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11. 发明申请

US20120196849A1 COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS 审中-公开
标题翻译：化合物和组合物作为HEDGEHOG PATHWAY调制器
公开(公告)号：US20120196849A1
公开(公告)日：2012-08-02
申请号：US13443631
申请日：2012-04-10
申请人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
发明人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
IPC分类号： A61K31/553 , C07D295/26 , C07D295/155 , C07D401/14 , C07D401/04 , A61K31/5375 , A61K31/5377 , A61K31/551 , A61K31/55 , A61K31/496 , A61P1/18 , A61P13/08 , A61P35/00 , C12N5/09 , C07D413/04
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译：本发明提供了一种调节刺猬蛋白信号通路活性的方法。特别地，本发明提供了一种抑制由诸如Ptc功能丧失，hedgehog功能增益，平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法，包括使细胞接触与足量的式I化合物反应。

12. 发明申请

US20110003790A1 PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS 失效
标题翻译：吡咯烷[4,3-D]嘧啶酮衍生物作为激酶抑制剂
公开(公告)号：US20110003790A1
公开(公告)日：2011-01-06
申请号：US12865367
申请日：2009-01-27
申请人： Qiang Ding , Yahua Liu , Xu Wu , Qihui Jin , Jianwei Che , S. Frank Yan
发明人： Qiang Ding , Yahua Liu , Xu Wu , Qihui Jin , Jianwei Che , S. Frank Yan
IPC分类号： A61K31/519 , C07D213/75 , C07D471/04 , C07D498/04 , A61K31/397 , A61K31/5377 , A61K31/497 , A61K31/5383 , A61K31/551 , A61K31/541 , A61P11/08 , A61P11/00 , A61P11/02 , A61P17/00 , A61P17/06 , A61P29/00 , A61P25/00 , A61P35/00 , A61P31/18 , A61P37/02
CPC分类号： C07D471/04
摘要： The invention provides a class of compounds of Formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly Syk, ZAP70, KDR, FMS, FLT3, c-Kit, RET, TrkA, TrkB, TrkC, IGR-IR, AIk, c-FMS, or combinations thereof.
摘要翻译：本发明提供一类式（I）的化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调的激酶活性相关的疾病或病症的方法，特别是Syk，ZAP70，KDR，FMS，FLT3， c-Kit，RET，TrkA，TrkB，TrkC，IGR-IR，AIk，c-FMS或其组合。

13. 发明授权

US07832276B2 Pressure measuring device and method 有权
标题翻译：压力测量装置及方法
公开(公告)号：US07832276B2
公开(公告)日：2010-11-16
申请号：US12334584
申请日：2008-12-15
申请人： Xu Wu , Arthur Hartog , Dimitri Cadere , Tsutomu Yamate
发明人： Xu Wu , Arthur Hartog , Dimitri Cadere , Tsutomu Yamate
IPC分类号： G01F9/00
CPC分类号： G01L9/0079 , G01L9/0077
摘要： A device to measure a fluid pressure comprises a pressure sensing element 10 and a pressure readout element 20. The pressure sensing element 10 comprises a cavity 11 capped by a flexible membrane 13, the cavity having a length d that varies with the fluid pressure P1 applied on the flexible membrane 13. The pressure readout element 20 comprises a light source 24 for providing an incident beam of a determined wavelength range directed towards the cavity and an optical spectral analyzer 25 for measuring a power spectrum of a return beam reflected by the cavity, and processing means 27 for determining the cavity length d and the fluid pressure P1 based on the power spectrum.
摘要翻译：用于测量流体压力的装置包括压力感测元件10和压力读数元件20.压力感测元件10包括由柔性膜13封盖的空腔11，空腔具有随施加的流体压力P1而变化的长度d 压力读出元件20包括用于提供朝向空腔的确定的波长范围的入射光束的光源24和用于测量由空腔反射的返回光束的功率谱的光谱分析器25，以及用于基于功率谱确定腔长度d和流体压力P1的处理装置27。

