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11. 发明授权

US08834839B2 Labeled molecular imaging agents, methods of making and methods of use 有权
标题翻译：标记分子成像剂，制备方法和使用方法
公开(公告)号：US08834839B2
公开(公告)日：2014-09-16
申请号：US12430573
申请日：2009-04-27
申请人： Paul Schaffer , Brian Duh-Lan Lee , Kande Kankanamalage Dayarathna Amarasinghe , Faisal Ahmed Syud , Rong Zhang , Jack Mathew Webster , Jennifer Lynne Huntington
发明人： Paul Schaffer , Brian Duh-Lan Lee , Kande Kankanamalage Dayarathna Amarasinghe , Faisal Ahmed Syud , Rong Zhang , Jack Mathew Webster , Jennifer Lynne Huntington
IPC分类号： A61K51/04 , C07C323/59 , C07B59/00 , A61K49/00 , C07C323/58 , C07F5/02
CPC分类号： A61K51/0406 , A61K49/0019 , A61K49/0052 , C07B59/001 , C07B2200/05 , C07C323/58 , C07C323/59 , C07F5/022
摘要： Imaging agents that comprise labeled substrates of the cystine/glutamate antiporter of cells, whereby the methods of use comprise introducing the labeled agents into cells via the cystine/glutamate antiporter, which are then reduced to a labeled cysteine, and subsequently detected in the cell.
摘要翻译：包含细胞的胱氨酸/谷氨酸反转录酶的标记底物的成像剂，其中使用的方法包括将经标记的试剂通过胱氨酸/谷氨酸反转运体引入细胞，然后将其还原成标记的半胱氨酸，随后在细胞中检测。

12. 发明授权

US08765977B2 Hydroxylated contrast enhancement agents and imaging method 有权
标题翻译：羟基化对比增强剂和成像方法
公开(公告)号：US08765977B2
公开(公告)日：2014-07-01
申请号：US13077746
申请日：2011-03-31
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang , Jeannette Christine Roberts
IPC分类号： C07D319/08 , C07D309/30
CPC分类号： A61K49/103
摘要： A method of diagnostic imaging is disclosed comprising administering a medical formulation to a subject, the formulation comprising a contrast enhancement agent having structure I and salts thereof wherein R1 is independently at each occurrence a hydroxy group, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R2-R7 are independently at each occurrence hydrogen, a C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R1-R7 is a hydroxy group or a C1-C3 hydroxyalkyl group; and wherein Q is one or more charge balancing counterions; and one or more pharmaceutically acceptable carriers and excipients. The subject is subjected to a diagnostic imaging technique such as magnetic resonance imaging. The technique may be used in a variety of diagnostic imaging regimes, such as imaging of circulatory systems, genitourinary systems, hepatobiliary systems, central nervous systems, tumors, and abscesses among others.
摘要翻译：公开了一种诊断成像方法，其包括向受试者施用药物制剂，所述制剂包含具有结构I的对比增强剂及其盐，其中R1在每次出现时独立地为羟基，C1-C3羟烷基或C1 -C 3烷基，b为0-4; R2-R7各自独立地为氢，C1-C3羟基烷基或C1-C3烷基，条件是R1-R7中的至少一个为羟基或C1-C3羟烷基; 并且其中Q是一个或多个电荷平衡抗衡离子; 和一种或多种药学上可接受的载体和赋形剂。对受试者进行诸如磁共振成像的诊断成像技术。该技术可用于各种诊断成像方案，例如循环系统的成像，泌尿生殖系统，肝胆系统，中枢神经系统，肿瘤和脓肿等。

13. 发明授权

US08658129B2 Agents and methods for the imaging of myelin basic protein 有权
标题翻译：髓鞘碱性蛋白成像的试剂和方法
公开(公告)号：US08658129B2
公开(公告)日：2014-02-25
申请号：US13031349
申请日：2011-02-21
申请人： Rong Zhang , Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Victoria Eugenia Cotero , Bruce Fletcher Johnson
发明人： Rong Zhang , Tiberiu Mircea Siclovan , Cristina Abucay Tan Hehir , Victoria Eugenia Cotero , Bruce Fletcher Johnson
IPC分类号： A61K49/00 , A61K49/10 , A61K51/04 , A61K101/02 , A61B5/00 , A61B5/055
CPC分类号： A61K49/10 , A61K51/04
摘要： The present invention relates to agents capable of binding to myelin basic protein in a subject. Also provided are methods for the detection of myelin-associated neuropathy comprising identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, administering to a subject an agent that binds specifically to myelin basic protein, and determining myelination in the subject by detecting the agent present in the subject. A kit containing the agent or its derivatives for use in detecting myelin basic protein is also provided.
摘要翻译：本发明涉及能够与受试者中的髓磷脂碱性蛋白结合的试剂。还提供了用于检测髓鞘相关神经病变的方法，其包括鉴定处于或伴有髓磷脂相关神经病的风险的受试者，向受试者施用特异性结合髓磷脂碱性蛋白的试剂，以及通过检测来测定受试者的髓鞘形成该主体中存在的代理人。还提供了含有用于检测髓磷脂碱性蛋白质的试剂或其衍生物的试剂盒。

