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11. 发明授权

US08560092B2 Apparatus and method for model quality estimation and model adaptation in multivariable process control 有权
标题翻译：多变量过程控制中的模型质量估计和模型适应的装置和方法
公开(公告)号：US08560092B2
公开(公告)日：2013-10-15
申请号：US12786052
申请日：2010-05-24
申请人： Qingsheng Quinn Zheng , Hong Zhao
发明人： Qingsheng Quinn Zheng , Hong Zhao
IPC分类号： G06F19/00
CPC分类号： G05B13/048
摘要： Apparatuses and methods for model quality estimation and model adaptation in multivariable process control are disclosed. A method for updating a multiple input multiple output (MIMO) dynamical model of a process includes perturbing the process, auditing the controller model, identifying poor performing submodels and re-testing the relevant process variables, re-identifying submodels and adapting the model online while the process continues to operate within normal operating parameters. An apparatus comprises an online multivariable controller, a tester, a database to store data corresponding to manipulated variables and controlled variables, and a performance diagnosis module configured to identify problematic submodels and adapt a model used by the controller.
摘要翻译：公开了多变量过程控制中的模型质量估计和模型适应的装置和方法。用于更新过程的多输入多输出（MIMO）动态模型的方法包括扰动过程，审核控制器模型，识别执行不良的子模型并重新测试相关过程变量，重新识别子模型并在线适配模型该过程继续在正常操作参数内运行。一种装置包括在线多变量控制器，测试器，用于存储与操作变量和受控变量相对应的数据的数据库，以及性能诊断模块，被配置为识别有问题的子模型并适应控制器使用的模型。

12. 发明授权

US08544987B2 Thermally stable oleophobic low adhesion coating for inkjet printhead front face 有权
标题翻译：用于喷墨打印头前面的热稳定的疏油性低粘附性涂层
公开(公告)号：US08544987B2
公开(公告)日：2013-10-01
申请号：US12860660
申请日：2010-08-20
申请人： Varun Sambhy , Kock-Yee Law , Hong Zhao , Samarth Chugh
发明人： Varun Sambhy , Kock-Yee Law , Hong Zhao , Samarth Chugh
IPC分类号： B41J2/14 , B41J2/16 , B05D3/02 , C09D11/00
CPC分类号： B41J2/162 , B41J2/1606 , C08G18/5015 , C09D175/04
摘要： A coating for an ink jet printhead front face, wherein the coating comprises a oleophobic low adhesion coating. When the oleophobic low adhesion coating is disposed on an ink jet printhead front face surface, jetted drops of ultra-violet gel ink or jetted drops of solid ink exhibit a contact angle greater than 45° and a low sliding angle of less than about 30°. In embodiments, the oleophobic low adhesion coating is thermally stable wherein the surface contact angle and sliding angle show little degradation after the coating is subjected to high temperatures in a range between 180° and 320° or thereabout and high pressures in a range between 100 psi and 400 psi or thereabout during printhead fabrication and manufacturing.
摘要翻译：一种用于喷墨打印头前表面的涂层，其中涂层包括疏油性低粘附性涂层。当疏油性低粘附性涂层设置在喷墨打印头前表面上时，喷射的紫外线凝胶墨滴或固体墨水的喷射液滴呈现大于45°的接触角和小于约30°的低滑动角。在实施方案中，疏油性低粘附性涂层是热稳定的，其中在涂层经受180°至320°之间或高于100psi的范围内的高温下，表面接触角和滑动角度几乎不发生降解并且在打印头制造和制造期间为400psi。

13. 发明授权

US08540346B2 Patterned metallization on polyimide aperture plate for laser-ablated nozzel 有权
标题翻译：用于激光烧蚀喷嘴的聚酰亚胺孔板上的图案化金属化
公开(公告)号：US08540346B2
公开(公告)日：2013-09-24
申请号：US13095610
申请日：2011-04-27
申请人： Bryan R. Dolan , Peter M. Gulvin , Hong Zhao , John R. Andrews , Bradley J. Gerner , Antonio Williams , Kock-Yee Law , David P. Platt , Terrance L. Stephens
发明人： Bryan R. Dolan , Peter M. Gulvin , Hong Zhao , John R. Andrews , Bradley J. Gerner , Antonio Williams , Kock-Yee Law , David P. Platt , Terrance L. Stephens
IPC分类号： B41J2/14 , B41J2/16
CPC分类号： B41J2/162 , B41J2/161 , B41J2/1628 , B41J2/1629 , B41J2/1631 , B41J2/1634 , B41J2/1642 , B41J2/1645 , B41J2/1646
摘要： An aperture plate for a print head of a printer can include a first layer having a first emissivity which is covered by a second layer having a second emissivity which is less than the first emissivity. In an embodiment, the second layer can be etched at nozzle locations to form openings in the second layer which have widths/areas greater than widths/areas of nozzles formed in the first layer. In another embodiment, the second layer can have a smaller thickness at the nozzle locations and a larger thickness away from the nozzle locations. Forming the openings in the second layer which are larger than the nozzles, or forming the second layer thinner at the nozzle locations prior to forming the nozzles, can provide a well-formed nozzle and an aperture plate having a low emissivity.
摘要翻译：用于打印机的打印头的孔板可以包括具有第一辐射率的第一层，第一层被第二层覆盖，第二层的第二发射率小于第一发射率。在一个实施例中，可以在喷嘴位置处蚀刻第二层，以在第二层中形成具有大于第一层中形成的喷嘴的宽度/面积的宽度/面积的开口。在另一个实施例中，第二层可以在喷嘴位置处具有较小的厚度，并且距离喷嘴位置具有更大的厚度。在形成喷嘴之前，在第二层中形成大于喷嘴的开口，或在喷嘴位置处形成较薄的第二层，可以提供具有低发射率的良好形成的喷嘴和孔板。