14. 发明申请

US20090151423A1 PRESSURE MEASURING DEVICE AND METHOD 有权
标题翻译：压力测量装置和方法
公开(公告)号：US20090151423A1
公开(公告)日：2009-06-18
申请号：US12334584
申请日：2008-12-15
申请人： Xu Wu , Arthur Hartog , Dimitri Cadere , Tsutomu Yamate
发明人： Xu Wu , Arthur Hartog , Dimitri Cadere , Tsutomu Yamate
IPC分类号： G01L27/00 , E21B47/06 , G01B9/02 , G02B6/00 , G01L7/06 , G01K13/00
CPC分类号： G01L9/0079 , G01L9/0077
摘要： A device to measure a fluid pressure comprises a pressure sensing element 10 and a pressure readout element 20. The pressure sensing element 10 comprises a cavity 11 capped by a flexible membrane 13, the cavity having a length d that varies with the fluid pressure P1 applied on the flexible membrane 13. The pressure readout element 20 comprises a light source 24 for providing an incident beam of a determined wavelength range directed towards the cavity and an optical spectral analyzer 25 for measuring a power spectrum of a return beam reflected by the cavity, and processing means 27 for determining the cavity length d and the fluid pressure P1 based on the power spectrum.
摘要翻译：用于测量流体压力的装置包括压力感测元件10和压力读数元件20.压力感测元件10包括由柔性膜13封盖的空腔11，空腔具有随施加的流体压力P1而变化的长度d 压力读出元件20包括用于提供朝向空腔的确定的波长范围的入射光束的光源24和用于测量由空腔反射的返回光束的功率谱的光谱分析器25，以及用于基于功率谱确定腔长度d和流体压力P1的处理装置27。

15. 发明授权

US07075062B2 Apparatus and methods for downhole determination of characteristics of formation fluids 有权
公开(公告)号：US07075062B2
公开(公告)日：2006-07-11
申请号：US10013157
申请日：2001-12-10
申请人： Felix Chen , Gary Corris , Oliver Mullins , Xu Wu , John Fitzgerald , Anthony R. H. Goodwin
发明人： Felix Chen , Gary Corris , Oliver Mullins , Xu Wu , John Fitzgerald , Anthony R. H. Goodwin
IPC分类号： G01V5/08
CPC分类号： G01V5/12
摘要： An oil sample is subjected to nuclear electromagnetic irradiation downhole, and the electron and/or mass density of the oil sample is determined by measuring the attenuation of the irradiation and relating the attenuation to the electron density. If the irradiation is high energy gamma ray irradiation, the attenuation is considered to be a function of Compton scattering only, which in turn is related to the electron density of the sample. If X-rays are utilized, attenuation is preferably measured in two energy windows. Using the two different attenuation values found in the different windows, the attenuation due to Compton scattering can be found and related to the electron and/or mass density of the sample. In addition, attenuation due to photoelectric absorption may also be determined and related to the presence of one or more heavy elements in the oil (e.g., sulfur) and/or sanding.

16. 发明授权

US06268603B1 Method and apparatus for interpreting fluorescence logging data 有权
标题翻译：用于解释荧光测井数据的方法和装置
公开(公告)号：US06268603B1
公开(公告)日：2001-07-31
申请号：US09204447
申请日：1998-12-03
申请人： Oliver C. Mullins , Xu Wu , Charles Flaum
发明人： Oliver C. Mullins , Xu Wu , Charles Flaum
IPC分类号： G01V802
CPC分类号： G01V8/02 , E21B49/005
摘要： Methods and apparatuses for investigating formations surrounding a borehole involve acquiring a fluorescent signal over a portion of the borehole and analyzing the signal to detect the presence of crude oil. Analyzing the signal to detect the presence of crude oil may involve distinguishing mineral fluorescence from oil fluorescence. The signal may be analyzed further to distinguish characteristics of the crude oil, such as its grade (light, medium or heavy), and to indicate a physical property correlated with the fluorescence, such as the presence of laminations or formation permeability. In some embodiments, fluorescence signals from illuminating the portion of the borehole with at least two different wavelengths of light are analyzed.
摘要翻译：用于研究钻孔周围地层的方法和装置涉及在钻孔的一部分上获取荧光信号，并分析该信号以检测原油的存在。分析信号以检测原油的存在可能涉及区分矿物荧光和油荧光。可以进一步分析信号以区分原油的特性，例如其等级（轻，中等或重），并指示与荧光相关的物理性质，例如叠层或地层渗透性的存在。在一些实施例中，分析用至少两个不同波长的光照射钻孔部分的荧光信号。

