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11. 发明申请

US20070135722A1 SYSTEMS AND METHODS FOR DETECTING OR VALIDATING SIGNALS IN THE PRESENCE OF NOISE 有权
标题翻译：用于在噪声存在下检测或确认信号的系统和方法
公开(公告)号：US20070135722A1
公开(公告)日：2007-06-14
申请号：US11625432
申请日：2007-01-22
申请人： Yayun Lin
发明人： Yayun Lin
IPC分类号： A61B5/04
CPC分类号： A61B5/7221 , A61B5/0452 , A61B5/046 , A61B5/7264 , A61N1/3704 , A61N1/3718
摘要： Detecting or validating signals such as cardiac beats can be performed in the presence of myopotential or other noise. An amplitude peak, which can be a candidate for a detected beat, can be used in a normalized or other weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result, the amplitude peak is either deemed an actual beat (e.g., depolarization or repolarization), or noise. The described systems, devices, and methods can improve the accuracy of detecting an actual beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable device.
摘要翻译：检测或验证心脏搏动等信号可以在有电位或其他噪声的情况下进行。可以作为检测到的拍子的候选者的振幅峰值可以与归一化或其他加权平均值一起使用，以及前一个和后续的采样。将加权平均值与噪声阈值进行比较。基于该结果，振幅峰值被认为是实际的搏动（例如去极化或复极化）或噪声。所描述的系统，装置和方法可以提高在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际搏动的准确性。这反过来又提高了可植入装置输送或保留治疗的准确性。

12. 发明授权

US06321122B1 Single pass defibrillation/pacing lead with passively attached electrode for pacing and sensing 失效
标题翻译：单次除颤/起搏导联带有被动连接的电极用于起搏和感测
公开(公告)号：US06321122B1
公开(公告)日：2001-11-20
申请号：US09121018
申请日：1998-07-22
申请人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
发明人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
IPC分类号： A61N100
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.
摘要翻译：适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。引线包括具有第一导电表面的第一远端电极。引线体还具有具有第二导电表面的第二电极。第二电极适于定位并固定在心脏心房的壁上。被动固定元件可以用作第二电极的一部分。引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

13. 发明授权

US09119547B2 Arrhythmia discrimination based on determination of rate dependency 有权
标题翻译：基于速率依赖性确定的心律失常辨别
公开(公告)号：US09119547B2
公开(公告)日：2015-09-01
申请号：US12686122
申请日：2010-01-12
申请人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Alberto Ricci
发明人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Alberto Ricci
IPC分类号： A61B5/0464 , A61B5/0452 , A61B5/00
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/7264
摘要： Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.
摘要翻译：心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

14. 发明授权

US08583228B2 Automatic multi-level therapy based on morphologic organization of an arrhythmia 有权
标题翻译：基于心律失常形态组织的自动多级疗法
公开(公告)号：US08583228B2
公开(公告)日：2013-11-12
申请号：US13048582
申请日：2011-03-15
申请人： Dan Li , Yayun Lin
发明人： Dan Li , Yayun Lin
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61B5/04525 , A61B5/0464 , A61N1/36585 , A61N1/3962
摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis, patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.
摘要翻译：描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。心律失常的形态学组织水平与心脏治疗有关。形态组织水平与心律失常的心脏信号形态有关。检测到心律失常发作，确定心律失常发作的形态组织水平。与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。例如，形态组织水平可以基于回顾性数据库分析，患者治疗耐受性和医师输入中的一种或多种与心脏疗法相关联。协会可以是静态的，或者可以基于治疗功效来动态调整。

15. 发明授权

US08483808B2 Methods and systems for characterizing cardiac signal morphology using K-fit analysis 有权
标题翻译：使用K-fit分析来表征心脏信号形态的方法和系统
公开(公告)号：US08483808B2
公开(公告)日：2013-07-09
申请号：US12879147
申请日：2010-09-10
申请人： Yanting Dong , Shijie Zhang , Dan Li , Yayun Lin
发明人： Yanting Dong , Shijie Zhang , Dan Li , Yayun Lin
IPC分类号： A61N5/0472 , A61B5/0452
CPC分类号： A61B5/04525 , G06K9/00536
摘要： A system and method for automatically analyzing a cardiac signal, including the step of providing an episode database on a computer storage medium including a plurality of episode data records of one or more patients. Each episode data record includes a cardiac signal from at least one data-generating device. The method also includes the step of selecting one or more of the N beats to be one or more beat templates, for at least a first cardiac signal having N beats. Another step is determining a value K for the cardiac signal using a computer system where K beat templates can represent all the N beats in the cardiac signal.
摘要翻译：一种用于自动分析心脏信号的系统和方法，包括在包括一个或多个患者的多个发作数据记录的计算机存储介质上提供情节数据库的步骤。每个剧集数据记录包括来自至少一个数据生成装置的心脏信号。该方法还包括为至少具有N次拍子的第一个心脏信号选择N个节拍中的一个或多个作为一个或多个节拍模板的步骤。另一步是使用计算机系统确定心脏信号的值K，其中K搏动模板可以表示心脏信号中的所有N个搏动。

