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11. 发明授权

US10105386B2 Compositions for the treatment of dry eye 有权
公开(公告)号：US10105386B2
公开(公告)日：2018-10-23
申请号：US14601781
申请日：2015-01-21
申请人： Allergan, Inc.
发明人： Joseph G. Vehige , Peter A. Simmons
IPC分类号： A61K31/717 , A61K9/00 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/38 , A61K31/205 , A61K33/22 , A61K36/47 , A61K31/047 , A61K31/34 , A61K31/745
摘要： The present invention relates to ophthalmic compositions and methods useful to treat dry eye, or to diagnose, cure, mitigate, treat, or prevent dry eye syndrome in man or other animals.

12. 发明申请

US20180264031A1 CHOLESTYRAMINE PELLETS AND METHODS FOR PREPARATION THEREOF 审中-公开
公开(公告)号：US20180264031A1
公开(公告)日：2018-09-20
申请号：US15988688
申请日：2018-05-24
申请人： Albireo AB
发明人： Per-Göran Gillberg , Nils Ove Gustafsson , Nils-Olof Lindberg , Jessica Elversson
IPC分类号： A61K31/745 , A61K9/20
CPC分类号： A61K31/745 , A61K9/1635 , A61K9/1652 , A61K9/2027 , A61K9/2054
摘要： The invention relates to small cholestyramine pellets that can be prepared by extrusion. The pellets have a high cholestyramine loading and are stable enough to be coated with one or more coating layers. The invention also relates to a process for the preparation of such pellets and to a multiparticulate drug delivery system comprising such pellets.

13. 发明授权

US09987362B2 Hydrogel formulation with mild adhesion 有权
公开(公告)号：US09987362B2
公开(公告)日：2018-06-05
申请号：US15147530
申请日：2016-05-05
申请人： ZOETIS SERVICES LLC
发明人： Christopher A. Zook , Michael T. Sweeney , Rebecca R. Quesnell , Fiona Patricia Clements , Claude-Raymond René , Bruktawit Asfaw , Sarah Barbara Kokotoff , Dominic Dominicovich Ugbedah
IPC分类号： A61K47/32 , A61K9/00 , A61K45/06 , A61K9/06 , A61K31/546 , A61K31/745
CPC分类号： A61K47/32 , A61K9/0017 , A61K9/06 , A61K31/546 , A61K31/745 , A61K45/06
摘要： The present disclosure relates to methods, compositions, and devices for treatments related to mammary tissue in subjects, including reducing the incidence of mastitis. In particular, the disclosure can relate to creating a physical barrier on a teat surface, in a teat canal, or in a teat cistern for prophylactic treatment of mammary disorders.

14. 发明申请

US20180064751A1 COMPOSITIONS AND METHODS FOR TREATING HYPERKALEMIA 审中-公开
公开(公告)号：US20180064751A1
公开(公告)日：2018-03-08
申请号：US15487967
申请日：2017-04-14
申请人： Ardelyx, Inc.
发明人： Dominique Charmot , James P. Davidson , Fangling Lin , Jeffrey W. Jacobs , Natalia Blinova , Eric Labonte , Ingrid Langsetmo , Robert C. Blanks
IPC分类号： A61K31/795 , A61K31/745 , C08F8/44 , A61K9/00 , A61K47/12 , A61K47/26 , A61K9/10 , C08F8/36 , C08F220/22 , A61K9/16 , C08F257/00 , B01J39/20 , C08F212/08 , C08F212/36 , C08F212/14
CPC分类号： A61K31/795 , A61K9/0053 , A61K9/0056 , A61K9/0095 , A61K9/10 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K31/745 , A61K47/12 , A61K47/26 , B01J39/20 , C08F8/36 , C08F8/44 , C08F212/14 , C08F220/22 , C08F257/00 , C08F2800/10 , C08F212/08 , C08F212/36 , C08F236/20 , C08F8/12 , C08F222/20
摘要： The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.

15. 发明申请

US20170182115A1 PHARMACEUTICAL COMBINATION COMPRISING AN IBAT INHIBITOR AND A BILE ACID BINDER 审中-公开
公开(公告)号：US20170182115A1
公开(公告)日：2017-06-29
申请号：US15230124
申请日：2016-08-05
申请人： Albireo AB
发明人： Per-Göran Gillberg , Hans Graffner , Ingemar Starke
IPC分类号： A61K38/05 , A61K31/495 , A61K31/785 , A61K31/745
CPC分类号： A61K38/05 , A61K9/2081 , A61K9/209 , A61K9/2846 , A61K9/4808 , A61K9/5026 , A61K9/5078 , A61K31/495 , A61K31/554 , A61K31/7088 , A61K31/745 , A61K31/785 , A61K45/06 , C07K5/06026 , C07K5/0606 , A61K2300/00
摘要： The present invention relates to a combination comprising a substance with inhibiting effect on the ileal bile acid transport system (I BAT) and at least one other active substance selected from an IBAT inhibitor; an enteroendocrine peptide or enhancer thereof; a dipeptidyl peptidase-IV inhibitor; a biguanidine; an incretin mimetic; a thiazolidinone; a PPAR agonist; a HMG Co-A reductase inhibitor; a bile acid binder; and a TGR5 receptor modulator; wherein the IBAT inhibitor compound and the at least one other active substance are adminstered simultaneously, sequentially or separately.

