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    • 13. 发明申请
    • BIOLOGICAL INFORMATION MEASURING SENSOR
    • 生物信息测量传感器
    • US20090116006A1
    • 2009-05-07
    • US11916432
    • 2006-06-06
    • Muneo Tokita
    • Muneo Tokita
    • G01J3/00
    • A61B5/1455A61B5/14532A61B5/14546A61B5/6817G01N21/314G01N2021/3174G01N2201/08
    • A biological information measuring sensor (10) has a light-receiving region (17) provided at a light-receiving element (16), a waveguide (15) provided in a waveguide formation member (14), filters (18a, 18b) for separating light emitted from an outlet-side opening portion (14b) of the waveguide (15) and irradiating the light-receiving region (17) with only light of a specific wavelength region, and a solenoid (20) for switching the filters (18a, 18b). The solenoid (20) switches between the filters (18a, 18b) to realize a first state where the light-receiving region (17) is irradiated with only light of a first wavelength region and a second state where the light-receiving region (17) is irradiated with only light of a second wavelength region. The construction simultaneously achieves both a reduction in size of a probe section and improvement of measurement accuracy.
    • 生物信息测量传感器(10)具有设置在光接收元件(16)的光接收区域(17),设置在波导形成构件(14)中的波导管(15),用于 分离从波导(15)的出口侧开口部(14b)发射的光并且仅使用特定波长区域的光照射光接收区(17),以及用于切换滤光器(18a)的螺线管 ,18b)。 螺线管(20)在滤光器(18a,18b)之间切换,以实现第一状态,其中光接收区域(17)仅照射第一波长区域和第二状态,其中光接收区域 )仅用第二波长区域的光照射。 该结构同时实现了探针部分尺寸的减小和测量精度的提高。
    • 15. 发明申请
    • Device for the pixel-by-pixel photoelectric measurement of a planar measured object
    • 用于平面测量对象的逐像素光电测量的装置
    • US20040066515A1
    • 2004-04-08
    • US10004787
    • 2001-12-07
    • Gretag-Macbeth AG
    • Hans Ott
    • G01N021/25
    • G01J3/02G01J3/0208G01J3/28G01J3/2803G01J3/2823G01J3/36G01J3/51G01J3/52G01J3/524G01N21/251G01N21/27G01N21/274G01N2021/3174
    • The device for the pixel-by-pixel photoelectric measurement of a planar measured object includes projection means (3,21) for the imaging of the measured object (M) onto a two-dimensional CCD image sensor (22), filter means (66) provided in the imaging light path for the wavelength selective filtering of the measuring light impinging on the image sensor, signal processing means (23) for the processing of the electrical signals produced by the image sensor and for the conversion thereof into corresponding digital raw measured data (71), as well as data processing means (7) for the processing of the raw measured data into image data (72) representing the colors of the individual image elements of the measured object. Furthermore, illumination means (4,41-43; 5,51-53) are provided which include a Fresnel lens (42:52), which illuminate the measured object (M) with at least one essentially parallel light bundle under an angle of incidence ({acute over (null)}) of essentially 45nullnull5null. The projection means which include at least one tele-lens (3) constructed as a Fresnel lens, are constructed as tele-centrical imaging optics (3,21), which image each point of the measured object (M) under essentially the same angle of observation of essentially 0null and with essentially the same aperture angle ({acute over (null)}) of essentially maximally 5null onto the light converter element array (22). The data processing means (7) carry out extensive correction measures.
