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11. 发明授权

US06643546B2 Multi-electrode apparatus and method for treatment of congestive heart failure 失效
公开(公告)号：US06643546B2
公开(公告)日：2003-11-04
申请号：US10075808
申请日：2002-02-13
申请人： Scott Mathis , John K. Prentice , John A. Schmidt , William B. Rottenberg
发明人： Scott Mathis , John K. Prentice , John A. Schmidt , William B. Rottenberg
IPC分类号： A61N118
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/3684 , A61N1/3686
摘要： An apparatus and method for treatment of congestive heart failure from the right side of the heart. An implantable cardiac stimulation system with a multi-electrode lead having three or more selectable electrodes, together with apparatus for identifying an optimal subset of electrodes, apparatus for shaping a propagating wave front, and apparatus for modifying the intrinsic ventricular cardiac activation sequence, or generating simultaneous or near simultaneous pacing pulses to the septum or right ventricular outflow tract during ventricular systole in order to improve left ventricular cardiac efficiency and reduce mitral regurgitation in patients with dilated cardiomyopathy. A three dimensional map of electrode placement may be calculated. A sub set of the available electrodes in the right side of the heart is selected for stimulation such that septal motion during systole is reduced or the mitral valve area is stiffened to reduce mitral regurgitation.

12. 发明授权

US06636765B2 Method and apparatus for timing events within an implantable medical device 失效
公开(公告)号：US06636765B2
公开(公告)日：2003-10-21
申请号：US09777649
申请日：2001-02-06
申请人： Jorge N. Amely-Velez
发明人： Jorge N. Amely-Velez
IPC分类号： A61N118
CPC分类号： A61N1/362 , A61N1/3956
摘要： A technique is described for timing hardware or software events for use in an implantable medical device capable of performing many concurrent processes. The technique exploits a first timer for timing events using a timing interval of one millisecond and a second timer or clock signal for timing events using a timing interval of two seconds. A receive unit receives timer requests from the many concurrent processes with each timer request specifying a time delay before an interrupt or other timer completion signal is required. A control unit uses either the first timer or the second timer to time the request based upon the time delay and the respective timing intervals. An interrupt or other timer completion signal is issued to the requesting device following the specified time delay as timed by the selected timer. For the purposes of prioritizing two or more timer requests to be timed by the same timer, the device also exploits the concept of a pseudo clock for tracking time up to a maximum pre-determined period of time of, for example, 65 seconds.

13. 发明授权

US06611716B2 Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system 有权
公开(公告)号：US06611716B2
公开(公告)日：2003-08-26
申请号：US09824519
申请日：2001-04-02
申请人： Vincent Chow , Alan Y. Chow
发明人： Vincent Chow , Alan Y. Chow
IPC分类号： A61N118
CPC分类号： A61N1/0543 , A61F9/08 , A61N1/05 , A61N1/36046
摘要： An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. The flattened cubic shape of the MMRI-4 will allow one or the other of the two flattened sides to be preferentially directed toward incident light when implanted in the subretinal space. Because both the PiN and NiP configurations are present on each of the flattened sides of the MMRI-4, electric currents which produce the sensation of light from a PiN current, or darkness from a NiP current, can be induced regardless of which the flattened photoactive sides faces incident light. Filter layers disposed on the PiN configuration will allow visible light to induce a PiN current, and filter layers disposed on the NiP configuration will allow infrared light to induce a NiP current. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the MMRI-4s, the nature of induced retinal images may be modulated and improved. An Adaptive Imaging Retinal Stimulation System (AIRES), with a Projection and Tracking Optical System (PTOS), which may be worn as a headset is used for this purpose, and is also disclosed. Color images may even be induced by programming the stimulating pulse durations and frequencies of the AIRES system. By creating both PiN and NiP currents, in close spatial positions and temporal sequences, electrolysis damage to cellular tissue from prolonged unidirectional electric currents is reduced. MMRI-4s may also be embedded in a flexible, biologically compatible sheet, with its electrodes exposed on both surfaces of the sheet. This sheet is then implanted on the nerve fiber layer surface of the retina, where electrical stimulation can also induce a form of artificial vision.

