专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US06319669B1 Modified green fluorescent proteins 失效
标题翻译：改良的绿色荧光蛋白
公开(公告)号：US06319669B1
公开(公告)日：2001-11-20
申请号：US08727452
申请日：1997-03-20
申请人： Roger Y. Tsien , Roger Heim
发明人： Roger Y. Tsien , Roger Heim
IPC分类号： C12Q168
CPC分类号： C07K14/43595 , C12N15/65 , G01N33/533 , G01N2333/43595 , Y10S530/855
摘要： Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an alteration in the ratio of two main excitation peaks observed with the product derived from wild-type GFP. In another class, the product derived from the modified GFP fluoresces at a shorter wavelength than the corresponding product from wild-type GFP. In yet another class of modifications, the product derived from the modified GFP exhibits only a single excitation peak and enhanced emission relative to the product derived from wild-type GFP.
摘要翻译： Aequorea野生型GFP序列的修饰提供了来自野生型GFP相应产物的产生明显不同的激发和发射光谱的产物。在一类修饰中，衍生自经修饰的GFP的产物表现出与用野生型GFP产生的产物观察到的两个主要激发峰的比例的变化。在另一类中，衍生自经修饰的GFP的产物在比来自野生型GFP的相应产物更短的波长处发荧光。在另一类修饰中，衍生自经修饰的GFP的产物相对于衍生自野生型GFP的产物仅显示单个激发峰和增强的发射。

12. 发明授权

US5625048A Modified green fluorescent proteins 失效
标题翻译：改良的绿色荧光蛋白
公开(公告)号：US5625048A
公开(公告)日：1997-04-29
申请号：US337915
申请日：1994-11-10
申请人： Roger Y. Tsien , Roger Heim
发明人： Roger Y. Tsien , Roger Heim
IPC分类号： C12N15/09 , C07K14/435 , C12N5/10 , C12N15/12 , C12N15/65 , C12P21/04 , C12Q1/25 , C12Q1/68 , G01N33/533 , C07H21/04
CPC分类号： C07K14/43595 , C12N15/65 , G01N33/533 , G01N2333/43595 , Y10S530/855
摘要： Modifications in the sequence of Aequorea wild-type GFP provide products having markedly different excitation and emission spectra from corresponding products from wild-type GFP. In one class of modifications, the product derived from the modified GFP exhibits an alteration in the ratio of two main excitation peaks observed with the product derived from wild-type GFP. In another class, the product derived from the modified GFP fluoresces at a shorter wavelength than the corresponding product from wild-type GFP. In yet another class of modifications, the product derived from the modified GFP exhibits only a single excitation peak and enhanced emission relative to the product derived from wild-type GFP.
摘要翻译： Aequorea野生型GFP序列的修饰提供了来自野生型GFP相应产物的产生明显不同的激发和发射光谱的产物。在一类修饰中，衍生自经修饰的GFP的产物表现出与用野生型GFP产生的产物观察到的两个主要激发峰的比例的变化。在另一类中，衍生自经修饰的GFP的产物在比来自野生型GFP的相应产物更短的波长处发荧光。在另一类修饰中，衍生自经修饰的GFP的产物相对于衍生自野生型GFP的产物仅显示单个激发峰和增强的发射。

13. 发明授权

US09827333B2 Host cells with artificial endosymbionts 有权
公开(公告)号：US09827333B2
公开(公告)日：2017-11-28
申请号：US15368995
申请日：2016-12-05
申请人： BELL BIOSYSTEMS, INC.
发明人： Caleb B. Bell, III , Alexey Bazarov
IPC分类号： C12Q1/02 , A61K49/00 , A61B5/05 , A61N2/12 , A61K49/18 , B82Y5/00 , B82Y15/00 , C12N15/03 , A01K67/027 , G01N21/64 , G01N33/50 , G01N33/574 , A61B5/055
CPC分类号： A61K49/0047 , A01K67/0275 , A61B5/05 , A61B5/055 , A61K49/1896 , A61N2/12 , B82Y5/00 , B82Y15/00 , C12N15/03 , C12Q1/02 , G01N21/6486 , G01N33/5005 , G01N33/574 , G01N2333/195 , G01N2333/43595
摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

