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11. 发明授权

US09977031B2 Highly sensitive system and method for analysis of troponin 有权
公开(公告)号：US09977031B2
公开(公告)日：2018-05-22
申请号：US15348120
申请日：2016-11-10
申请人： Singulex, Inc. , The Regents of the University of California
发明人： Philippe Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Allan H. B. Wu
IPC分类号： G01N33/58 , G01N33/68 , G01N33/577
CPC分类号： G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

12. 发明授权

US09952213B2 Method for evaluating ischemic heart disease by assaying complement factor H or D 有权
公开(公告)号：US09952213B2
公开(公告)日：2018-04-24
申请号：US14514523
申请日：2014-10-15
申请人： HITACHI, LTD.
发明人： Hiroko Hanzawa , Takeshi Sakamoto , Yuji Kuge
IPC分类号： G01N33/50 , G01N33/53 , A61P9/10 , G01N33/564 , C07K14/47 , C07K14/745 , C07K16/36
CPC分类号： G01N33/564 , A61P9/10 , C07K14/472 , C07K14/745 , C07K16/36 , G01N33/50 , G01N33/53 , G01N2333/4716 , G01N2800/324
摘要： It is intended to evaluate an ischemic heart disease with high accuracy by convenient operation. The method for evaluating an ischemic heart disease according to the present invention comprises the steps of: assaying complement factor H and/or complement factor D in a sample derived from the blood of a test subject; and comparing the concentration of the complement factor H and/or the concentration of the complement factor D assayed in the preceding step with a reference value(s), wherein it is determined that the seriousness of the ischemic heart disease is high when the concentration falls below the reference value.

13. 发明申请

US20180067138A1 Lipidomic Biomarkers for Identification of High-Risk Coronary Artery Disease Patients 审中-公开
公开(公告)号：US20180067138A1
公开(公告)日：2018-03-08
申请号：US15803252
申请日：2017-11-03
申请人： ZORA BIOSCIENCES OY
发明人： Reijo Laaksonen , Kim Ekroos , Reini Hurme , Riikka Katainen
IPC分类号： G01N33/92
CPC分类号： G01N33/92 , G01N2405/04 , G01N2405/06 , G01N2570/00 , G01N2800/324 , G01N2800/50 , G01N2800/52
摘要： The present invention inter alia provides a method, and use thereof, of predicting severe CVD complications such as AMI or CVD death by detecting the lipid concentrations or lipid ratios of a biological sample and comparing it to a control and has identified specific lipid markers that are more specific and sensitive in predicting these CVD complications than currently utilized clinical markers. Also provided is an antibodies towards said lipids, and the use thereof for predicting, diagnosing, preventing and/or treating CVD complications. The invention additionally relates to kits comprising lipids and/or an antibody thereto, for use in the prediction and/or diagnosis of CVD complications.

14. 发明申请

US20180028610A1 METHODS FOR DETECTING CARDIAC DAMAGE 审中-公开
公开(公告)号：US20180028610A1
公开(公告)日：2018-02-01
申请号：US15674053
申请日：2017-08-10
申请人： Acorda Therapeutics, Inc.
发明人： Xinhua Yan , Anthony O. Caggiano
IPC分类号： A61K38/18 , G01N33/68 , A61K49/00 , G01N33/50
CPC分类号： A61K38/1883 , A61K49/0004 , G01N33/5061 , G01N33/5091 , G01N33/6887 , G01N2333/47 , G01N2333/4712 , G01N2800/32 , G01N2800/324
摘要： The present mention relates to a method for detecting heart damage in a patient. The invention also relates to methods for treatment of patients identified as having heart damage. The invention further pertains to methods for evaluating the efficacy of an ongoing therapeutic regimen designated to treat a damaged heart in a patient.

