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    • 11. 发明授权
    • System and method for determining optimal atrioventricular delay based on intrinsic conduction delays
    • 基于内在传导延迟确定最佳房室延迟的系统和方法
    • US07248925B2
    • 2007-07-24
    • US10928586
    • 2004-08-27
    • Ken BruhnsXiaoyi MinPaul A. LevineEuljoon Park
    • Ken BruhnsXiaoyi MinPaul A. LevineEuljoon Park
    • A61N1/36
    • A61N1/3627A61N1/3682
    • A system and method for estimating optimal atrioventricular delay values for use in pacing the ventricles. Both the intrinsic inter-atrial conduction delay and the intrinsic atrioventricular conduction delay are determined for the patient and then the preferred atrioventricular pacing delay is derived therefrom. By taking into account intrinsic inter-atrial delay along with intrinsic atrioventricular delay, a more reliable estimate of the true optimal atrioventricular delay values for the patient can be achieved than with techniques that only take into account intrinsic atrioventricular delay values. In one example, the technique uses intracardiac electrogram (IEGM) signals and surface electrocardiogram (EKG) signals and hence can be performed by an external programmer without requiring Doppler echocardiography or other cardiac performance monitoring techniques. In another example, wherein the implanted device is equipped with a coronary sinus lead, the technique uses only IEGM signals and hence can be performed by the device itself.
    • 用于估计用于起搏心室的最佳房室延迟值的系统和方法。 对于患者确定内在的心房传导延迟和内在的房室传导延迟,然后从其导出优选的房室起搏延迟。 通过考虑内在的心房延迟以及内在的房室延迟,可以实现比仅考虑内在房室延迟值的技术更可靠的估计患者的真正最佳房室延迟值。 在一个示例中,该技术使用心内电描记图(IEGM)信号和表面心电图(EKG)信号,因此可以由外部编程器执行,而不需要多普勒超声心动图或其他心脏监测技术。 在另一示例中,其中植入的装置配备有冠状窦引线,该技术仅使用IEGM信号,因此可以由装置本身执行。
    • 12. 发明授权
    • Systems and methods for assessing heart failure and controlling cardiac resynchronization therapy using hybrid impedance measurement configurations
    • 用于评估心力衰竭并使用混合阻抗测量配置控制心脏再同步治疗的系统和方法
    • US08750981B2
    • 2014-06-10
    • US13217554
    • 2011-08-25
    • Gene A. BornzinXiaoyi MinLaurence S. SlomanSteve Koh
    • Gene A. BornzinXiaoyi MinLaurence S. SlomanSteve Koh
    • A61B5/05A61B5/053A61N1/36A61N1/368A61B5/0205
    • A61B5/053A61B5/0205A61B5/0538A61B5/686A61N1/36185A61N1/3627A61N1/3686
    • Techniques are provided for use with an implantable medical device for detecting and assessing heart failure and for controlling cardiac resynchronization therapy (CRT) based on impedance signals obtained using hybrid impedance configurations. The hybrid configurations exploit right atrial (RA)-based impedance measurement vectors and/or left ventricular (LV)-based impedance measurement vectors. In one example, current is injected between the device case and a ring electrode in the right ventricle (RV) or RA. RA-based impedance values are measured along vectors between the device case and an RA electrode. LV-based impedance values are measured along vectors between the device case and one or more electrodes of the LV. Heart failure and other cardiac conditions are detected and tracked using the measured impedance values. CRT delay parameters are also optimized based impedance. In this manner, multiple hybrid impedance measurement configurations are exploited whereby different vectors are used to inject current and measure impedance.
    • 提供技术用于可植入医疗装置,用于基于使用混合阻抗配置获得的阻抗信号来检测和评估心力衰竭并用于控制心脏再同步治疗(CRT)。 混合配置利用基于右心房(RA)的阻抗测量向量和/或左心室(LV))的阻抗测量向量。 在一个示例中,电流注入到装置壳体和右心室(RV)或RA中的环形电极之间。 基于RA的阻抗值是沿器件壳体和RA电极之间的矢量测量的。 基于LV的阻抗值在器件壳体和LV的一个或多个电极之间的矢量上测量。 使用测量的阻抗值检测和跟踪心力衰竭和其他心脏状况。 CRT延迟参数也是基于阻抗的优化。 以这种方式,利用多个混合阻抗测量配置,由此使用不同的矢量来注入电流并测量阻抗。
    • 19. 发明授权
    • Systems and methods for optimizing ventricular pacing delays for use with multi-pole leads
    • 用于优化与多极引线一起使用的心室起搏延迟的系统和方法
    • US08265755B2
    • 2012-09-11
    • US12507646
    • 2009-07-22
    • Xiaoyi Min
    • Xiaoyi Min
    • A61N1/00
    • A61N1/368A61N1/3684
    • Techniques are provided for use by implantable medical devices for controlling ventricular pacing using a multi-pole left ventricular (LV) lead. In one example, a single “V sense” test is performed to determine intrinsic interventricular conduction time delays (Δn) between the RV electrode and each of the LV electrodes of the multi-pole lead. Likewise, a single “RV pace” test is performed to determine paced interventricular conduction time delays (IVCD_RLn) between the RV electrode and each of the LV electrodes. A set of “LV pace” tests is then performed to determine paced interventricular conduction time delays (IVCD_LRn) between individual LV electrodes and the RV electrode. Optimal or preferred interventricular pacing delays are determined using the intrinsic interventricular conduction delay (Δn) values and a set of interventricular correction terms (εn) determined from the results of the RV pace test and the set of LV pace tests. With these techniques, overall test time can be reduced.
    • 提供技术用于可植入医疗装置,以使用多极左心室(LV)引线来控制心室起搏。 在一个示例中,执行单个“V感测”测试以确定RV电极与多极引线的每个LV电极之间的本征心室传导时间延迟(&Dgr; n)。 同样地,执行单个“RV步调”测试以确定RV电极和每个LV电极之间的节奏间心室传导时间延迟(IVCD_RLn)。 然后执行一组“LV步调”测试,以确定各个LV电极和RV电极之间的节奏间心室传导时间延迟(IVCD_LRn)。 最佳或优选的室间起搏延迟是使用从RV步速测试和一组LV步速测试结果确定的内在室间传导延迟(&Dgr; n)值和一组心室内校正术语(&egr; n)确定的。 通过这些技术,可以减少总体测试时间。