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11. 发明授权

US10765521B2 Biomimetic functional and regenerative cartilage implant 有权
公开(公告)号：US10765521B2
公开(公告)日：2020-09-08
申请号：US16332253
申请日：2017-10-19
申请人： Technische Universiteit Eindhoven , RWTH Aachen
发明人： Corrinus Cornelis van Donkelaar , Keita Ito , Tim Bolle
IPC分类号： A61F2/30 , A61L27/52 , A61L27/50 , A61L27/58
摘要： An artificial cartilage is provided whereby a fixed negative charged hydrogel has been infused within a restrictive swelling network, which limits and restricts the thickness of the artificial cartilage. At least 60% of the volume of the artificial cartilage is composed of the restricted and swollen hydrogel. The restrictive swelling network restricts the hydrogel to swell not more than 10% with respect to its maximum swelling capacity, i.e. a swelling capacity to swell 10-fold more is retained. The hydrogel within the restrictive swelling network has an equilibrium stiffness between 0.5 and 2 MPa to resist external loads applied to the top surface layer or the bottom surface layer of the artificial cartilage. The hydrogel has a fixed negative charge density of −0.17 to −0.23 mEg/ml and is capable of swelling between 2-15 times compared to the volume of the hydrogel without being restricted.

12. 发明申请

US20190194755A1 ANALYSIS OF METHYLATION STATUS AND COPY NUMBER 审中-公开
公开(公告)号：US20190194755A1
公开(公告)日：2019-06-27
申请号：US16324576
申请日：2017-08-10
申请人： Ramot at Tel-Aviv University Ltd. , Rheinisch-Westfalische Technische Hochschule (RWTH) Aachen
发明人： Yuval EBENSTEIN , Elmar WEINHOLD , Assaf GRUNWALD , Tslil GABRIELI
IPC分类号： C12Q1/6883 , C12Q1/683
CPC分类号： C12Q1/6883 , C12Q1/683 , C12Q2600/154 , C12Y301/21004
摘要： A method of diagnosing a disease associated with a DNA repeat sequence is disclosed. The method comprises: (a) determining the number of repeats of a DNA sequence in DNA molecules of a sample of the subject; and (b) determining the CpG methylation status of the DNA molecules, wherein the number of repeats of the DNA sequence and the CpG methylation status of the DNA molecules is indicative of the disease.

13. 发明申请

US20190017124A1 BIOMARKER FOR BREAST CANCER 审中-公开
公开(公告)号：US20190017124A1
公开(公告)日：2019-01-17
申请号：US16067139
申请日：2016-10-28
申请人： RHEINISCH-WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN
发明人： Edgar DAHL , Vera KLOTEN , Jolein MIJNES
IPC分类号： C12Q1/6886 , G16H50/20 , G16H50/30
摘要： The present invention relates in a first aspect to new methods for diagnosing or identifying breast cancer or pre-forms thereof in a subject as well as methods for monitoring the development or progress of breast cancer or pre-forms thereof in a subject and methods for the stratification of the therapeutic regimen of a subject suspected to be afflicted with breast cancer or being at risk of developing breast cancer or pre-forms thereof whereby the level or amount of methylation of at least one of the promoters selected from SPAG6-, PER1- and NKX2-6-gene in a sample of said subject is determined followed by the step of diagnosing or identifying breast cancer or pre-forms thereof based on the level on amount of methylation of the at least one promoter. Further, the present invention relates to the use of a kit in a method according to the present invention. Finally, the present invention relates to new biomarkers, namely, the promoter of the SPAG6-gene, the promoter of the PER1-gene and the promoter of the NKX2-6-gene, in particular, the level or amount of methylation of said promoters is a biomarker for breast cancer.

