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11. 发明授权

US08293212B2 Inhibitor screening method and atopic dermatitis like symptom inducing method which utilizes induction of production of interleukin 18 by keratinocyte and utilization of same 失效
标题翻译：抑制剂筛选方法和特应性皮炎，如通过角质形成细胞诱导产生白细胞介素18并利用其的症状诱导方法
公开(公告)号：US08293212B2
公开(公告)日：2012-10-23
申请号：US12499231
申请日：2009-07-08
申请人： Kenji Nakanishi , Hitoshi Mizutani , Hiroko Tsutsui
发明人： Kenji Nakanishi , Hitoshi Mizutani , Hiroko Tsutsui
IPC分类号： A61K49/00 , G01N33/53
CPC分类号： G01N33/5044 , C07K14/54 , G01N33/5008 , G01N33/5023 , G01N33/5088 , G01N33/6854 , G01N2333/54
摘要： The present invention provides methods which use induction phenomenon of production of interleukin 18 (IL-18) from keratinocyte (KC), and their usages. The methods are preferably applicable for understanding of pathogenic mechanisms of atopic dermatitis (AD) and AD-like symptoms, and for development of therapeutic drugs for AD and AD-like symptoms. For example, by applying, on skin of mice or the like, protein A (SpA) derived from Staphylococcus aureus, or transplanting, on mice, a skin graft which has developed an inflammatory skin disease like AD, it is possible to reproduce elevation of IgE to high level in serum, which elevation is generated in an AD-like lesion. As a result, it is possible, for example, to screen for an inhibitor which inhibits induction of production of IL-18 from KC.
摘要翻译：本发明提供了使用来自角质形成细胞（KC）的白细胞介素18（IL-18）的产生诱导现象及其用途的方法。该方法优选适用于了解特应性皮炎（AD）和AD样症状的致病机制，以及用于开发用于AD和AD样症状的治疗药物。例如，通过在小鼠等皮肤上施用衍生自金黄色葡萄球菌的蛋白A（SpA）或在小鼠上移植已经发展为AD的炎症性皮肤病的皮肤移植物，可以再现高度血清中IgE达到高水平，在AD样病变中产生升高。结果，例如可以筛选抑制KC诱导IL-18产生的抑制剂。

12. 发明申请

US20110273752A1 ILLUMINATING APPARATUS, IMAGE READING APPARATUS, AND IMAGE FORMING APPARATUS 有权
标题翻译：照明设备，图像读取装置和图像形成装置
公开(公告)号：US20110273752A1
公开(公告)日：2011-11-10
申请号：US13144874
申请日：2009-12-18
申请人： Yasuhiro Suto , Tomohiko Okada , Shohichi Fukutome , Hisashi Yamanaka , Kenji Nakanishi , Yoshihisa Yamada , Mitsuharu Yoshimoto , Eiji Kurimoto , Keiji Sakai
发明人： Yasuhiro Suto , Tomohiko Okada , Shohichi Fukutome , Hisashi Yamanaka , Kenji Nakanishi , Yoshihisa Yamada , Mitsuharu Yoshimoto , Eiji Kurimoto , Keiji Sakai
IPC分类号： H04N1/04 , F21S4/00
CPC分类号： G03B27/54 , G03G15/043 , H04N1/02815 , H04N1/02845 , H04N1/02865 , H04N1/1013 , H04N1/193 , H04N2201/0081
摘要： In a light source unit (210) serving as an embodiment of an illuminating apparatus, when P is a light-emitting element pitch [mm], and H is an optical axis distance [mm] between light-emitting elements (212) and an original (G), and when, in an illuminance cycle (T) representing repetition of bright and dark areas in a main scanning direction (X) on a light-irradiated face (Gs) of the original (G) caused by the light-emitting elements (212), the light-emitting element pitch (P) and the optical axis distance (H) are set such that unevenness [%] (M) (=(L1−L2)/L3 [%]) obtained by dividing a value obtained by subtracting a minimum illuminance value (L2) from a maximum illuminance value (L1) by an average illuminance value (L3) and an inter-unevenness distance [mm] (N) which is a half cycle of the illuminance cycle (T) satisfy the relation M≦N/2−5.5, and more preferably, M≦N/2−7.5.
摘要翻译：在作为照明装置的实施例的光源单元（210）中，当P是发光元件间距[mm]，H是发光元件（212）与发光元件（212）之间的光轴距离[mm] 原始（G），并且当在由发光元件（G）引起的原始（G）的光照射面（G）上的主扫描方向（X）上的亮区域的重复的照度周期（T）中，发光元件（212），发光元件间距（P）和光轴距离（H）被设定为使得通过划分获得的不平坦度[％]（M）（=（L1-L2）/ L3 [％] 通过从最大照度值（L1）减去作为照度周期的半周期的平均照度值（L3）和不等间距离（mm）（N）而得到的最小照度值（L2） T）满足关系M＆NlE; N / 2-5.5，更优选M＆lt; NE; N / 2-7.5。

