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11. 发明申请

US20020031545A1 Sustained-release preparation 有权
标题翻译：缓释制剂
公开(公告)号：US20020031545A1
公开(公告)日：2002-03-14
申请号：US09520150
申请日：2000-03-07
发明人： Hiroaki Okada , Yayoi Douken
IPC分类号： A61K009/52
CPC分类号： A61K9/1647 , A61K38/09 , Y10S514/963 , Y10S514/965
摘要： Disclosed is a sustained-release preparation comprising 1) a polymer of lactic acid having a weight-average molecular weight of about 25,000 to about 60,000 and 2) a physiologically active substance, and which releases the physiologically active substance over a period of at least about 5 months; the sustained-release preparation shows an almost continuous zero order release of the physiologically active substance over a period of as long as about 5 months.
摘要翻译：公开了一种持续释放制剂，其包含1）重均分子量为约25,000至约60,000的乳酸聚合物和2）生理活性物质，并且在至少约1周的时间内释放生理活性物质 5个月; 持续释放制剂在长达约5个月的时间内显示生理活性物质几乎连续的零级释放。

12. 发明授权

US06200590B1 Controlled, phased-release suppository and its method of production 失效
标题翻译：控释，分期栓剂及其生产方法
公开(公告)号：US06200590B1
公开(公告)日：2001-03-13
申请号：US09131591
申请日：1998-08-10
申请人： John Graham Eley
发明人： John Graham Eley
IPC分类号： A01N4322
CPC分类号： A61K9/5146 , A61K9/025 , A61K9/5153 , Y10S424/15 , Y10S514/965 , Y10S977/70 , Y10S977/801 , Y10S977/906 , Y10S977/915
摘要： A phased-release suppository delivery system is disclosed wherein microscopic polymeric “nanospheres” ladened with one or more active agents are homogeneously incorporated within a pharmaceutically acceptable suppository base. The preparation of the “nanospheres” allows the spheres to be transported, substantially intact, across fenestrated membranes such as the capillary membranes of the rectum. The method of preparation of the “nanospheres” allows for the controlled release of active agent(s) only after a substantial number of the spheres have been transported across the capillary membrane of the rectum or other body cavity and have been taken up into the systemic circulation system.
摘要翻译：公开了一种分阶段释放栓剂递送系统，其中用一种或多种活性剂负载的微观聚合物“纳米球”均匀地并入药学上可接受的栓剂基质中。 “纳米球”的制备允许将球体基本上完整地输送到诸如直肠毛细血管的开窗膜上。 “纳米球”的制备方法只有在将大量的球体输送穿过直肠或其他体腔的毛细血管膜并且已经被吸收到系统中才能控制释放活性剂流通系统。

13. 发明授权

US6126967A Extended release acetaminophen particles 有权
标题翻译：延长释放对乙酰氨基酚颗粒
公开(公告)号：US6126967A
公开(公告)日：2000-10-03
申请号：US146248
申请日：1998-09-03
申请人： Emmett Clemente , Aloysius O. Anaebonam , Robert W. Mendes , Abdel A. Fawzy , Eric M. Morrel
发明人： Emmett Clemente , Aloysius O. Anaebonam , Robert W. Mendes , Abdel A. Fawzy , Eric M. Morrel
IPC分类号： A61K9/50 , A61K9/52 , A61K9/54 , A61K9/62 , A61K9/16
CPC分类号： A61K9/5084 , A61K9/5047 , A61K9/5078 , Y10S514/964 , Y10S514/965
摘要： An extended release acetaminophen composition comprises a plurality of discrete particles containing acetaminophen which, when contained within a gelatin capsule and assayed in a USP Apparatus I rotating basket at 50 rpm in 900 mL of phosphate buffer at pH 5.8 and 37.degree. C., exhibits about 40 percent to about 53 percent acetaminophen dissolution at one-half hour, about 50 percent to about 68 percent dissolution at 45 minutes, about 57 percent to about 77 percent acetaminophen dissolution at one hour, and about 82 percent to about 92 percent acetaminophen dissolution at two hours. After six hours, the contemplated extended release acetaminophen composition exhibits substantially complete dissolution. A process for treating a human patient with the extended release acetaminophen composition is also disclosed.
摘要翻译：延长释放的对乙酰氨基酚组合物包含多个含对乙酰氨基酚的离散颗粒，当包含在明胶胶囊内并在USP装置I中以50rpm在900℃的pH5.8和37℃的磷酸盐缓冲液中测定时，在半小时内约40％至约53％的对乙酰氨基酚溶解，45分钟时约50％至约68％溶解，1小时时约57％至约77％的对乙酰氨基酚溶解，约82％至约92％的对乙酰氨基酚溶解于两个小时 6小时后，预期的延长释放对乙酰氨基酚组合物表现出基本上完全的溶解。还公开了用延长释放对乙酰氨基酚组合物治疗人类患者的方法。