14. 发明申请

US20180008972A1 METHOD FOR REDUCTION OF ORGANIC MOLECULES 审中-公开
公开(公告)号：US20180008972A1
公开(公告)日：2018-01-11
申请号：US15549908
申请日：2015-02-11
申请人： RHEINISCH-WESTFÄLISCHE TECHNISCHE (RWTH) AACHEN
发明人： Jürgen KLANKERMAYER , Walter Leitner , Markus Meuresch
IPC分类号： B01J31/24 , C07D307/06
CPC分类号： B01J31/2409 , B01J2231/645 , B01J2531/821 , C07C29/177 , C07C67/303 , C07D307/06 , C07D307/33 , C07C69/34 , C07C31/20
摘要： A method for the reduction organic molecules comprising a Ruthenium-Triphosphine complex with aromatic ligands at the phosphors which are ortho or meta substituted.

15. 发明申请

US20170174698A1 METHOD FOR THE SYNTHESIS OF PRIMARY ISOHEXIDE AMINES 有权
公开(公告)号：US20170174698A1
公开(公告)日：2017-06-22
申请号：US15327262
申请日：2014-07-18
申请人： RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHLULE (RWTH) AACHEN
发明人： Marcus ROSE , Regina PALKOVITS , Rebecca ENGEL , Alireza HAJI BEGLI , Christine KROENER
IPC分类号： C07D493/04 , B01J21/18 , B01J35/00 , B01J23/46
CPC分类号： C07D493/04 , B01J21/18 , B01J23/462 , B01J35/0006
摘要： A method for synthesizing a primary amine, having the steps of: a) providing at least one dianhydrohexitol, and b) aminating the dianhydrohexitol by reacting same with ammonia, the amination being performed by heterogeneous catalysis using a hydrogenation catalyst in the presence of hydrogen.

16. 发明授权

US09484705B2 Optically end-pumped slab amplifier comprising pump modules arranged in a distributed manner 有权
标题翻译：光学端泵板式放大器包括以分布式布置的泵模块
公开(公告)号：US09484705B2
公开(公告)日：2016-11-01
申请号：US14440643
申请日：2013-11-07
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. , RWTH AACHEN
发明人： Peter Russbueldt , Guido Rotarius , Thomas Sartorius , Johannes Weitenberg
IPC分类号： H01S3/06 , H01S3/08 , H01S3/094 , H01S3/16 , H01S3/0941
CPC分类号： H01S3/0604 , H01S3/0606 , H01S3/0625 , H01S3/08059 , H01S3/08081 , H01S3/08095 , H01S3/09408 , H01S3/094084 , H01S3/094096 , H01S3/09415 , H01S3/1618 , H01S3/1643 , H01S2301/02
摘要： An optically end-pumped amplifier with a plate-shaped optical gain medium has a plurality of pump laser units for optically pumping the gain medium through at least one of the narrow side surfaces thereof. The pump laser units are designed such that the pump laser radiation, upon passing through the gain medium, has an elongated beam cross section having a short axis and a long axis running parallel to the main surfaces of the gain medium and propagates freely through the gain medium with respect to the short axis. They are arranged such that in each case the principal axes of the beam bundles of the pump laser units impinge on one of the pumped side surfaces in a plane perpendicular to the short axis at an angle to one another, wherein the beam cross sections of the beam bundles are superimposed on one another.
摘要翻译：具有板状光学增益介质的光学端部泵浦放大器具有多个泵浦激光器单元，用于通过其增益介质中的至少一个窄侧面光学泵浦增益介质。泵浦激光器单元被设计成使得泵浦激光辐射在通过增益介质时具有细长的横截面，其具有短轴和平行于增益介质的主表面延伸的长轴，并且通过增益自由地传播介质相对于短轴。它们被布置成使得在每种情况下，泵激光单元的束束的主轴在垂直于短轴的平面中的一个泵浦侧表面上彼此成角度地撞击，其中梁的横截面束束彼此重叠。