14. 发明授权

US08420407B2 Growth method of Fe3N material 有权
标题翻译： Fe3N材料的生长方法
公开(公告)号：US08420407B2
公开(公告)日：2013-04-16
申请号：US12772508
申请日：2010-05-03
申请人： Rong Zhang , Zili Xie , Bin Liu , Xiangqian Xiu , Henan Fang , Hong Zhao , Xuemei Hua , Ping Han , Peng Chen , Youdou Zheng
发明人： Rong Zhang , Zili Xie , Bin Liu , Xiangqian Xiu , Henan Fang , Hong Zhao , Xuemei Hua , Ping Han , Peng Chen , Youdou Zheng
IPC分类号： H01L21/00 , H01L21/469 , H01L21/8246
CPC分类号： C23C16/0272 , C23C16/34 , C30B25/02 , C30B29/38 , H01L21/0242 , H01L21/02458 , H01L21/02502 , H01L21/0262
摘要： A kind of growth method of Fe3Nin the MOCVD system, comprising following process: 1) make the surface nitridation of sapphire substrate; 2) pump in carrier gas N2, ammonia and organic gallium sources, and grow low temperature GaN buffer on substrate; 3) raise temperature and grow the GaN supporting layer; 4) pump in FeCp2 as Fe sources, then grow Fe3N on the GaN supporting layer; the Fe3N granular films and the Fe3N single crystal films are obtained.
摘要翻译： MOCVD系统中Fe3N的一种生长方法，包括以下过程：1）使蓝宝石衬底的表面氮化; 2）在载气N2，氨和有机镓源中泵送，并在衬底上生长低温GaN缓冲液; 3）升高温度并生长GaN支撑层; 4）将FeCp2泵作为Fe源，然后在GaN支撑层上生长Fe3N; 得到Fe 3 N粒状膜和Fe 3 N单晶膜。

15. 发明授权

US08238757B2 Method and apparatus for generating optical duobinary signals with enhanced receiver sensitivity and spectral efficiency 有权
标题翻译： ODB发射机具有具有降低的中间光学水平的交错分数位延迟的三电平光双二进制信号
公开(公告)号：US08238757B2
公开(公告)日：2012-08-07
申请号：US11865508
申请日：2007-10-01
申请人： Yu Sheng Bai , Yanjun Zhu , Rong Zhang , Jizhong Liu , Jian Deng
发明人： Yu Sheng Bai , Yanjun Zhu , Rong Zhang , Jizhong Liu , Jian Deng
IPC分类号： H04B10/04
CPC分类号： H04B10/505 , H04B10/5167
摘要： An optical network transmitter comprising a fractional-bit delay module, an optical modulator coupled to the fractional-bit delay module, and a band-limiting optical filter coupled to the optical modulator. Also disclosed is a transmission system comprising a source configured to generate two complementary binary data streams, a fractional-bit delay module in communication with the source and configured to delay one of the complementary binary data streams, a modulation module in communication with the source and the fractional-bit delay module and configured to convert the undelayed complementary binary data streams and the delayed complementary binary data streams into a fractional-bit delayed optical duobinary signal, and a band-limiting node in communication with the modulation module and configured to filter and transmit the optical duobinary signal.
摘要翻译：一种光网络发射机，包括分数位延迟模块，耦合到分数位延迟模块的光调制器和耦合到光调制器的带限滤波器。还公开了一种传输系统，包括被配置为产生两个互补二进制数据流的源，与源通信的分数位延迟模块，并且被配置为延迟互补二进制数据流之一，与源通信的调制模块，所述分数位延迟模块并且被配置为将未延迟的互补二进制数据流和延迟的互补二进制数据流转换成分数位延迟的光双二进制信号，以及与调制模块通信的频带限制节点，并且被配置为过滤和传输光学双二进制信号。

16. 发明申请

US20120165650A1 HER2 BINDERS 审中-公开
公开(公告)号：US20120165650A1
公开(公告)日：2012-06-28
申请号：US12975425
申请日：2010-12-22
申请人： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Eriksson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
发明人： Faisal Ahmed Syud , Brian Duh-Lan Lee , Rong Zhang , Peter Brian Iveson , Paul Schaffer , Tove Eriksson , Elin Gunneriusson , Fredrik Frejd , Lars Abrahmsen , Joachim Feldwisch , Nina Herne , Christofer Lendel
IPC分类号： A61B5/055 , A61K49/00 , C07K14/00
CPC分类号： A61K51/088 , C07K14/71
摘要： Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
摘要翻译：包含与放射性核素和螯合剂缀合的分离的多肽的成像剂; 其中所述分离的多肽特异性结合HER2或其变体; 以及制备和使用这些成像剂的方法。