15. 发明授权

US09851362B2 1L1RL-1 as a cardiovascular disease marker and therapeutic target 有权
公开(公告)号：US09851362B2
公开(公告)日：2017-12-26
申请号：US14290465
申请日：2014-05-29
申请人： The Brigham and Women's Hospital, Inc.
发明人： Richard T. Lee
IPC分类号： C07K17/00 , A61K45/00 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/6869 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , G01N33/6893 , G01N2333/7155 , G01N2800/2871 , G01N2800/32 , G01N2800/324 , G01N2800/325 , G01N2800/52
摘要： This invention pertains to methods and compositions for the diagnosis and treatment of cardiovascular conditions. More specifically, the invention relates to isolated molecules that can be used to diagnose and/or treat cardiovascular conditions including cardiac hypertrophy, myocardial infarction, stroke, arteriosclerosis, and heart failure.

16. 发明申请

US20170296085A1 DECISION TREE BASED SYSTEMS AND METHODS FOR ESTIMATING THE RISK OF ACUTE CORONARY SYNDROME 审中-公开
公开(公告)号：US20170296085A1
公开(公告)日：2017-10-19
申请号：US15476560
申请日：2017-03-31
申请人： Abbott Laboratories
发明人： Agim Beshiri , Shaoqing Du , Janel Huang
IPC分类号： A61B5/0452 , G06F17/30 , G06F19/00
CPC分类号： A61B5/0452 , A61B5/0402 , A61B5/7267 , G01N33/6887 , G01N2333/4712 , G01N2800/324 , G01N2800/50 , G01N2800/56 , G06F16/322 , G16H50/30 , G16H50/50
摘要： The invention provides decision tree based systems and methods for estimating the risk of acute coronary syndrome (ACS) in subjects suspect of having ACS. In particular, systems and methods are provided that employ additive decision tree based algorithms to process a subject's initial cardiac troponin I or T (cTnI or cTnT) concentration, a subject's cTnI or cTnT rate of change, and at least one of the following: the subject's age, the subject's gender, the subject's ECG value, the subject's hematology parameter value, to generate an estimate risk of ACS. Such risk stratification allows, for example, patients to be ruled in or rule out with regard to needing urgent treatment.

17. 发明申请

US20170153248A1 Highly Sensitive System and Method for Analysis of Troponin 有权
公开(公告)号：US20170153248A1
公开(公告)日：2017-06-01
申请号：US15348120
申请日：2016-11-10
申请人： Singulex, Inc. , The Regents of the University of California
发明人： Philippe Goix , Robert Puskas , John Todd , Richard Livingston , Douglas Held , Allan H.B. Wu
IPC分类号： G01N33/68 , G01N33/577 , G01N33/58
CPC分类号： G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
摘要： The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

18. 发明授权

US09638663B2 Cartridge for diagnostic testing 有权
公开(公告)号：US09638663B2
公开(公告)日：2017-05-02
申请号：US14233008
申请日：2011-09-27
申请人： Mikhail Briman
发明人： Mikhail Briman
IPC分类号： G01N27/48 , G01N33/543 , B01L3/00
CPC分类号： G01N27/49 , B01L3/5027 , B01L3/502707 , B01L2200/16 , B01L2300/0645 , B01L2300/0672 , B01L2300/0681 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/161 , B01L2400/0478 , B01L2400/0487 , B01L2400/0638 , B01L2400/0655 , B01L2400/0683 , B01L2400/0694 , G01N27/3272 , G01N27/48 , G01N33/5438 , G01N33/6893 , G01N2333/4712 , G01N2800/324
摘要： The present invention relates to a cartridge for conducting diagnostic assays. The cartridge consists of an assembly of components that are easily assembled. The cartridge provides means for receiving a patient sample, precisely controlling fluid introduction, onboard storage of assay fluid and conducting different assay protocols and detection of a plurality of analytes. Methods of use for the cartridge are described. The disclosed invention is suitable for point of care environments or any place where rapid, ultrasensitive testing is required.