17. 发明授权

US6140637A Method and apparatus for fluorescence logging 失效
标题翻译：用于荧光测井的方法和装置
公开(公告)号：US6140637A
公开(公告)日：2000-10-31
申请号：US445121
申请日：1995-05-19
申请人： Oliver C. Mullins , Xu Wu , Philip Rabbito
发明人： Oliver C. Mullins , Xu Wu , Philip Rabbito
IPC分类号： G01V8/02 , G01V5/04
CPC分类号： G01V8/02 , E21B47/0002
摘要： A method of locating in situ hydrocarbons in underground formations comprises illuminating the borehole wall with light such as visible, infrared or ultraviolet light or combinations of these, from a source in a tool such as a wireline logging tool or an LWD tool, detecting any fluorescent radiation with a detector in the tool and analyzing the florescent radiation to determine the presence of hydrocarbon in the formation. The tool is moved through the borehole while irradiating the formation and detecting fluorescence. The borehole wall is illuminated and fluorescence detected through a window in the tool which is pressed against the borehole wall with sufficient force to displace any mudcake. The window is made of a wear resistant material such sapphire or diamond and is conveniently secured in a wear resistant housing which might be made of tungsten carbide or the like.
摘要翻译：在地下地层中定位原位碳氢化合物的方法包括用诸如可见光，红外线或紫外光的光或这些的组合从诸如电缆测井工具或LWD工具的工具中的光源照射钻孔壁，检测任何荧光用工具中的检测器辐射辐射，并分析荧光辐射以确定地层中烃的存在。工具在照射地层并检测荧光的同时移动穿过井眼。钻孔壁被照亮并通过工具中的窗口检测到荧光，该窗口以足够的力压靠钻孔壁以移动任何泥饼。窗户由诸如蓝宝石或金刚石的耐磨材料制成，并且方便地固定在可由碳化钨等制成的耐磨外壳中。

18. 发明授权

US06075611A Methods and apparatus utilizing a derivative of a fluorescene signal for measuring the characteristics of a multiphase fluid flow in a hydrocarbon well 失效
标题翻译：利用荧光信号衍生物测量烃井中多相流体流动特性的方法和装置
公开(公告)号：US06075611A
公开(公告)日：2000-06-13
申请号：US74082
申请日：1998-05-07
申请人： Elizabeth B. Dussan V. , Xu Wu , Oliver C. Mullins , Richard Gaylor , Rogerio Tadeu Ramos , Kenneth Stephenson
发明人： Elizabeth B. Dussan V. , Xu Wu , Oliver C. Mullins , Richard Gaylor , Rogerio Tadeu Ramos , Kenneth Stephenson
IPC分类号： G01F1/708 , G01F1/74 , G01N21/64 , G01N21/85 , G01N21/00
CPC分类号： G01N21/85 , G01F1/7086 , G01F1/74 , G01N21/64
摘要： Single point optical probes for measuring three-phase characteristics of fluid flow in a hydrocarbon well and methods of processing signals generated by the probe are disclosed. A single fiber optic probe is coupled to a light source and apparatus for detecting reflectance and fluorescence. Light is delivered to the tip of the probe where it exits the probe and illuminates the liquid ambient the probe tip or is internally reflected in the probe when gas is located at the probe tip. If the fluid at the probe tip is oil, the light exits the probe, illuminates the oil, and causes the oil to fluoresce. According to one signal processing method of the invention, the reflectance signal is binarized at a threshold to provide a gas/liquid quasi-binary signal which changes over time. A time fraction of the signal values is used to calculate the gas holdup. According to other signal processing methods of the invention, the fluorescence indication signal is processed by taking its derivative (and if desired a second derivative) to determine the "corners" of the fluorescence signal over time. The derivative signal exhibits a positive and a negative peak which are separated by time. The time between the peaks is used to calculate oil holdup and the amplitude of one of the peaks is used to calculate the velocity of the oil drop.
摘要翻译：公开了用于测量烃井中流体流动的三相特性的单点光学探针以及由探针产生的处理信号的方法。单个光纤探针耦合到光源和用于检测反射率和荧光的装置。当气体位于探针尖端时，光被传送到探头的尖端，在那里它离开探针并照亮探测尖端的液体环境或内部反射在探针中。如果探针尖端处的液体是油，则光离开探头，照亮油，并引起油发荧光。根据本发明的一种信号处理方法，反射信号以阈值二值化，以提供随时间变化的气/液准二值信号。信号值的时间分数用于计算气体滞留量。根据本发明的其他信号处理方法，通过取其衍生物（并且如果需要，二阶导数）来处理荧光指示信号，以确定荧光信号随时间的“角”。导数信号表现出正时和负峰，它们被时间分离。峰值之间的时间用于计算油滞留量，其中一个峰值的振幅用于计算油滴的速度。