17. 发明授权

US09240759B2 Amplifier assembly 有权
标题翻译：放大器组件
公开(公告)号：US09240759B2
公开(公告)日：2016-01-19
申请号：US14408517
申请日：2013-06-12
申请人： RWTH AACHEN
发明人： Renato Negra , Ahmed Aref
IPC分类号： H03F1/32 , H03F1/02 , H03F3/19 , H03F3/21 , H03G3/30
CPC分类号： H03F1/3252 , H03F1/0288 , H03F1/0294 , H03F3/19 , H03F3/211 , H03F2200/36 , H03F2200/451 , H03F2201/3215 , H03F2203/21106 , H03G3/3042
摘要： The invention relates to an amplifier assembly. The assembly comprises an input device for receiving a representation of an input signal (I, Q; A, phi), a signal-component separator, wherein the signal-component separator produces a first complex intermediate output signal (S1) and a second complex intermediate output signal (S2), wherein the signal-component separator produces the first complex intermediate output signal (S1) and the second complex intermediate output signal (S2) on the basis of the representation of the input signal (I, Q; A, phi), wherein the signal-component separator provides a plurality of amplitude levels, wherein the plurality of amplitude levels is selected in such a way that a sum of the first complex intermediate output signal (S1) and the second complex intermediate output signal (S2) is substantially a reflection of a complex input signal in accordance with the representation of the input signal (I, Q; A, phi) and the phase angle between the first complex intermediate output signal (S1) and the second complex intermediate output signal (S2) is small. Furthermore, the assembly comprises an amplifying device for amplifying the signals in the high-frequency state and a combining device for combining the signals.
摘要翻译：本发明涉及放大器组件。组件包括用于接收输入信号（I，Q; A，phi）的表示的输入装置，信号分量分离器，其中信号分量分离器产生第一复合中间输出信号（S1）和第二复合体中间输出信号（S2），其中所述信号分量分离器基于所述输入信号（I，Q; A，S）的表示来产生所述第一复合中间输出信号（S1）和所述第二复合中间输出信号（S2）其中所述信号分量分离器提供多个幅度电平，其中所述多个幅度电平被选择为使得所述第一复合中间输出信号（S1）和所述第二复合中间输出信号（S2 ）基本上是根据输入信号（I，Q; A，phi）的表示和第一复合中间输出信号（S1）和第二c的相位角的复数输入信号的反射 omplex中间输出信号（S2）很小。此外，该组件包括用于放大高频状态的信号的放大装置和用于组合信号的组合装置。

18. 发明授权

US08988766B2 Optical resonator with direct geometric access to the optical axis 有权
标题翻译：光学谐振器，直接几何访问光轴
公开(公告)号：US08988766B2
公开(公告)日：2015-03-24
申请号：US13978882
申请日：2011-12-21
申请人： Peter Russbuldt , Johannes Weitenberg , Joachim Pupeza , Thomas Udem
发明人： Peter Russbuldt , Johannes Weitenberg , Joachim Pupeza , Thomas Udem
IPC分类号： G02F1/37 , G02B17/00 , H01S3/00 , G02F1/35 , H01S3/08 , H01S3/081
CPC分类号： G02B17/004 , G02F2001/3542 , H01S3/0092 , H01S3/08068 , H01S3/0816
摘要： The present invention relates to a stable optical cavity, in which an obstacle is formed or arranged on the optical axis in the form of a through-opening in one of the mirrors or of an input- or output-coupling element, in order to enable a direct geometric access to the optical axis. The mirrors of the cavity are arranged such that a degeneracy of a plurality of transverse eigenmodes of the cavity occurs without an obstacle, by the combination of which an intensity minimum is obtained in the cavity with an obstacle at the position of the through-opening or of the input- or output-coupling element. With this configuration an optical cavity of high finesse which has a position of maximum intensity on the optical axis can be realized.
摘要翻译：本发明涉及一种稳定的光学腔，其中在其中一个反射镜或输入或输出耦合元件中以通孔的形式在光轴上形成或布置障碍物，以便使能直接几何访问光轴。空腔的反射镜被布置成使得空腔的多个横向本征模的简并发生而没有障碍物，其结合是在空腔中获得强度最小值，在通孔的位置处具有障碍物，或的输入或输出耦合元件。利用这种结构，可以实现在光轴上具有最大强度位置的高精细度的光学腔。

