modules and enzymatic domains characterizing the pathway provides convenient synthetic routes for leinamycins, leinamycin analogs, and various other polyketides, peptides, and hybrid peptide-polyketide natural products.
摘要翻译：本发明提供了负责合成链霉菌（Streptomyces atroolivaceus）中的莱茵霉素的基因簇的详细序列分析和表征。 leinamycin基因簇提供了一种杂合聚酮化合物合酶/非核糖体肽合成酶途径。阐明该途径表征的各种模块和酶结构域为莱米霉素，莱茵霉素类似物和各种其他聚酮化合物，肽和杂合肽 - 聚酮化合物天然产物提供了方便的合成途径。

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