14. 发明申请

US20130201219A1 Method for Managing Screen Orientation of a Portable Electronic Device 有权
标题翻译：便携式电子设备屏幕方向管理方法
公开(公告)号：US20130201219A1
公开(公告)日：2013-08-08
申请号：US13368853
申请日：2012-02-08
申请人： Hong Zhao , LieJun Tao , Dean E. Thorson
发明人： Hong Zhao , LieJun Tao , Dean E. Thorson
IPC分类号： G09G5/00
CPC分类号： G06F3/0346 , G06F1/1686 , G06F1/1694 , G06F3/012 , G06F3/013 , G06F2200/1614 , G06F2200/1637
摘要： There is described a portable electronic device capable of managing screen orientation. The portable electronic device comprises a display, a motion sensor, an image sensor and a processor. The display provides an image at a first orientation. The motion sensor attempts to detect a rotation of the portable electronic device. The image sensor attempts to detect one or more body features. The processor determines a second orientation of the image at the display based on the rotation detected at the motion sensor and/or the body feature or features detected at the image sensor. The portable electronic device may determine an orientation of the image at the display in response to detecting the rotation at the motion sensor and/or the body feature or features at the image sensor.
摘要翻译：描述了能够管理屏幕取向的便携式电子设备。便携式电子设备包括显示器，运动传感器，图像传感器和处理器。显示器以第一方向提供图像。运动传感器尝试检测便携式电子设备的旋转。图像传感器尝试检测一个或多个身体特征。处理器基于在运动传感器处检测到的旋转和/或在图像传感器处检测到的身体特征或特征来确定图像在显示器处的第二取向。响应于检测到运动传感器处的旋转和/或图像传感器处的身体特征或特征，便携式电子设备可以确定显示器处的图像的取向。

15. 发明授权

US08461343B2 Synthesis of thiohydantoins 有权
公开(公告)号：US08461343B2
公开(公告)日：2013-06-11
申请号：US12450423
申请日：2008-03-27
申请人： Ouathek Ouerfelli , Anna Dilhas , Guangbin Yang , Hong Zhao
发明人： Ouathek Ouerfelli , Anna Dilhas , Guangbin Yang , Hong Zhao
IPC分类号： C07D213/84
CPC分类号： C07D401/04 , C07C209/36 , C07C213/08 , C07C227/18 , C07C231/12 , C07C253/00 , C07C253/30 , C07C2601/04 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/72 , C07D213/74 , C07D213/76 , C07D213/84 , C07C211/52 , C07C217/58 , C07C255/46
摘要： A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

16. 发明授权

US08384748B2 Fabrication of improved aluminum rollers with low adhesion and ultra/super hydrophobicity and/or oleophobicity by electrospinning technique in solid ink-jet marking 有权
标题翻译：通过静电纺丝技术在固体喷墨标记中制造具有低粘附性和超/超疏水性和/或疏油性的改进的铝辊
公开(公告)号：US08384748B2
公开(公告)日：2013-02-26
申请号：US12511625
申请日：2009-07-29
申请人： Kock-Yee Law , Hong Zhao , Varun Sambhy
发明人： Kock-Yee Law , Hong Zhao , Varun Sambhy
IPC分类号： B41J2/00 , B29D17/00 , B05D1/32
CPC分类号： B41J13/076
摘要： Exemplary embodiments provide materials and methods for a printer member used in ink-jet marking systems that can include a layer electrospun over an aluminum roller to facilitate transport of a printable substrate having ink images thereon and to reduce ink offset from the printable substrate.
摘要翻译：示例性实施例提供了用于喷墨打标系统中的打印机构件的材料和方法，其可以包括在铝辊上的电纺丝，以便于在其上具有油墨图像的可印刷基底的输送并减少从可印刷基底的墨水偏移。

