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11. 发明申请

US20060258021A1 Biocompatible linkers for surface plasmon resonance biosensors 审中-公开
标题翻译：表面等离子体共振生物传感器的生物相容性接头
公开(公告)号：US20060258021A1
公开(公告)日：2006-11-16
申请号：US10567059
申请日：2004-08-12
申请人： Karl Booksh , Jean-Francois Masson
发明人： Karl Booksh , Jean-Francois Masson
IPC分类号： G01N1/28 , G01N33/543
CPC分类号： G01N33/54393 , B82Y15/00 , B82Y30/00 , B82Y40/00 , G01N33/54373
摘要： A method of coating an SPR biosensor specific for an analyte to reduce protein fouling, the method has the steps of providing an SPR biosensor, providing a solution of 11-mercaptoundecanol; incubating the SPR biosensor in the 11-mercaptoundecanol solution to form a self-assembling monolayer (SAM); incubating the SPR with SAM in a solution of epichlorohydrin and diglyme; next incubating the SPR in ethanolamine; preparing a solution of EDCNHS and a biocompatible polymer; incubating the SPR from ethanolamine in the EDC/NHS/polymer solution; providing a ligand specific for the analyte in a solution; incubating the polymer-coated SPR in the ligand solution to permit the ligand to react with the polymer-coated SPR; washing the ligand-coated SPR to remove unreacted ligand, thereby providing an SPR capable of reacting with the analyte. Another method replaces the solution for the SAM layer with a solution of MHA or NHS-MHA with HT, and attaches the ligand to the resulting SAM layer.
摘要翻译：一种涂覆专用于分析物的SPR生物传感器以减少蛋白质结垢的方法，该方法具有提供SPR生物传感器，提供11-巯基十一烷醇溶液的步骤; 将SPR生物传感器置于11-巯基十一烷醇溶液中以形成自组装单层（SAM）; 将SPR与SAM在表氯醇和二甘醇二甲醚溶液中孵育; 接着在乙醇胺中培养SPR; 制备EDCNHS和生物相容性聚合物的溶液; 在EDC / NHS /聚合物溶液中从乙醇胺中培养SPR; 提供溶液中分析物特异性的配体; 将配体溶液中的聚合物涂覆的SPR孵育以允许配体与聚合物涂覆的SPR反应; 洗涤配体涂覆的SPR以除去未反应的配体，从而提供能够与分析物反应的SPR。另一种方法用MHA或NHS-MHA与HT的溶液替代SAM层的溶液，并将配体连接到所得的SAM层。

12. 发明授权

US5426194A Isolation and structure of Halistatin 1 失效
标题翻译： Halistatin的分离和结构1
公开(公告)号：US5426194A
公开(公告)日：1995-06-20
申请号：US4851
申请日：1993-01-19
申请人： George R. Pettit , Rui Tan , Feng Gao
发明人： George R. Pettit , Rui Tan , Feng Gao
IPC分类号： A61K31/365 , A61K35/00 , A61K35/02 , A61K35/56 , A61P35/00 , A61P35/02 , C07D493/22 , C07H9/02 , C12P17/18 , C12P19/44 , C07D323/00
CPC分类号： C07H9/02 , C07D493/22 , C12P17/181 , C12P19/445
摘要： An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidation (primarily by high field NMR and mass spectrometry) of halistatin 1, a new polyether macrolide of the halipyran-type, from the Western Indian Ocean sponge Phakellia carteri. Halistatin 1 (8.8.times.10.sup.-7 % yield) caused the accumulation of cells arrested in mitosis, inhibited tubulin polymerization, and inhibited the binding of radiolabeled vinblastine and GTP to tubulin.
摘要翻译：对海洋生物进行深入的长期调查，作为新的抗癌药物的来源，导致了halistatin 1（Halipyran型的新型聚醚大环内酯类）的隔离和结构解释（主要是通过高场NMR和质谱），来自西方印度洋海绵Phakellia carteri。 Halistatin 1（8.8×10-7％产率）引起细胞中有丝分裂停滞的积累，抑制微管蛋白聚合，并抑制放射性标记的长春花碱和GTP与微管蛋白的结合。

