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11. 发明授权

US06625490B1 System and method of automatically adjusting sensing parameters based on temporal measurement of cardiac events 有权
标题翻译：基于心脏事件的时间测量自动调整感应参数的系统和方法
公开(公告)号：US06625490B1
公开(公告)日：2003-09-23
申请号：US09992739
申请日：2001-11-14
申请人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
发明人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/3704
摘要： A system and method for automatically adjusting the sensing parameters in an implantable cardiac stimulation device is described. The adjustment is based on the amplitudes and the onsets and ends of cardiac events, such as R-waves, T-waves, far-field R-waves, and/or far-field T-waves. Having determined the onset and termination of the cardiac events for a given number of cardiac cycles, particular variables that characterize these cardiac events can be averaged and stored in memory. Such variables include the peak amplitudes sampled during a cardiac event, the duration of the cardiac event, and the duration between cardiac events. Based on the averaged variables, the system automatically adjusts the sensing parameters, such as sensitivity, and blanking and refractory periods.
摘要翻译：描述了一种用于在可植入心脏刺激装置中自动调节感测参数的系统和方法。该调整基于心脏事件的振幅和开始和结束，例如R波，T波，远场R波和/或远场T波。在确定给定数量的心动周期的心脏事件的发作和终止之后，可以将表征这些心脏事件的特定变量平均并存储在存储器中。这些变量包括在心脏事件期间采集的峰值振幅，心脏事件的持续时间以及心脏事件之间的持续时间。基于平均变量，系统自动调整感应参数，如灵敏度，消隐和不应期。

12. 发明授权

US06618622B1 Method and apparatus of determining atrial capture threshold while avoiding pacemaker mediated tachycardia 失效
标题翻译：确定心房捕获阈值同时避免起搏器介导的心动过速的方法和装置
公开(公告)号：US06618622B1
公开(公告)日：2003-09-09
申请号：US09851715
申请日：2001-05-08
申请人： Brian M. Mann , Melinda Endaya , Paul A. Levine
发明人： Brian M. Mann , Melinda Endaya , Paul A. Levine
IPC分类号： A61N1362
CPC分类号： A61N1/3712 , A61N1/3714 , A61N1/37247
摘要： A pacemaker programmer and diagnostic system retrieves information stored within a pacemaker and analyzes the retrieved data in real time. The stored information can be retrieved by means of a telemetry communication link. The pacemaker automatically lengthens an AV delay. The pacemaker determines atrial capture by generating atrial stimulation pulses while maintaining the ventricular stimulation pulse amplitude at a level known to ensure ventricular capture, and by detecting loss of atrial capture. In response to the loss of atrial capture, a processor automatically records the atrial capture threshold, and restores the AV delay to its pre-test value. The pulse generator also delivers a backup atrial stimulation pulse concurrent with a ventricular stimulation pulse to reduce the possibility of a retrograde P-wave initiating a pacemaker-mediated tachycardia (PMT).
摘要翻译：起搏器程序员和诊断系统检索存储在起搏器内的信息，并实时分析检索到的数据。所存储的信息可以通过遥测通信链路来检索。起搏器自动延长AV延迟。起搏器通过产生心房刺激脉冲来确定心房捕获，同时将心室刺激脉冲幅度保持在已知的水平以确保心室捕获，并通过检测心房捕获的损失。响应于心房捕获的丢失，处理器自动记录心房捕获阈值，并将AV延迟恢复到其测试前值。脉冲发生器还提供与心室刺激脉冲同时的备用心房刺激脉冲，以减少起搏器介导的心动过速（PMT）的逆行P波的可能性。

13. 发明授权

US06591136B2 Automatic shock lead gain adjuster 有权
公开(公告)号：US06591136B2
公开(公告)日：2003-07-08
申请号：US09901319
申请日：2001-07-09
申请人： Jason W. Eberle , LeAnne Marie Mackey
发明人： Jason W. Eberle , LeAnne Marie Mackey
IPC分类号： A61N1362
CPC分类号： A61N1/372 , A61N1/3704 , Y10S128/902
摘要： A system and method for automatically adjusting the gain for a shock lead system in an implantable medical device is provided. The system and method operate when, after a pre-selected period of time, the gain has not been programmed. The system and method then automatically produce and set the gain for the shock lead system. The system and method poll and determine a maximum value for the output of the shock lead system amplifier and produce a new gain value to scale the output to facilitate providing useful data that is large enough to separate signal from noise but small enough to avoid clipping.

