专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

US20220233689A1 METHODS OF TREATING TUMORS 有权
公开(公告)号：US20220233689A1
公开(公告)日：2022-07-28
申请号：US17562958
申请日：2021-12-27
申请人： Bristol-Myers Squibb Company , Halozyme, Inc.
发明人： Masano Huang , Thomas Arthur Haby , Mehrnaz KHOSSRAVI , Scott Aaron HART , Rao Venkatramana MANTRI , Heather Elizabeth VEZINA , Amit ROY , Bindu Purnima MURTHY , Urvi Ashish ARAS , Kinjal SANGHAVI , Xiaochen ZHAO , Akintunde BELLO
IPC分类号： A61K39/395 , A61K38/47 , A61K9/00 , A61K47/26 , A61K47/22 , A61K47/18
摘要： The disclosure provides pharmaceutical compositions comprising an anti-PD-1 antibody or an anti-PD-L1 antibody. In some aspects, the pharmaceutical compositions are formulated for subcutaneous delivery. In some aspects, the pharmaceutical compositions further comprise an endoglycosidase hydrolase enzyme. Other aspects of the present disclosure are directed to methods of subcutaneously delivering a pharmaceutical composition comprising an anti-PD-1 antibody or an anti-PD-L1 antibody.

12. 发明授权

US11066656B2 PH20 polypeptide variants, formulations and uses thereof 有权
公开(公告)号：US11066656B2
公开(公告)日：2021-07-20
申请号：US16912590
申请日：2020-06-25
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K38/47 , A61K38/28 , A61K45/06 , A61K9/00 , A61K47/10 , C12Q1/34 , A61K38/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

13. 发明授权

US09993529B2 Stable formulations of a hyaluronan-degrading enzyme 有权
公开(公告)号：US09993529B2
公开(公告)日：2018-06-12
申请号：US13507262
申请日：2012-06-15
申请人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
发明人： Tzung-Horng Yang , Daniel Edward Vaughn , Michael James Labarre , Christopher L. Caster , Francois Nicol , Donghyun Kim
IPC分类号： C07K14/62 , C12N9/24 , A61K38/28 , A61K47/02 , C07K5/06 , C07K5/068 , A61K38/47 , A61K9/00
CPC分类号： A61K38/28 , A61K9/0019 , A61K38/47 , A61K47/02 , C07K5/06 , C07K5/06086 , C07K14/62 , C12N9/2402 , C12Y302/01035
摘要： Provided are compositions that are stable formulations of a hyaluronan-degrading enzyme or are stable co-formulations of a fast-acting insulin and a hyaluronan degrading enzyme, including a recombinant human PH20 (rHuPH20).

14. 发明授权

US09878046B2 Adverse side-effects associated with administration of an anti-hyaluronan agent and methods for ameliorating or preventing the side-effects 有权
公开(公告)号：US09878046B2
公开(公告)日：2018-01-30
申请号：US13135817
申请日：2011-07-15
申请人： Harold Michael Shepard , Curtis Thompson , Xiaoming Li , Gregory I. Frost
发明人： Harold Michael Shepard , Curtis Thompson , Xiaoming Li , Gregory I. Frost
IPC分类号： A61K31/573 , A61K47/48 , A61K31/37 , A61K31/42 , A61K38/47 , A61K9/00 , A61K47/60
CPC分类号： A61K47/60 , A61K9/0019 , A61K9/0053 , A61K31/37 , A61K31/42 , A61K31/573 , A61K38/47 , C12Y302/01035 , A61K2300/00
摘要： Provided herein are methods for ameliorating an adverse effect of systemic administration of a PEG hyaluronan degrading enzyme to a subject. The methods involve systemically administering a PEGylated hyaluronan degrading enzyme, particularly a PEGylated hyaluronidase, such as any of the animal or bacterial hyaluronidases, to the subject and administering an amount of a corticosteroid sufficient to ameliorate the adverse effect. Also provided are method of treating a hyaluronan-associated disease or condition for single-agent therapy or combination therapy.