13. 发明公开

US20230243829A1 Biomarkers for the early detection of breast cancer 审中-公开
公开(公告)号：US20230243829A1
公开(公告)日：2023-08-03
申请号：US18173892
申请日：2023-02-24
申请人： Arizona Board of Regents, a body corporate acting for and on behalf of Arizona State University , DANA-FARBER CANCER INSTITUTE, INC.
发明人： Joshua LABAER , Karen Sue ANDERSON , Garrick WALLSTROM , Sahar SIBANI , Niroshan RAMACHANDRAN
IPC分类号： G01N33/574 , C12Q1/6886 , C07K14/47 , C07K17/00 , C40B40/10
CPC分类号： G01N33/57415 , C12Q1/6886 , C07K14/47 , C07K17/00 , C40B40/10 , C12Q2600/158 , C12Y301/27004
摘要： The present invention provides reagents and methods for breast cancer detection.

14. 发明授权

US09857374B2 Biomarkers for the early detection of breast cancer 有权
公开(公告)号：US09857374B2
公开(公告)日：2018-01-02
申请号：US13809695
申请日：2011-08-15
申请人： Joshua LaBaer , Karen Sue Anderson , Garrick Wallstrom , Sahar Sibani , Niroshan Ramachandran
发明人： Joshua LaBaer , Karen Sue Anderson , Garrick Wallstrom , Sahar Sibani , Niroshan Ramachandran
IPC分类号： A61K45/00 , A61K39/00 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides reagents and methods for breast cancer detection.

15. 发明申请

US20130150259A1 BIOMARKERS FOR THE EARLY DETECTION OF BREAST CANCER 有权
标题翻译：早期检测乳腺癌的生物标志物
公开(公告)号：US20130150259A1
公开(公告)日：2013-06-13
申请号：US13809695
申请日：2011-08-15
申请人： Joshua LaBaer , Karen Sue Anderson , Garrick Wallstrom , Sahar Sibani , Niroshan Ramachandran
发明人： Joshua LaBaer , Karen Sue Anderson , Garrick Wallstrom , Sahar Sibani , Niroshan Ramachandran
IPC分类号： G01N33/574
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/158
摘要： The present invention provides reagents and methods for breast cancer detection.
摘要翻译：本发明提供了用于乳腺癌检测的试剂和方法。

16. 发明申请

US20130096656A1 NEUROSTIMULATOR 有权
标题翻译：神经细胞
公开(公告)号：US20130096656A1
公开(公告)日：2013-04-18
申请号：US13692530
申请日：2012-12-03
申请人： Arizona Board of Regents, a body corporate, actin
发明人： Bruce Towe , William Crisp
IPC分类号： A61N1/36
CPC分类号： A61N1/3787 , A61N1/05 , A61N1/32 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N7/00
摘要： Methods and devices for stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry, an acoustic transducer and a pair of electrodes.
摘要翻译：公开了刺激神经的方法和装置。在适于刺激可兴奋组织的一个实施例中，本发明包括驱动电路，声换能器和一对电极。

17. 发明授权

US08361786B2 Photobioreactor and uses therefor 失效
标题翻译：光生物反应器及其用途
公开(公告)号：US08361786B2
公开(公告)日：2013-01-29
申请号：US13561777
申请日：2012-07-30
申请人： Qiang Hu , Milton Sommerfeld
发明人： Qiang Hu , Milton Sommerfeld
IPC分类号： C12M1/00 , A01G7/00
CPC分类号： C12M41/12 , C12M21/02 , C12M23/02 , C12M23/04 , C12M23/44 , C12M23/50
摘要： The present invention provides novel photobioreactors, modules thereof, and methods for use in culturing and harvesting algae and cyanobacteria.
摘要翻译：本发明提供新颖的光生物反应器，其模块，以及用于培养和收获藻类和蓝细菌的方法。