14. 发明申请

US20170198364A1 Genetically Encoded Fluorescent Sensors for Detecting Intracellular Signalling Through Diacylglycerol Pathways 审中-公开
公开(公告)号：US20170198364A1
公开(公告)日：2017-07-13
申请号：US15407111
申请日：2017-01-16
申请人： MONTANA MOLECULAR LLC
发明人： Thomas E. HUGHES , Paul H. TEWSON , Anne Marie QUINN
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/92 , C07K14/435 , C12N9/12
CPC分类号： C12Q1/6897 , C07K14/00 , C07K14/43595 , C07K2319/60 , C12N9/12 , C12N9/1205 , C12Y207/11013 , G01N33/502 , G01N33/5041 , G01N33/582 , G01N33/92 , G01N2333/43595 , G01N2333/912 , G01N2333/916
摘要： Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.

15. 发明申请

US20170080109A1 HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS 审中-公开
公开(公告)号：US20170080109A1
公开(公告)日：2017-03-23
申请号：US15368995
申请日：2016-12-05
申请人： BELL BIOSYSTEMS, INC.
发明人： Caleb B. BELL, III , Alexey Bazarov
IPC分类号： A61K49/00 , G01N33/50 , B82Y5/00 , A61N2/12 , C12Q1/02 , A61K49/18 , A61B5/055 , C12N15/03 , B82Y15/00
CPC分类号： A61K49/0047 , A01K67/0275 , A61B5/05 , A61B5/055 , A61K49/1896 , A61N2/12 , B82Y5/00 , B82Y15/00 , C12N15/03 , C12Q1/02 , G01N21/6486 , G01N33/5005 , G01N33/574 , G01N2333/195 , G01N2333/43595
摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

16. 发明授权

US09528980B2 Host cells with artificial endosymbionts 有权
公开(公告)号：US09528980B2
公开(公告)日：2016-12-27
申请号：US15173683
申请日：2016-06-05
申请人： BELL BIOSYSTEMS, INC.
发明人： Caleb B. Bell, III , Alexey Bazarov
IPC分类号： C12Q1/02 , G01N33/50 , A61B5/05 , A61N2/12 , A61K49/18 , C12N15/03 , A01K67/027 , A61K49/00 , G01N21/64 , G01N33/574 , B82Y5/00 , B82Y15/00
CPC分类号： A61K49/0047 , A01K67/0275 , A61B5/05 , A61B5/055 , A61K49/1896 , A61N2/12 , B82Y5/00 , B82Y15/00 , C12N15/03 , C12Q1/02 , G01N21/6486 , G01N33/5005 , G01N33/574 , G01N2333/195 , G01N2333/43595
摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

17. 发明申请

US20160282331A1 HOST CELLS WITH ARTIFICIAL ENDOSYMBIONTS 有权
公开(公告)号：US20160282331A1
公开(公告)日：2016-09-29
申请号：US15173683
申请日：2016-06-05
申请人： BELL BIOSYSTEMS, INC.
发明人： Caleb B. BELL, III , Alexey Bazarov
IPC分类号： G01N33/50 , A61K49/18 , G01N33/574 , G01N21/64 , A61K49/00
CPC分类号： A61K49/0047 , A01K67/0275 , A61B5/05 , A61B5/055 , A61K49/1896 , A61N2/12 , B82Y5/00 , B82Y15/00 , C12N15/03 , C12Q1/02 , G01N21/6486 , G01N33/5005 , G01N33/574 , G01N2333/195 , G01N2333/43595
摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.