19. 发明申请

US20170083663A1 Methods, Systems and Computer Programs for Assessing CHD Risk Using Adjusted HDL Particle Number Measurements 审中-公开
公开(公告)号：US20170083663A1
公开(公告)日：2017-03-23
申请号：US15223237
申请日：2016-07-29
申请人： LipoScience, Inc.
发明人： James D. Otvos
IPC分类号： G06F19/12 , G01R33/465 , G06F19/24 , G06F19/00 , G01N33/483 , G01N15/06 , G01N24/08
CPC分类号： G16B5/00 , G01N15/0656 , G01N24/08 , G01N33/4833 , G01N2015/0065 , G01N2800/323 , G01N2800/324 , G01R33/465 , G06F19/34 , G16B40/00 , G16H50/20 , G16H50/30 , G16H50/50
摘要： Methods, computer program products and apparatus determine a subject's risk of having or developing CHD using a calculated HDL particle risk number and/or a mathematical model of risk associated with HDL particles that adjusts concentrations of at least one of the subclasses of small, medium and large HDL particle measurements to reflect predicted CHD risk. A calculated LDL particle risk number may also be generated as well as a lipoprotein particle index derived from the ratio of RLDL/RHDL.

20. 发明授权

US09581597B2 Myeloperoxidase, a risk indicator for cardiovascular disease 有权
标题翻译：髓过氧化物酶，心血管疾病的风险指标
公开(公告)号：US09581597B2
公开(公告)日：2017-02-28
申请号：US15135757
申请日：2016-04-22
申请人： THE CLEVELAND CLINIC FOUNDATION
发明人： Stanley L. Hazen , Renliang Zhang
IPC分类号： C12Q1/28 , G01N37/00 , G01N33/573 , G06F19/00 , G06Q50/22 , C12N1/28 , A61K31/616
CPC分类号： G01N33/573 , A61K31/616 , C12N1/28 , C12Q1/28 , C12Y111/01007 , G01N2333/908 , G01N2800/32 , G01N2800/324 , G01N2800/50 , G01N2800/52 , G06F19/00 , G06Q50/22 , G16H50/30 , Y02A90/22 , Y02A90/26
摘要： Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtained from the individual or test subject. In another embodiment, the diagnostic test comprises determining the level of MPO mass in a bodily sample obtained from the test subject. In another embodiment, the diagnostic test comprises determining the level of one or more select MPO-generated oxidation products in a bodily sample obtained from the test subject. The select MPO-generated oxidation products are dityrosine, nitrotyrosine, methionine sulphoxide or an MPO-generated lipid peroxidation products. Levels of MPO activity, MPO mass, or the select MPO-generated oxidation product in bodily samples from the test subject are then compared to a predetermined value that is derived from measurements of MPO activity, MPO mass, or the select MPO-generated oxidation product in comparable bodily samples obtained from the general population or a select population of human subjects. Such comparison characterizes the test subject's risk of developing CVD.
摘要翻译：用于描述个体发展或患有心血管疾病的风险的诊断测试。在一个实施方案中，本诊断测试包括确定从个体或测试对象获得的身体样品中髓过氧化物酶（MPO）活性的水平。在另一个实施例中，诊断测试包括确定从测试对象获得的身体样本中的MPO质量的水平。在另一个实施方案中，诊断测试包括确定从测试对象获得的身体样品中的一种或多种选择的MPO产生的氧化产物的水平。选择的MPO生成的氧化产物是二酪氨酸，硝基酪氨酸，甲硫氨酸亚砜或MPO产生的脂质过氧化产物。然后将来自测试受试者的身体样品中的MPO活性，MPO质量或选择的MPO生成的氧化产物的水平与从MPO活性，MPO质量或选择的MPO产生的氧化产物的测量得到的预定值进行比较在从一般人群或人类受试者的选择人群中获得的可比较的身体样本中。这种比较表征了测试对象发展CVD的风险。

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