16. 发明申请

US20160279163A1 Method of Treating Inflammation 审中-公开
标题翻译：治疗炎症的方法
公开(公告)号：US20160279163A1
公开(公告)日：2016-09-29
申请号：US15172209
申请日：2016-06-03
申请人： CytoSorbents Corporation
发明人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett , Humayra Begum Ali
IPC分类号： A61K31/745 , A61K9/00 , A61K47/48
CPC分类号： A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
摘要翻译：本发明涉及从患有或处于炎症风险的患者处理全身，局部或局部炎症的方法，其包括施用治疗有效剂量的吸附所述患者中的炎性介质的吸附剂。在一些优选实施方案中，吸附剂是生物相容性有机聚合物。

17. 发明申请

US20150079021A1 THERAPEUTIC USES OF OLIGOMERIC AND POLYMERIC MONOTERPENES 审中-公开
标题翻译：低分子和聚合单体的治疗用途
公开(公告)号：US20150079021A1
公开(公告)日：2015-03-19
申请号：US14543182
申请日：2014-11-17
申请人： REGENERA PHARMA LTD.
发明人： Zadik Hazan
IPC分类号： A61K31/745 , A61K31/765
CPC分类号： A61K31/745 , A61K31/01 , A61K31/015 , A61K31/765
摘要： A method of treating a skin or scalp disorder is disclosed. The method calls for topically (a) administering to a subject in need thereof a therapeutically effective amount of a composition has at least one oligomeric or polymeric form of a monoterpene, and is substantially devoid of the corresponding monomeric form of said monoterpene, and (b) treating a skin or scalp disorder. The monoterpene is selected from the group consisting of alloocimene, limonene, α-pinene, β-pinene, geranyl acetate, α-phellandrene, γ-terpinene, 3-carene and 2-carene, and a pharmaceutically acceptable carrier; and wherein the composition is substantially devoid of the corresponding monomeric form of said monoterpene.
摘要翻译：公开了一种治疗皮肤或头皮疾病的方法。该方法要求局部（a）向有需要的受试者施用治疗有效量的组合物，其具有至少一种低聚物或聚合形式的单萜，并且基本上不含所述单萜的相应单体形式，和（b ）治疗皮肤或头皮疾病。单萜选自异环烯烃，柠檬烯，α-蒎烯，蒎烯，乙酸香叶酯，α-蒎烯，γ-萜品烯，3- care ne和2- care烯，以及药学上可接受的载体; 并且其中所述组合物基本上不含所述单萜的相应单体形式。

18. 发明授权

US08956601B2 Therapeutic uses of mastic gum fractions 有权
$Therapeutic uses of mastic gum fractions$
标题翻译：乳香胶部分的治疗用途
公开(公告)号：US08956601B2
公开(公告)日：2015-02-17
申请号：US13254394
申请日：2010-03-04
申请人： Zadik Hazan
发明人： Zadik Hazan
IPC分类号： A61K31/74 , A61K36/22 , A61K31/745
CPC分类号： A61K36/22 , A61K31/745
摘要： The invention relates to pharmaceutical compositions and formulations comprising polymeric myrcene. More particularly, the invention relates to compositions comprising an isolated fraction of polymeric myrcene in a hydrophobic carrier and formulations which maintain the biological activity of the active polymer.
摘要翻译：本发明涉及包含聚合月桂烯的药物组合物和制剂。更具体地说，本发明涉及包含在疏水性载体中的分离级分的聚合月桂烯和保持活性聚合物的生物活性的制剂的组合物。

19. 发明申请

US20130195792A1 METHOD OF TREATING INFLAMMATION 有权
标题翻译：治疗炎症的方法
公开(公告)号：US20130195792A1
公开(公告)日：2013-08-01
申请号：US13637775
申请日：2011-04-01
申请人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett
发明人： Phillip P. Chan , Wei-Tai Young , Vincent J. Capponi , Thomas D. Golobish , Robert H. Bartlett
IPC分类号： A61K31/745
CPC分类号： A61K31/745 , A61K9/0053 , A61K9/16 , A61K9/50 , A61K31/74 , A61K31/75 , A61K47/58 , B01J20/261 , B01J20/28004 , B01J20/28073 , B01J20/28076 , B01J20/3064 , C08F212/36 , C08J9/26 , C08J2201/0444 , C08J2207/10 , C08J2325/02 , Y02A50/406 , Y02A50/411
摘要： The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
摘要翻译：本发明涉及从患有或处于炎症风险的患者处理全身，局部或局部炎症的方法，其包括施用治疗有效剂量的吸附所述患者中的炎性介质的吸附剂。在一些优选实施方案中，吸附剂是生物相容性有机聚合物。

20. 发明申请

US20120003175A1 THERAPEUTIC USES OF MASTIC GUM FRACTIONS 有权
标题翻译：主胶囊的治疗用途
公开(公告)号：US20120003175A1
公开(公告)日：2012-01-05
申请号：US13254394
申请日：2010-03-04
申请人： Zadik Hazan
发明人： Zadik Hazan
IPC分类号： A61K36/22 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/24 , A61K35/12 , A61P3/00 , A61P31/00 , A61P37/00 , A61K31/745 , C12N5/071 , A61P25/00 , A61P3/04
CPC分类号： A61K36/22 , A61K31/745
摘要： The invention relates to pharmaceutical compositions and formulations comprising polymeric myrcene. More particularly, the invention relates to compositions comprising an isolated fraction of polymeric myrcene in a hydrophobic carrier and formulations which maintain the biological activity of the active polymer.
摘要翻译：本发明涉及包含聚合月桂烯的药物组合物和制剂。更具体地说，本发明涉及包含在疏水性载体中的分离级分的聚合月桂烯和保持活性聚合物的生物活性的制剂的组合物。

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