13. 发明申请

US20100262389A1 ANALYZING APPARATUS 有权
标题翻译：分析装置
公开(公告)号：US20100262389A1
公开(公告)日：2010-10-14
申请号：US12747348
申请日：2008-12-04
申请人： Kenji Nakanishi , Masahito Shiraishi , Tsugio Wakita , Junji Tada , Kenji Okada , Yoshiyuki Fujii
发明人： Kenji Nakanishi , Masahito Shiraishi , Tsugio Wakita , Junji Tada , Kenji Okada , Yoshiyuki Fujii
IPC分类号： G01N35/00
CPC分类号： H02P5/60 , B01F11/0002 , B01F11/0008 , B01F11/0014 , B01F13/0059 , B01F15/0233 , B01L3/50273 , B01L2300/043 , B01L2300/0803 , B01L2300/087 , B01L2400/0409 , B01L2400/0433 , B04B9/10 , G01N35/025 , G01N35/04 , G01N2035/00495 , G01N2035/00524 , G01N2035/00534 , G01N2035/0449 , G01N2035/0486 , H02K11/215 , H02P25/032
摘要： Disclosed is an analyzing apparatus including a first drive part (71) for rotating a turntable (101) on which an analyzing device is set, a second drive part (72) selectively engaged with the first drive part (71) to reciprocate the analyzing device, and a third drive part (73) for relatively moving the first drive part (71) and the second drive part (72) a position where the first and second drive parts are engaged with each other and a position where the first and second drive parts are not engaged with each other. Thus in the mixing and agitation of a small amount of fluid, necessary acceleration can be obtained even in a short time.
摘要翻译：公开了一种分析装置，包括：第一驱动部（71），用于旋转其上设置有分析装置的转台（101）;选择性地与第一驱动部（71）接合的第二驱动部（72），使分析装置，以及第三驱动部（73），用于使第一驱动部（71）和第二驱动部（72）相对移动第一驱动部和第二驱动部彼此接合的位置和第一驱动部零件不互相接合。因此，在少量流体的混合搅拌中，即使在短时间内也可以获得必要的加速。

14. 发明授权

US07627281B2 Paper tray, paper feeder with the tray, and image forming device 失效
标题翻译：纸盘，带纸盘的进纸器和图像形成装置
公开(公告)号：US07627281B2
公开(公告)日：2009-12-01
申请号：US10548204
申请日：2004-04-01
申请人： Kenji Tanaka , Yoshiyuki Nishizato , Kenji Nakanishi , Tomohiko Okada , Akira Kohno
发明人： Kenji Tanaka , Yoshiyuki Nishizato , Kenji Nakanishi , Tomohiko Okada , Akira Kohno
IPC分类号： G03G15/00
CPC分类号： B65H7/04 , B65H2511/212 , B65H2511/51 , B65H2553/412 , B65H2553/612 , B65H2220/01 , B65H2220/11 , B65H2220/03
摘要： A sheet tray (1) includes at least one sheet detecting sensor (10) for detecting a sheet set on a sheet setting surface (2). The sheet detecting sensor (10) includes (i) a movable detecting section having a projecting section which projects from the sheet setting surface (2), and (ii) a detecting section for detecting rotation of the movable detecting section, and the projecting section have a ball-like shape. This makes it possible to provide (i) a sheet tray which is able to prevent breakage of sheet and breakage of the projecting section even when setting the sheet on the sheet setting surface from any direction and any angle; (ii) a sheet transporting apparatus including the sheet tray; and (iii) an image forming apparatus including the sheet tray.
摘要翻译：纸张托盘（1）包括用于检测纸张设置表面（2）上的纸张的至少一个纸张检测传感器（10）。片材检测传感器（10）包括（i）可动检测部分，具有从片材安置表面（2）突出的突出部分，以及（ii）用于检测可动检测部分的旋转的检测部分，以及突出部分有一个球状的形状。这使得可以提供（i）即使当从任何方向和任何角度将片材设置在片材安置表面上时，也能够防止片材的破损和突出部分断裂的片材托盘; （ii）包括所述纸张托盘的纸张输送装置; 和（iii）包括片材托盘的图像形成装置。