14. 发明授权

US06587722B2 Device for determining the effectiveness of stimulation in an electrical heart stimulator 有权
公开(公告)号：US06587722B2
公开(公告)日：2003-07-01
申请号：US09836841
申请日：2001-04-17
申请人： Luca Vitali , Luigi Silvestri
发明人： Luca Vitali , Luigi Silvestri
IPC分类号： A61N1362
CPC分类号： A61N1/371
摘要： A device for determining the effectiveness of the electrical stimulation of heart muscle from a signal having a post-potential component and, with effective stimulation, a superimposed evoked response component. The device includes a differential stage with a first input for application of the signal and a second input for application of a feedback signal. The differential stage generates a corresponding output signal whose level is determined by the levels of the signals present at the first and said second inputs. A comparator stage has feedback units able to act on the second input in a follower relationship with respect to the signal present at the first input avoiding saturation of the differential stage. The feedback units generate at least one compensation signal indicating the variation in the signal present at the first input over time. The compensation signal is indicative of the evoked response superimposed on the post-potential component.

15. 发明授权

US06561969B2 Method of reducing the volume of the heart 有权
标题翻译：减少心脏体积的方法
公开(公告)号：US06561969B2
公开(公告)日：2003-05-13
申请号：US09825647
申请日：2001-04-04
申请人： Andrew G. C. Frazier , Erik J. van der Burg , Michael D. Lesh
发明人： Andrew G. C. Frazier , Erik J. van der Burg , Michael D. Lesh
IPC分类号： A61N1362
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
摘要： Disclosed is a closure catheter, and methods for reducing the volume of a body cavity such as a vessel, or a portion of the heart. The closure catheter includes a plurality of deployable tissue anchors, which may be laterally deployed into surrounding tissue. The anchors may thereafter be used to draw the tissue radially inwardly, to reduce the volume of the body cavity. Methods are also disclosed.
摘要翻译：公开了一种闭合导管，以及用于减小诸如血管或心脏部分的体腔体积的方法。闭合导管包括多个可展开的组织锚，其可以横向地展开到周围的组织中。然后可以使用锚定件径向向内拉伸组织，以减小体腔的体积。还公开了方法。

16. 发明授权

US06512954B2 Implantable device and programmer system which permits multiple programmers 有权
公开(公告)号：US06512954B2
公开(公告)日：2003-01-28
申请号：US09981972
申请日：2001-10-16
申请人： James K. Fox , William B. Rottenberg , Bryan J. Thome
发明人： James K. Fox , William B. Rottenberg , Bryan J. Thome
IPC分类号： A61N1362
CPC分类号： A61N1/37252 , A61N1/37 , G06F19/00
摘要： A multiprogrammer system for monitoring and optimizing implantable device performance. In one embodiment, the system includes at least two programming devices and an implantable device. Each of the programming devices may be used to perform inquiry and programming operations on the implantable device. In an inquiry operation, the programming device retrieves some or all of the configuration parameters from the implantable device. In a programming operation, the programming device provides one or more modified parameters to the implantable device. As part of the programming operation, the programming device is configured to verify that it is aware of the implantable device's current parameters before sending the modified parameters. In other words, the current programming device verifies that the implantable device's parameters have not been altered by another programming device since the current programming device's last interaction with the implantable device. If the parameters have been altered, the current programming device aborts the programming operation and notifies the operator. In alternate embodiments, the verification may be performed by the implantable device, i.e. the implantable device may verify that the programming device is aware of the current device parameters before the implantable device accepts the modified parameters.

17. 发明授权

US06477420B1 Control of pacing rate in mode switching implantable medical devices 失效
标题翻译：模式切换植入式医疗设备中起搏速率的控制
公开(公告)号：US06477420B1
公开(公告)日：2002-11-05
申请号：US09842879
申请日：2001-04-27
申请人： Chester L. Struble , David Dunham
发明人： Chester L. Struble , David Dunham
IPC分类号： A61N1362
CPC分类号： A61N1/36542 , A61N1/3622 , A61N1/3684
摘要： An implantable medical device and method of pacing provide for switching from a first pacing mode to second pacing mode upon detection of a period of accelerated atrial arrhythmia. Generally, the second pacing mode has an associated predetermined lower pacing rate. At least initially, upon switching from the first pacing mode to the second pacing mode, the predetermined lower pacing rate is adjusted to an elevated adjusted lower rate. Further, this elevated adjusted lower rate may then be decelerated towards a programmed basic pacing rate during a deceleration period. Generally, the programmed basic pacing rate is elevated relative to the predetermined lower pacing rate.
摘要翻译：可植入医疗装置和起搏方法在检测到加速的心房心律失常的时段时提供从第一起搏模式切换到第二起搏模式。通常，第二起搏模式具有相关联的预定的起搏速率。至少最初，在从第一起搏模式切换到第二起搏模式时，将预定的较小的起搏速率调整到升高的调节的较低速率。此外，该升高的调整后的较低速率然后可以在减速期间向编程的基本起搏速率减速。通常，编程的基本起搏速率相对于预定的较低起搏速率升高。