16. 发明授权

US08078272B2 Systems and methods for detecting or validating signals in the presence of noise 有权
标题翻译：在存在噪声的情况下检测或验证信号的系统和方法
公开(公告)号：US08078272B2
公开(公告)日：2011-12-13
申请号：US11625432
申请日：2007-01-22
申请人： Yayun Lin
发明人： Yayun Lin
IPC分类号： A61B5/0402
CPC分类号： A61B5/7221 , A61B5/0452 , A61B5/046 , A61B5/7264 , A61N1/3704 , A61N1/3718
摘要： Detecting or validating signals such as cardiac beats can be performed in the presence of myopotential or other noise. An amplitude peak, which can be a candidate for a detected beat, can be used in a normalized or other weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result, the amplitude peak is either deemed an actual beat (e.g., depolarization or repolarization), or noise. The described systems, devices, and methods can improve the accuracy of detecting an actual beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable device.
摘要翻译：检测或验证心脏搏动等信号可以在有电位或其他噪声的情况下进行。可以作为检测到的拍子的候选者的振幅峰值可以与归一化或其他加权平均值一起使用，以及前一个和后续的采样。将加权平均值与噪声阈值进行比较。基于该结果，振幅峰值被认为是实际的搏动（例如去极化或复极化）或噪声。所描述的系统，装置和方法可以提高在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际搏动的准确性。这反过来又提高了可植入装置输送或保留治疗的准确性。

17. 发明授权

US07653431B2 Arrhythmia discrimination based on determination of rate dependency 有权
标题翻译：基于速率依赖性确定的心律失常辨别
公开(公告)号：US07653431B2
公开(公告)日：2010-01-26
申请号：US11312280
申请日：2005-12-20
申请人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
发明人： Shelley Cazares , Jaeho Kim , Yayun Lin , Carlos Ricci
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/04525 , A61B5/7264
摘要： Cardiac systems and methods provide for discriminating between supraventricular tachyarrhythmia and ventricular tachyarrhythmia based on a determination that the patient's supraventricular rhythm exhibits rate dependency. One approach involves determining if a patient's supraventricular rhythm exhibits rate dependent morphology. If the patient's supraventricular rhythm is determined to exhibit rate dependent morphology, an implantable device classifies a detected tachyarrhythmia episode based on one or more templates selected from a plurality of rate-indexed templates stored in the device. Determining if the supraventricular rhythm exhibits rate dependent morphology may also include determining one or more rates at which the rate dependent morphology occurs.
摘要翻译：心脏系统和方法基于确定患者的室上节律表现出速率依赖性，确定了室上性快速性心律失常与室性快速性心律失常之间的区别。一种方法涉及确定患者的室上节律是否表现出速率依赖性形态。如果确定患者的室上节律表现出与速率相关的形态，则可植入装置基于从存储在装置中的多个速率索引模板中选择的一个或多个模板来分类检测到的快速性心律失常发作。确定室性心律显示出速率依赖性形态还可以包括确定发生速率依赖形态的一个或多个速率。

18. 发明申请

US20070239218A1 HEMODYNAMIC STABILITY ASSESSMENT BASED ON HEART SOUNDS 有权
标题翻译：基于心脏声音的动态稳定性评估
公开(公告)号：US20070239218A1
公开(公告)日：2007-10-11
申请号：US11277773
申请日：2006-03-29
申请人： Gerrard Carlson , Yayun Lin
发明人： Gerrard Carlson , Yayun Lin
IPC分类号： A61N1/365
CPC分类号： A61N1/3962 , A61B5/02028 , A61B5/024 , A61B5/02405 , A61B7/04 , A61N1/3621 , A61N1/3627 , A61N1/36514 , A61N1/36578 , A61N1/37247 , A61N1/37282
摘要： A system comprising an implantable medical device (IMD). The IMD includes an implantable sensor operable to produce an electrical signal representative of mechanical activity of a heart of a subject and a controller circuit coupled to the sensor. The IMD also includes a heart sound sensor interface circuit to produce a heart sound signal, a tachyarrhythmia detector, and a controller circuit. The controller circuit includes a hemodynamic stability assessment module configured to determine that at least one episode of ventricular tachyarrhythmia is detected in a subject and obtain a measurement of hemodynamic stability of the ventricular tachyarrhythmia from the heart sound signal.
摘要翻译：一种包括可植入医疗装置（IMD）的系统。 IMD包括可植入传感器，其可操作以产生代表受试者心脏的机械活动的电信号和耦合到传感器的控制器电路。 IMD还包括产生心脏声音信号的心脏声音传感器接口电路，快速心律失常检测器和控制器电路。控制器电路包括血液动力学稳定性评估模块，其被配置为确定在受试者中检测到至少一次心室快速性心律失常发作，并且从心脏声音信号获得心室快速性心律失常的血液动力学稳定性的测量。

