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11. 发明授权

US07419986B2 Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans 失效
标题翻译：杂环稠合苯并二恶烷的抗抑郁药氮杂环甲基衍生物
公开(公告)号：US07419986B2
公开(公告)日：2008-09-02
申请号：US11513700
申请日：2006-08-31
申请人： Dahui Zhou , Gary Paul Stack
发明人： Dahui Zhou , Gary Paul Stack
IPC分类号： A61K31/44 , A61K31/445 , A61K31/40 , A61K31/405 , A61K31/335 , A61K31/35 , C07D261/20 , C07D411/00 , C07D405/00 , C07D409/00 , C07D205/00 , C07D333/52 , C07D319/14 , C07D307/78
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译：式的化合物可用于治疗抑郁症（包括但不限于严重抑郁障碍，儿童抑郁症和心境恶化），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为经前期综合征）注意力缺陷障碍（伴有或不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。

12. 发明申请

US20080167348A1 NOVEL SULFONAMIDE DERIVATIVES 失效
标题翻译：新型磺酰胺衍生物
公开(公告)号：US20080167348A1
公开(公告)日：2008-07-10
申请号：US11970628
申请日：2008-01-08
申请人： David Banner , Harald Mauser , Rudolf E. Minder , Hans P. Wessel
发明人： David Banner , Harald Mauser , Rudolf E. Minder , Hans P. Wessel
IPC分类号： A61K31/4427 , C07D333/52 , C07D409/02 , A61K31/38
CPC分类号： C07D333/62 , C07D213/42 , C07D401/12 , C07D403/12 , C07D409/12
摘要： The invention is concerned with the novel sulfonamide derivatives of formula (I) wherein A, R1 to R2″, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit chymase and can be used as medicaments.
摘要翻译：本发明涉及式（I）的新型磺酰胺衍生物，其中A，R 1至R 2“，X和Y如说明书中所定义，权利要求书及其生理上可接受的盐。这些化合物抑制胃促胰酶，可用作药物。

13. 发明授权

US07335666B2 Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans 失效
标题翻译：杂环稠合苯并二恶烷的抗抑郁药氮杂环甲基衍生物
公开(公告)号：US07335666B2
公开(公告)日：2008-02-26
申请号：US11513705
申请日：2006-08-31
申请人： Dahui Zhou , Gary Paul Stack
发明人： Dahui Zhou , Gary Paul Stack
IPC分类号： A61K31/44 , A61K31/445 , A61K31/40 , A61K31/405 , A61K31/335 , A61K31/35 , C07D261/20 , C07D411/00 , C07D405/00 , C07D409/00 , C07D205/00 , C07D333/52 , C07D319/14 , C07D307/78
CPC分类号： C07D491/04
摘要： Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa and bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.
摘要翻译：式的化合物可用于治疗抑郁症（包括但不限于严重抑郁症，儿童抑郁症和抑郁症），焦虑症，惊恐障碍，创伤后应激障碍，经前期焦虑障碍（也称为月经前综合征），注意力缺陷障碍（伴有和不伴有多动症），强迫症，社会焦虑症，广泛性焦虑症，肥胖症，进食障碍如神经性厌食症和神经性贪食症，血管舒缩性潮红，可卡因和酒精成瘾，性功能障碍及相关疾病。

