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11. 发明授权

US07277755B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US07277755B1
公开(公告)日：2007-10-02
申请号：US10937623
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/04 , A61N1/39 , A61N1/38
CPC分类号： A61N1/05 , A61N1/36071 , A61N1/36114 , A61N1/3622 , A61N1/3962
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

12. 发明授权

US07194304B1 Implantable cardiac defibrillation assembly including a self-evaluation system and method 失效
标题翻译：植入式心脏除颤组件包括自我评估系统和方法
公开(公告)号：US07194304B1
公开(公告)日：2007-03-20
申请号：US10702562
申请日：2003-11-05
申请人： Gene A. Bornzin , Eric Falkenberg , Mark W. Kroll , Gabriel A. Mouchawar
发明人： Gene A. Bornzin , Eric Falkenberg , Mark W. Kroll , Gabriel A. Mouchawar
IPC分类号： A61N1/365
CPC分类号： A61N1/3943
摘要： An implantable cardiac defibrillation assembly includes at least one implantable lead having a defibrillation electrode adapted for placement in a chamber of the heart. The lead includes a connector. The assembly further includes an implantable defibrillation device having a pulse generator that provides defibrillation pulses and that is configured to receive the connector to couple the defibrillation electrode to the pulse generator. The device further includes a system that evaluates and conditions the assembly to provide defibrillation therapy to the heart without requiring arrhythmia induction of the heart. The system may condition the device for defibrillation therapy by reforming the defibrillation output capacitor and evaluate defibrillation lead DC resistance, and R wave sensing and detection. In addition, the system may estimate defibrillation thresholds and electrical fields and condition the device by setting the device to provide an output voltage above the estimated threshold. All of the foregoing may be accomplished without inducing ventricular fibrillation.
摘要翻译：植入式心脏除颤组件包括至少一个可植入引线，其具有适于放置在心脏腔室中的除颤电极。引线包括一个连接器。组件还包括具有脉冲发生器的可植入除颤装置，该脉冲发生器提供除颤脉冲，并且被配置为接收连接器以将除颤电极耦合到脉冲发生器。该装置还包括一个系统，该系统评估和调节组件以向心脏提供除颤疗法，而不需要心律的心律失常诱导。该系统可以通过重整除颤输出电容器并评估去纤颤引导直流电阻和R波感测和检测来调节器件进行除颤治疗。此外，系统可以通过设置设备来提供高于估计阈值的输出电压来估计除颤阈值和电场并调节设备。所有上述可以在不引起心室颤动的情况下完成。

13. 发明授权

US07142911B2 Method and apparatus for monitoring drug effects on cardiac electrical signals using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置监测对心脏电信号的药物作用的方法和装置
公开(公告)号：US07142911B2
公开(公告)日：2006-11-28
申请号：US10608409
申请日：2003-06-26
申请人： Peter Boileau , Janice Barstad , Gene A. Bornzin , Kerry Bradley , Eric Falkenberg , Joseph J. Florio
发明人： Peter Boileau , Janice Barstad , Gene A. Bornzin , Kerry Bradley , Eric Falkenberg , Joseph J. Florio
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3622 , A61B5/0031 , A61B5/04525 , A61B5/4839 , A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/3553 , A61M2230/10 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H50/20 , Y10S514/821
摘要： An implantable cardiac stimulation device, such as a pacemaker or Implantable Cardioverter Defibrillator, is configured to automatically monitor the effects of antiarrhythmic drugs on cardiac electrical signals within a patient to verify the efficacy of the drugs taken. In one example, an analysis of patient cardiac electrical signals is performed by comparing the cardiac electrical signals with values representative of the effects of different classes of antiarrhythmic drugs. If the implantable device determines that the prescribed antiarrhythmic drugs have not been effective, a warning signal is generated. The warning signal is conveyed directly to the patient via a bedside monitor and to the patient's physician via remote connection to an external programmer device so that both are notified of the drug efficacy problems. Additionally, the implantable device may be configured to automatically adjust pacing and defibrillation control parameters in an attempt to compensate for any lack of efficacy in the drugs. For example, the aggressiveness of overdrive pacing may be increased. Alternatively, a drug pump is controlled to adjust the dosage of antiarrhythmic drugs if an initial dosage is found to be ineffective.
摘要翻译：可植入心脏刺激装置，例如起搏器或植入式心律转复除颤器，被配置为自动监测抗心律失常药物对患者内心脏电信号的影响，以验证所用药物的功效。在一个示例中，通过将心脏电信号与代表不同类别的抗心律失常药物的作用的值进行比较来进行对患者心电信号的分析。如果植入装置确定规定的抗心律不齐药物没有效果，则产生警告信号。警告信号通过床边监护仪直接传送给患者，并通过与外部编程器设备的远程连接向病人的医生传送，以便两者被通知药物功效问题。另外，可植入装置可被配置为自动调节起搏和除颤控制参数，以试图补偿药物中的任何功效缺乏。例如，可能会增加超速起搏的积极性。或者，如果发现初始剂量无效，则控制药物泵以调节抗心律失常药物的剂量。