14. 发明授权

US06606519B2 Microcurrent therapy device components stack and conductive pad 失效
标题翻译：微电流疗法器件组件和导电垫
公开(公告)号：US06606519B2
公开(公告)日：2003-08-12
申请号：US09847227
申请日：2001-05-02
申请人： Francis R. Powell
发明人： Francis R. Powell
IPC分类号： A61N118
CPC分类号： A61N1/205 , A61N1/0408 , A61N1/0456 , A61N1/0492 , A61N1/18 , A61N1/20 , H05K3/325
摘要： A microcurrent therapy device (MCTD) for use in applying a DC current of less than one milliampere between two conductive pads through the tissue of a therapy recipient has an electronic stack that can be placed in electrical connection with the user's skin and thus in electrical connection with the other skin contact plate, a profile minimizing system using an off the shelf “coin ” battery within the electronic stack, and a battery clip used in conjunction with a coin battery and the circuit board of the MCTD.
摘要翻译：用于通过治疗接受者的组织在两个导电垫之间施加小于1毫安的直流电流的微电流治疗装置（MCTD）具有电子堆叠，其可以放置成与使用者的皮肤电连接并因此与电连接与另一个皮肤接触板，使用电子堆栈内的现成“硬币”电池的轮廓最小化系统，以及与硬币电池和MCTD的电路板结合使用的电池夹。

15. 发明授权

US06587726B2 Stimulatory device and methods to electrically stimulate the phrenic nerve 有权
标题翻译：治疗患有休克的患者的方法
公开(公告)号：US06587726B2
公开(公告)日：2003-07-01
申请号：US10158528
申请日：2002-05-29
申请人： Keith G. Lurie , Todd M. Zielinski , Wolfgang Voelckel , Robert Patterson , Nemer Samniah , Scott McKnite , Karl Lindner
发明人： Keith G. Lurie , Todd M. Zielinski , Wolfgang Voelckel , Robert Patterson , Nemer Samniah , Scott McKnite , Karl Lindner
IPC分类号： A61N118
CPC分类号： A61H31/00 , A61H31/005 , A61H31/006 , A61H31/007 , A61H2031/002 , A61H2201/165 , A61H2201/5007 , A61H2201/5043 , A61H2201/5048 , A61H2201/5061 , A61M16/0084 , A61M16/04 , A61M16/0434 , A61M16/06 , A61M16/0683 , A61M16/205 , A61M16/209 , A61M2016/0027 , A61M2230/08 , A61M2230/205 , A61M2230/50 , A61N1/0456 , A61N1/046 , A61N1/3601 , A61N1/36014 , A61N1/39 , A61N2/002
摘要： The invention provides exemplary devices and methods electrically stimulating the phrenic nerve. In one embodiment, electrodes are placed posterior and anterior in the region of the cervical vertebrae. Electrical current having a multi-phasic waveform is periodically applied to the electrodes to stimulate the phrenic nerve, thereby causing the diaphragm to contract.
摘要翻译：本发明提供了电刺激膈神经的示例性装置和方法。在一个实施例中，电极在颈椎的区域中的后部和前部放置。周期性地向电极施加具有多相波形的电流以刺激膈神经，从而使隔膜收缩。