14. 发明申请

US20070260025A1 Organometallic Transition Metal Compound, Biscyclopentadienyl Ligand System, Catalyst System and Process for Preparing Polyolefins 失效
公开(公告)号：US20070260025A1
公开(公告)日：2007-11-08
申请号：US10578059
申请日：2004-11-02
申请人： Michael Elder , Robert Jones , John Ewen
发明人： Michael Elder , Robert Jones , John Ewen
IPC分类号： B01J31/16 , C07D209/56 , C07D307/93 , C07D311/00 , C07D333/00 , C07D333/52 , C07D345/00 , C07F11/00 , C07F17/00 , C07F7/00 , C07F7/02 , C07F9/02 , C07F9/28 , C07F9/74 , C07F9/90 , C08F4/42
CPC分类号： C07D333/54 , C07F7/0814 , C08F4/65912 , C08F10/00 , C08F110/02 , C08F110/06 , C08F210/06 , C08F4/65927 , C08F2500/17 , C08F2500/15 , C08F2500/03 , C08F210/16
摘要： The present invention relates to organometallic transition metal compounds of the formula (I) M1 is a metal of group 3, 4, 5 or 6 of the Periodic Table of the Elements or the lanthanicles, X are identical or different and are each an organic or inorganic radical, where two radicals X can also be joined to one another, n is a natural number from 1 to 4, T1, T2 are identical or different and are each a divalent group selected from the group consisting of —O—, —S—, —Se—, —Te—, —N(R13)_′—P(R13)—, —As(R13)—, Sb(R13)—, —Si(R13)2-, —C(R13 R14)—C(R13 R15)— and —C(R14)═C(R15)—, where R13, R14 and R15 are identical or different and are each hydrogen or an organic radical having from 1 to 40 carbon atoms, R1, R7 are identical or different and are each hydrogen or an organic radical having from 1 to 40 carbon atoms, R2 R8 are identical or different and are each hydrogen or an organic radical having from 1 to 40 carbon atoms, R3 R9 are identical or different and are each halogen or an organic radical having from 1 to 40 carbon atoms, where R3 is not methyl when T1 is —C(H)═C(H)—, R4, R5 R6, R10, R11 and R12 are identical or different and are each hydrogen, halogen or an organic radical having from 1 to 40 carbon atoms, or two adjacent radicals R4 , R5, R6, R10, R11 and R12 together with the atoms connecting them form a monocyclic or polycyclic, substituted or unsubstituted ring system which has from 1 to 40 carbon atoms and may also contain heteroatoms selected from the group consisting of the elements O, S, Se, Te, N, P, As, Sb and Si, or, if T1 or T2 is —O—, —S—, —Se— or —Te—, the radical R3 together with R4 and/or the radical R9 together with R10 forms a monocyclic or polycyclic, substituted or unsubstituted ring system which has from 1 to 40 carbon atoms and may also contain heteroatoms selected from the group consisting of the elements O, S, Se, Te, N, P, As, Sb and Si, and A is a bridge consisting of a divalent atom or a divalent group, biscyclopentadienyl ligand systems having such a substitution pattern, catalyst systems comprising at least one of the organometallic transition metal compounds of the present invention, a process for preparing polyolefins by polymerization or copolymerization of at least one olefin in the presence of one of the catalyst systems of the present invention and the polyolefins obtainable in this way, the use of the biscyclopentaclienyl ligand systems of the present invention for preparing organometallic transition metal compounds and a process for preparing organometallic transition metal compounds using the biscyclopentaclienyl ligand systems.

15. 发明申请

US20050233389A1 Methods and compositions for peptide and protein labeling 审中-公开
标题翻译：用于肽和蛋白质标记的方法和组合物
公开(公告)号：US20050233389A1
公开(公告)日：2005-10-20
申请号：US11040833
申请日：2005-01-20
申请人： Alice Ting , Irwin Chen
发明人： Alice Ting , Irwin Chen
IPC分类号： C12N9/00 , G01N33/58 , G01N33/53 , C07D333/52 , C07D409/02
CPC分类号： G01N33/582 , C12N9/93 , G01N2333/9015
摘要： The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ biotin ligase and biotin analogs.
摘要翻译：本发明提供了用于在体外或体内标记肽和蛋白质的组合物及其使用方法。本文描述的方法使用生物素连接酶和生物素类似物。

16. 发明申请

US20050228185A1 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists 有权
标题翻译： 10-羟基-11-二氢前列腺素类似物作为选择性EP4激动剂
公开(公告)号：US20050228185A1
公开(公告)日：2005-10-13
申请号：US10821705
申请日：2004-04-09
申请人： Yariv Donde
发明人： Yariv Donde
IPC分类号： C07D333/60 , C07D333/62 , A61K31/558 , C07D333/52 , C07F9/28 , C07D49/02
CPC分类号： C07D333/62
摘要： A compound comprising or a pharmaceutically acceptable salt or a prodrug thereof, wherein the dashed line represents the presence or absence of a double bond; J is C═O or CHOH; A is —(CH2)6—, or cis —CH2CH═CH—(CH2)3—, wherein 1 or 2 carbons may be substituted with S or O; B is CO2H, or CO2R, CONR2, CONHCH2CH2OH, CON(CH2CH2OH)2, CH2OR, P(O)(OR)2, CONRSO2R, SONR2, or R is H, C1-6 alkyl; D is —(CH2)n—, —X(CH2)n, or —(CH2)nX—, wherein n is from 0 to 3 and X is S or O; and E is an aromatic or heteroaromatic moiety having from 0 to 4 substituents, said substituents each comprising from 1 to 6 non-hydrogen atoms is disclosed herein. Methods, compositions, and medicaments related thereto, as well as experimental results showing prostaglandin EP4 selective agonist activity for certain compounds disclosed herein, are also disclosed.
摘要翻译：包含或其药学上可接受的盐或其前药的化合物，其中虚线表示双键的存在或不存在; J为C-O或CHOH; A是 - （CH 2 CH 2）6 - 或顺式-CH 2 CH-CH-（CH 2 CH 2））3，其中1或2个碳可以被S或O取代; B是CO 2 H，或CO 2 R，CONR 2，CONHCH 2 CH 2， OH，CON（CH 2 CH 2 OH）2，CH 2或OR，P（O ）（OR）2，CONRSO 2 R，SONR 2，或R为H，C 1-6烷基，烷基; D是 - （CH 2）n - ， - （CH 2 CH 2）n - 或 - （CH X - ，其中n为0至3，X为S或O; 并且E是具有0至4个取代基的芳族或杂芳族部分，所述取代基各自包含1至6个非氢原子。还公开了与其相关的方法，组合物和药物，以及显示本文公开的某些化合物的前列腺素EP4选择性激动剂活性的实验结果。

