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    • 16. 发明授权
    • Copper salts of ion exchange materials for use in the treatment and prevention of infections
    • 用于治疗和预防感染的离子交换材料的铜盐
    • US09205109B2
    • 2015-12-08
    • US13747165
    • 2013-01-22
    • CAREFUSION 2200, INC.
    • Scott A. TuftsJames BardwellMichael J. Baltezor
    • A61K33/34A61K31/717A61L15/18A61L15/22C08L1/08A61L26/00
    • A61K33/34A61K31/717A61L26/0004A61L26/0023C08L1/08Y02P20/582
    • Copper salts of ion exchange materials provide copper ions at levels suitable for use as an anti-infective agent. The copper salts of ion exchange materials may be formed using ether and ester derivatives of cellulose, such as carboxymethyl cellulose (CMC), ethylcellulose (EC), methylcellulose (MC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxyethyl methyl cellulose (HEMC), cellulose acetate, and cellulose triacetate. Wound dressings having copper salts of ion exchange materials incorporated therein are also provided, and may be used to reduce the incidence of infection in wounds. The wound dressings may also be used to prevent infections in long-term wounds, such as those formed at wound drain, catheter, and ostomy entry sites. Copper salts of ion exchange materials may be used to kill microorganisms, and may optionally be used with additional anti-infective agents.
    • 离子交换材料的铜盐提供适合用作抗感染剂的水平的铜离子。 离子交换材料的铜盐可以使用纤维素的醚和酯衍生物,如羧甲基纤维素(CMC),乙基纤维素(EC),甲基纤维素(MC),羟丙基纤维素(HPC),羟丙基甲基纤维素(HPMC),羟丙基甲基纤维素 甲基纤维素(HEMC),乙酸纤维素和三醋酸纤维素。 还提供了掺入其中的具有离子交换材料的铜盐的伤口敷料,并且可以用于降低伤口感染的发生率。 伤口敷料也可用于预防长期伤口中的感染,例如在伤口排泄,导管和造口术入口部位形成的伤口。 可以使用离子交换材料的铜盐来杀死微生物,并且可以任选地与另外的抗感染剂一起使用。
    • 19. 发明授权
    • Nanocomposite biomaterials of nanocrystalline cellulose (NCC) and polylactic acid (PLA)
    • 纳米晶纤维素(NCC)和聚乳酸(PLA)的纳米复合生物材料
    • US08829110B2
    • 2014-09-09
    • US13014205
    • 2011-01-26
    • Wadood Y. HamadChuanwei Miao
    • Wadood Y. HamadChuanwei Miao
    • C08B37/00C08G63/48C08G63/91C08G18/38C08L1/08B82Y40/00C08G63/08D01F1/10D01F6/62C08L67/04C08L1/02B82Y30/00C08J5/18
    • C08L1/02B82Y30/00B82Y40/00C08G63/08C08J5/18C08J2301/02C08J2367/04C08L67/04C08L2205/14D01F1/10D01F6/625
    • A new approach is conceived for the development of sustainable biomaterials comprising nanocrystalline cellulose (NCC) and polylactic acid (PLA) nanocomposites. The invention deals with advancing a method based on in situ ring opening polymerization of L-lactide in the presence of NCC particles to form NCC-PLA supramolecular nanocomposite materials. This material is hydrophobic and compatible with a wide range of synthetic and natural polymers. NCC-PLA nanocomposites have enhanced functionality (e.g. gas barrier), rheological and mechanical performance, as well as dimensional stability (i.e. less hygroexpansivity) relative to PLA. They are made from entirely renewable resources, and are potentially biocompatible as well as recyclable. NCC-PLA supramolecular nanocomposites can be suspended in most organic solvents or dried to form a solid substance. They can be processed using conventional polymer processing techniques to develop 3-dimensional structures, or spun into fibers, yarns or filaments.
    • 构想了一种新的方法来开发包含纳米晶体纤维素(NCC)和聚乳酸(PLA)纳米复合材料的可持续生物材料。 本发明涉及在NCC颗粒存在的情况下推进基于L-丙交酯的原位开环聚合以形成NCC-PLA超分子纳米复合材料的方法。 该材料是疏水性的,与广泛的合成和天然聚合物相容。 NCC-PLA纳米复合材料具有增强的功能(例如阻气性),流变性和机械性能,以及相对于PLA的尺寸稳定性(即较低的湿膨胀性)。 它们由完全可再生资源制成,具有潜在的生物兼容性和可回收利用。 NCC-PLA超分子纳米复合材料可以悬浮在大多数有机溶剂中或干燥形成固体物质。 它们可以使用常规的聚合物加工技术来加工,以开发三维结构,或者纺成纤维,纱线或细丝。