14. 发明授权

US07103414B1 Combined programming wand and PSA for pacemaker and ICD programmer system 有权
标题翻译：组合编程棒和PSA用于起搏器和ICD程序员系统
公开(公告)号：US07103414B1
公开(公告)日：2006-09-05
申请号：US10829907
申请日：2004-04-21
申请人： John W. Poore , Eric Falkenberg , Gene A. Bornzin
发明人： John W. Poore , Eric Falkenberg , Gene A. Bornzin
IPC分类号： A61N1/18 , A61N1/372
CPC分类号： A61N1/37235
摘要： A combined programming wand and PSA for physician programmers. A programmer/PSA wand can be connected to known programmers and PSA application software can be installed on the programmer to provide a system with the functionality of a PSA and a programmer in a single piece of clinical equipment. The programmer/PSA wand includes electronics to sense, pace, and shock to facilitate evaluation of indwelling leads during implantation of the implantable device and leads to facilitate programming of the device. The system includes one or more displays and control inputs that can provide information to a clinician at a single point that is typically provided with separate programmer and PSA equipment. The system provides increased efficiency, reduced opportunities for errors and/or equipment malfunction, and integrated data collection.
摘要翻译：用于医师程序员的组合编程棒和PSA。程序员/ PSA棒可以连接到已知的程序员，PSA应用软件可以安装在程序员上，以便在单个临床设备中为系统提供PSA和程序员的功能。编程器/ PSA棒包括用于感测，速度和冲击的电子装置，以便在植入可植入装置期间评估留置线，并且促进装置的编程。该系统包括一个或多个显示器和控制输入，其可以在通常具有单独的编程器和PSA设备的单个点向临床医生提供信息。该系统提供更高的效率，减少错误和/或设备故障的机会以及集成的数据收集。