    • 用于平面测量对象的逐像素光电测量的装置包括用于将测量对象(M)成像到二维CCD图像传感器(22)上的投影装置(3,21),滤光器装置(66) ),用于对入射到图像传感器上的测量光进行波长选择滤光的信号处理装置(23),用于处理由图像传感器产生的电信号并将其转换为相应的数字原始测量 数据(71)以及用于将原始测量数据处理成表示测量对象的各个图像元素的颜色的图像数据(72)的数据处理装置(7)。 此外,提供照明装置(4,41-43; 5,51-53),其包括菲菲尔透镜(42:52),其以至少一个基本平行的光束照射被测物体(M),角度为 发病率(&agr)基本为45°±5°。 包括构造为菲涅尔透镜的至少一个远摄镜头(3)的投影装置被构造为远摄中心成像光学器件(3,21),其将被测物体(M)的每个点基本上相同的角度 观察基本上为0°,并且基本上具有相当于光转换器元件阵列(22)上的最大5°的孔径角(&agr)。 数据处理装置(7)执行广泛的校正措施。
    • 16. 发明授权
    • Method for non-invasively determining the concentration of an analyte by compensating for the effect of tissue hydration
    • 通过补偿组织水合的影响非侵入性地测定分析物的浓度的方法
    • US06635491B1
    • 2003-10-21
    • US09627859
    • 2000-07-28
    • Omar S. KhalilJohannes Sake KangerRene′ Alexander BoltFrits Frans Maria de Mul
    • Omar S. KhalilJohannes Sake KangerRene′ Alexander BoltFrits Frans Maria de Mul
    • G01N3300
    • A61B5/1455A61B5/14514A61B5/14532G01N21/31G01N21/314G01N21/359G01N21/49G01N2021/3133G01N2021/3155G01N2021/3174Y10T436/144444
    • A method for determining the concentration of an analyte in tissues. The method involves compensating for a change in the value of an optical property of the tissues, such as, for example, the scattering coefficient, resulting from a change in the hydration status of the tissues. The method comprises the steps of: (a) measuring at least one optical property of a tissue sample at at least one wavelength at an initial time; (b) calculating the absorption coefficient and the scattering coefficient of the tissue sample at the initial time; (c) repeating the measurement of the at least one optical property of the tissue sample at at least a later time at the at least one wavelength; (d) calculating the absorption coefficient and scattering coefficient of the tissue sample at at least the later time; (e) calculating the change in the value of the absorption coefficient at the at least one wavelength to indicate the change in the water content of the tissue sample and the change in the value of the scattering coefficient to indicate both the change in the water content of the tissue sample and the change in concentration of an analyte in the tissue sample; (f) correcting the value of the scattering coefficient to account for the effect of the change in the water content of the tissue sample; and (g) calculating the concentration of the analyte by means of the corrected value of the scattering coefficient.
    • 确定组织中分析物浓度的方法。 该方法包括补偿组织的光学性质的变化值,例如由于组织的水合状态变化而产生的散射系数。 该方法包括以下步骤:(a)在初始时间测量至少一种波长的组织样品的至少一种光学性质;(b)计算初始时间组织样品的吸收系数和散射系数; (c)至少在稍后时间至少一个波长处重复所述组织样品的至少一种光学性质的测量;(d)至少在稍后时间计算组织样品的吸收系数和散射系数 ;(e)计算在至少一个波长处的吸收系数的值的变化,以指示组织样品的水含量的变化和散射系数的值的变化,以指示水的变化 组织样品的含量和组织样品中分析物的浓度变化;(f)校正散射系数的值,以考虑到水分含量变化的影响 组织样品; 和(g)通过散射系数的校正值计算分析物的浓度。
    • 20. 发明授权
    • Multiple component gas analyzer
    • 多组分气体分析仪
    • US4914719A
    • 1990-04-03
    • US321897
    • 1989-03-10
    • Brendan ConlonJames Dittmar
    • Brendan ConlonJames Dittmar
    • G01N21/31G01N21/35
    • G01N21/3504G01N2021/3129G01N2021/3174G01N21/61
    • A gas multiple component analyzer includes an infrared source that passes at least one measuring beam through a sample cell that contains the gas to be analyzed. Three measuring signals are generated in response to the measuring beam, and each is indicative of optical energy from the source transmitted through the sample cell in a respective optical region characterized by a respective optical center wave-length and a respective band pass. The three measuring signals are algebraically combined to automatically determine which of the three end gases is present in the sample cell in the greatest concentration, and the concentration thereof. The disclosed system measures concentration of three separate gases having overlapping absorption spectra.
    • 一种气体多分量分析仪包括红外源,其将至少一个测量光束通过含有待分析气体的样品池。 响应于测量光束产生三个测量信号,并且每个测量信号指示在由相应的光学中心波长和相应的带通特征的相应光学区域中来自通过采样单元的光源的光能。 三个测量信号被代数组合,以自动确定最大浓度的样品池中存在三种终端气体中的哪一种及其浓度。 所公开的系统测量具有重叠吸收光谱的三种分离气体的浓度。