14. 发明授权

US6113943A Sustained-release preparation capable of releasing a physiologically active substance 失效
标题翻译：能够释放生理活性物质的缓释制剂
公开(公告)号：US6113943A
公开(公告)日：2000-09-05
申请号：US962347
申请日：1997-10-31
申请人： Hiroaki Okada , Yayoi Douken
发明人： Hiroaki Okada , Yayoi Douken
IPC分类号： A61K9/107 , A61K9/16 , A61K9/52 , A61K38/09 , A61K47/30 , A61K9/50 , A61K9/14
CPC分类号： A61K9/1647 , A61K38/09 , Y10S514/963 , Y10S514/965
摘要： Disclosed is a sustained-release preparation comprising 1) a polymer of lactic acid having a weight-average molecular weight of about 25,000 to about 60,000 and 2) a physiologically active substance, and which releases the physiologically active substance over a period of at least about 5 months; the sustained-release preparation shows an almost continuous zero order release of the physiologically active substance over a period of as long as about 5 months.
摘要翻译：公开了一种持续释放制剂，其包含1）重均分子量为约25,000至约60,000的乳酸聚合物和2）生理活性物质，并且在至少约1周的时间内释放生理活性物质 5个月; 持续释放制剂在长达约5个月的时间内显示生理活性物质几乎连续的零级释放。

15. 发明授权

US6071973A Repellent for ants 失效
标题翻译：排斥蚂蚁
公开(公告)号：US6071973A
公开(公告)日：2000-06-06
申请号：US798162
申请日：1997-02-10
申请人： Robert K. Vander Meer , William A. Banks , Clifford S. Lofgren
发明人： Robert K. Vander Meer , William A. Banks , Clifford S. Lofgren
IPC分类号： A01N31/02 , A01N35/02 , A01N37/02 , A01N37/06 , A01N37/36
CPC分类号： A01N31/02 , A01N35/02 , A01N37/02 , A01N37/06 , A01N37/36 , Y10S424/10 , Y10S514/919 , Y10S514/953 , Y10S514/964 , Y10S514/965
摘要： A method has been discovered for repelling ants by treating objects or areas with effective amounts of compositions that include (a) one or more C.sub.6 to C.sub.8 carboxylic acids; (b) one or more C.sub.6 to C.sub.14 alcohols; (c) one or more esters which are reaction products of (a) and (b) or an ester which is a reaction product of the repellents and other carboxylic acids or alcohols; (d) one or more C.sub.6 to C.sub.11 carboxylic acid esters; (e) one or more C.sub.6 to C.sub.14 ketones; or (f) mixtures thereof.
摘要翻译：已经发现通过用有效量的组合物处理物体或区域排斥蚂蚁的方法，所述组合物包括（a）一种或多种C 6至C 8羧酸; （b）一种或多种C 6至C 14醇; （c）一种或多种作为（a）和（b）的反应产物的酯或作为驱避剂和其它羧酸或醇的反应产物的酯; （d）一种或多种C 6至C 11羧酸酯; （e）一种或多种C 6至C 14酮; 或（f）它们的混合物。

