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11. 发明授权

US09939623B2 Microscope system with transillumination-based autofocusing for photoluminescence imaging 有权
公开(公告)号：US09939623B2
公开(公告)日：2018-04-10
申请号：US14886998
申请日：2015-10-19
申请人： MOLECULAR DEVICES, LLC
发明人： Matthew Chan , Nia W. Fong , Robert Malcolm Watson, Jr.
IPC分类号： G02B15/22 , G02B21/24 , G02B21/16 , G02B21/08 , G01N21/64 , G02B7/38 , G02B21/36 , G02B21/26
CPC分类号： G02B21/244 , G01N21/6452 , G01N21/6458 , G02B7/38 , G02B21/086 , G02B21/16 , G02B21/26 , G02B21/367
摘要： Microscope system for, and methods of, imaging a sample including biological cells. In an exemplary method, light transmitted through the sample may be detected for a first set of focal positions to collect a first stack of images. Values of a focus metric may be calculated for the first stack of images. A candidate focal position may be determined based on the values. Photoluminescence may be detected from the sample for a second set of focal positions to collect a second stack of images. The second set of focal positions may define a smaller range than the first set of focal positions. At least one focal position of the second set of focal positions may be based on the candidate focal position. In other words, the candidate focal position may serve as a guide for finding a suitable photoluminescence focal position.

12. 发明申请

US20170330321A1 TESTING EQUIPMENT WITH MAGNIFYING FUNCTION 有权
公开(公告)号：US20170330321A1
公开(公告)日：2017-11-16
申请号：US15603783
申请日：2017-05-24
申请人： Bonraybio Co., Ltd.
发明人： Cheng-Teng HSU , Hsuan-Yu HUANG , Chih-Pin CHANG , Kuang-Li HUANG , Yu-Chiao CHI
IPC分类号： G06T7/00 , H04N5/225 , G02B21/36 , G02B21/24 , G02B21/14 , G01N21/80 , G01N15/14 , H04N7/18 , G01N15/06
CPC分类号： G06T7/0012 , A61B5/14507 , A61B5/1455 , A61B5/43 , A61B10/0058 , A61K35/00 , C12M21/06 , C12M31/02 , C12M41/06 , C12M41/46 , C12N5/0612 , G01N15/06 , G01N15/1429 , G01N15/1468 , G01N21/80 , G01N33/689 , G01N2015/0693 , G01N2015/1006 , G01N2015/1075 , G01N2015/1486 , G01N2015/1497 , G02B21/0008 , G02B21/082 , G02B21/086 , G02B21/14 , G02B21/244 , G02B21/34 , G02B21/361 , G02B21/365 , G06K9/00147 , G06K9/00496 , G06K9/00744 , G06K9/209 , G06K9/228 , G06K9/38 , H04N5/2257 , H04N7/181
摘要： Embodiments disclose a device for testing biological specimen. The device includes a sample carrier and a detachable cover. The sample carrier includes a specimen holding area. The detachable cover is placed on top of the specimen holding area. The detachable cover includes a magnifying component configured to align with the specimen holding area. The focal length of the magnifying component is from 0.1 mm to 8.5 mm. The magnifying component has a linear magnification ratio of at least 1. Some embodiments further include a multi-camera configuration. These embodiments include a first camera module and a second camera module arranged to capture one or more images of the first holding area and the second holding area, respectively. The processor may perform different analytic processes on the captured images of different holding areas to determine an outcome with regard to the biological specimen.