19. 发明申请

US20150071184A1 METHOD FOR A TRANSMITTER FOR A MULTI-CHANNEL COMMUNICATION SYSTEM FOR SENDING REAL-TIME DATA 有权
标题翻译：用于发送实时数据的多信道通信系统的发射机的方法
公开(公告)号：US20150071184A1
公开(公告)日：2015-03-12
申请号：US14110493
申请日：2012-04-05
申请人： Christian Dombrowski , James Gross
发明人： Christian Dombrowski , James Gross
IPC分类号： H04L5/00
CPC分类号： H04L5/0053 , H04B1/74 , H04L1/0009 , H04L1/04 , H04L1/0625 , H04L1/08 , H04L5/003
摘要： The invention relates to a method for a transmitter for a multi-channel communication system for sending real-time sensitive data D, wherein the communication system has n sub-channels, wherein n is greater than 1, wherein the sub-channels are spatially different and/or the sub-channels have different frequencies. The method comprises the steps of receiving information about the channel state of the n sub-channels, receiving information about the number of statistically independent sub-channels m, wherein m is less than or equal to n, and receiving dataD intended to be sent. When the method is performed, data D intended to be sent are divided into Ifragments and a plurality o of messages to be sent to at least one receiver are provided, wherein the number of messages o is less than or equal to the number of statistically independent sub-channels m, wherein each of the messages has at least one fragment, wherein one of the messages additionally has at least one part of a fragment, wherein at least one fragment in the plurality o of messages is contained at least r times in different messages as a fragment and/or at least as the part of the fragment, wherein r is greater than or equal to 1, and wherein r is determined on the basis of the number of statistically independent sub-channels m present and the size of the data to be sent. Then said plurality o of messages is sent, wherein each message is sent by means of a different channel of the o channels.
摘要翻译：本发明涉及一种用于发送实时敏感数据D的多信道通信系统的发射机的方法，其中通信系统具有n个子信道，其中n大于1，其中子信道在空间上不同和/或子通道具有不同的频率。该方法包括以下步骤：接收关于n个子信道的信道状态的信息，接收关于统计上独立的子信道m的数量的信息，其中m小于或等于n，并接收预期发送的数据D。当执行该方法时，要发送的数据D被划分成Ifragments，并且提供要发送给至少一个接收器的多个消息，其中消息的数量o小于或等于统计独立的数量子信道m，其中每个消息具有至少一个片段，其中所述消息中的一个附加地具有片段的至少一部分，其中所述多个消息中的至少一个片段至少包含r次的不同消息作为片段和/或至少作为片段的一部分，其中r大于或等于1，并且其中r基于当前存在的统计独立子信道的数量和所述片段的大小来确定要发送的数据然后发送所述多个消息，其中每个消息通过o个信道的不同信道发送。

20. 发明申请

US20140064734A1 WDM TELECOMMUNICATIONS LINK WITH COHERENT DETECTION AND OPTICAL FREQUENCY COMB SOURCES 有权
标题翻译： WDM电信联盟与相关检测和光电频率源
公开(公告)号：US20140064734A1
公开(公告)日：2014-03-06
申请号：US14114872
申请日：2012-04-27
申请人： Jeremy Witzens
发明人： Jeremy Witzens
IPC分类号： H04B10/61 , H04J14/02
CPC分类号： H04B10/6164 , H04B10/64 , H04J14/002 , H04J14/02
摘要： An optical data link has a transmitter and a receiver with coherent detection at the receiver and more than one optical carrier frequency. The optical carrier frequencies are generated by a frequency comb source in both the transmitter and the receiver. The frequency comb sources generate frequency combs that have frequency components and a free spectral range. The optical carrier frequencies transport more than one optical channel. Either at least one frequency component or the free spectral range of the optical comb generated at the receiver is locked to the comb generated at the transmitter by an optical phase locked loop, or an electrical phase locked loop or a feed-forward carrier recovery generates an intermediate frequency carrier reference that is routed to more than one channel to demodulate the data.
摘要翻译：光学数据链路具有在接收机处具有相干检测的发射机和接收机以及多于一个的光载波频率。光载波频率由发射机和接收机中的频率梳源产生。频率梳源产生具有频率分量和自由光谱范围的频率梳。光载波频率传输多于一个光通道。在接收机处产生的光梳的至少一个频率分量或自由频谱范围通过光锁相环锁定在发射机处产生的梳，或者电锁相环或前馈载波恢复产生路由到多个信道以解调数据的中频载波参考。

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