15. 发明授权

US07491803B2 Human anti-human interleukin-18 antibody, fragment thereof and method for using same 失效
标题翻译：人抗人白介素-18抗体及其片段及其使用方法
公开(公告)号：US07491803B2
公开(公告)日：2009-02-17
申请号：US10555074
申请日：2004-04-30
申请人： Kazuhisa Sugimura , Kenji Nakanishi , Toshihiro Nakashima
发明人： Kazuhisa Sugimura , Kenji Nakanishi , Toshihiro Nakashima
IPC分类号： C07K16/00 , C12N15/09
CPC分类号： C07K16/244 , C07K2317/21 , C07K2317/565
摘要： A human-derived human anti-human IL-18 antibody of the present invention is an antibody against human IL-18, the antibody including: an H-chain complementarity determining region consisting of (a) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 4 to 6, or (b) a polypeptide which is a mutant of the polypeptide (a) and which serves as the H-chain complementarity determining region; and an L-chain complementarity determining region against human interleukin-18 consisting of (c) a polypeptide consisting of amino-acid sequences represented by SEQ ID NOS: 10 to 12, or (d) a polypeptide which is a mutant of the polypeptide (c) and which serves as the L-chain complementarity determining region. This makes it possible to provide a human anti-human IL-18 antibody and a method for using the antibody.
摘要翻译：本发明的人衍生的人抗人IL-18抗体是针对人IL-18的抗体，所述抗体包括：H链互补决定区，其由（a）由氨基酸序列表示的多肽组成通过SEQ ID NO：4至6，或（b）多肽（a）的突变体并用作H链互补决定区的多肽; 和由（c）由SEQ ID NO：10至12表示的氨基酸序列组成的多肽的人白介素-18组成的L链互补决定区，或（d）多肽突变体的多肽（ c）并且其用作L链互补决定区。这使得可以提供人抗人IL-18抗体和使用该抗体的方法。

16. 发明申请

US20060216088A1 Paper tray, paper feeder with the tray, and image forming device 失效
标题翻译：纸盘，带纸盘的进纸器和图像形成装置
公开(公告)号：US20060216088A1
公开(公告)日：2006-09-28
申请号：US10548204
申请日：2004-04-01
申请人： Kenji Tanaka , Yoshiyuki Nishizato , Kenji Nakanishi , Tomohiko Okada , Akira Kohno
发明人： Kenji Tanaka , Yoshiyuki Nishizato , Kenji Nakanishi , Tomohiko Okada , Akira Kohno
IPC分类号： G03G15/00
CPC分类号： B65H7/04 , B65H2511/212 , B65H2511/51 , B65H2553/412 , B65H2553/612 , B65H2220/01 , B65H2220/11 , B65H2220/03
摘要： A sheet tray (1) includes at least one sheet detecting sensor (10) for detecting a sheet set on a sheet setting surface (2). The sheet detecting sensor (10) includes (i) a movable detecting section having a projecting section which projects from the sheet setting surface (2), and (ii) a detecting section for detecting rotation of the movable detecting section, and the projecting section have a ball-like shape. This makes it possible to provide (i) a sheet tray which is able to prevent breakage of sheet and breakage of the projecting section even when setting the sheet on the sheet setting surface from any direction and any angle; (ii) a sheet transporting apparatus including the sheet tray; and (iii) an image forming apparatus including the sheet tray.
摘要翻译：纸张托盘（1）包括用于检测纸张设置表面（2）上的纸张的至少一个纸张检测传感器（10）。片材检测传感器（10）包括（i）可动检测部分，具有从片材安置表面（2）突出的突出部分，以及（ii）用于检测可动检测部分的旋转的检测部分，以及突出部分有一个球状的形状。这使得可以提供（i）即使当从任何方向和任何角度将片材设置在片材安置表面上时，也能够防止片材的破损和突出部分断裂的片材托盘; （ii）包括所述纸张托盘的纸张输送装置; 和（iii）包括片材托盘的图像形成装置。