19. 发明授权

US5912459A Method and apparatus for fluorescence logging 失效
公开(公告)号：US5912459A
公开(公告)日：1999-06-15
申请号：US873849
申请日：1997-06-12
申请人： Oliver C. Mullins , Xu Wu , Philip Rabbito
发明人： Oliver C. Mullins , Xu Wu , Philip Rabbito
IPC分类号： G01V8/02
CPC分类号： G01V8/02 , E21B47/0002
摘要： A method of locating in situ hydrocarbons in underground formations comprises illuminating the borehole wall with light such as visible, infrared or ultraviolet light or combinations of these, from a source in a tool such as a wireline logging tool or an LWD tool, detecting any fluorescent radiation with a detector in the tool and analyzing the florescent radiation to determine the presence of hydrocarbon in the formation. The tool is moved through the borehole while irradiating the formation and detecting fluorescence. The borehole wall is illuminated and fluorescence detected through a window in the tool which is pressed against the borehole wall with sufficient force to displace any mudcake. The window is made of a wear resistant material such sapphire or diamond and is conveniently secured in a wear resistant housing which might be made of tungsten carbide or the like.

20. 发明授权

US5859430A Method and apparatus for the downhole compositional analysis of formation gases 失效
标题翻译：地层气体井下成分分析方法及装置
公开(公告)号：US5859430A
公开(公告)日：1999-01-12
申请号：US827647
申请日：1997-04-10
申请人： Oliver C. Mullins , Xu Wu
发明人： Oliver C. Mullins , Xu Wu
IPC分类号： E21B47/10 , E21B49/10 , G01N21/05 , G01N21/35 , G01N33/28 , G01N33/24
CPC分类号： E21B47/102 , E21B49/10 , G01N21/0303 , G01N21/05 , G01N21/359
摘要： A borehole tool analyzes the composition of gases flowing from a formation. The tool includes an optical fluid analyzer (OFA) and a gas analysis module (GAM). The OFA determines when fluid flowing into the tool has become substantially only gas. The gas is then diverted to the GAM, thereby avoiding the possibility of oil depositing itself on a optical window and interfering with a proper analysis. The GAM includes a near infrared ray light source, at least one photo-detector, a gas sample cell (or cells) having portions with different path lengths, each portion having an optical window, and fiber optics which direct light in first paths from the source to the sample cell, and from the sample cell to the photo-detectors. By providing cells with different path lengths, issues of dynamic range are obviated. The GAM also preferably includes a second optical path which goes directly from the light source to the photo-detectors and is used for canceling drift, and a third optical path which goes from the light source, through a known standard such as methane to the photo-detectors and is used for compensation of shifts in actual hydrocarbon peak locations or shifts in optical filter wavelengths. Analysis of the different hydrocarbon gas components of the gas stream is conducted by analysis of selected CH vibrational peaks in the 5700 cm.sup.-1 to 6100 cm.sup.-1 range.
摘要翻译：井眼工具分析了从地层流出的气体的组成。该工具包括光学流体分析仪（OFA）和气体分析模块（GAM）。 OFA确定流入工具的流体何时已经变得基本上只有气体。然后将气体转移到GAM，从而避免了将油自身沉积在光学窗口上并干扰适当分析的可能性。 GAM包括近红外线光源，至少一个光检测器，具有不同路径长度的部分的气体样品池（或电池），每个部分都具有光学窗口，以及光纤，其将来自第一路径的光引导来源于样品池，以及从样品池到光电探测器。通过为单元提供不同的路径长度，可以避免动态范围的问题。 GAM还优选地包括直接从光源到光电检测器并且用于抵消漂移的第二光路和从光源通过已知标准例如甲烷到照片的第三光路用于补偿实际碳氢化合物峰值位置的偏移或光学滤波器波长的偏移。通过分析5700cm-1至6100cm -1范围内选择的CH振动峰，分析气流的不同烃气体成分。

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