17. 发明申请

US20120127270A1 DEPTH ESTIMATION BASED ON GLOBAL MOTION 有权
标题翻译：基于全球运动的深度估计
公开(公告)号：US20120127270A1
公开(公告)日：2012-05-24
申请号：US13301225
申请日：2011-11-21
申请人： Rong Zhang , Ying Chen , Marta Karczewicz
发明人： Rong Zhang , Ying Chen , Marta Karczewicz
IPC分类号： H04N13/00
CPC分类号： G06T7/0071 , G06T7/579
摘要： This disclosure describes techniques for estimating a depth of image objects for a two-dimensional (2D) view of a video presentation. For example, a plurality of feature points may be determined for a 2D view. The plurality of feature points may be used to estimate global motion, e.g., motion of an observer (e.g., camera), of the 2D view. For example, the plurality of feature points may be used to generate a global motion frame difference. The global motion frame difference may be used to create a depth map for the 2D view, which may be used to generate an alternative view of the video presentation that may be used to display a three-dimensional (3D) video presentation.
摘要翻译：本公开描述了用于估计视频呈现的二维（2D）视图的图像对象的深度的技术。例如，可以为2D视图确定多个特征点。多个特征点可以用于估计2D视图的全局运动，例如观察者（例如，照相机）的运动。例如，可以使用多个特征点来产生全局运动帧差。全局运动帧差可以用于创建2D视图的深度图，其可以用于生成可用于显示三维（3D）视频呈现的视频呈现的替代视图。

18. 发明申请

US20110245511A1 Intermediates for Hydroxylated Contrast Enhancement Agents 有权
标题翻译：羟基对比增强剂中间体
公开(公告)号：US20110245511A1
公开(公告)日：2011-10-06
申请号：US12751286
申请日：2010-03-31
申请人： Brian James Grimmond , Michael James Rishel , Rong Zhang
发明人： Brian James Grimmond , Michael James Rishel , Rong Zhang
IPC分类号： C07F9/40 , C07F7/10 , C07F9/38 , C07F7/18
CPC分类号： C07F9/091 , C07F9/4006 , C07F9/65522 , Y02P20/55
摘要： In one aspect, the present invention provides a protected ligand precursor having structure XX wherein R8 is independently at each occurrence a protected hydroxy group, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, and b is 0-4; R9-R11 are independently at each occurrence hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group, with the proviso that at least one of R8-R11 is a protected hydroxy group or a protected C1-C3 hydroxyalkyl group; and R12 and R13 are independently at each occurrence a protecting group is selected from the group consisting of C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, and C2-C30 aromatic radicals.
摘要翻译：一方面，本发明提供具有结构XX的保护配体前体，其中R8在每次出现时独立地为保护的羟基，受保护的C1-C3羟烷基或C1-C3烷基，b为0-4; R 9 -R 11在每次出现时独立地为氢，被保护的C 1 -C 3羟基烷基或C 1 -C 3烷基，条件是R 8 -R 11中的至少一个为被保护的羟基或被保护的C 1 -C 3羟烷基 ; 并且R 12和R 13在每次出现时独立地为保护基团，选自C 1 -C 30脂族基，C 3 -C 30环脂族基和C 2 -C 30芳族基。

19. 发明授权

US07989216B2 Two helix binders 有权
标题翻译：两个螺旋粘合剂
公开(公告)号：US07989216B2
公开(公告)日：2011-08-02
申请号：US12337948
申请日：2008-12-18
申请人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
发明人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
IPC分类号： A61K38/00 , G01N33/53 , G01N33/574
CPC分类号： C07K14/31
摘要： An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of different natural amino acid mutations in the polypeptide are provided here. Also provided are methods of using the two-helix binders.
摘要翻译：衍生自葡萄球菌蛋白A的B结构域的分离的多肽Z结构域，其包含能够结合靶的一对反平行α螺旋。在此提供了多肽中不同天然氨基酸突变的引入。还提供了使用双螺旋粘合剂的方法。

20. 发明授权

US07977118B2 Two helix binders 有权
标题翻译：两个螺旋粘合剂
公开(公告)号：US07977118B2
公开(公告)日：2011-07-12
申请号：US12337945
申请日：2008-12-18
申请人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
发明人： Rong Zhang , Faisal Ahmed Syud , Jack Mathew Webster
IPC分类号： G01N33/566 , C07K14/00
CPC分类号： C07K14/31
摘要： An isolated polypeptide, Z domain, derived from B domain of Staphylococcal protein A, comprising a pair of anti-parallel alpha helices that are capable of binding a target, is provided herein. Introduction of an un-natural amino acid in the polypeptide is provided here. Also provided are methods of using the two-helix binders.
摘要翻译：衍生自葡萄球菌蛋白A的B结构域的分离的多肽Z结构域，其包含能够结合靶的一对反平行α螺旋。在此提供了多肽中非天然氨基酸的引入。还提供了使用双螺旋粘合剂的方法。

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