17. 发明授权

US06666536B2 Ink jet device with movable platen 有权
标题翻译：具有可移动压板的喷墨装置
公开(公告)号：US06666536B2
公开(公告)日：2003-12-23
申请号：US09927356
申请日：2001-08-13
申请人： Kenji Nakanishi , Yasushi Matsutomo , Susumu Hashimoto , Masanobu Deguchi , Takashi Kubo , Yasuaki Fukada
发明人： Kenji Nakanishi , Yasushi Matsutomo , Susumu Hashimoto , Masanobu Deguchi , Takashi Kubo , Yasuaki Fukada
IPC分类号： B41J25308
CPC分类号： B41J11/20
摘要： A pair of drive conveyer rollers are provided for a platen that guides recording media. The follower conveyer roller is supported by a roller support plate which is coupled at its side with a lever so that the rotation of this lever is able to press the platen downward. When the paired drive conveyer rollers hold recording paper between them, the follower conveyer roller moves upward, which causes the roller support plate to rotate. This rotational force is transmitted to the lever so that the platen is pressed down to thereby adjust the gap between the printer head and the platen appropriately.
摘要翻译：为引导记录介质的台板提供一对驱动输送辊。从动输送辊由一个辊支撑板支撑，该滚轮支撑板的侧面与一个杠杆相连，使得该杠杆的旋转能够将压板向下压。当成对的驱动输送辊在它们之间保持记录纸时，从动输送辊向上移动，这导致辊支撑板旋转。该旋转力被传递到杠杆，使得压板被压下，从而适当地调节打印机头和压板之间的间隙。

18. 发明授权

US5936255A X-ray, neutron or electron diffraction method using an imaging plate and apparatus therefor 失效
$X-ray, neutron or electron diffraction method using an imaging plate and apparatus therefor$
标题翻译：使用成像板的X射线，中子或电子衍射方法及其装置
公开(公告)号：US5936255A
公开(公告)日：1999-08-10
申请号：US890623
申请日：1997-07-09
申请人： Kenji Nakanishi , Akira Tsukamoto , Keiichi Tanabe
发明人： Kenji Nakanishi , Akira Tsukamoto , Keiichi Tanabe
IPC分类号： G01N23/20 , G01N23/205 , G01N23/223 , G21K1/06 , G21K4/00 , G01N23/207
CPC分类号： G21K1/06 , G21K2201/068
摘要： An X-ray, neutron or electron diffraction method, which is devoid of the defects of conventional diffraction apparatus using an imaging plate, which can analyzing a sample, in a non-destructive mode without contact and with a good S/N ratio, even when the sample significantly generates fluorescence or scattered X-rays. The method includes the steps of irradiating a predetermined area of the sample with an X-ray, neutron or electron beam whose axis is oriented at a fixed direction to obtain a diffraction ray, rotating the sample while maintaining the irradiated predetermined area substantially unchanged and while maintaining the angle between the axis of the X-ray, neutron or electron beam relative to the tangential plane of the predetermined area substantially unchanged, forming an image of the diffraction ray from the sample during the rotation of the sample through every predetermined angle using an imaging plate, reading a data of the image formed on the imaging plate to obtain an output data for each rotation of the sample through the predetermined angle, and processing the output data to obtain desired analysis information.
摘要翻译：一种X射线，中子或电子衍射方法，其不含常规的使用成像板的衍射装置的缺陷，该成像板能够以非破坏性的方式分析样品，无接触和良好的S / N比，甚至当样品显着产生荧光或散射的X射线。该方法包括以下步骤：用X轴，中子或电子束照射样品的预定区域，该X射线，中子或电子束的轴线沿固定方向取向以获得衍射光线，使样品旋转，同时保持照射的预定面积基本上不变，同时保持X射线，中子或电子束相对于预定面积的切向面之间的角度基本上不变，在样品旋转期间通过每个预定角度形成来自样品的衍射光线的图像，使用读取形成在成像板上的图像的数据，以获得用于样品的每次旋转的预定角度的输出数据，并处理输出数据以获得期望的分析信息。