16. 发明授权

US06516226B1 Percutaneous electrical therapy system for minimizing electrode insertion discomfort 失效
标题翻译：用于尽量减少电极插入不适的经皮电疗系统
公开(公告)号：US06516226B1
公开(公告)日：2003-02-04
申请号：US09452510
申请日：1999-12-01
申请人： Jon M. Bishay , Paul Leonard
发明人： Jon M. Bishay , Paul Leonard
IPC分类号： A61N118
CPC分类号： A61N1/0551 , A61N1/36017 , A61N1/36021 , A61N1/375 , Y10S128/907
摘要： In a preferred embodiment, a percutaneous electrical therapy system includes a control unit; an electrode electrically connected to the control unit to deliver electrical therapy to a patient, the electrode comprising a sharp point at a distal end adapted to be inserted into a patient's tissue at an electrode insertion point; and an electrode insertion pain reducer adapted to reduce pain experienced by the patient during insertion of the electrode into the patient's tissue. Both the electrode and electrode insertion pain reducer may be located apart from the control unit.
摘要翻译：在优选实施例中，经皮电疗系统包括控制单元; 电连接到所述控制单元以将电疗法递送到患者的电极，所述电极包括在远端处的尖锐点，其适于在电极插入点处插入患者组织中; 以及电极插入式疼痛减轻器，其适于减少将电极插入患者组织期间患者经历的疼痛。电极和电极插入疼痛减少器都可以与控制单元分开。

17. 发明授权

US06510344B1 Procedure alarm silence feature for medical telemetry system 有权
标题翻译：医疗遥测系统的程序报警静音功能
公开(公告)号：US06510344B1
公开(公告)日：2003-01-21
申请号：US09533317
申请日：2000-03-22
申请人： Arieh S. Halpern
发明人： Arieh S. Halpern
IPC分类号： A61N118
CPC分类号： A61B5/0002 , A61B5/0452
摘要： A medical telemetry system includes a procedure alarm silence feature that enables a clinician to remotely disable a monitoring station alarm in order to perform a patient procedure that might cause inadvertent false alarms. To disable the alarm for a preprogrammed time interval, the clinician presses keys on the telemetry unit according to a predefined key sequence that is selected so as to reduce a likelihood of accidental alarm disablement. The monitoring system responds to the predefined sequence by disabling an audible alarm for all alarm conditions except class 1 arrhythmias. A corresponding visual alarm at the monitoring station is maintained active. While the alarm is disabled, the monitoring station displays an indication of the amount of time until expiration of the preprogrammed time interval.
摘要翻译：医疗遥测系统包括程序警报静音功能，使临床医生能够远程禁用监视站警报，以执行可能导致意外的错误警报的病人过程。为了在预编程的时间间隔内禁用报警，临床医生按照所选择的预定义的键序列按遥测单元上的键，以减少意外报警禁用的可能性。监控系统通过对除1类心律失常之外的所有警报条件禁用声音报警来响应预定义的顺序。监控站对应的视觉警报保持有效。当警报被禁用时，监控站会显示一段时间的指示，直到预编程的时间间隔到期。

18. 发明授权

US06505075B1 Peripheral nerve stimulation method 有权
标题翻译：外周神经刺激法
公开(公告)号：US06505075B1
公开(公告)日：2003-01-07
申请号：US09577258
申请日：2000-05-22
申请人： Richard L. Weiner
发明人： Richard L. Weiner
IPC分类号： A61N118
CPC分类号： A61N1/0551 , A61N1/0504 , A61N1/0526 , A61N1/36071 , A61N1/40
摘要： A method for treating pain by subcutaneous electrical stimulation of a peripheral nerve is disclosed. A lead is placed subcutaneously over a peripheral nerve that is causing pain. The peripheral nerve is electrically stimulated to cause paresthesia. The method encompasses subcutaneous placement of an electrical lead near any peripheral nerve causing pain and subsequent electrical stimulation of the nerve to cause paresthesia. In particular, a method for treating intractable occipital neuralgia using percutaneous peripheral nerve electrostimulation techniques is disclosed.
摘要翻译：公开了一种通过皮下电刺激周围神经来治疗疼痛的方法。铅被皮下放置在引起疼痛的周围神经上。电刺激周围神经造成感觉异常。该方法包括在任何周围神经附近皮下放置电引线，引起疼痛和随后的电刺激神经以引起感觉异常。特别地，公开了使用经皮周围神经电刺激技术治疗难治性枕骨神经痛的方法。