15. 发明授权

US06968232B2 Method and apparatus for using a rest mode indicator to automatically adjust control parameters of an implantable cardiac stimulation device 失效
标题翻译：用于使用静止模式指示器自动调节可植入心脏刺激装置的控制参数的方法和装置
公开(公告)号：US06968232B2
公开(公告)日：2005-11-22
申请号：US10093225
申请日：2002-03-06
申请人： Joseph J. Florio , Gene A. Bornzin , Peter Boileau , Eric Falkenberg , Janice Barstad
发明人： Joseph J. Florio , Gene A. Bornzin , Peter Boileau , Eric Falkenberg , Janice Barstad
IPC分类号： A61N1/362 , A61N1/368 , A61N1/18
CPC分类号： A61N1/3622 , A61N1/3682
摘要： An implantable cardiac stimulation device is described wherein a controller of the cardiac stimulation device controls selected functions of the device based on whether the patient is at rest and further based on whether the patient is prone to vagally-mediated arrhythmias. Functions of the device that may be controlled include, for example, a pacing base rate, an AV/PV delay, and a refractory period as well as overdrive pacing parameters and diagnostic data gathering parameters. In one example, if the patient is not prone to vagally-mediated arrhythmias, the base rate is lowered while the patient is at rest. Also, overdrive pacing parameters are set to be less aggressive. As such, the operation of the cardiac stimulation device is controlled to make it easier for the patient to rest while also reducing power consumption. However, if the patient is prone to vagally-mediated arrhythmias, the base rate is not lowered while the patient is at rest. Overdrive pacing parameters are instead set to be more aggressive, rather than less aggressive. In this manner, the cardiac stimulation device attempts to compensate for any increased risk of arrhythmia that may occur while the patient, who is prone to vagally-mediated arrhythmias, is at rest. Numerous other parameters may be adjusted dependent upon whether the patient is at rest or dependent upon whether the patient is prone to vagally-mediated arrhythmias.
摘要翻译：描述了可植入心脏刺激装置，其中心脏刺激装置的控制器基于患者是否处于静止状态并且还基于患者是否易于经历迷走神经介导的心律失常来控制装置的选定功能。可以被控制的设备的功能包括例如起搏基准速率，AV / PV延迟和不应期，以及过速起搏参数和诊断数据采集参数。在一个示例中，如果患者不易于经历迷走神经介导的心律失常，则在患者静止时基础速率降低。此外，过度起搏参数设置为较不积极。因此，控制心脏刺激装置的操作以使患者更容易休息，同时也降低功率消耗。然而，如果患者容易出现迷走神经介导的心律失常，则在患者休息时基础速率不降低。相反，超速起搏参数设置为更具侵略性，而不是较不积极。以这种方式，心脏刺激装置试图补偿在容易发生迷走神经介导的心律失常的患者处于静止状态时可能出现的任何增加的心律失常风险。可以根据患者是否休息或依赖于患者是否易于经历迷走神经介导的心律失常而调整许多其他参数。

16. 发明授权

US08121680B2 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US08121680B2
公开(公告)日：2012-02-21
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

17. 发明授权

US07260433B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
公开(公告)号：US07260433B1
公开(公告)日：2007-08-21
申请号：US10937656
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/00 , A61B5/02 , A61B5/04
CPC分类号： A61N1/3627 , A61N1/0504 , A61N1/3702 , A61N1/37288 , A61N1/3756
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

18. 发明授权

US06741885B1 Implantable cardiac device for managing the progression of heart disease and method 有权
标题翻译：用于管理心脏疾病进展的植入式心脏装置和方法
公开(公告)号：US06741885B1
公开(公告)日：2004-05-25
申请号：US09908179
申请日：2001-07-17
申请人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
发明人： Euljoon Park , Eric Falkenberg , Gene A. Bornzin , Junyu Mai
IPC分类号： A61B504
CPC分类号： A61N1/3627 , A61N1/36514
摘要： An implantable cardiac device detects a progression or regression in heart disease such as congestive heart failure. An activity sensor and a respiration sensor generate raw signals indicative of the patient's activity level and respiration level. Degradation or improvement of the patient's activity and respiration over a predetermined time corresponds to an indication of the progression or regression of the heart disease. A processor coupled to the sensors is programmed to process the raw sensor signals over the predetermined time and stores the processed sensor signals in a memory having a data storage area. A telemetry circuit coupled to the memory is configured to transmit the stored sensor signals to an external monitor for subsequent display. The processor further controls pacing of the heart, adjusts pacing therapy responsive to the process signals, and process the raw respiration signals when the patient is in a number of different active states.
摘要翻译：可植入的心脏装置检测心脏病的进展或消退，例如充血性心力衰竭。活动传感器和呼吸传感器产生指示患者的活动水平和呼吸水平的原始信号。在预定时间内降低或改善患者的活动和呼吸对应于心脏病的进展或消退的指征。耦合到传感器的处理器被编程为在预定时间内处理原始传感器信号，并将经处理的传感器信号存储在具有数据存储区域的存储器中。耦合到存储器的遥测电路被配置为将存储的传感器信号发送到外部监视器用于随后的显示。处理器进一步控制心脏的起搏，响应于过程信号调整起搏治疗，并且当患者处于多个不同的活动状态时处理原始呼吸信号。