16. 发明授权

US5958456A Controlled release formulation (albuterol) 失效
标题翻译：控制释放制剂（沙丁胺醇）
公开(公告)号：US5958456A
公开(公告)日：1999-09-28
申请号：US886496
申请日：1997-07-01
申请人： Anand Baichwal , Troy W. McCall
发明人： Anand Baichwal , Troy W. McCall
IPC分类号： A61K9/20 , A61K9/22 , A61K9/28 , A61K9/30 , A61K31/137 , A61K31/40 , A61K31/44 , A61K47/36 , C08J3/075 , A61K9/14
CPC分类号： A61K31/137 , A61K9/2009 , A61K9/2018 , A61K9/205 , A61K9/2054 , A61K9/2866 , C08J3/075 , Y10S514/964 , Y10S514/965
摘要： A sustained release pharmaceutical formulation and methods of making and using the same are provided. The sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional hydrophobic material and/or hydrophobic coating, and a medicament for sustained oral administration.
摘要翻译：提供持续释放的药物制剂及其制备和使用方法。持续释放药物制剂包括持续释放赋形剂，其包括胶凝剂，惰性药物稀释剂，任选的疏水性材料和/或疏水涂层，以及用于持续口服给药的药物。

17. 发明授权

US5939380A Implant preparations containing bioactive macromolecule for sustained delivery 失效
标题翻译：含有生物活性大分子用于持续输送的植入物制剂
公开(公告)号：US5939380A
公开(公告)日：1999-08-17
申请号：US796023
申请日：1991-11-22
申请人： Paul Yao-Cheung Wang
发明人： Paul Yao-Cheung Wang
IPC分类号： A61K47/36 , A61K9/00 , A61K9/22 , A61K38/00 , A61K38/27 , A61K38/28 , A61K47/06 , A61K47/12 , A61K47/14 , A61K47/28 , A61K47/42 , A61K47/44 , A61L27/00 , A61P3/10
CPC分类号： A61K9/0024 , A61K9/2013 , Y10S514/884 , Y10S514/953 , Y10S514/964 , Y10S514/965
摘要： Implant preparations capable of sustained action when inserted are comprised of powder of a natural lipoidal substance in thorough admixture with bioactive macromolecule, followed by compression under pressure into a disc or rod that can be broken and used in small pieces as well.
摘要翻译：当插入时能够持续作用的植入物制剂由与生物活性大分子充分混合的天然脂质物质的粉末组成，然后在压力下压缩成可破碎并用于小块的盘或杆。

18. 发明授权

US5900425A Pharmaceutical preparations having controlled release of active compound and processes for their preparation 失效
标题翻译：具有控释活性化合物的药物制剂及其制备方法
公开(公告)号：US5900425A
公开(公告)日：1999-05-04
申请号：US934308
申请日：1997-09-19
申请人： Venkata-Rangarao Kanikanti , Wolfgang Muck , Andreas Ohm , Peter Kurka , Gerd Toppel
发明人： Venkata-Rangarao Kanikanti , Wolfgang Muck , Andreas Ohm , Peter Kurka , Gerd Toppel
IPC分类号： A61K9/14 , A61K9/20 , A61K31/44
CPC分类号： A61K9/146 , Y10S514/965
摘要： The invention relates to pharmaceutical preparations having controlled release of active compound and to processes for their preparation, in particular for poorly soluble active compounds having problematic bioavailability.
摘要翻译：本发明涉及具有控制释放活性化合物的药物制剂及其制备方法，特别是对具有有问题的生物利用度的难溶性活性化合物。