19. 发明授权

US09041907B2 Drawing device and drawing method 有权
标题翻译：绘图装置和绘图方法
公开(公告)号：US09041907B2
公开(公告)日：2015-05-26
申请号：US13086762
申请日：2011-04-14
申请人： Yoshiyuki Nakazawa , Yoshio Furuya , Ryosuke Ito , Kenji Nakanishi , Kazutaka Taniguchi , Ryo Yamada
发明人： Yoshiyuki Nakazawa , Yoshio Furuya , Ryosuke Ito , Kenji Nakanishi , Kazutaka Taniguchi , Ryo Yamada
IPC分类号： G03B27/68 , G03B27/32 , G03B27/50 , G03B27/52 , G03F7/20
CPC分类号： G03B27/32 , G03B27/50 , G03B27/52 , G03F7/70291 , G03F7/70308 , G03F7/70508
摘要： A drawing device draws a pattern on a substrate by radiating light from an optical head part on a target object (for example, substrate) which relatively moves with respect to the optical head part. Here, the optical head part has a spatial modulating unit which spatially modulates light from a light source, based on pattern data, and an optical path corrector which shifts the route of light spatially modulated in the spatial modulating unit at precision subdivided more than units of spatial modulation in the spatial modulating unit (more specifically, for example, units of pixels of spatial light modulator).
摘要翻译：绘图装置通过从相对于光学头部相对移动的目标物体（例如，基板）上的光学头部照射光而在基板上绘制图案。这里，光头部具有空间调制单元，其基于图案数据对来自光源的光进行空间调制，光路校正器使空间调制单元中的空间调制光的路径以精度细分多于空间调制单元中的空间调制（更具体地，例如，空间光调制器的像素的单位）。

20. 发明授权

US08787799B2 Illuminating device, image reading apparatus and image forming apparatus 有权
标题翻译：照明装置，图像读取装置和图像形成装置
公开(公告)号：US08787799B2
公开(公告)日：2014-07-22
申请号：US13062745
申请日：2009-10-09
申请人： Yoshihisa Yamada , Mitsuharu Yoshimoto , Yasuhiro Suto , Kenji Nakanishi , Shohichi Fukutome , Hisashi Yamanaka
发明人： Yoshihisa Yamada , Mitsuharu Yoshimoto , Yasuhiro Suto , Kenji Nakanishi , Shohichi Fukutome , Hisashi Yamanaka
IPC分类号： G03G15/04
CPC分类号： H04N1/02825 , F21V29/505 , F21V29/70 , F21V29/89 , G02B6/0001 , G02B6/0055 , G02B6/0085 , G03B27/54 , G03G15/04036 , G03G15/0435 , G03G15/326 , H04N1/02815 , H04N1/02835 , H04N1/02885 , H04N2201/0094 , H04N2201/02462 , H04N2201/02474 , H04N2201/02485
摘要： An illuminating device (210) according to an embodiment of the invention included in an image reading apparatus (100) and an image forming apparatus (D) includes light source portions (211a1), (211b1), (211a2) and (211b2), light-guiding members (213a) and (213b) for illuminating an illumination target (G) from an elongated light emitting face (M) that extends in a longitudinal direction (Y), by guiding light from the light source portions, and holding members (216a) and (216b) for holding the light-guiding members. The holding members include holding portions (2161a) and (2161b) for removably holding the light-guiding members, and tilted portions (2162a) and (2162b) that reflect light emitted from the light emitting face (M), the tilted portions extending from a front end on the light emitting face (M) side of the holding portions, obliquely widening with increasing distance from the light-guiding members.
摘要翻译：包括在图像读取装置（100）和图像形成装置（D）中的根据本发明实施例的照明装置（210）包括光源部分（211a1），（211b1），（211a2）和（211b2），用于通过引导来自光源部的光而从沿长度方向（Y）延伸的细长发光面（M）照射照明对象物（G）的导光部件（213a）和（213b）（216a）和（216b），用于保持导光构件。保持构件包括用于可拆卸地保持导光构件的保持部分（2161a）和（2161b）以及反射从发光面（M）发出的光的倾斜部分（2162a）和（2162b），倾斜部分从在保持部的发光面（M）侧的前端，随着与导光部件的距离的增加而倾斜地变宽。

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