13. 发明申请

US20170227519A1 OPTICAL VIEWING DEVICE 审中-公开
公开(公告)号：US20170227519A1
公开(公告)日：2017-08-10
申请号：US15411512
申请日：2017-01-20
申请人： Aidmics Biotechnology Co., Ltd.
发明人： Cheng-Ming LIN , Chang-Yu CHEN , Tsun-Chao CHIANG , Shu-Sheng LIN
IPC分类号： G01N33/487 , G02B21/06 , G02B21/36
CPC分类号： G01N33/487 , G02B21/0008 , G02B21/06 , G02B21/086 , G02B21/36 , G02B21/361
摘要： An optical viewing device includes a first assembly and a second assembly. The first assembly includes a first body and a light source. The second assembly includes a second body, a convex lens and an image capturing module. The first body has a first connecting portion and a light output hole, and the first connecting portion is disposed on at least one side of the light output hole. The light source is disposed within the first body. The second body has a second connecting portion, which is disposed corresponding to the first connecting portion. The convex lens and the image capturing module are disposed within the second body, and the light outputted from the light output hole passes through the convex lens and then enters the image capturing module. The first connecting portion and the second connecting portion are connected with each other to form a chamber.

14. 发明申请

US20170192219A1 IMAGE GENERATING SYSTEM, IMAGE GENERATING METHOD, AND IMAGE GENERATING APPARATUS 审中-公开
公开(公告)号：US20170192219A1
公开(公告)日：2017-07-06
申请号：US15388159
申请日：2016-12-22
申请人： Panasonic Intellectual Property Management Co., Ltd.
发明人： YUMIKO KATO , YOSHIHIDE SAWADA , MASAHIRO IWASAKI , YASUHIRO MUKAIGAWA , HIROYUKI KUBO
IPC分类号： G02B21/36 , G06T7/70 , G02B21/18 , H04N5/232 , G02B21/08 , H04N5/225 , H04N5/235
CPC分类号： G02B21/18 , G02B21/086 , G02B21/361 , G02B21/367 , H04N5/2256 , H04N5/23229 , H04N5/2354
摘要： An image generating system that generates a focal image of a target object on a virtual focal plane located between a plurality of illuminators and an image sensor (b) carries out the following (c) through (f) for each of a plurality of pixels constituting the focal image, (c) carries out the following (d) through (f) for each of the positions of the plurality of illuminators, (d) calculates a position of a target point that is a point of intersection of a straight line connecting a position of the pixel on the focal plane and a position of the illuminator and a light receiving surface of the image sensor, (e) calculates a luminance value of the target point in the captured image by the illuminator on the basis of the position of the target point, (f) applies the luminance value of the target point to the luminance value of the pixel, and (g) generates the focal image of the target object on the focal plane by using a result of applying the luminance value at each of the plurality of pixels.

15. 发明申请

US20170108686A1 Microscope System With Transillumination-Based Autofocusing for Photoluminescense Imaging 有权
公开(公告)号：US20170108686A1
公开(公告)日：2017-04-20
申请号：US14886998
申请日：2015-10-19
申请人： MOLECULAR DEVICES, LLC
发明人： Matthew Chan , Nia W. Fong , Robert Malcolm Watson, JR.
IPC分类号： G02B21/24 , G02B21/08 , G02B21/26 , G02B7/38 , G02B21/36 , G02B21/16 , G01N21/64
CPC分类号： G02B21/244 , G01N21/6452 , G01N21/6458 , G02B7/38 , G02B21/086 , G02B21/16 , G02B21/26 , G02B21/367
摘要： Microscope system for, and methods of, imaging a sample including biological cells. In an exemplary method, light transmitted through the sample may be detected for a first set of focal positions to collect a first stack of images. Values of a focus metric may be calculated for the first stack of images. A candidate focal position may be determined based on the values. Photoluminescence may be detected from the sample for a second set of focal positions to collect a second stack of images. The second set of focal positions may define a smaller range than the first set of focal positions. At least one focal position of the second set of focal positions may be based on the candidate focal position. In other words, the candidate focal position may serve as a guide for finding a suitable photoluminescence focal position.