19. 发明授权

US5880150A Antimicrobial agent containing allyl isothiocyanate and method for controlling release speed of allyl isothiocyanate 失效
标题翻译：含有异硫氰酸烯丙酯的抗微生物剂和控制异硫氰酸烯丙酯释放速度的方法
公开(公告)号：US5880150A
公开(公告)日：1999-03-09
申请号：US481401
申请日：1995-07-10
申请人： Masao Fujita , Kiyoshi Kamei , Kiyoko Kawazu , Yuichi Mizukami , Yasushi Sekiyama
发明人： Masao Fujita , Kiyoshi Kamei , Kiyoko Kawazu , Yuichi Mizukami , Yasushi Sekiyama
IPC分类号： A01N47/46 , A01N25/00 , A01N25/08 , A01N25/10 , A01N25/18 , A01N25/34 , B65D81/28
CPC分类号： A01N47/46 , Y10S514/964 , Y10S514/965 , Y10T428/4935
摘要： An antimicrobial agent comprising allyl isothiocyanate (AIT) packaged in a packaging material having a structure wherein part of the pores of a porous packaging substrate is filled with, or said pores are partially or entirely narrowed by a resin impervious to AIT vapor, and a method for controlling the AIT vapor release speed comprising enclosing AIT in the above-mentioned packaging material. According to the present invention, the AIT vapor release speed can be controlled, whereby enabling sustained release of AIT vapor and persistent effect of antimicrobial action. In addition, the antimicrobial agent of the present invention can be widely applied to food industries and various other fields where breeding and reproduction of deleterious microorganisms pose problems, since it is economical, compact and easy to use. The method of the present invention can control the release of the AIT vapor to the outside of the packaging material, to a desired release speed, whereby the antimicrobial action is effectively exerted while preventing the pollution of the environment and damages to the objects to be treated with the antimicrobial agent, which are caused by AIT vapor. In addition, the antimicrobial action can be sustained for a long time with a small amount of AIT.
摘要翻译： PCT No.PCT / JP94 / 01904 Sec。 371日期：1995年7月10日 102（e）日期1995年7月10日PCT 1994年11月10日PCT PCT。第WO95 / 12981号公报日期1995年5月8日包含包装在包装材料中的烯丙基异硫氰酸酯（AIT）的抗微生物剂，其具有填充有多孔包装基材的孔的一部分的结构，或者所述孔部分或全部被不能透过AIT蒸气的树脂变窄以及一种用于控制AIT蒸气释放速度的方法，包括将AIT封装在上述包装材料中。根据本发明，可以控制AIT蒸汽释放速度，从而使得AIT蒸汽的持续释放和抗微生物作用的持久作用。此外，本发明的抗微生物剂可以广泛地应用于食品工业以及有害微生物的繁殖和繁殖构成问题的各种其它领域，因为其经济，紧凑且易于使用。本发明的方法可以控制将AIT蒸气释放到包装材料的外部，达到所需的释放速度，从而有效地发挥抗菌作用，同时防止环境污染和对待处理物体的损害与由AIT蒸气引起的抗菌剂。此外，抗微生物作用可以用少量的AIT持续很长时间。

20. 发明授权

US5869094A Solid form of administration of isosorbide 5-mononitrate 失效
标题翻译：异山梨醇5-单硝酸盐的固体形式
公开(公告)号：US5869094A
公开(公告)日：1999-02-09
申请号：US788295
申请日：1997-01-24
申请人： Cornelia Alida Maria Van Egmond , Andre Pullen , Sibo Wytse De Jong , Adrianus Petrus De Jong , Jan Bron
发明人： Cornelia Alida Maria Van Egmond , Andre Pullen , Sibo Wytse De Jong , Adrianus Petrus De Jong , Jan Bron
IPC分类号： A61K9/28 , A61K9/22 , A61K9/50 , A61K9/52 , A61K31/34 , A61K47/14 , A61K47/32 , A61K47/38
CPC分类号： A61K31/34 , A61K9/5078 , Y10S514/964 , Y10S514/965
摘要： A solid form of oral administration of isosorbide 5-mononitrate with a controlled, pH-independent release of the active substance in the gastro-intestinal tract is constituted by a pellet coated with a depot layer and a release prolonging lacquer layer. The lacquer layer contains ethyl cellulose and polymethacrylate in a weight ratio from 3:1 to 3:2. The new form of administration is characterized in that it is less costly to produce.
摘要翻译：口服给予5-单硝酸异山梨酯的固体形式，其具有控制的pH独立性释放胃肠道中的活性物质由涂覆有贮库层和释放延长漆层的颗粒构成。漆层含有重量比为3：1至3：2的乙基纤维素和聚甲基丙烯酸酯。新的管理形式的特点是生产成本较低。

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