19. 发明授权

US06487449B1 Method and apparatus for reducing noise and detecting electrode faults in medical equipment 有权
标题翻译：降低医疗设备噪声和检测电极故障的方法和装置
公开(公告)号：US06487449B1
公开(公告)日：2002-11-26
申请号：US09576304
申请日：2000-05-23
申请人： Wilhelm J. Kaiser , Horst Weber , Wolfgang Winter
发明人： Wilhelm J. Kaiser , Horst Weber , Wolfgang Winter
IPC分类号： A61N118
CPC分类号： A61B5/0424
摘要： A system and apparatus for detecting electrode faults in a physiological activity acquisition system or device. The system includes at least one signal sensing electrode attached to the subject and a signal processor coupled to the at least one signal sensing electrode. The signal sensing electrode senses a combined signal from the subject. The combined signal has an activity portion and a carrier portion. The signal processor receives the combined signal from the electrode. The signal processor processes the combined signal and generates a noise-redeuced ECG and an electrode fault signal, if an electrode fault exists.
摘要翻译：一种用于检测生理活动获取系统或装置中的电极故障的系统和装置。该系统包括附接到对象的至少一个信号感测电极和耦合到该至少一个信号感测电极的信号处理器。信号感测电极感测来自被摄体的组合信号。组合信号具有活动部分和载体部分。信号处理器接收来自电极的组合信号。如果存在电极故障，则信号处理器处理组合信号并产生噪声消除的ECG和电极故障信号。

20. 发明授权

US06459936B2 Methods for responsively treating neurological disorders 有权
标题翻译：反应性治疗神经系统疾病的方法
公开(公告)号：US06459936B2
公开(公告)日：2002-10-01
申请号：US09932175
申请日：2001-08-17
申请人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton
发明人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton
IPC分类号： A61N118
CPC分类号： A61N1/36135 , A61N1/36017 , A61N1/36025 , A61N1/36064 , A61N1/36067 , A61N1/36075 , A61N1/37252
摘要： Disclosed is a multiple electrode, closed-loop, responsive system for the treatment of certain neurological diseases such as epilepsy, migraine headaches and Parkinson's disease. Brain electrodes would be placed in close proximity to the brain or deep within brain tissue. When a neurological event such as the onset of an epileptic seizure occurs, EEG signals from the electrodes are processed by signal conditioning means in a control module that can be placed beneath the patient's scalp, within the patient's chest, or situated externally on the patient. Neurological event detection means in the control module will then cause a response to be generated for stopping the neurological event. The response could be an electrical signal to brain electrodes or to electrodes located remotely in the patient's body. The response could also be the release of medication or the application of a sensory input such as sound, light or mechanical vibration or electrical stimulation of the skin. The response to the neurological event can originate from devices either internal or external to the patient. The system also has the capability for multi-channel recording of EEG related signals that occur both before and after the detection of a neurological event. Programmability of many different operating parameters of the system by means of external equipment provides adaptability for treating patients who manifest different symptoms and who respond differently to the response generated by the system.
摘要翻译：公开了一种用于治疗某些神经系统疾病如癫痫，偏头痛和帕金森病的多重电极闭环应答系统。脑电极将放置在靠近脑部或脑组织深处。当出现诸如癫痫发作的神经系统事件时，来自电极的EEG信号由控制模块中的信号调节装置处理，该控制模块可以放置在患者的头皮之下，患者的胸部内，或者位于病人的外部。然后，控制模块中的神经事件检测装置将产生用于停止神经系统事件的响应。响应可以是对脑电极或位于病人身体远端的电极的电信号。该反应也可以是药物的释放或者诸如声音，光或机械振动或电刺激皮肤的感觉输入的应用。对神经系统事件的反应可以来自患者内部或外部的装置。该系统还具有在检测神经系统事件之前和之后发生的EEG相关信号的多通道记录的能力。通过外部设备对系统的许多不同操作参数的可编程性提供了适应性，用于治疗表现不同症状的患者，并且对系统产生的反应有不同的反应。

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