18. 发明申请

US20160003854A1 GENETICALLY ENCODED FLUORESCENT SENSORS FOR DETECTING INTRACELLULAR SIGNALLING THROUGH DIACYLGLYCEROL PATHWAYS 有权
标题翻译：用于通过双歧杆菌途径检测细胞内信号的基因编码荧光传感器
公开(公告)号：US20160003854A1
公开(公告)日：2016-01-07
申请号：US14384464
申请日：2013-03-15
申请人： MONTANA MOLECULAR LLC
发明人： Thomas E. Hughes , Paul H. Tewson , Anne Marie Quinn
IPC分类号： G01N33/92 , C07K14/00 , C12N9/12
CPC分类号： C12Q1/6897 , C07K14/00 , C07K14/43595 , C07K2319/60 , C12N9/12 , C12N9/1205 , C12Y207/11013 , G01N33/502 , G01N33/5041 , G01N33/582 , G01N33/92 , G01N2333/43595 , G01N2333/912 , G01N2333/916
摘要： Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and hosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in amultiplex assay on standard fluorescent plate readers or live cell imaging systems.
摘要翻译：本文描述了基于循环置换的荧光蛋白的二酰基甘油（DAG）和高磷脂酰肌醇4,5-二磷酸（PIP2）的新型荧光传感器。这些传感器使用比基于FRET的传感器更少的可见光谱，产生强烈的荧光变化，并且可以在标准荧光板读数器或活细胞成像系统的多路复用测定中彼此或与其他传感器组合。

19. 发明授权

US09056840B2 Coelenterazine analogues and coelenteramide analogues 有权
标题翻译：肠杆菌素类似物和coelenteramide类似物
公开(公告)号：US09056840B2
公开(公告)日：2015-06-16
申请号：US14324962
申请日：2014-07-07
申请人： JNC Corporation , National University Corporation Tokyo Medical and Dental University
发明人： Satoshi Inouye , Yuiko Sahara , Takamitsu Hosoya
IPC分类号： C07D241/20 , C07D495/14 , C07D495/04 , C07D409/14 , C07D409/04 , C07D241/12 , C07D487/04 , C12N9/96 , C12Q1/66 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/573 , C07D241/12 , C07D241/20 , C07D409/04 , C07D409/14 , C07D487/04 , C07D495/04 , C07D495/14 , C12N9/96 , C12Q1/66 , C12Q1/68 , G01N21/6428 , G01N33/53 , G01N2333/43595 , G01N2333/90241
摘要： Coelenterazine analogs with different luminescence properties from conventional ones and coelenteramide analogs with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogs modified at the 8-position of coelenterazine and coelenteramide analogs modified at the 2- or 3-position of coelenteramide.
摘要翻译：已经期望具有不同于常规荧光发光性质的Coelenterazine类似物和具有不同于常规荧光性质的coelenteramide类似物。本发明提供在coelenterazine的8位修饰的肠溶素类似物和在肠腔酰胺的2-或3-位修饰的coelenteramide类似物。

20. 发明申请

US20140273203A1 Host Cells with Artificial Endosymbionts 有权
标题翻译：宿主细胞与人造内分泌物
公开(公告)号：US20140273203A1
公开(公告)日：2014-09-18
申请号：US14034528
申请日：2013-09-23
申请人： Bell Biosystems, Inc.
发明人： Caleb B. Bell, III , Alexey Bazarov
IPC分类号： C12N15/03
CPC分类号： A61K49/0047 , A01K67/0275 , A61B5/05 , A61B5/055 , A61K49/1896 , A61N2/12 , B82Y5/00 , B82Y15/00 , C12N15/03 , C12Q1/02 , G01N21/6486 , G01N33/5005 , G01N33/574 , G01N2333/195 , G01N2333/43595
摘要： The present invention is directed generally to eukaryotic cells comprising single-celled organisms that are introduced into the eukaryotic cell through human intervention and which transfer to daughter cells of the eukaryotic cell through at least five cell divisions, and methods of introducing such single-celled organisms into eukaryotic cells. The invention also provides methods of using such eukaryotic cells. The invention further provides single-celled organisms that introduce a phenotype to eukaryotic cells that is maintained in daughter cells. The invention additionally provides eukaryotic cells containing magnetotactic bacteria.
摘要翻译：本发明一般涉及包含单细胞生物的真核细胞，其通过人类干预被引入真核细胞，并通过至少五个细胞分裂转移到真核细胞的子细胞，以及引入这种单细胞生物体的方法进入真核细胞。本发明还提供了使用这种真核细胞的方法。本发明还提供了将单核细胞生物体引入到保留在子细胞中的真核细胞的表型。本发明另外提供含有磁力细菌的真核细胞。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式