17. 发明授权

US08367065B2 Targeted polymeric prodrugs containing multifunctional linkers 失效
标题翻译：含有多功能接头的靶向聚合物前药
公开(公告)号：US08367065B2
公开(公告)日：2013-02-05
申请号：US12402839
申请日：2009-03-12
申请人： Hong Zhao , Prasanna Reddy , Maria Belen Rubio
发明人： Hong Zhao , Prasanna Reddy , Maria Belen Rubio
IPC分类号： A61K47/48 , A61K31/4015 , A61K31/4025 , A61K31/444 , A61K31/44 , A61K31/7088 , A61K39/395 , C07H21/02 , C07K16/00 , C07K17/02 , C07D207/40 , C07D403/12
CPC分类号： C07K7/08 , A61K47/551 , A61K47/60 , A61K47/64 , C07D207/416 , C07D207/448 , C07D213/71 , C07D487/04 , C07K5/0821 , C07K7/06
摘要： The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供了含有多功能接头的单链抗体定向聚合前药。还公开了制备聚合物递送系统的方法和使用其的治疗哺乳动物的方法。

18. 发明授权

US08348390B2 Enhancing superoleophobicity and reducing adhesion through multi-scale roughness by ALD/CVD technique in inkjet application 有权
标题翻译：通过ALD / CVD技术在喷墨应用中提高超亲水性并通过多尺度粗糙度降低附着力
公开(公告)号：US08348390B2
公开(公告)日：2013-01-08
申请号：US13110216
申请日：2011-05-18
申请人： Kock-Yee Law , Hong Zhao
发明人： Kock-Yee Law , Hong Zhao
IPC分类号： B41J2/04
CPC分类号： B41J2/1606 , B41J2/14
摘要： Various embodiments provide a device having a multi-scale superoleophobic surface and methods for forming and using the device, wherein a particulate composite layer including metal-containing particulates is formed on a textured micron-/sub-micron surface of a semiconductor layer to provide device with multi-scale rough surface.
摘要翻译：各种实施方案提供了具有多尺度超疏油表面的装置和用于形成和使用该装置的方法，其中包含含金属微粒的颗粒复合层形成在半导体层的纹理微米/亚微米表面上以提供装置具有多尺度粗糙表面。

19. 发明申请

US20120296090A1 Drug Repositioning Methods For Targeting Breast Tumor Initiating Cells 审中-公开
标题翻译：用于靶向乳腺肿瘤起始细胞的药物重新定位方法
公开(公告)号：US20120296090A1
公开(公告)日：2012-11-22
申请号：US13439626
申请日：2012-04-04
申请人： Stephen TC Wong , Hong Zhao , Guangxu Jin
发明人： Stephen TC Wong , Hong Zhao , Guangxu Jin
IPC分类号： G06F19/00 , C07D305/14 , C07C233/15 , C07D413/12
CPC分类号： G16H50/50 , Y02A90/26
摘要： Disclosed are systems biology-based methods for repositioning known pharmaceutical compounds to new indications, through the identification of network-based signatures. In particular, the invention provides new and useful methods for selecting drugs or combinations of drugs (and preferably previously-approved drugs) for use in new therapeutic indications. Also disclosed are methods for identifying anti-breast tumor initiating cell (TIC)-based therapeutics from within populations of target compounds. In illustrative embodiments, the invention provides methods and computer programs for the repositioning of FDA-approved pharmaceutical compounds to new indications using network-based signature analysis coupled with conventional in vitro and in vivo testing of identified drug candidates. The invention also allows identification of drugs or drug combinations for treating unmet medical needs including, for example, “orphan” diseases.
摘要翻译：公开了基于系统生物学的方法，通过识别基于网络的签名将已知药物化合物重新定位到新的指示。特别地，本发明提供用于选择用于新的治疗适应症的药物或药物组合（并优选先前认可的药物）的新的和有用的方法。还公开了用于从目标化合物群体内鉴定抗乳腺肿瘤起始细胞（TIC）的治疗剂的方法。在说明性实施例中，本发明提供了使用基于网络的签名分析与常规的体外和体内测定鉴定的候选药物来重新定位FDA批准的药物化合物到新的适应症的方法和计算机程序。本发明还允许鉴定用于治疗未满足的医疗需要的药物或药物组合，包括例如孤儿疾病。

20. 发明授权

US08299089B2 Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers 失效
标题翻译：用于治疗乳腺癌，结肠直肠癌，胰腺癌，卵巢癌和肺癌的7-乙基-10-羟基喜树碱的多臂聚合物缀合物
公开(公告)号：US08299089B2
公开(公告)日：2012-10-30
申请号：US12762434
申请日：2010-04-19
申请人： Hong Zhao , Maria Belen Rubio , Dechun Wu , Puja Sapra
发明人： Hong Zhao , Maria Belen Rubio , Dechun Wu , Puja Sapra
IPC分类号： A61K31/4745 , C07D491/22
CPC分类号： A61K31/121 , A61K31/4745 , A61K47/55 , A61K47/60 , C07D491/22 , C07D519/00
摘要： A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.
摘要翻译：公开了四臂聚乙二醇-7-乙基-10-羟基喜树碱缀合物。还公开了制备缀合物的方法和使用其的治疗哺乳动物的方法。

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