16. 发明授权

US09594241B2 Transmitted-light microscope and method for transmitted-light microscopy 有权
标题翻译：透射光显微镜和透射光显微镜的方法
公开(公告)号：US09594241B2
公开(公告)日：2017-03-14
申请号：US14795530
申请日：2015-07-09
申请人： Carl Zeiss Microscopy GmbH
发明人： Peter Schoen , Ralf Steinmeyer , Maik Sommer , Klaus Becker
IPC分类号： G02B21/08 , G01N21/03 , G01N21/11 , G02B21/26
CPC分类号： G02B21/086 , G01N21/0303 , G01N21/11 , G01N2021/0325 , G02B21/26
摘要： A transmitted-light microscope for imaging well-shaped, liquid-containing sample vessels, wherein the transmitted-light microscope has an illumination beam path for illuminating the sample vessel with an illumination beam bundle, from above, along an optical axis, wherein the illumination beam path has an illuminating element aligned to the optical axis, which element irradiates the illumination beam bundle onto the sample vessel, an imaging beam path for imaging the sample vessel from below along the optical axis and a pipette access channel for introducing a reagent into the sample vessel, wherein the illuminating element is annular and has an opening on the optical axis through which opening runs the pipette access channel.
摘要翻译：一种透射光显微镜，用于成像良好形状的含液体的样品容器，其中透射光显微镜具有用于从上方沿着光轴用照明束束照射样品容器的照明光束路径，其中照明光束路径具有与光轴对准的照明元件，该元件将照射束束照射到样品容器上，用于沿着光轴从下方对样品容器进行成像的成像光束路径和用于将试剂引入到样品容器样品容器，其中所述照明元件是环形的并且在所述光轴上具有开口，通过所述开口穿过所述移液管通道。

17. 发明授权

US09497379B2 Variable-illumination fourier ptychographic imaging devices, systems, and methods 有权
标题翻译：可变照明光栅成像设备，系统和方法
公开(公告)号：US09497379B2
公开(公告)日：2016-11-15
申请号：US14466481
申请日：2014-08-22
申请人： California Institute of Technology
发明人： Xiaoze Ou , Roarke Horstmeyer , Guoan Zheng , Changhuei Yang
IPC分类号： G01B11/02 , H04N5/232 , H04N5/225 , H04N5/32
CPC分类号： H04N5/23232 , G02B21/06 , G02B21/084 , G02B21/086 , G02B21/125 , G02B21/361 , G02B21/367 , G02B27/1066 , G02B27/58 , H04N5/2256 , H04N5/32
摘要： Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier ptychographic imaging systems.
摘要翻译：某些方面涉及傅里叶片状图像成像系统，装置和方法，例如高NA傅里叶立体图像成像系统和反射型NA傅立叶Ptychographic成像系统。

18. 发明申请

US20160091701A1 GENERATING PERSPECTIVE VIEWS IN MICROSCOPY 有权
标题翻译：生成显微镜视角
公开(公告)号：US20160091701A1
公开(公告)日：2016-03-31
申请号：US14501903
申请日：2014-09-30
申请人： Agilent Technologies, Inc.
发明人： Varun Raghunathan
IPC分类号： G02B21/00 , G02B21/06 , H04N5/232
CPC分类号： G02B21/367 , G02B21/086
摘要： A microscope includes a spatial light modulator configured for adjusting the perspective angle of a view imaged at the light detector. The spatial light modulator is positioned at a pupil plane, or at an equivalent conjugate plane thereof, in the illumination light path or in the detection light path. The microscope enables perspective views of a sample at different angles, which may be utilized to generate a three-dimensional image of the sample.
摘要翻译：显微镜包括被配置用于调节在光检测器处成像的视图的透视角的空间光调制器。空间光调制器位于照明光路或检测光路中的光瞳平面或其等效共轭平面处。该显微镜能够以不同的角度观察样品的透视图，其可用于产生样品的三维图像。