17. 发明申请

US20040127723A1 Process for preparing heterocyclic indene analogs 失效
标题翻译：制备杂环茚类似物的方法
公开(公告)号：US20040127723A1
公开(公告)日：2004-07-01
申请号：US10763296
申请日：2004-01-22
发明人： Michelangelo Scalone , Thomas Albert Zeibig
IPC分类号： C07D333/52 , C07D307/87
CPC分类号： C07D405/12 , C07D209/12 , C07D209/88
摘要： A process for the preparation heterocyclic indene analogs, especially with the preparation of 4-hydroxycarbazole or N-protected 4-hydroxycarbazole, involves cyclocarbonylation followed by saponification. This process avoids high temperatures and high catalyst loadings.
摘要翻译：制备杂环茚类似物的方法，特别是制备4-羟基咔唑或N-保护的4-羟基咔唑的方法涉及环化羰基化，随后皂化。该过程避免了高温和高催化剂负载。

18. 发明申请

US20020173663A1 Aryloxyacetic acids for diabetes and lipid disorders 失效
标题翻译：糖尿病和脂质障碍的芳氧基乙酸
公开(公告)号：US20020173663A1
公开(公告)日：2002-11-21
申请号：US09932834
申请日：2001-08-17
发明人： Kun Liu , Libo Xu , A. Brian Jones
IPC分类号： C07D333/52 , C07D311/04 , C07D275/04 , C07D261/20 , C07D231/56 , C07D29/04
CPC分类号： C07D261/20 , A61K31/00 , A61K45/06
摘要： A class of aryloxyacetic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.
摘要翻译：一类芳氧基乙酸包括作为PPARα和/或γ的有效激动剂的化合物，因此可用于治疗，控制或预防非胰岛素依赖性糖尿病（NIDDM），高血糖症，血脂异常，高脂血症，高胆固醇血症，高甘油三酯血症，动脉粥样硬化，肥胖症，血管再狭窄，炎症和其它PPARα和/或γ介导的疾病，病症和病症。

19. 发明申请

US20020107280A1 NEW BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS 失效
标题翻译：新的苯并呋喃和苯并噻吩衍生物作为抗炎剂
公开(公告)号：US20020107280A1
公开(公告)日：2002-08-08
申请号：US10006349
申请日：2001-12-03
发明人： Kevin L. McLaren , David Bernard Smith , Jahari Laurant Tracy
IPC分类号： C07D339/02 , C07D333/52 , C07D333/72
CPC分类号： C07D307/84 , C07D333/70
摘要： This invention relates to compounds, which are generally anti-inflammatory and analgesic compounds, and which are represented by Formula I: 1 wherein A is a nullCH2null, nullC(O)null, nullOnull, nullSnull, nullS(O)null, or nullS(0)2null and the other substituents are as defined in the specification; or prodrugs, individual isomers, mixtures of isomers, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.
摘要翻译：本发明涉及通常为抗炎和镇痛化合物的化合物，其由式I表示：其中A是-CH 2 - ， - C（O） - ， - O - ， - S - ， - S（ O） - 或-S（O）2-，其它取代基如说明书中所定义; 或前药，各异构体，异构体的混合物及其药学上可接受的盐。本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。

20. 发明申请

US20020041976A1 Novel compounds and their manufacture and use 审中-公开
标题翻译：新型化合物及其制备和使用
公开(公告)号：US20020041976A1
公开(公告)日：2002-04-11
申请号：US09817778
申请日：2001-03-26
发明人： Sally Anderson , Michael Stuart Weaver
IPC分类号： H05B033/00 , C07D333/52 , C07D29/04 , C07D37/78 , C08G061/00
CPC分类号： C08G61/02 , A61K38/00 , C08G61/12
摘要： Benzofuran, benzothiophene or indole oligomers, co-oligomers, polymers and copolymers, methods for their production, and their use in charge transport and light emission regions of electroluminescent devices are described.
摘要翻译：描述了苯并呋喃，苯并噻吩或吲哚低聚物，共低聚物，聚合物和共聚物，其制备方法及其在电致发光器件的电荷传输和发光区域中的应用。

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