18. 发明授权

US08241895B2 Methods of algal growth in photobioreactors 失效
标题翻译：光生物反应器中藻类生长的方法
公开(公告)号：US08241895B2
公开(公告)日：2012-08-14
申请号：US13273161
申请日：2011-10-13
申请人： Qiang Hu , Milton Sommerfeld
发明人： Qiang Hu , Milton Sommerfeld
IPC分类号： C12M1/00 , C12M1/36 , A01G7/00 , C12N1/12
CPC分类号： C12M41/12 , C12M21/02 , C12M23/02 , C12M23/04 , C12M23/44 , C12M23/50
摘要： The present invention provides novel photobioreactors, modules thereof, and methods for use in culturing and harvesting algae and cyanobacteria.
摘要翻译：本发明提供新颖的光生物反应器，其模块，以及用于培养和收获藻类和蓝细菌的方法。

19. 发明申请

US20120041499A1 Neurostimulator 失效
标题翻译：神经刺激器
公开(公告)号：US20120041499A1
公开(公告)日：2012-02-16
申请号：US13214077
申请日：2011-08-19
申请人： Bruce C. Towe , William E. Crisp
发明人： Bruce C. Towe , William E. Crisp
IPC分类号： A61N1/36 , A61N7/00
CPC分类号： A61N1/3787 , A61N1/05 , A61N1/32 , A61N1/36071 , A61N1/36125 , A61N1/37205 , A61N7/00
摘要： Methods and devices for stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry, an acoustic transducer and a pair of electrodes.
摘要翻译：公开了刺激神经的方法和装置。在适于刺激可兴奋组织的一个实施例中，本发明包括驱动电路，声换能器和一对电极。

20. 发明申请

US20110272744A1 Laterally Varying II-VI Alloys and Uses Thereof 有权
标题翻译： II-VI型合金及其用途
公开(公告)号：US20110272744A1
公开(公告)日：2011-11-10
申请号：US13126864
申请日：2009-11-06
申请人： Cun-zheng Ning , Anlian Pan
发明人： Cun-zheng Ning , Anlian Pan
IPC分类号： H01L29/221 , H01B1/10 , H01L29/225 , H01L21/40 , B82Y99/00 , B82Y40/00
CPC分类号： H01L21/02557 , H01L21/02422 , H01L21/02491 , H01L21/0256 , H01L21/02562 , H01L21/02568 , H01L21/0262 , H01L21/02636 , H01L31/0296 , H01L31/0352 , H01L33/02 , H01L33/28 , H01L2924/0002 , H01S5/1042 , H01S5/327 , H01L2924/00
摘要： Described herein are semiconductor structures comprising laterally varying II-VI alloy layer formed over a surface of a substrate. Further, methods are provided for preparing laterally varying II-VI alloy layers over at least a portion of a surface of a substrate comprising contacting at least a portion of a surface of a substrate within a reaction zone with a chemical vapor under suitable reaction conditions to form a laterally varying II-VI alloy layer over the portion of the surface of the substrate, wherein the chemical vapor is generated by heating at least two II-VI binary compounds; and the reaction zone has a temperature gradient of at least 50-100° C. along an extent of the reaction zone. Also described here are devices such as lasers, light emitting diodes, detectors, or solar cells that can use such semiconductor structures. In the case of lasers, spatially varying wavelength can be realized while in the case of solar cells and detectors multiple solar cells can be achieved laterally where each cell absorbs solar energy of a given wavelength range such that entire solar spectrum can be covered by the said solar cell structure. For LED applications, spatial variation of alloy composition can be used to engineer colors of light emission.
摘要翻译：这里描述的是包括在衬底的表面上形成的横向变化的II-VI合金层的半导体结构。此外，提供了用于在衬底的表面的至少一部分上制备横向变化的II-VI合金层的方法，包括使反应区内的衬底的至少一部分表面与合适的反应条件下的化学蒸气接触，在衬底的表面的部分上形成横向变化的II-VI合金层，其中通过加热至少两种II-VI二元化合物产生化学蒸气; 并且反应区沿着反应区的程度具有至少50-100℃的温度梯度。这里还描述了可以使用这种半导体结构的诸如激光器，发光二极管，检测器或太阳能电池的装置。在激光器的情况下，可以实现空间变化的波长，而在太阳能电池和检测器的情况下，可以横向实现多个太阳能电池，其中每个电池吸收给定波长范围的太阳能，使得整个太阳能光谱可被所述太阳能电池结构。对于LED应用，合金成分的空间变化可用于工程发光的颜色。

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