19. 发明申请

US20150355446A1 METHOD FOR THE MICROSCOPE IMAGING OF SAMPLES ADHERING TO BOTTOMS OF FLUID FILLED WELLS OF A MICROTITER PLATE 审中-公开
标题翻译：用于显微镜成像的装置用于微型板的流体填充孔的底部
公开(公告)号：US20150355446A1
公开(公告)日：2015-12-10
申请号：US14732018
申请日：2015-06-05
申请人： Thorsten Kues , Peter Schoen
发明人： Thorsten Kues , Peter Schoen
IPC分类号： G02B21/06
CPC分类号： G02B21/06 , G02B21/086 , G02B21/34 , G02B21/365 , G06T5/008 , G06T2207/10056 , G06T2207/30024
摘要： A method for microscope imaging of a sample, wherein a sample well is filled with liquid with the sample adhered to the bottom, illuminating and imaging the sample well from the underside and capturing at least one sample image thereof, wherein any inhomogeneity of the illumination is equalized by providing a test well with the same structure filled with liquid but no sample, making a reference measurement of the test well by illuminating the test well, imaging the illuminated test well from the underside and capturing a reference image which covers the entire bottom, analyzing the reference image to determine a brightness correction specification based on brightness fluctuation, and using the brightness correction specification to correct the sample image, including determining a position of at least a part of the sample image and using a value of the brightness correction specification assigned to the position.
摘要翻译：一种用于样品的显微镜成像的方法，其中样品孔充满液体，样品粘附到底部，从下侧照射和成像样品井，并捕获其至少一个样品图像，其中照明的任何不均匀性为通过提供具有填充液体但没有样品的相同结构的测试井来均衡，通过照射测试井进行测试井的参考测量，从下侧成像照射的测试井并且捕获覆盖整个底部的参考图像，分析参考图像以基于亮度波动来确定亮度校正规范，并且使用亮度校正规范来校正样本图像，包括确定样本图像的至少一部分的位置并使用分配的亮度校正规格的值到位

20. 发明申请

US20150062447A1 Apparatus and Method for Transmitted Light Illumination for Light Microscopes and Microscope System 审中-公开
标题翻译：用于光显微镜和显微镜系统的透射光照明的装置和方法
公开(公告)号：US20150062447A1
公开(公告)日：2015-03-05
申请号：US14345336
申请日：2012-08-16
申请人： Detlef Hein , Axel Laschke
发明人： Detlef Hein , Axel Laschke
IPC分类号： G02B21/06 , G02B21/02 , G02B21/26
CPC分类号： G02B21/06 , G02B21/025 , G02B21/086 , G02B21/26
摘要： The invention relates to an apparatus for transmitted light illumination for light microscopes having changing effective entrance pupil of an objective. The apparatus has a light source for emitting an illuminating light beam, and a holding device for holding a sample to be examined, and at least one diaphragm edge for trimming the illuminating light beam bundle, wherein the diaphragm edge is arranged between the holding device and the light source and extends transversely to an optical axis, wherein a beam path of the illuminating light between the diaphragm edge and a sample held by the holding device is free from beam focussing components. The apparatus is characterised in that the means are provided for enquiring concerning a microscope setting and/or a microscope configuration of a light microscope, which means are positionable at the device for transmitted light illumination; means are provided for variable positioning of the diaphragm edge in a direction transverse to the optical axis, and a control device is provided and configured to position the diaphragm edge in the direction transverse to the optical axis via the means for variable positioning. The invention also relates to a method for transmitted light illumination for a light microscope and a microscope system.
摘要翻译：本发明涉及一种用于具有变化的物镜的有效入射光瞳的光学显微镜的透射光照明装置。该装置具有用于发射照明光束的光源和用于保持待检测样品的保持装置和用于修整照明光束的至少一个光阑边缘，其中所述光阑边缘布置在所述保持装置和光源并且横向于光轴延伸，其中在光阑边缘和由保持装置保持的样本之间的照明光的光束路径没有光束聚焦部件。该装置的特征在于提供了用于查询光学显微镜的显微镜设置和/或显微镜配置的装置，该装置可以在用于透射光照明的装置处定位; 提供了用于在横向于光轴的方向上可变地定位光阑边缘的装置，并且提供并配置控制装置，用于经由用于可变定位的装置在垂直于光轴的方向上定位光阑边缘。本发明还涉及一种用于光学显微镜和显微镜系统的透射光照射的方法。

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