19. 发明授权

US07630767B1 System and method for communicating information using encoded pacing pulses within an implantable medical system 失效
标题翻译：用于在可植入医疗系统内使用编码的起搏脉冲传送信息的系统和方法
公开(公告)号：US07630767B1
公开(公告)日：2009-12-08
申请号：US11440723
申请日：2006-05-24
申请人： John W. Poore , Gene A. Bornzin , Eric Falkenberg
发明人： John W. Poore , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/372
CPC分类号： A61N1/37288 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3727
摘要： Techniques are provided for delivering cardiac pacing therapy to the heart of a patient using an epicardial left ventricular satellite pacing device in conjunction with primary pacemaker having at least a right ventricular pacing lead. In one embodiment described herein, right ventricular pulses generated by the primary pacemaker are detected by the satellite pacer and analyzed to determine the timing pattern employed by the primary pacemaker. The timing pattern is then used to specify the delivery times of epicardial left ventricular pulses so as to be synchronized with right ventricular pulses. In another embodiment described herein, the primary pacemaker modulates the right ventricular pulses to encode timing information, which is then detected and decoded by the satellite pacemaker. In this manner, biventricular pacing therapy, such as cardiac resynchronization therapy, may be conveniently delivered using a non-biventricular pacemaker in combination with an epicardial satellite pacer.
摘要翻译：提供技术用于使用心外膜左心室卫星起搏装置与具有至少右心室起搏引线的主起搏器一起向患者的心脏递送心脏起搏治疗。在本文描述的一个实施例中，由主起搏器产生的右心室脉冲由卫星起搏器检测并分析以确定主要起搏器采用的定时模式。然后使用定时模式来指定心外膜左心室脉冲的递送时间，以便与右心室脉冲同步。在本文所述的另一个实施例中，主起搏器调制右心室脉冲以编码定时信息，然后由卫星起搏器检测和解码定时信息。以这种方式，可以使用非心室起搏器与心外膜卫星踏板组合地方便地进行双心室起搏治疗，例如心脏再同步治疗。

20. 发明授权

US07403819B1 Parasympathetic nerve stimulation for control of AV conduction 有权
标题翻译：副交感神经刺激用于控制AV传导
公开(公告)号：US07403819B1
公开(公告)日：2008-07-22
申请号：US10460145
申请日：2003-06-11
申请人： Anne M. Shelchuk , Gene A. Bornzin , Eric Falkenberg
发明人： Anne M. Shelchuk , Gene A. Bornzin , Eric Falkenberg
IPC分类号： A61N1/34 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/36114
摘要： Exemplary methods for affecting conduction and/or operation of the AV node and/or AV bundle. Various exemplary methods include delivery of one or more stimulation pulses to affect conduction and/or operation of an AV node and/or AV bundle. Such delivery optionally stimulates nerves and/or tissue. Nerve stimulation optionally includes parasympathetic nerve stimulation to decrease conduction of the AV node and/or AV bundle. Tissue stimulation optionally causes tissue to enter a refractory period. Various exemplary methods include delivering one or more stimulation pulses during postinspiration. Other exemplary methods and/or devices are also disclosed.
摘要翻译：用于影响AV节点和/或AV束的传导和/或操作的示例性方法。各种示例性方法包括递送一个或多个刺激脉冲以影响AV节点和/或AV束的传导和/或操作。这种递送可选地刺激神经和/或组织。神经刺激任选地包括副交感神经刺激以减少AV结和/或AV束的传导。组织刺激任选地使组织进入不应期。各种示例性方法包括在后吸烟期间递送一个或多个刺激脉冲。还公开了其它示例性方法和/或设备。

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