19. 发明授权

US07215993B2 Cardiac rhythm management systems and methods for detecting or validating cardiac beats in the presence of noise 有权
标题翻译：心脏节律管理系统和在有噪声的情况下检测或验证心脏搏动的方法
公开(公告)号：US07215993B2
公开(公告)日：2007-05-08
申请号：US10213364
申请日：2002-08-06
申请人： Yayun Lin
发明人： Yayun Lin
IPC分类号： A61B5/0456
CPC分类号： A61B5/7221 , A61B5/0452 , A61B5/046 , A61B5/7264 , A61N1/3704 , A61N1/3718
摘要： This document describes systems, devices, and methods for detecting or validating cardiac beats, such as in the presence of myopotential or other noise. In one example, an amplitude peak, which is a candidate for a detected cardiac beat, is used in a weighted average, along with a preceding and subsequent sample. The weighted average is compared to a noise threshold. Based on the result of comparison, the amplitude peak is either deemed an actual cardiac beat, or otherwise is deemed noise. The described systems, devices, and methods improve the accuracy of detecting an actual cardiac beat in the presence of noise, during normal sinus rhythm or during an arrhythmia such as ventricular fibrillation. This, in turn, improves the accuracy with which therapy is delivered or withheld by an implantable cardiac rhythm management device. In one example, such as where the system includes a cardiac signal detector with automatic gain control (AGC) circuitry, the weighted average is normalized.
摘要翻译：本文件描述了用于检测或验证心脏搏动的系统，设备和方法，例如在存在神经或其他噪声的情况下。在一个示例中，作为检测到的心跳的候选者的振幅峰值与加权平均值一起使用，以及之前和随后的样本。将加权平均值与噪声阈值进行比较。基于比较结果，振幅峰值被认为是实际心跳，或者被认为是噪声。所描述的系统，装置和方法提高了在正常窦性心律期间或在诸如心室颤动的心律失常期间在噪声存在下检测实际心搏的准确性。这反过来又提高了植入式心律管理装置的治疗的输送或保留的准确性。在一个示例中，例如系统包括具有自动增益控制（AGC）电路的心脏信号检测器的地方，加权平均值被归一化。

20. 发明申请

US20070049974A1 Automatic multi-level therapy based on morphologic organization of an arrhythmia 失效
标题翻译：基于心律失常形态组织的自动多级疗法
公开(公告)号：US20070049974A1
公开(公告)日：2007-03-01
申请号：US11209976
申请日：2005-08-23
申请人： Dan Li , Yayun Lin
发明人： Dan Li , Yayun Lin
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61B5/04525 , A61B5/0464 , A61N1/36585 , A61N1/3962
摘要： Methods and systems for selecting tachyarrhythmia therapy based on the morphological organization level of the arrhythmia are described. Morphological organization levels of arrhythmias are associated with cardiac therapies. The morphological organization levels are related to cardiac signal morphologies of the arrhythmias. An arrhythmia episode is detected and the morphological organization level of the arrhythmia episode is determined. A cardiac therapy associated with the morphological organization level of the arrhythmia episode is delivered to treat the arrhythmia. For example, the morphological organization levels may be associated with the cardiac therapies based on one or more of retrospective database analysis patient therapy tolerance, and physician input. The associations may be static or may be dynamically adjusted based on therapy efficacy.
摘要翻译：描述了基于心律失常形态组织水平选择快速性心律失常治疗的方法和系统。心律失常的形态学组织水平与心脏治疗有关。形态组织水平与心律失常的心脏信号形态有关。检测到心律失常发作，确定心律失常发作的形态组织水平。与心律失常发作的形态组织水平相关的心脏治疗被递送以治疗心律失常。例如，形态组织水平可以基于回顾性数据库分析患者治疗耐受性和医师输入中的一种或多种与心脏治疗相关联。协会可以是静态的，或者可以基于治疗功效来动态调整。

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