18. 发明授权

US06473645B1 System and method for programmably controlling electrode activation sequence in a multi-site cardiac stimulation device 有权
标题翻译：用于可编程地控制多位点心脏刺激装置中的电极激活序列的系统和方法
公开(公告)号：US06473645B1
公开(公告)日：2002-10-29
申请号：US09904056
申请日：2001-07-11
申请人： Paul A. Levine
发明人： Paul A. Levine
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3918
摘要： An implant able multi-chamber cardiac stimulation device includes flexibly programmable electrode sensing configurations, and is capable of precisely controlling the stimulation sequence between multiple sites. The stimulation device provides a plurality of connection ports that allow independent connection of each electrical lead associated with a particular stimulation site in the heart. Each connection port further provides a unique terminal for making electrical contact with only one electrode such that no two electrodes are required to be electrically coupled. Furthermore, each electrode, whether residing on a unipolar, bipolar or multipolar lead, may be selectively connected or disconnected through programmable switching circuitry that determines the electrode configurations to be used for sensing and for stimulating at each stimulation site. The stimulation device possesses unique sensing and output configurations associated with each stimulation site, such that depolarizations occurring at each stimulation site can be detected independently of events occurring at other sites within the heart, and such that each site can be stimulated independently of other sites or on a precisely timed basis triggered by events occurring at other sites. The stimulation device is further capable of uniquely programming coupling intervals for precisely controlling the activation sequence of stimulated sites. Coupling intervals are selected so as to provide optimal hemodynamic benefit to the patient.
摘要翻译：可植入式多室心脏刺激装置包括灵活的可编程电极感测配置，并且能够精确地控制多个部位之间的刺激序列。刺激装置提供多个连接端口，其允许与心脏中的特定刺激部位相关联的每个电引线的独立连接。每个连接端口还提供用于仅与一个电极进行电接触的唯一端子，使得不需要两个电极电耦合。此外，无论是驻留在单极双极还是多极引线上的每个电极可以通过确定用于感测和用于在每个刺激部位刺激的电极配置的可编程开关电路来选择性地连接或断开。刺激装置具有与每个刺激部位相关联的独特的感测和输出配置，使得可以独立于在心脏内的其他部位发生的事件独立地检测在每个刺激部位发生的去极化，并且使得可以独立于其它部位刺激每个部位，在其他站点发生的事件触发的精确定时的基础上。刺激装置还能够独特地编程耦合间隔，以精确控制受激部位的激活序列。选择偶联间隔以便为患者提供最佳的血液动力学益处。

19. 发明授权

US06456878B1 Cardiac pacing system delivering multi-site pacing in a predetermined sequence triggered by a sense event 有权
标题翻译：心律起搏系统以感测事件触发的预定顺序提供多位置起搏
公开(公告)号：US06456878B1
公开(公告)日：2002-09-24
申请号：US09439569
申请日：1999-11-12
申请人： Charles G. Yerich , Karen J. Kleckner , Carleen J. Juran
发明人： Charles G. Yerich , Karen J. Kleckner , Carleen J. Juran
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/368 , A61N1/3684
摘要： A system for pacing in a right and its corresponding left heart chamber provides a predetermined or programmable triggered delay in a predetermined or programmable, right-to-left or left-to right sequence without first determining from which of the two chambers a triggering event originated. Devices that provide cardio defibrillation today often have pacemakers for delivering adjunct therapies, and such devices can also use the invention.
摘要翻译：用于在右侧和其相应的左心室中进行起搏的系统在预定或可编程的从右到左或从左到右的序列中提供预定的或可编程的触发延迟，而不首先确定两个腔室中的哪一个起始于触发事件。今天提供心脏除颤的装置通常具有用于递送辅助治疗的起搏器，并且这种装置也可以使用本发明。

20. 发明授权

US06453201B1 Implantable medical device with voice responding and recording capacity 有权
公开(公告)号：US06453201B1
公开(公告)日：2002-09-17
申请号：US09473466
申请日：1999-12-28
申请人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
发明人： Douglas R. Daum , Qingsheng Zhu , Bruce H. KenKnight
IPC分类号： A61N1362
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.

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