15. 发明授权

US09683985B2 Methods for assessing and identifying or evolving conditionally active therapeutic proteins 有权
公开(公告)号：US09683985B2
公开(公告)日：2017-06-20
申请号：US13200666
申请日：2011-09-27
申请人： Lalitha Kodandapani , Louis H. Bookbinder , Gregory I. Frost , Philip Lee Sheridan , Harold Michael Shepard , Ge Wei , Lei Huang
发明人： Lalitha Kodandapani , Louis H. Bookbinder , Gregory I. Frost , Philip Lee Sheridan , Harold Michael Shepard , Ge Wei , Lei Huang
IPC分类号： G01N33/50 , C07K16/28 , C07K16/30 , C07K16/44 , G01N33/53
CPC分类号： G01N33/5011 , C07K16/2863 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/5014 , G01N33/5088 , G01N33/53 , G01N2333/71
摘要： Methods for evolving or selecting or producing therapeutic proteins that exhibit reduced adverse side-effects and the resulting proteins are provided. For example, provided herein is an in vitro assay to identify conditionally active therapeutic proteins that exhibit better activity within one in vivo environment compared to another in vivo environment. The methods include the steps of a) testing the activity of a protein under conditions in which normal or increased activity is desired; b) testing the activity of the protein under conditions in which reduced activity compared to normal is desired; and c) comparing the activity in a) with b) and selecting/identifying a protein that has greater activity in a) compared to b). The selected/identified protein is a conditionally active protein.

16. 发明授权

US09284543B2 Neutral active soluble truncated PH20 polypeptides and uses thereof 有权
标题翻译：中性活性可溶性截短的PH20多肽及其用途
公开(公告)号：US09284543B2
公开(公告)日：2016-03-15
申请号：US13385527
申请日：2012-02-21
申请人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
发明人： Ge Wei , Krishnasamy Panneer Selvam , Louis Bookbinder , Gregory I. Frost
IPC分类号： C12N9/26 , A61K47/48 , A61K38/00
CPC分类号： C12N9/2408 , A61K38/00 , A61K47/60 , A61K47/61 , A61K47/6435 , C12N9/2474
摘要： Soluble PH20 polypeptides are provided, including extended soluble PH20 polypeptides, and uses thereof. Also provided are other C-terminally truncated PH20 polypeptides and partially deglycosylated PH20 polypeptides and uses thereof.
摘要翻译：提供可溶性PH20多肽，包括延长的可溶性PH20多肽及其应用。还提供了其它C末端截短的PH20多肽和部分去糖基化的PH20多肽及其用途。

17. 发明申请

US20140350087A9 Oncovector Nucleic Acid Molecules and Methods of Use 审中-公开
标题翻译： Oncovector核酸分子和使用方法
公开(公告)号：US20140350087A9
公开(公告)日：2014-11-27
申请号：US13801940
申请日：2013-03-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Gregory I. Frost , Mark Roman , Frank McCormick , Tanja Meyer Tamgüney
IPC分类号： A61K48/00 , A61K31/513 , C12N15/85
CPC分类号： A61K48/0058 , A61K31/513 , C07K14/82 , C12N15/85 , C12N2710/16233 , C12N2710/22033 , C12N2810/6054 , C12N2810/6063 , C12N2810/6081 , C12N2820/002 , C12N2820/60 , C12N2830/20 , C12N2840/203
摘要： Provided herein are non-viral nucleic acid vectors, including non-viral oncovectors, that are autonomously replicating plasmids (ARPs). The non-viral nucleic acid vectors exhibit fusogenic activity and can exhibit other anti-tumor or cytotoxic activities. Also provided herein are methods and uses of the non-viral nucleic acid vectors for treating cancer.
摘要翻译：本文提供的是非病毒核酸载体，包括非病毒载体，其是自主复制的质粒（ARP）。非病毒核酸载体表现出融合活性并且可以表现出其它抗肿瘤或细胞毒活性。本文还提供了非病毒核酸载体治疗癌症的方法和用途。

18. 发明授权

US08815558B2 Human chondroitinase glycoprotein (CHASEGP), process for preparing the same, and pharmaceutical compositions comprising thereof 有权
标题翻译：人类软骨素酶糖蛋白（CHASEGP），其制备方法和由其组成的药物组合物
公开(公告)号：US08815558B2
公开(公告)日：2014-08-26
申请号：US12475221
申请日：2009-05-29
申请人： Gregory I. Frost , Anirban Kundu , Louis H. Bookbinder
发明人： Gregory I. Frost , Anirban Kundu , Louis H. Bookbinder
IPC分类号： C12N9/24 , C12P21/06 , C12N15/00 , C12N1/20 , C12N5/00 , C07H21/04
CPC分类号： C12N9/88 , A61K38/47 , C12Y402/02004
摘要： The invention relates to the discovery of novel Chondroitinase Glycoproteins (CHASEGPs), methods of manufacture, and potential uses in conditions where removal of chondroitin sulfates may be of therapeutic benefit. Chondroitinase Glycoproteins require both a substantial portion of the catalytic domain of the CHASEGP polypeptide and asparagine-linked glycosylation for optimal chondroitinase activity. The invention also includes carboxy-terminal deletion variants of CHASEGP that result in secreted variants of the protein to facilitate manufacture of a recombinant CHASEGP. Further described are suitable formulations of a substantially purified recombinant CHASEGP glycoprotein derived from a eukaryotic cell that generate the proper glycosylation required for its optimal activity. CHASEGP is useful for the degradation of glycosaminoglycans and chondroitin sulfate proteoglycans under clinical conditions where their removal is of therapeutic value.
摘要翻译：本发明涉及在去除硫酸软骨素可能具有治疗益处的条件下发现新型软骨素酶糖蛋白（CHASEGP），制造方法和潜在用途。软骨素酶糖蛋白需要CHASEGP多肽的大部分催化结构域和天冬酰胺连接的糖基化以获得最佳的软骨素酶活性。本发明还包括CHASEGP的羧基末端缺失变体，其导致蛋白质的分泌型变体以促进重组CHASEGP的制备。进一步描述了衍生自真核细胞的基本上纯化的重组CHASEGP糖蛋白的合适制剂，其产生其最佳活性所需的适当糖基化。 CHASEGP可用于在其去除具有治疗价值的临床条件下降解糖胺聚糖和硫酸软骨素蛋白聚糖。

19. 发明授权

US12104185B2 PH20 polypeptide variants, formulations and uses thereof 有权
公开(公告)号：US12104185B2
公开(公告)日：2024-10-01
申请号：US18599428
申请日：2024-03-08
申请人： Halozyme, Inc.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

20. 发明授权

US12037618B2 PH20 polypeptide variants, formulations and uses thereof 有权
公开(公告)号：US12037618B2
公开(公告)日：2024-07-16
申请号：US17327586
申请日：2021-05-21
申请人： HALOZYME, INC.
发明人： Ge Wei , H. Michael Shepard , Qiping Zhao , Robert James Connor
IPC分类号： C12N9/26 , A61K9/00 , A61K38/00 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34
CPC分类号： C12N9/2474 , A61K9/0019 , A61K38/28 , A61K38/47 , A61K45/06 , A61K47/10 , A61P35/00 , C07K14/47 , C12Q1/34 , C12Y302/01035 , A61K38/00 , C07K2319/30 , G01N2333/926 , G01N2333/928 , Y02A50/30 , A61K38/28 , A61K2300/00 , A61K38/47 , A61K2300/00
摘要： Modified PH20 hyaluronidase polypeptides, including modified polypeptides that exhibit increased stability and/or increased activity, are provided. Also provided are compositions and formulations and uses thereof.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式